Table 2. Selected case reports in which acanthosis nigricans improved with treatment of the underlying condition. (*) HAIR-AN = hyperandrogenism, insulin resistance, and acanthosis nigricans, (**) case series, all 10 patients with Cushing syndrome and AN improved
Condition |
Treatment(s) |
Obesity/Hyperinsulinemia |
Diet/weight loss[78] |
|
Octreotide[79] |
HAIR-AN* |
Bariatric surgery[80] |
|
Hypocaloric diet and weight loss[81] |
|
Ketoconazole[82] |
Cushing syndrome** |
Transsphenoidal surgery[83] |
Congenital generalized lipodystrophy |
Leptin[84] |
Nicotinic acid use |
Nicotinic acid discontinued[40] |
Amprenavir use |
Substitution with efavirenz[45] |
Triazinate (folate antagonist) use |
Triazinate discontinued[85] |
Gastric adenocarcinoma |
5-fluorouracil, cisplatin, epirubicin[86] |
Melanoma |
Excision[65] |
Primary biliary cirrhosis |
Liver transplantation[39] |