Table 1. Activity of Adapalene, Indomethacin (IN), Betamethasone-17-Valerate (BMV), Tretinoin (RA), Isotretinoin (13RA) and Etretinate (ET) in In Vitro Models

Using Isolated Enzymes or Blood PMNs

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

*ID50 = dose inhibiting activity by 50%.

 

Adapted with permission from Hensby C, et al.17

 

 

Table 2. Activity of Adapalene, Indomethacin (IN), Betamethasone-17-Valerate (BMV), Tretinoin (RA), Isotretinoin (13RA) and Etretinate (ET) in In Vivo Animal Models

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

NS = nonsignificant; IP = intraperitoneal.

*Very significant inhibition P<0.001.

†Weak significant inhibition P<0.01.

‡Significant inhibition P<0.005 by paired Student t-test.

 

Adapted with permission from Hensby C, et al.17