Sepsis in Pregnancy: Recognition and Resuscitation

The normal physiologic changes of pregnancy complicate evaluation for sepsis and subsequent management. Previous sepsis studies have specifically excluded pregnant patients. This narrative review evaluates the presentation, scoring systems for risk stratification, diagnosis, and management of sepsis in pregnancy. Sepsis is potentially fatal, but literature for the evaluation and treatment of this condition in pregnancy is scarce. While the definition and considerations of sepsis have changed with large, randomized controlled trials, pregnancy has consistently been among the exclusion criteria. The two pregnancy-specific sepsis scoring systems, the modified obstetric early warning scoring system (MOEWS) and Sepsis in Obstetrics Score (SOS), present a number of limitations for application in the emergency department (ED) setting. Methods of generation and subsequently limited validation leave significant gaps in identification of septic pregnant patients. Management requires consideration of a variety of sources in the septic pregnant patient. The underlying physiologic nature of pregnancy also highlights the need to individualize resuscitation and critical care efforts in this unique patient population. Pregnant septic patients require specific considerations and treatment goals to provide optimal care for this particular population. Guidelines and scoring systems currently exist, but further studies are required.


INTRODUCTION
In the United States, sepsis is the fourth leading cause of maternal death. [1][2][3] Mortality in pregnant patients rose consistently at an average of 9% per year from 2001 to 2010 despite sepsis guidelines updates. 1,4,5 As sepsis occurs in only 0.001% of pregnancies and in 0.002-0.01% of postpartum patients, data and consensus are limited regarding diagnostic and therapeutic interventions. 4 Additionally, pregnancy is an exclusion criterion in all major sepsis trials to date, relinquishing clinical decisions to provider preference and expert opinion. [6][7][8]

METHODS
In the following narrative review, we sought to comprehensively review the recent literature regarding sepsis in pregnancy. While pregnancy has been an exclusion criterion in every major sepsis trial as well as disease-specific trials, we identified all major observational trials, retrospective cohort studies for clinical rule derivation, and their subsequent validation studies. [6][7][8] We also searched PubMed and Google of mother and fetus, as physiologic changes brought on by sepsis in pregnancy in the mother can generate untoward effects on the fetus. It is essential to understand physiologic changes of normal pregnancy to appropriately approach sepsis in pregnancy. These changes occur secondary to altered hormonal levels that continue from conception to post-delivery, as well as anatomic transformations with fetal growth and uterine enlargement. 9 Normal changes in pregnancy include a relative anemia due to expanding plasma volume that outpaces red blood cell growth. 10 A baseline respiratory alkalosis develops from a rise in respiratory tidal volume with increased minute ventilation. 11 Specific gastrointestinal differences likewise affect both normal baseline and disease resuscitation. The gravid uterus increases intragastric pressures, and high levels of progesterone and relaxin decrease lower esophageal sphincter tone. 12,13 A normal delay in gastric emptying and elevation of the diaphragm up to four centimeters (cm) increase aspiration risk, elevating the risk of aspiration pneumonia and complicating intubating conditions. 14 Throughout pregnancy the cardiovascular system undergoes a multitude of changes contributing to the physiology of mother and fetus. Systemic vasodilation begins early in the first trimester, decreasing systemic vascular resistance (SVR) by up to 35-40%, maintaining cardiac output due to a compensatory increase in heart rate. 15 Late in the third trimester, heart rate peaks at rates up to 24% higher than the prepartum baseline. 15,16 This translates to heart rate increases up to 30 beats per minute. [17][18][19] Multiple gestations can further increase maternal heart rates. 20 These compensatory cardiovascular changes generally return to baseline within two weeks of delivery, although a small proportion of patients maintain their pregnant cardiovascular measures at 12 weeks postpartum. 9,21 Blood pressure may fall by 10-15 millimeters of mercury (mm Hg) in a normal pregnancy and nadir around 24 weeks gestation. 18,21,22 Expanding plasma volume and red blood cell mass further work to offset lowered SVR and to maintain normotension from as early as six weeks into pregnancy until 34 weeks gestation. 19 Pregnancy alone can increase white blood cell (WBC) counts to double pregestational levels. 23 WBC counts may reach levels as high as 25,000 cubic millimeters (mm 3 ) in a normal pregnancy. [24][25][26][27] The physiologic stress of the peripartum period can push this leukocytosis further as high as 25,000/mm 3 immediately postpartum. 24 WBC counts may rise even higher in pre-eclampsia, complicating laboratory data interpretation. 28,29 A clinical suspicion for pre-eclampsia taken with immunologic changes may cloud an infectious differential. 30 Further normal physiologic changes in pregnancy are highlighted in Table 1.
Other pre-existing comorbidities may complicate physiologic alterations of pregnancy. Long-term medication use in pregnancy has increased commensurately with rates of obesity, non-insulin dependent diabetes mellitus, and hypertension. 31,32 Prescription medication use during pregnancy has increased as much as 60% over the last 30-40 years. 33 In the setting of infection, medications targeting blood pressure and glucose control can obscure physiologic responses. Non-or poorly-compliant pregnant patients further complicate this already-cloudy picture.

