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    <title>Recent ucdavismath items</title>
    <link>https://escholarship.org/uc/ucdavismath/rss</link>
    <description>Recent eScholarship items from Department of Mathematics</description>
    <pubDate>Wed, 24 Jun 2026 03:21:49 +0000</pubDate>
    <item>
      <title>Multiscale Hodge scattering networks for data analysis</title>
      <link>https://escholarship.org/uc/item/80j0t30k</link>
      <description>We propose new scattering networks for signals measured on simplicial complexes, which we call Multiscale Hodge Scattering Networks (MHSNs). Our construction builds on multiscale basis dictionaries on simplicial complexes—namely, the κ-GHWT and κ-HGLET—which we recently developed for simplices of dimension κ ∈ N in a given simplicial complex by generalizing the node-based Generalized Haar–Walsh Transform (GHWT) and Hierarchical Graph Laplacian Eigen Transform (HGLET). Both the κ-GHWT and the κ-HGLET form redundant sets (i.e., dictionaries) of multiscale basis vectors and the corresponding expansion coefficients of a given signal. Our MHSNs adopt a layered structure analogous to a convolutional neural network (CNN), cascading the moments of the modulus of the dictionary coefficients. The resulting features are invariant to reordering of the simplices (i.e., node permutation of the underlying graphs). Importantly, the use of multiscale basis dictionaries in our MHSNs admits a natural...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/80j0t30k</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Saito, Naoki</name>
        <uri>https://orcid.org/0000-0001-5234-4719</uri>
      </author>
      <author>
        <name>Schonsheck, Stefan C</name>
      </author>
      <author>
        <name>Shvarts, Eugene</name>
      </author>
    </item>
    <item>
      <title>Explainable and Class-Revealing Signal Feature Extraction via Scattering Transform and Constrained Zeroth-Order Optimization</title>
      <link>https://escholarship.org/uc/item/4kh0431d</link>
      <description>We propose a new method to extract discriminant and explainable features from a particular machine learning model, i.e., a combination of the scattering transform and the multiclass logistic regression. Although this model is well-known for its ability to learn various signal classes with high classification rate, it remains elusive to understand why it can generate such successful classification, mainly due to the nonlinearity of the scattering transform. In order to uncover the meaning of the scattering transform coefficients selected by the multiclass logistic regression (with the Lasso penalty), we adopt zeroth-order optimization algorithms to search an input pattern that maximizes the class probability of a class of interest given the learned model. In order to do so, it turns out that imposing sparsity and smoothness of input patterns is important. We demonstrate the effectiveness of our proposed method using a couple of synthetic time-series classification problems.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4kh0431d</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Saito, Naoki</name>
        <uri>https://orcid.org/0000-0001-5234-4719</uri>
      </author>
      <author>
        <name>Weber, David</name>
      </author>
    </item>
    <item>
      <title>Explainable and Class-Revealing Signal Feature Extraction via Scattering Transform and Constrained Zeroth-Order Optimization</title>
      <link>https://escholarship.org/uc/item/28t9z2kq</link>
      <description>We propose a new method to extract discriminant and explainable features from
a particular machine learning model, i.e., a combination of the scattering
transform and the multiclass logistic regression. Although this model is
well-known for its ability to learn various signal classes with high
classification rate, it remains elusive to understand why it can generate such
successful classification, mainly due to the nonlinearity of the scattering
transform. In order to uncover the meaning of the scattering transform
coefficients selected by the multiclass logistic regression (with the Lasso
penalty), we adopt zeroth-order optimization algorithms to search an input
pattern that maximizes the class probability of a class of interest given the
learned model. In order to do so, it turns out that imposing sparsity and
smoothness of input patterns is important. We demonstrate the effectiveness of
our proposed method using a couple of synthetic time-series classification
problems.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/28t9z2kq</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Saito, Naoki</name>
        <uri>https://orcid.org/0000-0001-5234-4719</uri>
      </author>
      <author>
        <name>Weber, David</name>
      </author>
    </item>
    <item>
      <title>Plabic tangles and cluster promotion maps</title>
      <link>https://escholarship.org/uc/item/6rp7629z</link>
      <description>Inspired by the BCFW recurrence for tilings of the amplituhedron, we introduce the general framework of plabic tangles that utilizes plabic graphs to define rational maps between products of Grassmannians called promotions. The central conjecture of the paper is that promotion maps are quasi-cluster homomorphisms, which we prove for several classes of promotions. In order to define promotion maps, we utilize m-vector-relation configurations (m-VRCs) on plabic graphs. We relate m-VRCs to the degree (a.k.a ‘intersection number’) of the amplituhedron map on positroid varieties and characterize all plabic trees with intersection number one and their VRCs. Finally, we show that promotion maps admit an operad structure and, supported by the class of 4-mass box promotions, we point at new positivity properties for non-rational maps beyond cluster algebras. Promotion maps have important connections to the geometry and cluster structure of the amplituhedron and singularities of scattering...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6rp7629z</guid>
      <pubDate>Wed, 11 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Even-Zohar, Chaim</name>
      </author>
      <author>
        <name>Parisi, Matteo</name>
      </author>
      <author>
        <name>Sherman-Bennett, Melissa</name>
      </author>
      <author>
        <name>Tessler, Ran</name>
      </author>
      <author>
        <name>Williams, Lauren</name>
      </author>
    </item>
    <item>
      <title>Hook-Valued Tableau Uncrowding and Tableau Switching</title>
      <link>https://escholarship.org/uc/item/4bd954vc</link>
      <description>Hook-Valued Tableau Uncrowding and Tableau Switching</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4bd954vc</guid>
      <pubDate>Wed, 11 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Jang, Jihyeug</name>
      </author>
      <author>
        <name>Kim, Jang Soo</name>
      </author>
      <author>
