Table 3: Non-cutaneous sarcoidosis preceding neoplasias
Reference |
Age |
Evidence of sarcoidosis |
Time course |
Associated malignancy |
Alliot C (2000) [73] |
26 M |
LNp, neurosarcoid |
2.75 yr |
HD |
Brandt L (1977) [74] |
60 M |
pLN, lung (interstit) |
14 yr |
AML |
Brennan NJ (1983) [75] |
52 F |
Mediast LN, lung |
1.6 yr |
NHL (inguinal LN, liver, BM, well differentiated) |
Brincker H (1974) [18] Case 17 |
40 F |
LNp, mediast LN, lung |
8 yr |
HD (mixed-cell, LN para-aortic) |
Buckle RM (1960) [76] |
28 F |
Lung (interstitial) |
6 mo |
NHL (undifferentiate reticsarcoma), LN and chest wall mass |
Caras WE (2003) [77] Case 2 |
38 BM |
Hilar LN |
9 yr |
Stomach adenocarcinoma (mod diff) |
Corda L (1996) [30] |
65 F |
Hilar & mediast LN, lung (int), uveitis, gastric |
8 yr |
Kaposi’s sarcoma |
de la Figuera M (1985) [78] |
26 F |
b/l hilar LN, inc ESR |
8 mo |
RCC |
Echigo T (2003) [79] |
68 F |
Hilar LN, eye (uveitis), muscul |
3 yr |
Melanoma |
Falcao RP (2000) [80] |
46 F |
Lung (interst) |
~ 3 mo |
LGL (leuk & lymphoma) |
Finke R (1986) [81] |
56WM |
pLN, hilar LN, liver, muscle, bone, inc ESR |
3.5 yr |
Immunocytoma (lymphoplasmacytoid lymphoma) |
Foon K (1981) [82] |
32 F |
Mediast LN |
1.5 yr |
Histiocytic NHL |
Fukuda T (1997) [83] |
23 M |
pLN, lung, liver, eye |
3 yr |
NHL stomach (large cell) |
Goldfarb BL (1970) [84] |
71 WF |
LNp, mediast LN, lung (int) liver, sicca, joints |
8 mo |
HD (LN cervical, BM) |
Goldberg DJ (1986) [85] |
44WM |
Lung, kidney, hilar LN |
12 yr |
Subungual SCC |
Hatake K (1983) [86] |
51 F |
Hilar LN, lung (int), uveitis, inc ACE |
4 yr |
AMML |
Karakantza M (1996) [35] Cases 1, 4, 5 |
65WM |
LN mediast/hilar |
2 yr |
NHL (LN, low-grade, lymphoplasmacytic) |
24WM |
pLN, hilar LN, uveitis |
8 yr |
LGL (large granul leukemia) |
|
47 WM |
Hilar and mediast LN |
4 yr |
NHL (MCL) |
|
Masuda R (1992) [87] |
? F |
LNp, hilar LN, eye |
15 yr |
NHL (DLBCL gastric) |
Murphy EA (1991) [88] |
52 M |
Uveitis, joints, BM, liver |
10 yr |
AML, MPGN, Porphyria Cut Tarda |
Panelatti G (1992) [89] |
49 F |
b/l hilar LN, uveitis, I Ca |
3 yr |
ATCLL (HTLV +) |
Pollock JL (1979) [90] |
38 M |
Hilar LN, pLN, lung (interstitial) |
3 yr |
Parotid gland ductal carcinoma (metastatic) |
Ponticelli P (1981) [91] |
16 M |
LNp, liver, spleen |
5 yr |
HD |
Romero J (1997) [92] |
58M |
LNp, hilar LN, neuro (transv myel) |
5 yr |
NHL (B-cell low-grade marg z), epidermoid carcinoma |
Sarkar TK (1970) [93] |
36 F |
Lung (nod), endobronch, ESR, +Kveim test |
6 mo |
Lung Ca (undiff-SCLC/NSCLC) |
Sen F (2002) [94] |
49 BF |
Lungs, LNp, eyes, parotid |
5 yr |
Multiple myeloma |
Silver HM (1967) [95] |
47 M |
Mediast LN, arthritis, parotid |
16 mo |
NHL (lymphosarcoma, diffuse LN) |
Spitzer T (1986) [96] |
58 WM |
pLN, b/l hilar LN, liver, splenomeg |
29 yr |
HD, autoimmune hemol anemia |
Stoker TA (1971) [97] |
36 M |
LNp |
6 yr |
HD (cervical LN) |
Tamura A (1984) [98] |
43 M |
Eye, liver |
1.6 yr |
NHL (T-cell) |
Trier H (1985) [99] |
49 M |
Hilar LN, inc ESR |
2.5 yr |
HD |
Wong VS (1999) [100] |
27 M |
Liver, spleen |
26 yr |
Hepatocellular carcinoma |
|
|
|
|
|
Present report (5 cases) |
33 M |
Mediast, hilar LN, lung interst |
1 yr |
RCC |
63 M |
Mediast, hilar, perivasc LN, lung interst, ACE |
20 yr |
ADK parotid (basal cell) |
|
37 WF |
Mediast LN |
2 yr |
MF |
|
46WM |
Hilar LN, lung interstitial |
3 yr |
DLBCL (periph LN) |
|
38F |
LNp, lung (nodules) |
1 yr |
ADK parotid (cystic) |