- Main
Daily energy expenditure through the human life course
- Pontzer, Herman;
- Yamada, Yosuke;
- Sagayama, Hiroyuki;
- Ainslie, Philip N;
- Andersen, Lene F;
- Anderson, Liam J;
- Arab, Lenore;
- Baddou, Issaad;
- Bedu-Addo, Kweku;
- Blaak, Ellen E;
- Blanc, Stephane;
- Bonomi, Alberto G;
- Bouten, Carlijn VC;
- Bovet, Pascal;
- Buchowski, Maciej S;
- Butte, Nancy F;
- Camps, Stefan G;
- Close, Graeme L;
- Cooper, Jamie A;
- Cooper, Richard;
- Das, Sai Krupa;
- Dugas, Lara R;
- Ekelund, Ulf;
- Entringer, Sonja;
- Forrester, Terrence;
- Fudge, Barry W;
- Goris, Annelies H;
- Gurven, Michael;
- Hambly, Catherine;
- Hamdouchi, Asmaa El;
- Hoos, Marjije B;
- Hu, Sumei;
- Joonas, Noorjehan;
- Joosen, Annemiek M;
- Katzmarzyk, Peter;
- Kempen, Kitty P;
- Kimura, Misaka;
- Kraus, William E;
- Kushner, Robert F;
- Lambert, Estelle V;
- Leonard, William R;
- Lessan, Nader;
- Martin, Corby;
- Medin, Anine C;
- Meijer, Erwin P;
- Morehen, James C;
- Morton, James P;
- Neuhouser, Marian L;
- Nicklas, Teresa A;
- Ojiambo, Robert M;
- Pietiläinen, Kirsi H;
- Pitsiladis, Yannis P;
- Plange-Rhule, Jacob;
- Plasqui, Guy;
- Prentice, Ross L;
- Rabinovich, Roberto A;
- Racette, Susan B;
- Raichlen, David A;
- Ravussin, Eric;
- Reynolds, Rebecca M;
- Roberts, Susan B;
- Schuit, Albertine J;
- Sjödin, Anders M;
- Stice, Eric;
- Urlacher, Samuel S;
- Valenti, Giulio;
- Van Etten, Ludo M;
- Van Mil, Edgar A;
- Wells, Jonathan CK;
- Wilson, George;
- Wood, Brian M;
- Yanovski, Jack;
- Yoshida, Tsukasa;
- Zhang, Xueying;
- Murphy-Alford, Alexia J;
- Loechl, Cornelia;
- Luke, Amy H;
- Rood, Jennifer;
- Schoeller, Dale A;
- Westerterp, Klaas R;
- Wong, William W;
- Speakman, John R;
- Consortium§, IAEA DLW Database
- et al.
Published Web Location
https://doi.org/10.1126/science.abe5017Abstract
Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
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