        <name>Pan, Jianping</name>
      </author>
      <author>
        <name>Pappe, Joseph</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
    </item>
    <item>
      <title>Braid variety cluster structures, II: general type</title>
      <link>https://escholarship.org/uc/item/0vb996s2</link>
      <description>We show that braid varieties for any complex simple algebraic group G$$G$$ are cluster varieties. This includes open Richardson varieties inside the flag variety G/B$$G/B$$.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0vb996s2</guid>
      <pubDate>Wed, 11 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Galashin, Pavel</name>
      </author>
      <author>
        <name>Lam, Thomas</name>
      </author>
      <author>
        <name>Sherman-Bennett, Melissa</name>
      </author>
    </item>
    <item>
      <title>The symplectic isotopy problem for rational cuspidal curves</title>
      <link>https://escholarship.org/uc/item/82c4q4tr</link>
      <description>We define a suitably tame class of singular symplectic curves in 4-manifolds, namely those whose singularities are modeled on complex curve singularities. We study the corresponding symplectic isotopy problem, with a focus on rational curves with irreducible singularities (rational cuspidal curves) in the complex projective plane. We prove that every such curve is isotopic to a complex curve in degrees up to five, and for curves with one singularity whose link is a torus knot. Classification results of symplectic isotopy classes rely on pseudo-holomorphic curves together with a symplectic version of birational geometry of log pairs and techniques from four-dimensional topology.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/82c4q4tr</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Golla, Marco</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
    </item>
    <item>
      <title>Rational cuspidal curves and symplectic fillings</title>
      <link>https://escholarship.org/uc/item/3dd6v4x8</link>
      <description>Rational cuspidal curves and symplectic fillings</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3dd6v4x8</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Golla, Marco</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
    </item>
    <item>
      <title>Equivariant Perturbation in Gomory and Johnson’s Infinite Group Problem. VII. Inverse Semigroup Theory, Closures, Decomposition of Perturbations</title>
      <link>https://escholarship.org/uc/item/5cx7z609</link>
      <description>In this self-contained paper, we present a theory of the piecewise linear minimal valid functions for the 1-row Gomory–Johnson infinite group problem. The non-extreme minimal valid functions are those that admit effective perturbations. We give a precise description of the space of these perturbations as a direct sum of certain finite- and infinite-dimensional subspaces. The infinite-dimensional subspaces have partial symmetries; to describe them, we develop a theory of inverse semigroups of partial bijections, interacting with the functional equations satisfied by the perturbations. Our paper provides the foundation for grid-free algorithms for the Gomory–Johnson model, in particular for testing extremality of piecewise linear functions whose breakpoints are rational numbers with huge denominators.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5cx7z609</guid>
      <pubDate>Sat, 14 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Hildebrand, Robert</name>
      </author>
      <author>
        <name>Köppe, Matthias</name>
      </author>
      <author>
        <name>Zhou, Yuan</name>
      </author>
    </item>
    <item>
      <title>Dual-feasible functions for integer programming and combinatorial optimization: Algorithms, characterizations, and approximations</title>
      <link>https://escholarship.org/uc/item/5c33591q</link>
      <description>Within the framework of the superadditive duality theory of integer programming, we study two types of dual-feasible functions of a single real variable (Alves et al., 2016). We introduce software that automates testing piecewise linear functions for maximality and extremality, enabling a computer-based search. We build a connection to cut-generating functions in the Gomory–Johnson and related models, complete the characterization of maximal functions, and prove analogues of the Gomory–Johnson 2-slope theorem and the Basu–Hildebrand–Molinaro approximation theorem.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5c33591q</guid>
      <pubDate>Sat, 14 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Köppe, Matthias</name>
      </author>
      <author>
        <name>Wang, Jiawei</name>
      </author>
    </item>
    <item>
      <title>Integer points in arbitrary convex cones: the case of the PSD and SOC cones</title>
      <link>https://escholarship.org/uc/item/5jq3z5r6</link>
      <description>We investigate the semigroup of integer points inside a convex cone. We extend classical results in integer linear programming to integer conic programming. We show that the semigroup associated with nonpolyhedral cones can sometimes have a notion of finite generating set with the help of a group action. We show this is true for the cone of positive semidefinite matrices (PSD) and the second-order cone (SOC). Both cones have a finite generating set of integer points, similar in spirit to Hilbert bases, under the action of a finitely generated group. We also extend notions of total dual integrality, Gomory-Chvátal closure, and Carathéodory rank to integer points in arbitrary cones.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5jq3z5r6</guid>
      <pubDate>Wed, 11 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Marsters, Brittney</name>
      </author>
      <author>
        <name>Xu, Luze</name>
      </author>
      <author>
        <name>Zhang, Shixuan</name>
      </author>
    </item>
    <item>
      <title>On contact 3‐manifolds that admit a nonfree toric action</title>
      <link>https://escholarship.org/uc/item/01b6946f</link>
      <description>Abstract  We classify all contact structures on 3‐manifolds that admit a nonfree toric action, up to contactomorphism, and present them through explicit topological descriptions. Our classification is based on Lerman's classification of toric contact 3‐manifolds up to equivariant contactomorphism [Lerman, J. Symplectic Geom. 1 (2003), 785–828]. We also prove that every contact 3‐manifold with a nonfree toric action arises as the concave boundary of a toric linear plumbing over spheres inspired by Marinković et&amp;nbsp;al. As a corollary of both results, we classify which contact 3‐manifolds arise as the concave boundary of a linear plumbing of&amp;nbsp;spheres.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/01b6946f</guid>
