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Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014.
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330837/No data is associated with this publication.
Abstract
Background and purpose
Slow recruitment in acute stroke trials hampers the evaluation of new therapies and delays the adoption of effective therapies into clinical practice. This systematic review evaluates whether recruitment efficiency and rates have increased in acute stroke trials from 1990 to 2014.Methods
Acute stroke trials from 2010 to 2014 were identified by a search of PubMed, Medline, the Cochrane Database of Research in Stroke, and the Stroke Trials Registry. These trials were compared to a previously published data set of trials conducted from 1990 to 2004.Results
The median recruitment efficiency of trials from 1990 to 2004 was 0.41 participants/site/month compared with 0.26 participants/site/month from 2010 to 2014 (P=0.14). The median recruitment rate of trials from 1990 to 2004 was 26.8 participants/month compared with 19.0 participants/month from 2010 to 2014 (P=0.13).Conclusions
For acute stroke trials, neither recruitment efficiency nor recruitment rates have increased over the past 25 years and, if anything, have declined.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.