Table 4 Trials involving imiquimod
Reference |
Patients |
Design |
Clearance |
Recurrence |
Fife et al, 2001 19 |
110 |
Randomized Controlled |
The optimal dosage regimen was three times a week, with an overall improvement of 90% for three times a week |
No data |
Moore et al, 2001 20 |
|
Reviewed published randomized controlled trials |
Complete clearance of warts at the end of treatment occurred in 51% of patients treated with imiquimod 2% or 5% cream and 6% of placebo treated patients |
Recurrence occurred in 18/112 patients of those treated 5%, 2/30 with imiquimod 1%, and 1/13 with placebo. For the three large trials only 27/121 (22%) of these had a recurrence |
Tyring ST,et al 1998 21 |
|
Randomized Controlled |
Clearance during treatment with imiquimod. Regression of warts was strongly associated with a decrease in HPV DNA and in mRNA expression for both early and late viral proteins. |
|
Edwards et al, 1998 22 |
311 |
Randomized double blind placebo |
50% of 109 patients who received 5% imiquimod cream, 21% of those who received 1% imiquimod cream, and 11% of patients treated with vehicle cream experienced eradication of all treated baseline warts. Five percent imiquimod cream is an effective and safe self-administered therapy |
The recurrence rate is low. |
Beutner et al., 1998 23 |
108 |
Prospective double blind, placebo controlled trial |
An 80% reduction in baseline wart area in 62% of imiquimod-treated patients versus a 4% of the placebo group. A 50% reduction was noted in 76% of imiquimod-treated patients versus 8% of placebo. |
|