      <pubDate>Wed, 28 Jan 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Marinković, Aleksandra</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
    </item>
    <item>
      <title>An extended Vinogradov’s mean value theorem</title>
      <link>https://escholarship.org/uc/item/795990w4</link>
      <description>&lt;p&gt;In this paper, we provide novel mean value estimates for exponential sums related to the extended main conjecture of Vinogradov’s mean value theorem, by developing the Hardy-Littlewood circle method together with a refined shifting variables argument.&lt;/p&gt; &lt;p&gt; Let    be a natural number and    . Define the exponential sum    For    , consider mean values of the exponential sums    where we wrote    . By making use of the aforementioned tools, we obtain the sharp upper bound for    , for    and    . Furthermore, for    , we obtain analogous results depending on a small cap decoupling inequality for the moment curves in    . &lt;/p&gt;</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/795990w4</guid>
      <pubDate>Sun, 7 Dec 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Oh, Changkeun</name>
      </author>
      <author>
        <name>Yeon, Kiseok</name>
      </author>
    </item>
    <item>
      <title>The contact cut graph and a Weinstein L$\mathcal {L}$‐invariant</title>
      <link>https://escholarship.org/uc/item/47c6420j</link>
      <description>Abstract  We define and study the contact cut graph which is an analogue of Hatcher and Thurston's cut graph for contact geometry, inspired by contact Heegaard splittings (Giroux, Proceedings of the International Congress of Mathematicians , Beijing, 2002; Torisu, Internat. Math. Res. Notices (2000), 441–454). We show how oriented paths in the contact cut graph correspond to Lefschetz fibrations and multisection with divides diagrams. We also give a correspondence for achiral Lefschetz fibrations. We use these correspondences to define a new invariant of Weinstein domains, the Weinstein ‐invariant , that is a symplectic analogue of the Kirby–Thompson's ‐invariant of smooth 4‐manifolds. We discuss the relation of Lefschetz stabilization with the Weinstein ‐invariant. We present topological and geometric constraints of Weinstein domains with . We also give two families of examples of multisections with divides that have arbitrarily large ‐invariant.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/47c6420j</guid>
      <pubDate>Mon, 1 Dec 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Castro, Nickolas A</name>
      </author>
      <author>
        <name>Islambouli, Gabriel</name>
      </author>
      <author>
        <name>Min, Jie</name>
      </author>
      <author>
        <name>Sakallı, Sümeyra</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
      <author>
        <name>Wu, Angela</name>
      </author>
    </item>
    <item>
      <title>Morse actions of discrete groups on symmetric spaces: local-to-global principle</title>
      <link>https://escholarship.org/uc/item/3dv5k0qb</link>
      <description>Our main result is a local-to-global principle for Morse quasigeodesics, maps and actions. As an application of our techniques we show algorithmic recognizability of Morse actions and construct Morse “Schottky subgroups” of higher-rank semisimple Lie groups via arguments not based on Tits pingpong. Our argument is purely geometric and proceeds by constructing equivariant Morse quasiisometric embeddings of trees into higher-rank symmetric spaces.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3dv5k0qb</guid>
      <pubDate>Wed, 24 Sep 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
      <author>
        <name>Leeb, Bernhard</name>
      </author>
      <author>
        <name>Porti, Joan</name>
      </author>
    </item>
    <item>
      <title>The Combinatorial Theory Flip</title>
      <link>https://escholarship.org/uc/item/92p0s02x</link>
      <description>The Combinatorial Theory Flip</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/92p0s02x</guid>
      <pubDate>Wed, 27 Aug 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
    </item>
    <item>
      <title>Interview with Anne Schilling</title>
      <link>https://escholarship.org/uc/item/2rs1x74j</link>
      <description>Interview with Anne Schilling</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2rs1x74j</guid>
      <pubDate>Wed, 27 Aug 2025 00:00:00 +0000</pubDate>
    </item>
    <item>
      <title>Complexity of Finite Semigroups: History and Decidability</title>
      <link>https://escholarship.org/uc/item/7bg31125</link>
      <description>Margolis, Rhodes and Schilling recently submitted two papers that proved that the complexity of a finite semigroup is computable. The purpose of this paper is to survey the basic results of Krohn–Rhodes complexity of finite semigroups and to outline the proof of its computability.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7bg31125</guid>
      <pubDate>Wed, 13 Aug 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Margolis, Stuart</name>
      </author>
      <author>
        <name>Rhodes, John</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
    </item>
    <item>
      <title>Weinstein Handlebodies for Complements of Smoothed Toric Divisors</title>
      <link>https://escholarship.org/uc/item/5hx005cj</link>
      <description>&lt;p&gt; We study the interactions between toric manifolds and Weinstein handlebodies. We define a partially-centeredness condition on a Delzant polytope, which we prove ensures that the complement of a corresponding partial smoothing of the total toric divisor supports an explicit Weinstein structure. Many examples which fail this condition also fail to have Weinstein (or even exact) complement to the partially smoothed divisor. We investigate the combinatorial possibilities of Delzant polytopes that realize such Weinstein domain complements. We also develop an algorithm to construct a Weinstein handlebody diagram in Gompf standard form for the complement of such a partially smoothed total toric divisor. The algorithm we develop more generally outputs a Weinstein handlebody diagram for any Weinstein 4-manifold constructed by attaching 2-handles to the disk cotangent bundle of any surface&amp;nbsp;    , where the 2-handles are attached along the co-oriented conormal lifts of curves on&amp;nbsp;...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5hx005cj</guid>
      <pubDate>Thu, 17 Jul 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Acu, Bahar</name>
      </author>
      <author>
        <name>Capovilla-Searle, Orsola</name>
      </author>
      <author>
        <name>Gadbled, Agnès</name>
      </author>
      <author>
        <name>Marinković, Aleksandra</name>
      </author>
      <author>
        <name>Murphy, Emmy</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
      <author>
        <name>Wu, Angela</name>
      </author>
    </item>
    <item>
