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Sending Mixed Messages for Cell Population Control
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https://doi.org/10.1016/j.cell.2014.08.013Abstract
Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.
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