The Evolution of Sepsis: Issues with Diagnosis and Guidance
The definition of sepsis continues to evolve. Previously,  34 Although these studies excluded pregnant patients, SIRS criteria nevertheless remained the primary standardized assessment tool for sepsis recognition. 34 Before the second update to the sepsis guidelines in 2012, guidelines did not accurately identify maternal sepsis, identifying less than two-thirds of obstetric patients in retrospective reviews, highlighting the need to delineate pregnancy-specific guidelines. 3,35 Working in parallel to the Surviving Sepsis Campaign, other parties presented criteria aimed at identifying maternal sepsis. The World Health Organization (WHO) modified the definition of maternal sepsis to "puerperal sepsis." 36 This narrow definition limited pregnant or postpartum sepsis to genitourinary tract infections between the time of rupture of membranes and six-weeks postpartum. 37,38 The WHO provided a definition for septic abortion, which likewise remained isolated to genitourinary tract infections. 36,38 As a result, many early maternal sepsis studies focused solely on the diagnosis and treatment of only these infections. [39][40][41][42][43][44][45] Diagnoses were most recently supplemented in the Third International Consensus Definitions for sepsis and septic shock in 2016 by the Sepsis-related Organ Failure Assessment (SOFA) and the quick Sepsis-related Organ Failure Assessment (qSOFA) using SIRS criteria as fundamental principles. 46,47 Similar to preceding trials, pregnancy was an exclusion criterion in these studies that established and validated the SOFA and qSOFA scores, thereby minimizing their utility in the pregnant population. 46,47 As of this review, no studies have externally validating SOFA or qSOFA scores in pregnant patients, despite the fact that the components of these scores have been validated in various combinations in pregnant populations. 37 The creation of two scores, the modified early warning scoring systems (MOEWS) and the sepsis in obstetrics (SOS) score, attempted to stratify pregnant patients with concern for sepsis; however, attempts to validate these scores have generated varying utility. 35,48 MOEWS has a number of international variants (Table 2), limiting its application across regions and settings. MOEWS is generally hindered by its outcome "to help detect the early signs of illness and trigger timely medical review with appropriate intervention," rather than specifically to target sepsis identification. 49 The lone major MOEWS validation study analyzed 913 cases of chorioamnionitis, but only five cases met the definition of severe sepsis. 48 Intended to predict severe sepsis by 2.0 guidelines, MOEWS restricts its utility not only by using a recently redefined term, but also by generating a myopic view of sepsis in pregnancy by focusing on chorioamnionitis and not the broader scope of sepsis sources. 49 In 2014 the SOS sought to establish an obstetric-focused scoring system, incorporating the previously highlighted physiological changes in the cardiovascular, respiratory, and immune systems in pregnancy (Table 3). 50 Based on the surviving sepsis campaign, the SIRS criteria overestimated morbidity and mortality in an obstetric cohort without accounting for normal physiologic changes. [51][52][53][54][55] With this tailored scoring system, the authors sought to identify pregnant patients at high risk for sepsis with a primary outcome of intensive care unit (ICU) admission within 48 hours of admission. However, ICU admission criteria were not standardized.
Most recently, a single, prospective, internal validation trial of the SOS attempted to evaluate its performance with the same primary outcome. 56 An SOS score of less than six points had a 64% sensitivity and 98.6% negative predictive value for excluding sepsis, although a score of six points or greater had a sensitivity of only 64% to diagnosis sepsis. 56 Furthermore, of the 1250 pregnant patients presenting to the ED over a three-year study period, only 1.1% were admitted to the ICU, although ICU admission criteria remain unknown. 56 While this lone, prospective validation study demonstrates a significant negative predictive value, additional validation studies and a larger sample population are needed to determine its utility in populations with different prevalence of septic pregnant patients.
Despite the need for obstetric-focused scoring systems in sepsis, emergency providers lack substantially validated criteria or schema to bolster decision-making and hospital admission when confronted with a sick pregnant or postpartum patient. Bridwell et al.

