- Wang, Chong;
- Tan, Lan;
- Wang, Hui-Fu;
- Yu, Wan-Jiang;
- Liu, Ying;
- Jiang, Teng;
- Tan, Meng-Shan;
- Hao, Xiao-Ke;
- Zhang, Dao-Qiang;
- Yu, Jin-Tai
- Editor(s): Nacmias, Benedetta
The phospholipase D3 (PLD3) gene has shown association with Alzheimer's disease (AD). However, the role of PLD3 common variants in amyloid-β (Aβ) pathology remains unclear. We examined the association of thirteen common single nucleotide polymorphisms (SNPs) with cerebrospinal fluid (CSF) Aβ(1- 42) levels and florbetapir retention on florbetapir 18F amyloid positron emission tomography (AV45-PET) in a large population. We found that one SNP (rs11667768) was significantly associated with CSF Aβ(1- 42) levels in the normal cognition group. We did not observe an association of any SNP with florbetapir retention. Our study predicted the potential role of PLD3 variants in Aβ pathology.