http://www.rssboard.org/rss-specification 720 https://escholarship.org/uc/ucd_ome_posters_mmi/rss Recent eScholarship items from Medical Microbiology and Immunology Tue, 23 Jun 2026 15:21:14 +0000 https://escholarship.org/uc/item/31q0k6d1 <p>Salmonella Typhi is the causative agent of typhoid fever, which is a life-threatening, systemic disease, with an estimated global disease burden of 21.6 million cases annually, resulting in about 220,000 deaths. Due to the absence of convenient animals models to study S. Typhi and other typhoidal Salmonella serovars, our understanding of typhoid fever pathogenesis is still incomplete.</p><p>Like other Salmonella serovars, S. Typhi is phagocytosed by host macrophages and survives and replicates intracellularly within these macrophages. Interestingly, one important virulence factor of S. Typhi is the polysaccharide capsular antigen Vi, which, like many of the bacterial capsules produced by extracellular bacteria, has long been thought to play a role in preventing phagocytosis and complement killing of S. Typhi.</p><p>Thus, we encounter a paradox in which a bacteria that survives and replicates within macrophages as part of its life cycle, also possesses an anti-phagocytic capsule,... https://escholarship.org/uc/item/31q0k6d1 Wed, 25 Jun 2025 00:00:00 +0000 Zhang, Lillian Hiyoshi, Hirotaka Lepenies, Bernd Bäumler, Andreas https://escholarship.org/uc/item/3ng623tm Salmonella Typhi is the causative agent of typhoid fever, which is a lifethreatening, systemic disease, with an estimated global disease burden of 21.6 million cases annually, resulting in about 220,000 deaths. Due to the absence of convenient animals models to study S. Typhi and other typhoidal Salmonella serovars, our understanding of typhoid fever pathogenesis is still incomplete. https://escholarship.org/uc/item/3ng623tm Thu, 17 Oct 2024 00:00:00 +0000 Zhang, Lillian F. Hiyoshi, Hirotaka Lepenies, Bernd Baumler, Andreas J.