|
Table 1:Calcium channel subtypes (adapted from refs [1,3]) |
|||
|
Type |
Voltage |
Distribution |
Major functions |
|
L |
High |
Myocardium, vascular smooth muscle(arterioral and venous), nonvascular smooth muscle (bronchial, gastrointestinal, genitourinary, uterine), noncontracticle tissues (pancreas, pituitary, adrenal glands, salivary glands, gastric mucosa, white cells, platelets, lacrimal tissue) |
Muscular contraction |
|
N(neuronal) |
High |
Presynaptic nerve terminals |
Catecholamine release |
|
P(Purkinje) |
High |
Presynaptic nerve terminals, mainly in cerebellar Purkinje neurons |
Neurotrasmitter release |
|
Q |
High |
Presynaptic nerve terminals |
Neurotrasmitter release |
|
R |
High |
Neural tissue |
Neurotrasmitter release |
|
T(transient) |
Low |
Postsynaptic nerve terminals and nodal tissue(sinoatrial, atrioventricular) |
Pacemaker activity |