Table 2: Mean ± SD values for pharmacokinetic parameters

Parameter	Alefacept SC n = 42	Alefacept IM n = 42
AUC_last, h*μg/ml	472.7 ± 139.6	461.8 ± 169.7
C_max, μg/ml	1.37 ± 0.50	1.47 ± 0.79
AUC_¥, h*μg/ml^a	591.4 ± 190.6	589.3 ± 238.2
T_max, h	94.7 ± 79.7	76.1 ± 34.3
T_½, h^a	281.6 ± 77.4	293.7 ± 98.5
Clearance, ml/h/kg^a	0.38 ± 0.12	0.39 ± 0.13
Volume of distribution, ml/kg^a	149.9 ± 46.3	153.4 ± 36.5

AUC_¥, area under the serum concentration-time curve to infinity; AUC_last, area under the serum concentration-time curve to the last measurable value; C_max, peak serum concentration; IM, intramuscular; SC, subcutaneous; SD, standard deviation; T_max, time to peak serum concentration; T_½, half-life.

^an = 41/group; excludes one subject for whom this parameter could not be estimated.