Reference

Patients

Design

Clearance

Recurrence

Lacey et al 2003¹³

358

Randomized controlled

Compares podophyllotoxin solution, podophyllotoxin cream, and podophyllin. Podophyllotoxin showed greater efficacy and cost effectiveness than clinic based treatment with podophyllin.

No data

Tyring S et al, 1998 ¹⁵

326

Double-blind, randomized trial

After 8 weeks, 64% treated with 0.5% podofilox gel were cleared versus 12% in the vehicle-treated group. The 0.5% podofilox gel was generally well tolerated, with predominantly mild or moderate local reactions

No data

Claesson et al 1996 ¹⁶

Randomized prospective study

Compared podophyllotoxin cream 0.15% and 0.3% versus 0.5% solution, showing no statistically significant differences between the 3 treatments with regard to both efficacy and safety.

No data

Bonnez W, et al, 1994 ¹⁷

103

Randomized Controlled Trial

Showing efficacy and tolerance of 0.5% podofilox in the treatment of anogenital warts.

Podophyllotoxin is superior when patient-administered  over the vehicle alone as prophylaxis against recurrence of lesions.