Long-term Neurological Outcomes in Adults with Traumatic Intracranial Hemorrhage Admitted to ICU versus Floor

Introduction The objective of this study was to compare long-term neurological outcomes in low-risk patients with traumatic intracranial hemorrhage (tICH) admitted to the ICU (intensive care unit) versus patients admitted to the floor. Methods This retrospective study was conducted at a Level 1 trauma center from October 1, 2008, to February 1, 2013. We defined low-risk patients as age less than 65 years, isolated head injury, normal admission mental status, and no shift or swelling on initial head CT (computed tomography). Clinical data were abstracted from a trauma registry and linked to a brain injury database. We compared the Extended Glasgow Outcome Scale (GOS-E) score at six months between patients admitted to the ICU and patients admitted to the floor. We did a risk-adjusted analysis of the influence of floor admission on a normal GOS-E. Results We identified 151 patients; 45 (30%) were admitted to the floor and 106 (70%) to the ICU. Twenty-three (51%; 95% CI [36–66%]) patients admitted to the floor and 55 (52%; 95% CI [42–62%]) patients admitted to the ICU had a normal GOS-E. On adjusted analysis; the odds ratio for floor admission was 0.77 (95% CI [0.36–1.64]) for a normal GOS-E at six months. Conclusion Long-term neurological outcomes in low-risk patients with tICH were not markedly different between patients admitted to the ICU and those admitted to the floor. However, we were unable to demonstrate non-inferiority on adjusted analysis. Future work aimed at a larger, prospective cohort may better evaluate the relative impacts of admission type on outcomes.


INTRODUCTION
Each year traumatic brain injury (TBI) accounts for an estimated 1.4 million emergency department (ED) visits in the United States. 1 Approximately 95% of patients with TBI are categorized as mild. 2 In patients with mild TBI with intracranial hemorrhage, routine admission to the hospital for early detection of secondary brain injury is recommended. 2 Comparison of Long-term Neurological Outcomes Nishijima et al.
We recently derived a clinical instrument that identified a subset of patients with mild TBI with intracranial hemorrhage who likely do not require ICU admission. 7 While this study demonstrated that low-risk patients are unlikely to require ICU resources during hospitalization, it is unknown whether ICU admission might impart indirect benefits reflected in long-term neurological outcomes.
The primary objective of this study was to compare long-term neurological outcomes with ICU versus floor admission among low-risk patients with traumatic intracranial hemorrhage (tICH). The secondary objective was to compare hospital length of stay. We hypothesized that floor admission was not inferior to admission to the ICU for a favorable neurological outcome at six months. Specifically, we tested the null hypothesis that in adjusted analysis, floor admission provided no more than half the odds of a favorable neurological outcome at six months as admission to the ICU.

Study design and setting
We conducted this retrospective, registry-based cohort study at a Level 1 trauma center. The study was approved by the institutional review board at the study site. At the study site, low-risk patients with tICH are generally admitted to the ICU although admission status decisions are ultimately at the discretion of the admitting trauma surgeon. Patients with tICH admitted to the ICU typically have neurological checks every hour while patients admitted to the floor typically have neurological checks every two hours or greater. All patients with tICH are evaluated by the neurosurgery service. Patients with tICH are seen for cognitive evaluation and education by speech therapists prior to hospital discharge.

Selection of participants
Adult patients (18 years and older) with ED visits from October 1, 2008, to February 1, 2013, were identified from the hospital trauma registry using the International Classification of Diseases, 9 th Revision, Clinical Modification codes specific for tICH (codes 851-854).We identified low-risk patients from this cohort based on our previously derived clinical decision instrument criteria: admission Glasgow Coma Scale (GCS) score of 15, isolated head injury (defined as abbreviated injury score [AIS] less than three in all non-head body regions), age less than 65 years old, and initial head computed tomography (CT) imaging without evidence of shift or mass effect. 7 To obtain long-term neurological outcomes, these low-risk patients were then linked to an institutional TBI database using medical record numbers and ED visit dates. Patients included in the TBI database met at least one of the following criteria that prompted neurosurgical consultation: (1) suspected TBI due to clinical history, clinical symptoms, or signs of neurological deficits on physical examination, or (2) traumatic findings on CT including any tICH. Longterm neurological outcomes were prospectively collected by trained research personnel using a standardized data collection form. Patients or their surrogates underwent a structured interview by trained research personnel at six months to assess global functioning using the Extended Glasgow Outcome Scale (GOS-E). 8

