- Main
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
- Robertson, A Gordon;
- Kim, Jaegil;
- Al-Ahmadie, Hikmat;
- Bellmunt, Joaquim;
- Guo, Guangwu;
- Cherniack, Andrew D;
- Hinoue, Toshinori;
- Laird, Peter W;
- Hoadley, Katherine A;
- Akbani, Rehan;
- Castro, Mauro AA;
- Gibb, Ewan A;
- Kanchi, Rupa S;
- Gordenin, Dmitry A;
- Shukla, Sachet A;
- Sanchez-Vega, Francisco;
- Hansel, Donna E;
- Czerniak, Bogdan A;
- Reuter, Victor E;
- Su, Xiaoping;
- de Sa Carvalho, Benilton;
- Chagas, Vinicius S;
- Mungall, Karen L;
- Sadeghi, Sara;
- Pedamallu, Chandra Sekhar;
- Lu, Yiling;
- Klimczak, Leszek J;
- Zhang, Jiexin;
- Choo, Caleb;
- Ojesina, Akinyemi I;
- Bullman, Susan;
- Leraas, Kristen M;
- Lichtenberg, Tara M;
- Wu, Catherine J;
- Schultz, Nicholaus;
- Getz, Gad;
- Meyerson, Matthew;
- Mills, Gordon B;
- McConkey, David J;
- Network, TCGA Research;
- Akbani, Rehan;
- Al-Ahmadie, Hikmat;
- Albert, Monique;
- Alexopoulou, Iakovina;
- Ally, Adrian;
- Antic, Tatjana;
- Aron, Manju;
- Balasundaram, Miruna;
- Bartlett, John;
- Baylin, Stephen B;
- Beaver, Allison;
- Bellmunt, Joaquim;
- Birol, Inanc;
- Boice, Lori;
- Bootwalla, Moiz S;
- Bowen, Jay;
- Bowlby, Reanne;
- Brooks, Denise;
- Broom, Bradley M;
- Bshara, Wiam;
- Bullman, Susan;
- Burks, Eric;
- Cárcano, Flavio M;
- Carlsen, Rebecca;
- Carvalho, Benilton S;
- Carvalho, Andre L;
- Castle, Eric P;
- Castro, Mauro AA;
- Castro, Patricia;
- Catto, James W;
- Chagas, Vinicius S;
- Cherniack, Andrew D;
- Chesla, David W;
- Choo, Caleb;
- Chuah, Eric;
- Chudamani, Sudha;
- Cortessis, Victoria K;
- Cottingham, Sandra L;
- Crain, Daniel;
- Curley, Erin;
- Czerniak, Bogdan A;
- Daneshmand, Siamak;
- Demchok, John A;
- Dhalla, Noreen;
- Djaladat, Hooman;
- Eckman, John;
- Egea, Sophie C;
- Engel, Jay;
- Felau, Ina;
- Ferguson, Martin L;
- Gardner, Johanna;
- Gastier-Foster, Julie M;
- Gerken, Mark;
- Getz, Gad;
- Gibb, Ewan A;
- Gomez-Fernandez, Carmen R;
- Gordenin, Dmitry A;
- Guo, Guangwu;
- Hansel, Donna E;
- Harr, Jodi;
- Hartmann, Arndt;
- Herbert, Lynn M;
- Hinoue, Toshinori;
- Ho, Thai H;
- Hoadley, Katherine A;
- Holt, Robert A;
- Hutter, Carolyn M;
- Jones, Steven JM;
- Jorda, Merce;
- Kahnoski, Richard J;
- Kanchi, Rupa S;
- Kasaian, Katayoon;
- Kim, Jaegil;
- Klimczak, Leszek J;
- Kwiatkowski, David J;
- Lai, Phillip H;
- Laird, Peter W;
- Lane, Brian R;
- Leraas, Kristen M;
- Lerner, Seth P;
- Lichtenberg, Tara M;
- Liu, Jia;
- Lolla, Laxmi;
- Lotan, Yair;
- Lu, Yiling;
- Lucchesi, Fabiano R;
- Ma, Yussanne;
- Machado, Roberto D;
- Maglinte, Dennis T;
- Mallery, David;
- Marra, Marco A;
- Martin, Sue E;
- Mayo, Michael;
- McConkey, David J;
- Meraney, Anoop;
- Meyerson, Matthew;
- Mills, Gordon B;
- Moinzadeh, Alireza;
- Moore, Richard A;
- Pinero, Edna M Mora;
- Morris, Scott;
- Morrison, Carl;
- Mungall, Karen L;
- Mungall, Andrew J;
- Myers, Jerome B;
- Naresh, Rashi;
- O'Donnell, Peter H;
- Ojesina, Akinyemi I;
- Parekh, Dipen J;
- Parfitt, Jeremy;
- Paulauskis, Joseph D;
- Pedamallu, Chandra Sekhar;
- Penny, Robert J;
- Pihl, Todd;
- Porten, Sima;
- Quintero-Aguilo, Mario E;
- Ramirez, Nilsa C;
- Rathmell, W Kimryn;
- Reuter, Victor E;
- Rieger-Christ, Kimberly;
- Robertson, A Gordon;
- Sadeghi, Sara;
- Saller, Charles;
- Salner, Andrew;
- Sanchez-Vega, Francisco;
- Sandusky, George;
- Scapulatempo-Neto, Cristovam;
- Schein, Jacqueline E;
- Schuckman, Anne K;
- Schultz, Nikolaus;
- Shelton, Candace;
- Shelton, Troy;
- Shukla, Sachet A;
- Simko, Jeff;
- Singh, Parminder;
- Sipahimalani, Payal;
- Smith, Norm D;
- Sofia, Heidi J;
- Sorcini, Andrea;
- Stanton, Melissa L;
- Steinberg, Gary D;
- Stoehr, Robert;
- Su, Xiaoping;
- Sullivan, Travis;
- Sun, Qiang;
- Tam, Angela;
- Tarnuzzer, Roy;
- Tarvin, Katherine;
- Taubert, Helge;
- Thiessen, Nina;
- Thorne, Leigh;
- Tse, Kane;
- Tucker, Kelinda;
- Van Den Berg, David J;
- van Kessel, Kim E;
- Wach, Sven;
- Wan, Yunhu;
- Wang, Zhining;
- Weinstein, John N;
- Weisenberger, Daniel J;
- Wise, Lisa;
- Wong, Tina;
- Wu, Ye;
- Wu, Catherine J;
- Yang, Liming;
- Zach, Leigh Anne;
- Zenklusen, Jean C;
- Zhang, Jiashan;
- Zhang, Jiexin;
- Zmuda, Erik;
- Zwarthoff, Ellen C;
- Weinstein, John N;
- Kwiatkowski, David J;
- Lerner, Seth P
- et al.
Published Web Location
https://doi.org/10.1016/j.cell.2017.09.007Abstract
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments.
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