Recent ucd_ome_posters_hematologyoncology items

High-plex spatial RNA profiling reveals cell type-specific biomarker expression in early-stage melanoma

Wed, 25 Jun 2025 00:00:00 +0000

• Melanoma, the deadliest of the common skin cancers, develops through a gradual accumulation of mutations and overcomes environmental regulation

• Markers of early melanoma evolution and predictors of durable treatment response remain largely undiscovered

• Spatially resolved techniques are likely to outperform bulk molecular profiling for discovery of early stage and predictive biomarkers

• Previous studies revealed the importance of keratinocyte-derived growth factors and cell adhesion molecules in limiting melanocyte proliferation and elucidated mechanisms by which malignant melanocytes escape this regulation

• However, prior studies did not capture the spatial element of melanocyte-keratinocyte interactions in situ in patient-derived primary melanomas and benign melanocytic tumors

Investigating the role of saposin B in HMA-mediated toxicity toward breast cancer cells

Thu, 5 Dec 2024 00:00:00 +0000

Therapy-resistant cancer cells can be targeted using novel cationic amphiphilic drugs such as HMA that induce lysosomal cell death. Parallel alteration of lysosomal protein Saposin B could sensitize cells to HMA, reducing off-target effects.

Analyzing gene expression in androgen resistant prostate cancer

Thu, 5 Dec 2024 00:00:00 +0000

Prostate cancer is the 2nd leading cause of cancer related deaths in men the USA. Although anti-androgen therapies have prevailed as treatments, resistance to anti-androgen therapies leads to metastasis resulting in high mortality.

Developing PRISM-Spanish: A psychosocial skills-based intervention for Spanish-speaking adolescents and young adults with cancer

Tue, 22 Oct 2024 00:00:00 +0000

Adolescents and young adults (AYAs; 12-25 years old) with cancer are at high risk for elevated distress and poorer mental health outcomes than their peers. Studies have shown that, in particular, Spanish-speaking Latinos with cancer are at risk for increased psychosocial burden, lower quality of life, and higher depressive symptoms when compared to their non-Latino counterparts. Despite this, a systemic review of the literature finds a severe lack of interventional studies being conducted among Hispanic/Latinx cancer patients and survivors. PRISM (Promoting Resilience in Stress Management) is an intervention built on the premise that promoting resilience resources will reduce distress and improve outcomes. However, its efficacy has only been tested in English-speaking populations. Studies show that translating a psychosocial intervention without considering key cultural differences will inevitably be ineffective. The aim of this study is to lay the groundwork for an adaptation...

Fragmentation of Care for Young Adults with Sickle Cell Disease in California

Fri, 11 Oct 2024 00:00:00 +0000

- Sickle Cell Disease (SCD) predominantly affects people of African ancestry and a multidisciplinary complex care model has been suggested to optimize care

- Young adults (YA) 18-25 years of age transition from pediatric to adult models of care and the effect of receiving care at multiple medical facilities (fragmentation) during this time on outcomes has not been well-described

- We sought to examine fragmentation of care for YA SCD patients and the potential effect of fragmentation on mortality.

Low Income Areas Predict T Stage in Patients with Head and Neck Cancer

Wed, 4 Sep 2024 00:00:00 +0000

A strong predictor of mortality in patients with head and neck cancer (HNC) is the stage of tumor at time of diagnosis. Studies suggest that income level is associated with poor putcomes in HNC patients.

An Integrated Multidisciplinary Evaulation Platform and Early Experience for Precision Therapy in Resectable NSCLC

Fri, 30 Aug 2024 00:00:00 +0000

Lung cancer is the leading cause of cancer related deaths in the US, with 85% of cases classified as non-small cell lung cancer (NSCLC). 20-25% of patients with NSCLC present with resectable disease.

Amiloride Derivative Compound 10357 in the Treatment of B-Cell Acute Lymphoblastic Leukemia

Fri, 30 Aug 2024 00:00:00 +0000

Compound 10357 is an amiloride derivative with potential promise as an adjunct to current chemotherapeutics. This study investigates the therapeutic efficacy of Compound 10357 in B-Cell Acute Lymphoblastic Leukemia (B-ALL).

MEK Inhibitor-Based Combination Strategies in Selected Molecular Subsets of Non-Small Cell Lung Cancer (NSCLC): rationale for the Design of Phase I Clinical Trials

Fri, 30 Aug 2024 00:00:00 +0000

Lung cancer is the leading cause of both cancer and cancer-related mortality in the United States. Targeting different receptor tyrosine kinase pathways has proven to be a potent therapeutic strategy for such cancers.

Sarcopenia and Frailty as Predictors of Surgical Morbidity and Oncologic Outcomes in Retroperitoneal Sarcoma

Thu, 29 Aug 2024 00:00:00 +0000

Retroperitoneal sarcomas (RPS) are rare tumors accounting for 1%–2% of all solid malignancies and 10%–20% of sarcomas. Surgery is the main treatment modality for patients with RPS. To date, there is no established model to predict perioperative risks for RPS patients. In this study, we evaluate the association between preoperative sarcopenia,hypoalbuminemia, and frailty and 30-dayperioperative morbidity and survival in patientswith RPS undergoing surgical resection. Ourgoal is to determine the ability of these factorsto predict surgical and oncological outcomes inthese cases.

Feasibility of a Symptomatic Screening Program for Early Detection of Gastric Cancer in Roatan, Honduras: Preliminary Results

Thu, 29 Aug 2024 00:00:00 +0000

Feasibility of a Symptomatic Screening Program for Early Detection of Gastric Cancer in Roatan, Honduras: Preliminary Results

Which non-phamacologic interventions are most effective at addressing chemotherapy related cognitive impairment (CRCI) in adolescent and young adult cancer survivors?

Thu, 29 Aug 2024 00:00:00 +0000

It often presents during and after treatment with memory impairment, concentration deficits, and depression. 25.75% prevalence in adolescent and young adult (AYA) cancer survivors. It significantly impacts school, work, daily activities, and overall quality of life.

Pathogenesis of Endometriosis in Non-Human Primates: A Critical Literature Review

Wed, 28 Aug 2024 00:00:00 +0000

Endometriosis: ectopic endometrial tissue that responds to cyclical hormonal changes during a normal menstrual cycle, becoming trapped in an endometrioma and causing pain. NHPs have been used to study endometriosis: baboons, cynomolgus, rhesus, and marmoset monkeys.

Views of Non-Physician Stakeholders on Barriers & Facilitators to AYA Cancer Care in Latin America

Tue, 27 Aug 2024 00:00:00 +0000

Cancer is the fourth leading cause of death in adolescent and young adults (AYA: ages15-39) worldwide. Over 90% of AYAs with cancer live in low-and-middle-incomecountries (LMIC). Little is known about thecurrent landscape of AYA oncology care in these settings. Guidelines for the care of thisunique population in LMIC in Latin America are lacking.