Therapy

Administration

Major side effects

Efficacy

Permethrin 5% cream

Topically overnight on day 1 and day 8

Contact allergic reaction to formaldehyde

Used to be excellent, but tolerance beginning to appear

Lindane 1% lotion

Topically overnight on day 1 and day 8

CNS side effects, pregnancy, package insert lists numerous caveats

Used to be excellent, but resistance becoming somewhat common

Sulfur 5%

Topically overnight on day 1,2, 3 and 8

None

Fair to good

Crotamiton 10%

Topically overnight on day 1,2 and 8

None

Poor

Ivermectin (200 – 250 µg/kg

Orally on day 1 and 8

Avoid if less than 30 lbs in weight, Avoid if pregnant

Excellent