Patient |
Age |
Sex |
Distribution of rash |
Agent |
Management |
Outcome |
Course of Illness |
1 |
68 |
M |
Generalised |
Dilantin |
-Removal of agent -IV hydrocortisone |
Rash improved on day 5 |
Recovered on day 12 |
2 |
22 |
F |
Face,lips,trunk with pustules |
Unknown |
-Removal of agent -IV hydrocortisone, IVIG, Klacid -Topical elomet lotion |
Shortness of breath, required prophylactic intubation in ICU |
Recovered on day 21 |
3 |
51 |
F |
Face, limbs, perioral, perineum, sole and palm |
Ciproxin, NSAID |
-Removal of agent -IV hydrocortisone |
Rash improved on day 5 |
Recovered on day 18 |
4 |
40 |
M |
Perioral, Conjunctiva,Buccal mucosa |
Acyclovir |
-Removal of agent -IV hydrocortisone, -Topical Elomet, thymol gargle, Nadexin eye drop |
Fever and rash started to improve on day 6 |
Recovered on day 16 |
5 |
32 |
F |
Haemorrhagic spots over the face,lips, buccal mucosa and generalised MP rash. |
Acyclovir , Tegretol |
-Removal of agent -Oral prednisolone, -Topical Daktacort, difflam mouthwash |
Fever and rash improved on day 7 |
Recovered on day 17 |
6 |
46 |
F |
Generalised MP rash and buccal mucosa haemorrhagic spots |
Augmentin,Allopurinol |
-Removal of agent -IV hydrocortisone, Klacid |
Fever and rash improved on day 4 |
Subsided on day 17 |
7 |
65 |
M |
Truncal MP rash and mucosa ulcer |
Cloxacillin, Ticlid |
-Removal of agent -IV hydrocortisone, Acyclovir -Topical Synalar
|
Rash improved on day 3 |
Subsided on day 14 |
Table 1. Summary of details of patients treated at United Christian Hospital between 2001-2002. It may be noticed that the common causative agent is drug-induced. SJS commonly occurs in adults age>40. Male and female are equally affected. The rash usually starts improving on day 4-5 upon the routine treatment, i.e., IV corticosteroid. Most of our patients require more than 14 days to have their rash totally subsided.