Treatment Considerations Specific to Pregnancy
Pneumonia Pneumonia is responsible for 30% of infections in pregnant patients with severe sepsis, carrying significant morbidity for both mother and fetus. 5 In one study, up to one-fifth of pregnant patients experienced a delay in pneumonia diagnosis, while half experienced significant morbidities such as empyema and respiratory failure. 57 Initial diagnosis is often made by chest radiograph. Appropriate shielding of the abdomen exposes the fetus to less than 0.01 milliGray (mGy), well below the threshold of adverse effects. 58 The lung may be upwardly displaced by the growing uterus, and the increased density of parenchyma can make definitive diagnosis difficult. 59 Ultrasound (US) has a 94-97% sensitivity and 94-96% specificity for pneumonia diagnosis in a recent meta-analysis. 59,60 Although chest computed tomography (CT) is rarely required, it can be safely performed if needed for diagnosis. 46 The most common microbial causes of pneumonia in pregnancy include S. pneumoniae and H. influenzae. 61 Antibiotic coverage should treat these pathogens. However, other sources to consider include Legionella spp., Varicella zoster, and Pneumocystis jirovecii in patients with human immunodeficiency virus (HIV). 13 While fluoroquinolones should be avoided, penicillins, cephalosporins, and macrolides are all considered safe to use in pregnancy. 62 For pregnant patients admitted to the ICU, both S. pneumoniae and Legionella spp. should be covered. 62 A pneumococcal beta lactam, such as cefotaxime or, if not peripartum, ceftriaxone, and a macrolide should be administered. 13,62 Vancomycin and linezolid do not currently have established safety in pregnancy, but should be considered in cases where methicillin-resistant Staphylococcus aureus is suspected.
In a small case series, 59% of pregnant patients with pneumocystis pneumonia required mechanical ventilation due to respiratory failure. 63 The authors found a 50% mortality rate for the mothers and 41% mortality for combined fetus and neonates. 63 These patients should be treated similarly to their nonpregnant counterparts with trimethoprim-sulfamethoxazole and corticosteroids if the A-a gradient is greater than 35 or the partial pressure of oxygen (PaO 2 ) is less than 70 mm Hg. 64 The mother should also be monitored for immune reconstitution inflammatory syndrome . 64 If treatment is active at the time of delivery, the neonate should be monitored for hyperbilirubinemia. 64 The course of pneumonia in pregnant patients can be further complicated by decreased secretion clearance and worsening airway obstruction. 13,61 Secondary to pregnancy physiology and treatments routinely administered in the course of delivery, aspiration during labor represents another significant source of infection. 14 Epidural blocks may blunt or inhibit the cough reflex, further increasing the risk of aspiration pneumonitis and pneumonia. 65 Pregnancy was an exclusion criteria in the PROTECT (prophylaxis for thromboembolism in critical care) trial, which examined risk factors for mortality secondary to pneumonia in patients admitted to the ICU. 66 ICU admission threshold should be lower for pregnant individuals, as they have decreased tolerance for hypoxemia and may quickly deteriorate with pneumonia. 13 Blood gas interpretation in pregnant patients should take into account the expected physiologic alkalemia, which may blunt initial laboratory findings of hypercapneic respiratory failure. 14 Anatomical compression of the inferior vena cava in late pregnancy can reduce cardiac preload causing hypotension, exacerbated by the addition of positive pressure from mechanical ventilation. 11,24 This may necessitate placing the patient in the left lateral decubitus position. 67 Prevention of maternal hypoxemia is critical, as this quickly leads to fetal decompensation. Thus, maintaining a PaO 2 greater than 70 mm Hg can prevent deleterious effects on the fetus. 68

