Table 1. Response of underlying cancer to treatment with EGFR inhibition in reported cases of trichomegaly. All cases associated with trichomegaly occurred in females and associated no progression of the tumor (either stable disease or an objective response of the cancer).



Publication Patient age and gender EGFR

inhibitor

Effect on

Eye lashes

Type of Cancer Response of Cancer Time from starting EGFR inhibitor to development of trichomegaly
Braideth F et al. 2008 57 F Erlotinib Trichomegaly Lung Major response N/A
Lane K et al. 2007 70 F Erlotinib Trichomegaly Lung Durable stable disease and symptomatic improvement Several months
Zhang G et al. 2007 Case 1 :58 F Gefitinib&

Erlotinib

Trichomegaly Lung Stable disease or better N/A
Zhang G et al. 2007 Case 2:

87 F

Gefitinib Trichomegaly Lung Stable disease or better 8 months
Carser JE et al. 2996 61 F Erlotinib Trichomegaly Lung Stable disease and symptomatic improvement 3 months
Bouche O et al. 2005 74 F Cetuximab Trichomegaly Rectal Stable disease 5 months
Dueland S et al. 2003 26 F Cetuximab Trichomegaly Colon Tumor response

(47% shrink)

10 weeks
Pascual JC et al. 2004 51 F Gefitinib Trichomegaly Lung Significant

response

7 weeks
Garibaldi DC et al. 2007 49 M Cetuximab Maderosis Colon Tumor progression weeks