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Open Access Publications from the University of California

Scholarly Works (86 results)

  • Article
  • Peer Reviewed
Dermatology Online Journal, Volume 29, Issue 5 (2023)
Pigmented purpuric lichenoid dermatitis (PPLD) is a rare subtype of pigmented purpuric dermatosis, which classically presents with a mixture of lichenoid papules and patches on the bilateral lower extremities. Herein, we describe an unusual case of a 47-year-old man with PPLD who presented with 1-3mm discrete papules without the presence of larger patches. The diagnosis of PPLD should be considered for patients presenting with bilateral symmetric discrete papules on the legs.
    Cover page: An unusual presentation of pigmented purpuric lichenoid dermatitisCreative Commons 'BY-NC-ND' version 4.0 license
    • Article
    • Peer Reviewed
    Dermatology Online Journal, Volume 25, Issue 5 (2019)
    We present a woman with a history of years of evolution of confluent hyperkeratotic papules and plaques with a generalized linear and reticulate pattern. Histopathological characteristics concordant with keratosis lichenoides chronica were finally evidenced after several non-specific biopsies. The cutaneous manifestations, chronicity. histopathology findings, and refractoriness to therapies are typical of this rare dermatosis.
      Cover page: Keratosis lichenoides chronica: First case reported in ChileCreative Commons 'BY-NC-ND' version 4.0 license
      • Article
      • Peer Reviewed
      Dermatology Online Journal, Volume 26, Issue 7 (2020)
      Terbinafine is an antifungal agent used in the treatment of hair, nail, and skin dermatophyte infections. Skin side effects to terbinafine are not common. Lichenoid drug eruption is a medication-related adverse cutaneous event; the lesion morphology and pathology mimic lichen planus. A woman with onychomycosis developed a lichenoid drug eruption one week after starting terbinafine. The features of her dermatosis and the characteristics of two additional men who also experienced terbinafine-induced lichenoid drug eruption are discussed. They were receiving a daily terbinafine dosage of either 125mg or 250mg to treat onychomycosis or tinea cruris. The lichenoid drug eruption presented as diffuse or symmetric lesions within one to two weeks after starting terbinafine treatment. The extremities, chest, abdomen, and/or trunk were common sites. Less frequent locations were the lips, nails, palms, soles, and suprapubic region; lesions did not occur on the oral or genital mucosa. The eruption resolved after discontinuation of the medication (with or without treatment using topical corticosteroids, systemic corticosteroids, or both). In addition, more frequently occurring terbinafine-associated cutaneous adverse events (such as urticaria, erythematous eruptions, pruritus, acute generalized exanthematous pustulosis, subacute cutaneous lupus erythematosus, and papulosquamous conditions) are reviewed.
        Cover page: Terbinafine-induced lichenoid drug eruption: case report and review of terbinafine-associated cutaneous adverse eventsCreative Commons 'BY-NC-ND' version 4.0 license
        • Article
        • Peer Reviewed
        Dermatology Online Journal, Volume 25, Issue 5 (2019)
        Ashy dermatosis is characterized by asymptomatic, symmetrically-distributed, gray-colored macules located on the trunk, neck, face, and upper extremities. The condition occurs most commonly in patients with Fitzpatrick phototype III-V skin. The etiology is unknown, but drug ingestion, infection, and genetic factors have been suggested to elicit ashy dermatosis. No gold standard treatments have been established yet. The most successful treatment to date has been clofazimine, although topical tacrolimus, oral dapsone, narrowband ultraviolet light B phototherapy, and isotretinoin have shown treatment success. Ashy dermatosis is primarily a cosmetic concern, but can be a very distressing condition, especially for dark skinned individuals. Therefore, an increase in clinician awareness and more studies are needed to further understand the etiology and treatment options for this disease. This review serves as a single source for clinicians to stay up-to-date regarding the history, clinical presentation, histology, pathogenesis, differential diagnosis, and management options for ashy dermatosis. It also suggests an alternative name that more appropriately encompasses the clinical and histopathologic features, while acknowledging our lack of understanding of its etiology: macular hyperpigmentation of indeterminate etiology.
          Cover page: Ashy dermatosis: a reviewCreative Commons 'BY-NC-ND' version 4.0 license
          • Article
          • Peer Reviewed
          Dermatology Online Journal, Volume 21, Issue 2 (2015)

          Granulomatous pigmented purpuric dermatosis (PPD) is a rare subtype of pigmented purpuric dermatosis that is typically seen in women of Far East Asian descent on the distal lower extremities and feet. Granulomatous PPD is a benign condition that does not typically require treatment. Hyperlipidemia has been seen in over half of the eighteen cases reported in the literature. We report an unusual presentation of granulomatous PPD seen in a 71 year-old Caucasian female with hyperlipidemia.

