Table 1. Immunohistochemical Distinction of Cutaneous CD30(+) T-cell Lymphomas
|
|
C-CD30(+) LPD |
S-ALK- ALCL |
S-ALK+ ALCL |
PTCL, NOS |
|
ALK |
- |
- |
+ |
- |
|
EMA |
+/- |
+ |
+ |
- |
|
PAX5 |
- |
- |
- |
- |
|
EBV |
- |
- |
- |
- |
|
BCL6 |
- |
- |
+ |
- |
|
GrB |
+ |
+/- |
+ |
- |
|
Perforin |
+ |
+/- |
+ |
- |
|
TIA1 |
+ |
+/- |
+ |
- |
|
CD2 |
+ |
+/- |
+/- |
+ |
|
CD3 |
+/- |
+/- |
-/+ |
+ |
|
CD4 |
+ |
+/- |
+/- |
+/- |
|
CD5 |
+/- |
+/- |
+/- |
-/+ |
|
CD7 |
- |
-/+ |
-/+ |
-/+ |
|
CD8 |
- |
-/+ |
-/+ |
-/+ |
|
CD15 |
- |
- |
- |
- |
|
CD25 |
+ |
+ |
+ |
- |
|
CD30 |
+ |
+ |
+ |
-/+ |
C-CD30+ LPD: Cutaneous CD30 positive lymphoproilferative disorder; S-ALK- ALCL: Systemic ALK negative anaplastic large cell lymphoma; S-ALK+ ALCL: Systemic ALK positive anaplastic large cell lymphoma; PTCL, NOS: Peripheral T-cell lymphoma not otherwise specified; ALK: Alkaline phosphatase; PAX5: Paired box protein; EBV: Ebstein barr virus; BCL6: B-cell lymphoma 6; GrB: Granzyme B; Perforin: T-cell-restricted intracellular antigen-1; CD2: Cluster designation 2; CD3: Cluster designation 3; CD4: Cluster designation 4; CD5: Cluster designation 5; CD7: Cluster designation 7; CD8: Cluster designation 8; CD15: Cluster designation 15; CD25: Cluster designation 25; CD30: Cluster designation 30.