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Table 2, Classification of calcium antagonists (adapted from Ref [3]) |
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Group |
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First |
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Second generation |
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Third |
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(tissue selectivity) |
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generation |
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IIa |
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IIb |
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generation |
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Dihydropyridine(artery>cardiac) |
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Nifedipine (L) |
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Nifedipine SR/GITS |
Bernidipine (L) |
Amlodipine (L/N) |
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Nicardipine (L) |
Nicardipine SR |
Elgodipine (L) |
Barnidipine (L) |
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Felodipine ER (L) |
Cilnidipine (L/N) |
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Fendilline (L) |
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Efonidipine (L/T) |
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Isradipine (L) |
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Lacidipine (L) |
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Manidipine (L) |
Lercanidipine |
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Nilvadipine (L) |
Vatanidipine (L/N) |
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Nimodipine (L) |
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Nisoldipine (L) |
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Nitradipine (L) |
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Benzothiazepine(artery=cardiac) |
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Diltiazem (L) |
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Diltiazem SR |
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Phenylalkylamine(artery=<cardiac) |
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Verapamil (L) |
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Verapamil SR |
Gallopamil (L) |
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Tetraols(Benzilimidazolyl)(artery>cardiac) |
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Mibefradil (L/T++) |
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Bepridil (L/Na+) |
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Monatepil (L/a1-blocker) |
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SR=Sustained Release, ER=Extended release, GITS=GastroIntestinal Therapeutic System |
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In parentheses the target subtype Ca channel for each drug (see also Tab. 1) |
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-Bepridil also blocks sodium(Na+) channels (It is a 3d gen. agent) |
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-Monatepil also has a1-adrenoreceptor blocking activity (3d gen.agent) |
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