      <title>Optimization tools for computing colorings of [ 1 , … , n ] with few monochromatic solutions on 3-variable linear equations</title>
      <link>https://escholarship.org/uc/item/5c22v7db</link>
      <description>A famous result in arithmetic Ramsey theory says that for many linear homogeneous equations E there is a threshold value Rk(E) (the Rado number of E) such that for any k-coloring of the integers in the interval [1,n], with n≥Rk(E), there exists at least one monochromatic solution. But one can further ask, how many monochromatic solutions is the minimum possible in terms of n? Several authors have estimated this function before, here we offer new tools from integer and semidefinite optimization that help find either optimal or near optimal 2-colorings minimizing the number of monochromatic solutions of several families of 3-variable non-regular homogeneous linear equations. In the last part of the paper we further extend to three and more colors for the Schur equation, improving earlier work.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5c22v7db</guid>
      <pubDate>Sun, 25 May 2025 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Ventura, Denae</name>
      </author>
      <author>
        <name>Wang, Liuyue</name>
      </author>
      <author>
        <name>Wesley, William J</name>
      </author>
    </item>
    <item>
      <title>Lipschitz decompositions of domains with bilaterally flat boundaries</title>
      <link>https://escholarship.org/uc/item/5pg5p7j7</link>
      <description>Abstract: 
We study classes of domains in  with sufficiently flat boundaries that admit a decomposition or covering of bounded overlap by Lipschitz graph domains with controlled total surface area. This study is motivated by the following result proved by Peter Jones as a piece of his proof of the Analyst's Traveling Salesman Theorem in the complex plane: Any simply connected domain  with finite boundary length  can be decomposed into Lipschitz graph domains with total boundary length at most  for some  independent of . In this paper, we prove an analogous Lipschitz decomposition result in higher dimensions for domains with Reifenberg flat boundaries satisfying a uniform beta‐squared sum bound. We use similar techniques to show that domains with general Reifenberg flat or uniformly rectifiable boundaries admit similar Lipschitz decompositions while allowing the constituent domains to have bounded overlaps rather than be&amp;nbsp;disjoint.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5pg5p7j7</guid>
      <pubDate>Mon, 28 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Krandel, Jared</name>
      </author>
    </item>
    <item>
      <title>The geometry of colors in van Gogh’s Sunflowers</title>
      <link>https://escholarship.org/uc/item/11g508gv</link>
      <description>“Paintings fade like flowers”: van Gogh’s prediction on the impact of age on paintings came true for most of his paintings. We have studied the consequences of this aging on the Sunflowers in a vase with a yellow background series, namely its original, F454, currently in London, and two replicates, F457, in Tokyo, and F458, in Amsterdam, which van Gogh painted using the original as a model. The background and flower renditions in those paintings have faded and turned brown, making them less vibrant that van Gogh had most likely intended. We have attempted to restore van Gogh’s intent using a computational approach based on data science. After identifications of regions of interest (ROI) within the three paintings F454, F457, and F458 that capture the flowers, stems of the flowers, and background, respectively, we studied the geometry of the color space (in RGB representation) occupied by those ROIs. By comparing those color spaces with those occupied by similar ROIs in photographs...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/11g508gv</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Liao, Shuting</name>
      </author>
      <author>
        <name>Koehl, Patrice</name>
      </author>
      <author>
        <name>Schultens, Jennifer</name>
        <uri>https://orcid.org/0000-0003-3898-0051</uri>
      </author>
      <author>
        <name>Hsieh, Fushing</name>
        <uri>https://orcid.org/0000-0002-9292-6980</uri>
      </author>
    </item>
    <item>
      <title>Continued fractions and lines across the Stern–Brocot diagram</title>
      <link>https://escholarship.org/uc/item/50h793r6</link>
      <description>Continued fractions and lines across the Stern–Brocot diagram</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/50h793r6</guid>
      <pubDate>Wed, 9 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Abramson, Heather</name>
      </author>
      <author>
        <name>Chesebro, Eric</name>
      </author>
      <author>
        <name>Cummins, Vivian</name>
      </author>
      <author>
        <name>Emlen, Cory</name>
      </author>
      <author>
        <name>Grady, Ryan</name>
      </author>
      <author>
        <name>Ke, Kenton</name>
      </author>
    </item>
    <item>
      <title>Farey recursive functions</title>
      <link>https://escholarship.org/uc/item/4js6x7qf</link>
      <description>Farey recursive functions</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4js6x7qf</guid>
      <pubDate>Wed, 9 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Chesebro, Eric</name>
      </author>
      <author>
        <name>Emlen, Cory</name>
      </author>
      <author>
        <name>Ke, Kenton</name>
      </author>
      <author>
        <name>LaFontaine, Denise</name>
      </author>
      <author>
        <name>McKinnie, Kelly</name>
      </author>
      <author>
        <name>Rigby, Catherine</name>
      </author>
    </item>
    <item>
      <title>The lattice of submonoids of the uniform block permutations containing the symmetric group</title>
      <link>https://escholarship.org/uc/item/8hn3k54s</link>
      <description>We study the lattice of submonoids of the uniform block permutation monoid containing the symmetric group (which is its group of units). We prove that this lattice is distributive under union and intersection by relating the submonoids containing the symmetric group to downsets in a new partial order on integer partitions. Furthermore, we show that the sizes of the J$$\mathscr {J}$$-classes of the uniform block permutation monoid are sums of squares of dimensions of irreducible modules of the monoid algebra.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8hn3k54s</guid>
      <pubDate>Wed, 26 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Orellana, Rosa</name>
      </author>
      <author>
        <name>Saliola, Franco</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Zabrocki, Mike</name>
      </author>
    </item>
    <item>
      <title>The immersion poset on partitions</title>
      <link>https://escholarship.org/uc/item/55v4v3jk</link>
      <description>Abstract: 

