Table I: Main differences between DLE in children and adults (1-7)
|
|
DLE in children |
DLE in adults |
|
Epidemiology |
No female predominance/ photosensitivity + |
Female predominance/ photosensitivity +++ |
|
Clinically |
Localized DLE |
Localized DLE |
|
Cutaneous histology |
Epidermal damages +/- BMZ anomalies Dermal lymphocytic infiltration. T helper cells +++ |
Epidermal damages ++ BMZ anomalies Dermal lymphocytic infiltration. T helper and suppressor cells +++ |
|
DIF in lesional skin |
Granular IgG, IgM or complement deposits along BMZ (80%) |
Granular IgG, IgM or complement deposits along BMZ (50 to 90%) |
|
TTT/Outcome |
Photoprotection, TC+ +/- AM/ Frequent progression to SLE (about 30%) |
Photoprotection, TC+ +/- AM/ Possible progression to SLE (6%) |
BMZ: Basement membrane zone, DIF: Direct immunofluorescence, TTT: Treatment, AM: Antimalarials, TC: Topical corticosteroid