Sepsis in Pregnancy: Recognition and Resuscitation
Bridwell et al.
asthma data and therefore controversial, partial pressure of carbon dioxide should be maintained between 28-32 mm Hg to prevent fetal acidemia and maternal hypercapnia. 69 Pyelonephritis Pyelonephritis in pregnancy is a complicated infection requiring intravenous (IV) antibiotics and admission for continued monitoring of mother and fetus. 70,71 Pyelonephritis occurs in approximately 2% of pregnancies in the U.S. but accounts for the largest proportion of maternal inpatient admissions. 71 Up to 20% of cases occur in the second and third trimester. [70][71][72] Numerous factors predispose pregnant women to pyelonephritis: dilation of the renal calyces secondary to progesterone; stagnation of ureteral peristalsis; mechanical compression of the bladder; and increased glomerular filtration rate, resulting in glucosuria and alkaluria facilitating bacterial growth. 73 Acute pyelonephritis in pregnancy can significantly increase the risk of maternal anemia, acute renal failure, respiratory distress, and preterm birth. 4 Additionally, patients with maternal pyelonephritis demonstrate a 33% increased risk of chorioamnionitis, further predisposing them to sepsis. 74 More than 80% of acute pyelonephritis cases in pregnancy are from E coli, but other uropathogens include Klebsiella, Streptococcal spp., Proteus mirabilis, and Enterococcus. 74,75 Although pregnant patients are specifically excluded from Infectious Diseases Society of America (IDSA) guidelines, ceftriaxone, cefepime, or ampicillin plus gentamicin are feasible treatment options. 74,75 In patients less than 24 weeks gestation, intramuscular ceftriaxone has demonstrated equal efficacy in length of hospitalization and days until resolution of infection compared to IV ampicillin and gentamicin or cefazolin. 76 Ceftriaxone should be avoided in the periparturition period, however, due to the risk of neonatal kernicterus. 67 Urine culture and local resistance patterns should guide empiric therapy. 73 Carbapenems or piperacillin-tazobactam could be considered for broader coverage in immunocompromised patients or those with severe pyelonephritis impairing urinary drainage; however, imipenem should be avoided due to adverse fetal effects demonstrated in vivo. 70,73 E. coli and other gram-negative rods cause the vast majority of pyelonephritis in pregnancy, carrying the potential for large-scale endothelial cell damage in capillary beds from endotoxin release. [73][74][75] This endothelial damage commonly affects renal and pulmonary tissue, resulting in acute respiratory distress syndrome in 1-8% of cases, further complicating the maternal patient. 73 Unlike the non-pregnant population, a test of cure is required in maternal patients following clinical resolution. 67

Appendicitis
Appendicitis occurs less frequently in pregnancy (approximately 1 in 1500) and peaks in the second trimester compared to the non-pregnant population. [77][78][79] However, 1 in 1000 pregnancies undergo surgical evaluation for possible appendicitis, with increased rates of surgical intervention due to increased perforation risk as well as mortality. 77,78 Maternal mortality secondary to appendicitis is 4%, and complications of perforated appendicitis result in an estimated 43% fetal mortality rate. 80,81 Physiologic changes of pregnancy and atypical presentation make maternal diagnosis particularly challenging. The fundus rises and displaces the appendix from the right lower quadrant (RLQ). 81 Fundal displacement of the omentum prevents it from sealing off an inflamed appendix. 82 RLQ pain and tenderness are the presenting symptoms in 75% of maternal appendicitis, while another 20% of cases present with right upper quadrant pain. 83 However, up to 45% of these cases present with rectal tenderness, which is not commonly associated with or examined with suspected appendicitis. 83 Nausea and vomiting, common in pregnancy, can further complicate the clinical picture. Therefore clinicians should note any significant changes to the patient's "normal" course of "morning sickness" during the history. Maternal leukocytosis is not reliable for diagnosing appendicitis or perforation due to normal physiologic changes. However, the presence of bilirubinemia greater than 1.0 milligrams per deciliter (mg/dL) has demonstrated sensitivity of 70% and specificity of 86% in evaluating for perforation in appendicitis, which may aid clinical judgment. 84 While ultrasound (US) is safe in pregnancy, wide variation in appendiceal location makes evaluation difficult. Sensitivity and specificity of US for the diagnosis of maternal appendicitis ranges from 67-100% and 83-95%, respectively. 85 The lower range is significantly less compared to non-pregnant populations in ED-performed bedside US, where sensitivity and specificity approximate 49.5-86.2% and 91.4-99.7%, respectively. 86 In cases where US is equivocal, magnetic resonance imaging (MRI) is recommended, sparing ionizing radiation to both mother and fetus. 87 A meta-analysis of MRI in the diagnosis of maternal appendicitis demonstrated a sensitivity of 96.8% and a specificity of 99.2%. 88 MRIs are routinely run without gadolinium, which poses no hypothetical risk to the fetus. 87 Early antibiotic coverage should be initiated with a second-generation cephalosporin and clindamycin or metronidazole. 89 Prompt surgical consultation should be obtained, as the risk of perforation rises with delaying surgical involvement for more than 24 hours. 89,90 Additionally, the risk of fetal loss increases with perforation of the appendix, with a 36% rate of fetal loss, compared to 1.5% without appendiceal rupture, underscoring the importance of early surgical consult in conjunction with antibiotics. 91