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          • 1 supplemental file
          Cover page: Granulomatous pigmented purpuric dermatosis: an unusual variant associated with hyperlipidemiaCreative Commons 'BY-NC-ND' version 4.0 license
          • Article
          • Peer Reviewed
          Dermatology Online Journal, Volume 23, Issue 11 (2017)

          Background: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.

          Objectives: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia. Methods: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. Results: The patient cohort comprised 7 females and 3 males with the mean age of 60 years. Widely distributederythematous cutaneous lesions were present in 6 cases whereas a more localized distribution was seen in three cases. The most frequently implicated drugsassociated with the eruption were antidepressants and statins. Histologic examination showed a morphologic picture identical to PL including marked epitheliotropism of mildly atypical lymphocytes, psoriasiform epidermal hyperplasia, dyskeratosis, hemorrhage, and a thick parakeratotic scale. Therewas a significant reduction in the expression of CD7 and CD62L amid the T cells. Regression of the eruption occurred in all cases excluding one. Conclusion: Thefindings conform the categorization of this process as a form of T-cell dyscrasia albeit one that is reversible, dependent on the drug withdrawal. The limitationof our study includes the retrospective design of the study.

            Cover page: Pityriasis lichenoides-like drug reaction: A clinical histopathologic study of 10 casesCreative Commons 'BY-NC-ND' version 4.0 license
            • Article
            • Peer Reviewed
            Dermatology Online Journal, Volume 30, Issue 6 (2024)
            Wolf isotopic response refers to a new skin disorder manifesting in the area of a previous skin lesion that has healed. A variety of disease processes and dermatoses have been described that evoke an isotopic response. We report a man with metastatic hepatocellular carcinoma who received palliative radiation and later experienced a pembrolizumab-induced lichenoid dermatitis at the same site of radiation, representing a cutaneous immune-related adverse event displaying an isotopic response.
              Cover page: Wolf isotopic response: immunotherapy-related lichenoid eruption localizing to prior radiation siteCreative Commons 'BY-NC-ND' version 4.0 license
              • Article
              • Peer Reviewed
              Dermatology Online Journal, Volume 25, Issue 10 (2019)
              Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatoses (PPD) that is characterized by a linear or pseudo-dermatomal eruption on a single extremity. Although clinically distinct from the other PPD, it shares histopathologic features with this group. Herein, we present a man in his 50s who presented with asymptomatic macules and scaly papules on the left lower extremity in a linear distribution. The eruption persisted despite treatment with topical triamcinolone 0.1% and oral rutocide.
                Cover page: Persistent dermatomal eruption on a legCreative Commons 'BY-NC-ND' version 4.0 license
                • Article
                • Peer Reviewed
                Dermatology Online Journal, Volume 23, Issue 10 (2017)

                Lichen nitidus typically presents as shiny pin-head sized papules on the trunk and extremities, often affecting children and young adults. In this prototypical form, it rarely presents a diagnostic challenge being characterized by distinctive clinical and histopathologic findings. We describe a rare variant of lichen nitidus, which we term “hyperkeratotic and hypertrophic lichen nitidus."

                  Cover page: Hyperkeratotic and hypertrophic lichen nitidusCreative Commons 'BY-NC-ND' version 4.0 license
                  • Article
                  • Peer Reviewed
                  Dermatology Online Journal, Volume 24, Issue 7 (2018)
                  Lichen striatus is a rare inflammatory dermatosis that follows the lines of Blaschko. This paper discusses an unusual presentation of lichen striatus following hepatitis B vaccination and reviews the literature of vaccine-induced lichen striatus.
                    Cover page: Lichen striatus-like eruption in an adult following hepatitis B vaccination: a case report and review of the literatureCreative Commons 'BY-NC-ND' version 4.0 license
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