- Main
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice
- Townsend, Elizabeth C;
- Murakami, Mark A;
- Christodoulou, Alexandra;
- Christie, Amanda L;
- Köster, Johannes;
- DeSouza, Tiffany A;
- Morgan, Elizabeth A;
- Kallgren, Scott P;
- Liu, Huiyun;
- Wu, Shuo-Chieh;
- Plana, Olivia;
- Montero, Joan;
- Stevenson, Kristen E;
- Rao, Prakash;
- Vadhi, Raga;
- Andreeff, Michael;
- Armand, Philippe;
- Ballen, Karen K;
- Barzaghi-Rinaudo, Patrizia;
- Cahill, Sarah;
- Clark, Rachael A;
- Cooke, Vesselina G;
- Davids, Matthew S;
- DeAngelo, Daniel J;
- Dorfman, David M;
- Eaton, Hilary;
- Ebert, Benjamin L;
- Etchin, Julia;
- Firestone, Brant;
- Fisher, David C;
- Freedman, Arnold S;
- Galinsky, Ilene A;
- Gao, Hui;
- Garcia, Jacqueline S;
- Garnache-Ottou, Francine;
- Graubert, Timothy A;
- Gutierrez, Alejandro;
- Halilovic, Ensar;
- Harris, Marian H;
- Herbert, Zachary T;
- Horwitz, Steven M;
- Inghirami, Giorgio;
- Intlekofer, Andrew M;
- Ito, Moriko;
- Izraeli, Shai;
- Jacobsen, Eric D;
- Jacobson, Caron A;
- Jeay, Sébastien;
- Jeremias, Irmela;
- Kelliher, Michelle A;
- Koch, Raphael;
- Konopleva, Marina;
- Kopp, Nadja;
- Kornblau, Steven M;
- Kung, Andrew L;
- Kupper, Thomas S;
- LeBoeuf, Nicole R;
- LaCasce, Ann S;
- Lees, Emma;
- Li, Loretta S;
- Look, A Thomas;
- Murakami, Masato;
- Muschen, Markus;
- Neuberg, Donna;
- Ng, Samuel Y;
- Odejide, Oreofe O;
- Orkin, Stuart H;
- Paquette, Rachel R;
- Place, Andrew E;
- Roderick, Justine E;
- Ryan, Jeremy A;
- Sallan, Stephen E;
- Shoji, Brent;
- Silverman, Lewis B;
- Soiffer, Robert J;
- Steensma, David P;
- Stegmaier, Kimberly;
- Stone, Richard M;
- Tamburini, Jerome;
- Thorner, Aaron R;
- van Hummelen, Paul;
- Wadleigh, Martha;
- Wiesmann, Marion;
- Weng, Andrew P;
- Wuerthner, Jens U;
- Williams, David A;
- Wollison, Bruce M;
- Lane, Andrew A;
- Letai, Anthony;
- Bertagnolli, Monica M;
- Ritz, Jerome;
- Brown, Myles;
- Long, Henry;
- Aster, Jon C;
- Shipp, Margaret A;
- Griffin, James D;
- Weinstock, David M
- et al.
Published Web Location
https://doi.org/10.1016/j.ccell.2016.03.008Abstract
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-