Pelvic Inflammatory Disease
Although rare, maternal sepsis from pelvic inflammatory disease (PID) is associated with high-mortality for mother and fetus, as well as increased risk of preterm delivery. 92 PID in pregnancy presents typically in the first trimester with fever and abdominal pain, adnexal tenderness, and cervical motion tenderness. Bacteria can ascend prior to the mucus plug sealing off the decidua around 12 weeks. 93 PID may rapidly progress to Bridwell et al.
Sepsis in Pregnancy: Recognition and Resuscitation tubo-ovarian abscess (TOA), with a mortality up to 9%. 94 TOA presents similarly to an infected ectopic pregnancy with fever and adnexal tenderness. The presentation of fever, leukocytosis, and diarrhea should prompt consideration of TOA, independently predicted by elevated C-reactive protein. 95 Pregnancy with PID requires hospitalization for treatment. 92 Doxycycline, the mainstay treatment for PID per IDSA guidelines, has been repeatedly proven to have severe teratogenicity and therefore should not be used. 92 Azithromycin should be substituted, in conjunction with an IV second-generation cephalosporin such as cefotetan or cefoxitin. 92 Penicillin cross-reactivity with secondgeneration cephalosporins is negligible, providing effective treatment in pencillin-allergic patients. 96,97 This regimen also covers Mycoplasma genitalium, which accounts for up to 8.7% of non-chlamydial and non-gonococcal PID cases. 98

Endometritis
Endometritis presents with postpartum fever, tachycardia, and foul lochia or malodorous vaginal discharge and occurs with ascension of bacteria during labor that colonizes amniotic fluid and decidua. 67 Cases are generally polymicrobial, with two-thirds containing both anaerobic (Bacteroides, Clostridium, and Peptostreptococcus spp.) and aerobic bacteria (Group B Streptococcus, E. coli, and enterococcus). 99 The presence of a hematoma is concerning for S. pyogenes and S. aureus and toxic shock syndrome. 77 IV gentamicin and clindamycin are efficacious, although this regimen does not cover enterococcus. 100 Doxycycline plus cefoxitin or ampicillin/sulbactam is an additional regimen. In those who do not respond within the first 48-72 hours, ampicillin is added to cover for these pathogens. 101 In patients delivering via cesarean section (C-section) who develop endometritis, parametrial cellulitis with phlegmon formation in the broad ligament or, less-commonly, parametrial phlegmon can cause persistent fevers and require interventional radiology consult for drainage. 101 Venous drainage post-Csection can also spread infection, generating septic pelvic thrombophlebitis. 102 Pelvic thrombophlebitis is usually refractory to broadspectrum antibiotics alone and requires anticoagulation with broad polymicrobial coverage. [102][103][104] Liberal use of postpartum CT has significantly impacted management. In a retrospective cohort study of 238 postpartum patients, the use of CT resulted in alteration of antibiotic therapy in 10%, addition of low-molecular weight heparin (LMWH) in 12%, and surgical intervention in 17%. 105 This study demonstrated that the addition of CT significantly impacted the clinical course of approximately 40% of patients. 105 Table 4 summarizes these infections.