          We introduce the immersion poset 
              
                $$({\mathcal {P}}(n), \leqslant _I)$$
                
                  
                    (
                    P
                    
                      (
                      n
                      )
                    
                    ,
                    
                      ⩽
                      I
                    
                    )
                  
                
              
             on partitions, defined by 
              
                $$\lambda \leqslant _I \mu $$
                
                  
                    λ
                    
                      ⩽
                      I
                    
                    μ
                  
                
              
             if and only if 
              
                $$s_\mu (x_1, \ldots , x_N) - s_\lambda (x_1, \ldots , x_N)$$
                
                  
      ...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/55v4v3jk</guid>
      <pubDate>Wed, 12 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Johnston, Lisa</name>
      </author>
      <author>
        <name>Kenepp, David</name>
      </author>
      <author>
        <name>Nguyen, Evuilynn</name>
      </author>
      <author>
        <name>Paul, Digjoy</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Simone, Mary Claire</name>
      </author>
      <author>
        <name>Zhou, Regina</name>
      </author>
    </item>
    <item>
      <title>Corrigendum: A Demazure crystal construction for Schubert polynomials</title>
      <link>https://escholarship.org/uc/item/3z3793p9</link>
      <description>We give a corrigendum to our paper&amp;nbsp;[4] entitled “A Demazure crystal construction for Schubert polynomials”.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3z3793p9</guid>
      <pubDate>Wed, 26 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Assaf, Sami</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
    </item>
    <item>
      <title>The strong Haken theorem via sphere complexes</title>
      <link>https://escholarship.org/uc/item/7rd3q8kt</link>
      <description>The strong Haken theorem via sphere complexes</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7rd3q8kt</guid>
      <pubDate>Wed, 29 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hensel, Sebastian</name>
      </author>
      <author>
        <name>Schultens, Jennifer</name>
      </author>
    </item>
    <item>
      <title>Tree polynomials identify a link between co-transcriptional R-loops and nascent RNA folding</title>
      <link>https://escholarship.org/uc/item/7hf1p79d</link>
      <description>R-loops are a class of non-canonical nucleic acid structures that typically form during transcription when the nascent RNA hybridizes the DNA template strand, leaving the non-template DNA strand unpaired. These structures are abundant in nature and play important physiological and pathological roles. Recent research shows that DNA sequence and topology affect R-loops, yet it remains unclear how these and other factors contribute to R-loop formation. In this work, we investigate the link between nascent RNA folding and the formation of R-loops. We introduce tree-polynomials, a new class of representations of RNA secondary structures. A tree-polynomial representation consists of a rooted tree associated with an RNA secondary structure together with a polynomial that is uniquely identified with the rooted tree. Tree-polynomials enable accurate, interpretable and efficient data analysis of RNA secondary structures without pseudoknots. We develop a computational pipeline for investigating...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7hf1p79d</guid>
      <pubDate>Mon, 20 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Liu, Pengyu</name>
      </author>
      <author>
        <name>Lusk, Jacob</name>
      </author>
      <author>
        <name>Jonoska, Nataša</name>
      </author>
      <author>
        <name>Vázquez, Mariel</name>
      </author>
    </item>
    <item>
      <title>THE BEST WAYS TO SLICE A POLYTOPE</title>
      <link>https://escholarship.org/uc/item/83s1w0m9</link>
      <description>We study the structure of the set of all possible affine hyperplane sections of a convex polytope. We present two different cell decompositions of this set, induced by hyperplane arrangements. Using our decomposition, we bound the number of possible combinatorial types of sections and craft algorithms that compute optimal sections of the polytope according to various combinatorial and metric criteria, including sections that maximize the number of k-dimensional faces, maximize the volume, and maximize the integral of a polynomial. Our optimization algorithms run in polynomial time in fixed dimension, but the same problems show computational complexity hardness otherwise. Our tools can be extended to intersection with halfspaces and projections onto hyperplanes. Finally, we present several experiments illustrating our theorems and algorithms on famous polytopes.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/83s1w0m9</guid>
      <pubDate>Fri, 17 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Brandenburg, Marie-charlotte</name>
      </author>
      <author>
        <name>De Loera, Jesus A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Meroni, Chiara</name>
      </author>
    </item>
    <item>
      <title>Weighted Ehrhart theory: Extending Stanley's nonnegativity theorem</title>
      <link>https://escholarship.org/uc/item/7hv0d6r8</link>
      <description>We generalize R. P. Stanley's celebrated theorem that the h⁎-polynomial of the Ehrhart series of a rational polytope has nonnegative coefficients and is monotone under containment of polytopes. We show that these results continue to hold for weighted Ehrhart series where lattice points are counted with polynomial weights, as long as the weights are homogeneous polynomials decomposable as sums of products of linear forms that are nonnegative on the polytope. We also show nonnegativity of the h⁎-polynomial as a real-valued function for a larger family of weights. We explore the case when the weight function is the square of a single (arbitrary) linear form. We show stronger results for two-dimensional convex lattice polygons and give concrete examples showing tightness of the hypotheses. As an application, we construct a counterexample to a conjecture by Berg, Jochemko, and Silverstein on Ehrhart tensor polynomials.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7hv0d6r8</guid>
      <pubDate>Fri, 17 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Bajo, Esme</name>
      </author>
      <author>
        <name>Davis, Robert</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Garber, Alexey</name>
      </author>
      <author>
        <name>Mora, Sofía Garzón</name>
      </author>
      <author>
        <name>Jochemko, Katharina</name>
      </author>
      <author>
        <name>Yu, Josephine</name>
      </author>
    </item>
    <item>
      <title>The discrete yet ubiquitous theorems of Carathéodory, Helly, Sperner, Tucker, and Tverberg</title>
      <link>https://escholarship.org/uc/item/58b3n6qb</link>
      <description>We discuss five fundamental results of discrete mathematics: the lemmas of Sperner and Tucker from combinatorial topology and the theorems of Carathéodory, Helly, and Tverberg from combinatorial geometry. We explore their connections and emphasize their broad impact in application areas such as data science, game theory, graph theory, mathematical optimization, computational geometry, etc.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/58b3n6qb</guid>
      <pubDate>Fri, 17 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Goaoc, Xavier</name>
      </author>
      <author>
        <name>Meunier, Frédéric</name>
      </author>
      <author>
        <name>Mustafa, Nabil H</name>
      </author>
    </item>
    <item>
      <title>Klein–Maskit combination theorem for Anosov subgroups: Amalgams</title>
      <link>https://escholarship.org/uc/item/5m15t3g3</link>
      <description>Abstract: 

