- Main
Synthetic studies towards the total synthesis of norzoanthamine
Abstract
The work presented herein is the conclusion of synthetic studies toward the total synthesis of norzoanthamine. This dissertation on the norzoanthamine synthetic studies will be divided into 3 sections: (1) an introduction describing the norzoanthamine family along with their biological significance and previous studies; (2) a stereoselective synthesis of the ABC ring system, and the crucial development of the fully functionalized C ring; (3) a biomimetic approach towards norzoanthamine; which will discuss studies to create the C ring from a polyene system through a Diels-Alder reaction, studies to synthesize the A ring through a sigmatropic rearrangement, studies to generate the BC ring through an intramolecular Diels-Alder reaction from carvone as a chiral pool, development of isocarvone, and studies of 2-acylamino 1,3 dienes as a viable synthon to form the BC ring through a [4+2] cycloaddition reaction
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-