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Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation
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https://doi.org/10.1534/genetics.114.170241Abstract
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
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