Methods and Measurements
Data collection followed previously published guidelines on retrospective chart review. 9 Variables abstracted from the trauma registry included age, sex, mechanism of injury, initial ED GCS score, initial systolic blood pressure (SBP), heart rate, and respiratory rate, revised trauma score (physiological scoring system based on initial GCS, SBP, and respiratory rate), 10 blood alcohol level, initial hematocrit, AIS score and injury severity score (ISS) (anatomical scoring system), 11 ED disposition, hospital length of stay, in-hospital mortality, and hospital disposition. Variables abstracted from the TBI database included admission GCS score (GCS score at the time of admission), initial platelet count and international normalized ratio (INR), initial CT characteristics and prognostic score (Rotterdam CT score), 12 in-hospital neurosurgical interventions, and GOS-E score at six months.

Outcomes
Our primary outcome measure was a dichotomized GOS-E score at six months (8 [fully recovered] versus 1-7 [not fully recovered]). The GOS-E is the most commonly used measure of global functional performance after TBI and has been recommended as the criterion standard outcome measure for TBI studies. 13,14 It uses an 8-category score that is typically dichotomized between 8 and 1-7 for mild TBI to facilitate interpretation. 15 It has excellent interrater reliability and content validity. 8 We also conducted a sensitivity analysis adjusting the dichotomization at GOS-E 1-6 versus GOS-E 7 and 8. The secondary outcome measure was hospital length of stay (days in the hospital). Outcomes were collected independent of the knowledge of ED disposition.

Analysis
We conducted data formatting and recoding of variables ducted using STATA 11.0 statistical software (STATA Corp, College Station, TX). The study population was characterized using descriptive statistics. Non-normal interval data were reported with medians and interquartile ranges, and proportions were presented with 95% confidence intervals (CIs). We analyzed categorical data with chisquare test or Fischer's exact test in cases of small cell size. Continuous data were analyzed with Student's t-test if normally distributed. We used Wilcoxon rank-sum test for nonparametric data or ordinal data. Since inherent differences likely existed between low-risk patients admitted Volume XVI, NO. 2 : March 2015

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Comparison of Long-term Neurological Outcomes to the ICU and those admitted to the floor we created boxplots to analyze the distribution of key independent variables (age, initial systolic blood pressure, AIS head and neck score, and Rotterdam CT score) by hospital admission location (floor versus ICU). Boxplots were also created to analyze outcome measures. Bivariate analyses on these variables and GOS-E score were also done to evaluate which variables may have influenced the GOS-E score. We then fit a logistic regression model with these variables using the dichotomized GOS-E score (8 versus <8) as the dependent variable and ED disposition as the independent variable of primary interest. A linear regression model was created to analyze hospital length of stay. To evaluate for missing data bias, we compared key characteristics between patients with and without GOS-E at six months.

