Treatments

Duration (months)

Dosage

Initial result

Side effects

Outcome

Acitrecin

6

25 mg /day

Improvement

1.      Increase of cholesterol levels

2.      Acute paronychia

3.      Severe cheilitis

4.      Pruritus

5.      Arhralgia, myalgia

6.      Alopecia (eyebrows, scalp)

Discontinuation

Methotrexate

6

25 mg / week

Unresponsive

1.       2^nd development of inverse psoriasis

2.      Increase of alanine aminotransferase levels

Discontinuation

Cyclosporin

11

200 mg /day

Improvement

1.      Relapse during withdrawl (at 1.5 mg/kgr)

Discontinuation

Efalizumab

8

1.0 mg/kg/week

Improvement

1.       Severe hypetrichosis because of increase of free testosterone levels

2.      Exacerbation after 2 months of therapy

Discontinuation

Etanercept

2

50 mg / week

Unresponsive

1.       1^st development of inverse psoriasis

2.      Purulent infection of the auricular duct

Discontinuation

Infliximab

3

5 mg/kg every 2 months

Improvement

1.       Pruritus of soles

2.      Exacerbation after the 3^rd injection

3.      Exacerbation of psoriasis affecting scalp (new location)

Discontinuation

Adalimumab

3

40 mg every 2 weeks

Unresponsive

1.      Exacerbation of psoriasis affecting palms (new location)

Discontinuation

Ustekinumab

14

45 mg every  3 months

Improvement

1.      Progressive but delayed improvement

Clearance after the 5^th injection