               The classical Klein–Maskit combination theorems provide sufficient conditions to construct new Kleinian groups using old ones.
There are two distinct but closely related combination theorems: the first deals with amalgamated free products, whereas the second deals with HNN extensions.
This article gives analogs of both combination theorems for Anosov subgroups.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5m15t3g3</guid>
      <pubDate>Wed, 20 Nov 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Dey, Subhadip</name>
      </author>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
    </item>
    <item>
      <title>From Quasi-Symmetric to Schur Expansions with Applications to Symmetric Chain Decompositions and Plethysm</title>
      <link>https://escholarship.org/uc/item/1b48z46c</link>
      <description>It is an important problem in algebraic combinatorics to deduce the Schur function expansion of a symmetric function whose expansion in terms of the fundamental quasisymmetric function is known. For example, formulas are known for the fundamental expansion of a Macdonald symmetric function and for the plethysm of two Schur functions, while the Schur expansions of these expressions are still elusive. Based on work of Egge, Loehr and Warrington, Garsia and Remmel provided a method to obtain the Schur expansion from the fundamental expansion by replacing each quasisymmetric function by a Schur function (not necessarily indexed by a partition) and using straightening rules to obtain the Schur expansion. Here we provide a new method that only involves the coefficients of the quasisymmetric functions indexed by partitions and the quasi-Kostka matrix. As an application, we identify the lexicographically largest term in the Schur expansion of the plethysm of two Schur functions. We provide...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1b48z46c</guid>
      <pubDate>Wed, 20 Nov 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Orellana, Rosa</name>
      </author>
      <author>
        <name>Saliola, Franco</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Zabrocki, Mike</name>
      </author>
    </item>
    <item>
      <title>Fair Data Representation for Machine Learning at the Pareto Frontier.</title>
      <link>https://escholarship.org/uc/item/67z9r23d</link>
      <description>As machine learning powered decision-making becomes increasingly important in our daily lives, it is imperative to strive for fairness in the underlying data processing. We propose a pre-processing algorithm for fair data representation via which  -objective supervised learning results in estimations of the Pareto frontier between prediction error and statistical disparity. Particularly, the present work applies the optimal affine transport to approach the post-processing Wasserstein barycenter characterization of the optimal fair  -objective supervised learning via a pre-processing data deformation. Furthermore, we show that the Wasserstein geodesics from learning outcome marginals to their barycenter characterizes the Pareto frontier between  -loss and total Wasserstein distance among the marginals. Numerical simulations underscore the advantages: (1) the pre-processing step is compositive with arbitrary conditional expectation estimation supervised learning methods and unseen...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/67z9r23d</guid>
      <pubDate>Wed, 13 Nov 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Xu, Shizhou</name>
      </author>
      <author>
        <name>Strohmer, Thomas</name>
      </author>
    </item>
    <item>
      <title>Complete characterizations of hyperbolic Coxeter groups with Sierpiński curve boundary and with Menger curve boundary</title>
      <link>https://escholarship.org/uc/item/2br289rp</link>
      <description>Complete characterizations of hyperbolic Coxeter groups with Sierpiński curve boundary and with Menger curve boundary</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2br289rp</guid>
      <pubDate>Wed, 23 Oct 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Danielski, Daniel</name>
      </author>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
      <author>
        <name>Świątkowski, Jacek</name>
      </author>
    </item>
    <item>
      <title>A multiscale predictive digital twin for neurocardiac modulation</title>
      <link>https://escholarship.org/uc/item/4sn2p0kg</link>
      <description>Cardiac function is tightly regulated by the autonomic nervous system (ANS). Activation of the sympathetic nervous system increases cardiac output by increasing heart rate and stroke volume, while parasympathetic nerve stimulation instantly slows heart rate. Importantly, imbalance in autonomic control of the heart has been implicated in the development of arrhythmias and heart failure. Understanding of the mechanisms and effects of autonomic stimulation is a major challenge because synapses in different regions of the heart result in multiple changes to heart function. For example, nerve synapses on the sinoatrial node (SAN) impact pacemaking, while synapses on contractile cells alter contraction and arrhythmia vulnerability. Here, we present a multiscale neurocardiac modelling and simulator tool that predicts the effect of efferent stimulation of the sympathetic and parasympathetic branches of the ANS on the cardiac SAN and ventricular myocardium. The model includes a layered...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4sn2p0kg</guid>
      <pubDate>Mon, 16 Sep 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Yang, Pei‐Chi</name>
        <uri>https://orcid.org/0000-0002-5753-1131</uri>
      </author>
      <author>
        <name>Rose, Adam</name>
      </author>
      <author>
        <name>DeMarco, Kevin R</name>
      </author>
      <author>
        <name>Dawson, John RD</name>
      </author>
      <author>
        <name>Han, Yanxiao</name>
      </author>
      <author>
        <name>Jeng, Mao‐Tsuen</name>
      </author>
      <author>
        <name>Harvey, Robert D</name>
      </author>
      <author>
        <name>Santana, L Fernando</name>
      </author>
      <author>
        <name>Ripplinger, Crystal M</name>
      </author>
      <author>
        <name>Vorobyov, Igor</name>
        <uri>https://orcid.org/0000-0002-4767-5297</uri>
      </author>
      <author>
        <name>Lewis, Timothy J</name>
      </author>
      <author>
        <name>Clancy, Colleen E</name>
      </author>
    </item>
    <item>
      <title>Domains of discontinuity of Lorentzian affine group actions</title>
      <link>https://escholarship.org/uc/item/8cw787s3</link>
      <description>We prove nonemptyness of domains of proper discontinuity of Anosov groups of affine Lorentzian transformations of Rn.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8cw787s3</guid>
      <pubDate>Wed, 14 Aug 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
      <author>
        <name>Leeb, Bernhard</name>
      </author>
    </item>
    <item>
      <title>Klein–Maskit combination theorem for Anosov subgroups: free products</title>
      <link>https://escholarship.org/uc/item/56j6m623</link>
      <description>We prove a generalization of the classical Klein–Maskit combination theorem, in the free product case, in the setting of Anosov subgroups. Namely, if Γ A and Γ B are Anosov subgroups of a semisimple Lie group G of noncompact type, then under suitable topological assumptions, the group generated by Γ A and Γ B in G is again Anosov, and is naturally isomorphic to the free product Γ A∗ Γ B . Such a generalization was conjectured in Dey et al. (Math Z 293(1–2):551–578, 2019).</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/56j6m623</guid>
      <pubDate>Wed, 14 Aug 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Dey, Subhadip</name>
      </author>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
    </item>
    <item>
      <title>Affine Springer Fibers and Generalized Haiman Ideals (with an Appendix by Eugene Gorsky and Joshua P. Turner)</title>
      <link>https://escholarship.org/uc/item/57r3c1m9</link>
      <description>Abstract: 