Approach to Resuscitation in Pregnancy
Optimal stabilization of the fetus depends on adequate resuscitation of the mother. 77 Initial resuscitation should include IV fluid administration and optimized positioning. The left lateral decubitus position maximizes patient hemodynamics in the third trimester, improving preload by decreasing inferior vena cava compression. 77 Fluid resuscitation should begin within the first three hours of presentation with an initial recommended volume of 30 milliters per kilogram of crystalloid if either hypotension or lactic acid >4 millimoles per liter (mmol/L) is present. 107 Due to increased blood volume in pregnancy, a lactic acid threshold of 4 mmol/L may lack sensitivity in this population. In a retrospective cohort of 159 septic pregnant patients, the mean lactic acid level of those admitted for ICU level care was 2.6 mmol/L, and those

Sepsis in Pregnancy: Recognition and Resuscitation
Bridwell et al.
with positive blood cultures had a level of 2.2 mmol/L. 108 This study found increased morbidity with elevated lactic acid, with an adjusted odds ratio of 2.34 per 1 mmol/L increase in lactic acid. 108 No specific guidelines exist for vasopressors preference in pregnant patients. Although there is no explicit recommendation for mean arterial pressure optimization for sepsis in pregnancy, 65 mm Hg is a reasonable resuscitation goal. 107 Fetal monitoring can provide further titration feedback. 109 The 2016 Society of Critical Care Medicine guidelines do not offer recommendations tailored for the pregnant patient, although their current data support the use of norepinephrine as the first-line vasopressor in pregnant septic patients. 77,107,110 Due to the paucity of data, there is scant evidence to suggest that administration of norepinephrine causes negative fetal outcomes, or to suggest how norepinephrine administration impacts fetal outcome. 111 The choice for second-line vasopressor has been extrapolated from controlled studies with spinal anesthetics and is therefore controversial for application in sepsis. [112][113][114][115][116] Phenylephrine and ephedrine are often used as second-line agents, although with known tachyphylaxis. 1107, 114,116 Unlike ephedrine, phenylephrine does not alter the fetal acid-base status, although its alpha stimulation generates reflex maternal bradycardia and diminished cardiac output. 114,115 In comparison, ephedrine does not generate bradycardia, although its indirect action to release pre-existing maternal catecholamines may prove less efficacious in a septic patient who has already exhausted her endogenous stores and expended her cardiac reserve. [113][114][115] The data on vasopressor use in pregnancy are typically derived from C-section deliveries, many of which are elective. 65,113,114 In the Task Force on Obstetric Anesthesia, the American Society of Anesthesiologists recommended phenylephrine over ephedrine because of the preferred fetal acid-base status, as ephedrine causes fetal acidemia. 112 While this choice was supported by an international consensus of counterpart agencies, these data are extrapolated from a different physiologic context. 117 In the rare setting of septic myocarditis, dobutamine is the preferred inotrope. 113 Despite its very limited use in the nonpregnant septic population, dobutamine presents a viable option to improve inotropy in pregnant patients already on vasopressors and fluids. 112,118 Based on previous ovine models, dobutamine provides inotropy in pregnant sheep, although it decreases uterine blood flow; it requires further study in humans. 119 Other treatment considerations in maternal sepsis include glucose control, steroids, and venous thromboembolism (VTE) prophylaxis. Maternal hyperglycemia can directly cause fetal hyperglycemia and ultimately acidosis, decreasing uterine blood flow and lowering fetal oxygenation. 109 Maternal blood glucose should be maintained less than 180 grams per deciliter. 109 Steroids are recommended by the American College of Obstetrics and Gynecology in women between 24 weeks and 33 weeks and six days who are at risk of a preterm delivery within seven days, which is inclusive of those with rupture of membranes. 120 Hydrocortisone should be considered in those patients who do not improve with IV fluids and vasopressors. 107,110 Pregnancy alone confers a five-fold increased risk of deep vein thrombosis as compared to the non-pregnant population. 122 In individuals in septic shock on VTE prophylaxis, there was a 37% incidence in VTEs despite these prophylactic interventions. As septic pregnant patients are at high risk of VTE, patients without contraindications should receive both intermittent compression devices and either daily LMWH or 2-3 times daily administration of unfractionated heparin. 109,122 Direct oral anticoagulants are not currently recommended. 109

CONCLUSION
The anatomic and physiologic changes of pregnancy pose a challenge in early recognition and management of sepsis. Current sepsis guidelines were extrapolated from randomized control trials that specifically excluded pregnant patients. Although new guidelines have been created to risk stratify pregnant patients, they are without significant validation. Further research and validation are needed to help properly recognize and treat this small but critically ill population to improve outcomes for both mother and fetus.