Table 6.
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Psoriasis Vulgaris skin lesions HIV Peripheral blood
IL-2 ¯
IFN-γ* or ↔ TNF-α ¯
“Type 2” cytokines:
IL-4 ¯ or absent or ↔
IL-5 ? or ↔
IL-6 ¯
IL-10 ¯ or absent
Plasma/B Cells absent or few
IgG absent or low
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Table 6. Relative cytokine profiles in peripheral blood T cells of HIV patients and from T cells in
psoriatic lesions. Note the opposite cytokine expression in psoriatic skin compared to HIV peripheral
blood for all cytokines except IFN-γ, which is increased in both cases. (↑, increased; ↓, decreased; ↔, stable;
?, no published data available; *,CD8+ lymphocytes are primarily responsible for this increased production
of IFN-γ)