               We compute the Borel–Moore homology of unramified affine Springer fibers for $\textrm{Gr}_n$ under the assumption that they are equivariantly formal and relate them to certain ideals discussed by Haiman. For $n=3$, we give an explicit description of these ideals, compute their Hilbert series, generators, and relations, and compare them to generalized $(q,t)$-Catalan numbers. We also compare the homology to the Khovanov–Rozansky homology of the associated link, and prove a version of a conjecture of Oblomkov, Rasmussen, and Shende in this case.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/57r3c1m9</guid>
      <pubDate>Thu, 25 Jul 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Turner, Joshua P</name>
      </author>
    </item>
    <item>
      <title>Effect of fluid elasticity on the emergence of oscillations in an active elastic filament</title>
      <link>https://escholarship.org/uc/item/3415f5nh</link>
      <description>Many microorganisms propel themselves through complex media by deforming their flagella. The beat is thought to emerge from interactions between forces of the surrounding fluid, the passive elastic response from deformations of the flagellum and active forces from internal molecular motors. The beat varies in response to changes in the fluid rheology, including elasticity, but there are limited data on how systematic changes in elasticity alter the beat. This work analyses a related problem with fixed-strength driving force: the emergence of beating of an elastic planar filament driven by a follower force at the tip of a viscoelastic fluid. This analysis examines how the onset of oscillations depends on the strength of the force and viscoelastic parameters. Compared to a Newtonian fluid, it takes more force to induce the instability in viscoelastic fluids, and the frequency of the oscillation is higher. The linear analysis predicts that the frequency increases with the fluid relaxation...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3415f5nh</guid>
      <pubDate>Tue, 25 Jun 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Link, Kathryn G</name>
      </author>
      <author>
        <name>Guy, Robert D</name>
        <uri>https://orcid.org/0000-0002-0602-7015</uri>
      </author>
      <author>
        <name>Thomases, Becca</name>
      </author>
      <author>
        <name>Arratia, Paulo E</name>
      </author>
    </item>
    <item>
      <title>Reproducibility of 3D chromatin configuration reconstructions</title>
      <link>https://escholarship.org/uc/item/2f707966</link>
      <description>It is widely recognized that the three-dimensional (3D) architecture of eukaryotic chromatin plays an important role in processes such as gene regulation and cancer-driving gene fusions. Observing or inferring this 3D structure at even modest resolutions had been problematic, since genomes are highly condensed and traditional assays are coarse. However, recently devised high-throughput molecular techniques have changed this situation. Notably, the development of a suite of chromatin conformation capture (CCC) assays has enabled elicitation of contacts-spatially close chromosomal loci-which have provided insights into chromatin architecture. Most analysis of CCC data has focused on the contact level, with less effort directed toward obtaining 3D reconstructions and evaluating the accuracy and reproducibility thereof. While questions of accuracy must be addressed experimentally, questions of reproducibility can be addressed statistically-the purpose of this paper. We use a constrained...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2f707966</guid>
      <pubDate>Mon, 17 Jun 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Segal, Mark R</name>
      </author>
      <author>
        <name>Xiong, Hao</name>
      </author>
      <author>
        <name>Capurso, Daniel</name>
      </author>
      <author>
        <name>Vazquez, Mariel</name>
        <uri>https://orcid.org/0000-0001-8328-6806</uri>
      </author>
      <author>
        <name>Arsuaga, Javier</name>
      </author>
    </item>
    <item>
      <title>The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data</title>
      <link>https://escholarship.org/uc/item/2db2p1k7</link>
      <description>The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2db2p1k7</guid>
      <pubDate>Sun, 16 Jun 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Thompson, Paul M</name>
      </author>
      <author>
        <name>Stein, Jason L</name>
      </author>
      <author>
        <name>Medland, Sarah E</name>
      </author>
      <author>
        <name>Hibar, Derrek P</name>
      </author>
      <author>
        <name>Vasquez, Alejandro Arias</name>
      </author>
      <author>
        <name>Renteria, Miguel E</name>
      </author>
      <author>
        <name>Toro, Roberto</name>
      </author>
      <author>
        <name>Jahanshad, Neda</name>
      </author>
      <author>
        <name>Schumann, Gunter</name>
      </author>
      <author>
        <name>Franke, Barbara</name>
      </author>
      <author>
        <name>Wright, Margaret J</name>
      </author>
      <author>
        <name>Martin, Nicholas G</name>
      </author>
      <author>
        <name>Agartz, Ingrid</name>
      </author>
      <author>
        <name>Alda, Martin</name>
      </author>
      <author>
        <name>Alhusaini, Saud</name>
      </author>
      <author>
        <name>Almasy, Laura</name>
      </author>
      <author>
        <name>Almeida, Jorge</name>
      </author>
      <author>
        <name>Alpert, Kathryn</name>
      </author>
      <author>
        <name>Andreasen, Nancy C</name>
      </author>
      <author>
        <name>Andreassen, Ole A</name>
      </author>
      <author>
        <name>Apostolova, Liana G</name>
      </author>
      <author>
        <name>Appel, Katja</name>
      </author>
      <author>
        <name>Armstrong, Nicola J</name>
      </author>
      <author>
        <name>Aribisala, Benjamin</name>
      </author>
      <author>
        <name>Bastin, Mark E</name>
      </author>
      <author>
        <name>Bauer, Michael</name>
      </author>
      <author>
        <name>Bearden, Carrie E</name>
      </author>
      <author>
        <name>Bergmann, Ørjan</name>
      </author>
      <author>
        <name>Binder, Elisabeth B</name>
      </author>
      <author>
        <name>Blangero, John</name>
      </author>
      <author>
        <name>Bockholt, Henry J</name>
      </author>
      <author>
        <name>Bøen, Erlend</name>
      </author>
      <author>
        <name>Bois, Catherine</name>
      </author>
      <author>
        <name>Boomsma, Dorret I</name>
      </author>
      <author>
        <name>Booth, Tom</name>
      </author>
      <author>
        <name>Bowman, Ian J</name>
      </author>
      <author>
        <name>Bralten, Janita</name>
      </author>
      <author>
        <name>Brouwer, Rachel M</name>
      </author>
      <author>
        <name>Brunner, Han G</name>
      </author>
      <author>
        <name>Brohawn, David G</name>
      </author>
      <author>
