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Scholarly Works (4 results)
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Article
2301
Johnson, Connor
Contemporary Music Score Collection
(2020)
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
Article
Three Strands
Johnson, Connor
Contemporary Music Score Collection
(2020)
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
Article
( [shift-9]
Johnson, Connor
Contemporary Music Score Collection
(2020)
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
Article
Peer Reviewed
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome
Parry, Erin M
;
Leshchiner, Ignaty
;
Guièze, Romain
;
Johnson, Connor
;
Tausch, Eugen
;
Parikh, Sameer A
;
Lemvigh, Camilla
;
Broséus, Julien
;
Hergalant, Sébastien
;
Messer, Conor
;
Utro, Filippo
;
Levovitz, Chaya
;
Rhrissorrakrai, Kahn
;
Li, Liang
;
Rosebrock, Daniel
;
Yin, Shanye
;
Deng, Stephanie
;
Slowik, Kara
;
Jacobs, Raquel
;
Huang, Teddy
;
Li, Shuqiang
;
Fell, Geoff
;
Redd, Robert
;
Lin, Ziao
;
Knisbacher, Binyamin A
;
Livitz, Dimitri
;
Schneider, Christof
;
Ruthen, Neil
;
Elagina, Liudmila
;
Taylor-Weiner, Amaro
;
Persaud, Bria
;
Martinez, Aina
;
Fernandes, Stacey M
;
Purroy, Noelia
;
Anandappa, Annabelle J
;
Ma, Jialin
;
Hess, Julian
;
Rassenti, Laura Z
;
Kipps, Thomas J
;
Jain, Nitin
;
Wierda, William
;
Cymbalista, Florence
;
Feugier, Pierre
;
Kay, Neil E
;
Livak, Kenneth J
;
Danysh, Brian P
;
Stewart, Chip
;
Neuberg, Donna
;
Davids, Matthew S
;
Brown, Jennifer R
;
Parida, Laxmi
;
Stilgenbauer, Stephan
;
Getz, Gad
;
Wu, Catherine J
UC San Diego Previously Published Works
(2023)
Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we computationally deconvoluted admixtures of CLL and RS cells from 52 patients with RS, evaluating paired CLL-RS whole-exome sequencing data. We discovered RS-specific somatic driver mutations (including IRF2BP2, SRSF1, B2M, DNMT3A and CCND3), recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which were confirmed in 45 independent RS cases and in an external set of RS whole genomes. Through unsupervised clustering, clonally related RS was largely distinct from diffuse large B cell lymphoma. We distinguished pathways that were dysregulated in RS versus CLL, and detected clonal evolution of transformation at single-cell resolution, identifying intermediate cell states. Our study defines distinct molecular subtypes of RS and highlights cell-free DNA analysis as a potential tool for early diagnosis and monitoring.
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