http://www.rssboard.org/rss-specification 720 https://escholarship.org/uc/csnd_pcmlcms/rss Recent eScholarship items from Physical chemistry of myelin lipids and changes in multiple sclerosis Fri, 19 Jun 2026 13:29:24 +0000 https://escholarship.org/uc/item/9xr5f8f3 <p>ABSTRACT In Multiple Sclerosis (MS) and Experimental Allergic Encephalomyelitis (EAE) in the common marmoset, demyelination appears to result from loss of adhesion between adjacent myelin lamellae and the formation of small myelin vesicles. Although proteins are involved in maintaining normal myelin structure, lipids may play an essential role in myelin stability. In the current study we focused on the effect that disturbed ratios of sphingomyelin (SM) and cholesterol may have on the regular distribution of those molecules. Mixtures of egg SMs (saturated) and bovine brain SMs (partially unsaturated) with cholesterol were made and examined with Langmuir isotherms. The cholesterol-induced condensations of the average molecular areas were determined by classic mean molecular area vs. composition plots. The results showed that egg SMs are significantly more expanded than bovine brain SMs, contrary to the fact that they are more saturated. We believe this is due to the fact that... https://escholarship.org/uc/item/9xr5f8f3 Tue, 14 Oct 2003 00:00:00 +0000 Koopman, Erik Husted, Cynthia A., Ph.D.