RESULTS
Among 188 patients with tICH who met our inclusion criteria, 151 (80%) had complete data; 106 (70%) patients were admitted to the ICU and 45 (30%) to the floor ( Figure  1). Median age in the cohort was 40 years (IQR 25-54 years) and 109 were male (72%). The most common mechanisms of injury were fall from standing (49 patients, 32%) and assault (48 patients, 32%). The most common head CT findings were subdural hematoma (56 patients, 37%) and subarachnoid hemorrhage (54 patients, 36%). One patient (admitted to ICU) required a neurosurgical intervention, which consisted of an elevation of skull fracture on hospital day 3. One patient died during hospitalization (hospital day 13) from hospitalacquired pneumonia and sepsis (see Table 1 for complete patient characteristics). Distributions of key independent variables are shown in Figure 2. The majority of patients had a GOS-E at six months of 8 (78; 52%) ( Table 2). Patients with GOS-E at six months were more likely to have a higher AIS head and neck compared to patients with a missing GOS-E at six months ( Table 3).
Distributions of GOS-E at six months and hospital length of stay by ED disposition are shown in Figure 3. On adjusted analysis, floor admission had an odds ratio of 0.77 (95% CI [0.36-1.64]) for a GOS-E score of 8 at six months. Given our tolerance margin of an odds ratio of 0.5, we failed to reject the null hypothesis of non-inferiority ( Figure 4). Only age was significantly associated with a normal GOS-E at six months (Table 4a). No variable was significant on adjusted analysis of hospital length of stay (Table 4b). In the sensitivity analysis, no variable was associated with GOS-E scores 7 and 8.

DISCUSSION
This was a hypothesis-generating study evaluating the impact of floor and ICU admission on a clinical (neurological outcome) and system outcome (hospital length of stay) in patients with low-risk tICH. Based on the results of our study, we were unable to reject the null hypothesis of inferiority; that is, we were unable to prove that floor admission was not inferior to ICU admission by our threshold margin, because the relatively wide 95% confidence interval for the adjusted odds ratio (0.36 to 1.64) included the value 0.50. To reduce the confidence interval width in an otherwise similar study would require a larger sample size.
Our study cohort consisted of low-risk patients with tICH with the definition for "low-risk" based on a recently published derivation of a clinical decision instrument identifying patients who are unlikely to receive a critical care intervention within 48 hours of hospital admission and thus, may not require ICU admission. 7 While these low-risk criteria narrowed the study population to a relatively homogenous, well-appearing cohort of patients with tICH, it is likely that there was still some selection bias with sicker patients more likely to be admitted to the ICU. Our analysis demonstrated that the cohort of patients admitted to the ICU were older and had a higher AIS head and neck score compared to the cohort admitted to the floor.
GOS-E scores at six months were similar to other studies evaluating patients with mild TBI. 15,16 Prior studies have demonstrated that injury severity (e.g., GCS score), demographic factors including age, gender, pre-injury education and employment, as well as post-injury cognitive and social factors may influence long-term neurological outcome after TBI. 17 To our knowledge this is the first study to evaluate the potential influence of hospital admission location on neurological outcomes. It is possible that ICU admission in low-risk patients with tICH imparts benefits such as close monitoring of neurological decline or intensive cognitive tlCH, traumatic intracranial hemorrhage; GOS-E, Glassgow Outcome Score Extended; ICU, intensive care unit a Low-risk defined as admission Glasgow Coma Scale score of 15, isolated head injury (defined as Abbreviated Injury Score less than three in all non-head body regions), age less than 65 years old, and initial head computed tomography imaging without evidence of shift or mass effect.  Initial respiratory rate (breaths/min), mean (SD) 17 (2) 18 (2) Revised trauma score, mean (SD Neurosurgical intervention, n (%) 0 (0) 1 (0.9) ICU, intensive care unit; CT, computed tomography *p<0.05

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Comparison of Long-term Neurological Outcomes this is a single center study, and the results may not be generalizable to other sites that have different resources or admission practices. Since these were low-risk patients with   the results of the study. We did evaluate key differences between patients with and without GOS-E and found that patients with GOS-E had higher AIS head and neck scores indicating more severe injuries compared to those with missing GOS-E scores. Finally, this study was underpowered to detect small but potentially clinically important differences in neurological outcomes.

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Comparison of Long-term Neurological Outcomes

CONCLUSION
In low-risk patients with tICH, six-month neurological outcomes were not markedly different between patients admitted to the ICU and those admitted to the floor. However, we were unable to demonstrate non-inferiority on adjusted analysis. Future work aimed at a larger, heterogeneous and prospective cohort may better evaluate the impact of ICU admission on outcomes in this patient population.