        <name>Buckner, Randy L</name>
      </author>
      <author>
        <name>Buitelaar, Jan</name>
      </author>
      <author>
        <name>Bulayeva, Kazima</name>
      </author>
      <author>
        <name>Bustillo, Juan R</name>
      </author>
      <author>
        <name>Calhoun, Vince D</name>
      </author>
      <author>
        <name>Cannon, Dara M</name>
      </author>
      <author>
        <name>Cantor, Rita M</name>
      </author>
      <author>
        <name>Carless, Melanie A</name>
      </author>
      <author>
        <name>Caseras, Xavier</name>
      </author>
      <author>
        <name>Cavalleri, Gianpiero L</name>
      </author>
      <author>
        <name>Chakravarty, M Mallar</name>
      </author>
      <author>
        <name>Chang, Kiki D</name>
      </author>
      <author>
        <name>Ching, Christopher RK</name>
      </author>
      <author>
        <name>Christoforou, Andrea</name>
      </author>
      <author>
        <name>Cichon, Sven</name>
      </author>
      <author>
        <name>Clark, Vincent P</name>
      </author>
      <author>
        <name>Conrod, Patricia</name>
      </author>
      <author>
        <name>Coppola, Giovanni</name>
        <uri>https://orcid.org/0000-0003-2105-1061</uri>
      </author>
      <author>
        <name>Crespo-Facorro, Benedicto</name>
      </author>
      <author>
        <name>Curran, Joanne E</name>
      </author>
      <author>
        <name>Czisch, Michael</name>
      </author>
      <author>
        <name>Deary, Ian J</name>
      </author>
      <author>
        <name>de Geus, Eco JC</name>
      </author>
      <author>
        <name>den Braber, Anouk</name>
      </author>
      <author>
        <name>Delvecchio, Giuseppe</name>
      </author>
      <author>
        <name>Depondt, Chantal</name>
      </author>
      <author>
        <name>de Haan, Lieuwe</name>
      </author>
      <author>
        <name>de Zubicaray, Greig I</name>
      </author>
      <author>
        <name>Dima, Danai</name>
      </author>
      <author>
        <name>Dimitrova, Rali</name>
      </author>
      <author>
        <name>Djurovic, Srdjan</name>
      </author>
      <author>
        <name>Dong, Hongwei</name>
      </author>
      <author>
        <name>Donohoe, Gary</name>
      </author>
      <author>
        <name>Duggirala, Ravindranath</name>
      </author>
      <author>
        <name>Dyer, Thomas D</name>
      </author>
      <author>
        <name>Ehrlich, Stefan</name>
      </author>
      <author>
        <name>Ekman, Carl Johan</name>
      </author>
      <author>
        <name>Elvsåshagen, Torbjørn</name>
      </author>
      <author>
        <name>Emsell, Louise</name>
      </author>
      <author>
        <name>Erk, Susanne</name>
      </author>
      <author>
        <name>Espeseth, Thomas</name>
      </author>
      <author>
        <name>Fagerness, Jesen</name>
      </author>
      <author>
        <name>Fears, Scott</name>
      </author>
      <author>
        <name>Fedko, Iryna</name>
      </author>
      <author>
        <name>Fernández, Guillén</name>
      </author>
      <author>
        <name>Fisher, Simon E</name>
      </author>
      <author>
        <name>Foroud, Tatiana</name>
      </author>
      <author>
        <name>Fox, Peter T</name>
      </author>
      <author>
        <name>Francks, Clyde</name>
      </author>
      <author>
        <name>Frangou, Sophia</name>
      </author>
      <author>
        <name>Frey, Eva Maria</name>
      </author>
      <author>
        <name>Frodl, Thomas</name>
      </author>
      <author>
        <name>Frouin, Vincent</name>
      </author>
      <author>
        <name>Garavan, Hugh</name>
      </author>
      <author>
        <name>Giddaluru, Sudheer</name>
      </author>
      <author>
        <name>Glahn, David C</name>
      </author>
      <author>
        <name>Godlewska, Beata</name>
      </author>
      <author>
        <name>Goldstein, Rita Z</name>
      </author>
      <author>
        <name>Gollub, Randy L</name>
      </author>
      <author>
        <name>Grabe, Hans J</name>
      </author>
    </item>
    <item>
      <title>Private measures, random walks, and synthetic data</title>
      <link>https://escholarship.org/uc/item/6k09x9vf</link>
      <description>Differential privacy is a mathematical concept that provides an information-theoretic security guarantee. While differential privacy has emerged as a de facto standard for guaranteeing privacy in data sharing, the known mechanisms to achieve it come with some serious limitations. Utility guarantees are usually provided only for a fixed, a priori specified set of queries. Moreover, there are no utility guarantees for more complex—but very common—machine learning tasks such as clustering or classification. In this paper we overcome some of these limitations. Working with metric privacy, a powerful generalization of differential privacy, we develop a polynomial-time algorithm that creates a private measure from a data set. This private measure allows us to efficiently construct private synthetic data that are accurate for a wide range of statistical analysis tools. Moreover, we prove an asymptotically sharp min-max result for private measures and synthetic data in general compact...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6k09x9vf</guid>
      <pubDate>Wed, 12 Jun 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Boedihardjo, March</name>
      </author>
      <author>
        <name>Strohmer, Thomas</name>
      </author>
      <author>
        <name>Vershynin, Roman</name>
      </author>
    </item>
    <item>
      <title>Early career Latinas in STEM: Challenges and solutions</title>
      <link>https://escholarship.org/uc/item/3rm3m38c</link>
      <description>Mexican, Puerto Rican, and Central American Ancestry (MPRCA) individuals represent 82% of US Latinos. An intergenerational group of MPRCA women and allies met to discuss persistent underrepresentation of MPRCA women in STEM, identifying multi-level challenges and solutions. Implementation of these solutions is important and will benefit MPRCA women and the entire academic community.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3rm3m38c</guid>
      <pubDate>Thu, 9 May 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Werner Washburne, Maggie</name>
      </author>
      <author>
        <name>Trejo, JoAnn</name>
        <uri>https://orcid.org/0000-0003-4405-6228</uri>
      </author>
      <author>
        <name>Zambrana, Ruth Enid</name>
      </author>
      <author>
        <name>Zavala, Maria Elena</name>
      </author>
      <author>
        <name>Martinic, Alice</name>
      </author>
      <author>
        <name>Riestra, Angelica</name>
      </author>
      <author>
        <name>Delgado, Tracie</name>
      </author>
      <author>
        <name>Edwards, Staci</name>
      </author>
      <author>
        <name>Escobar, Thelma</name>
      </author>
      <author>
        <name>Jamison-McClung, Denneal</name>
      </author>
      <author>
        <name>Vazquez, Mariel</name>
        <uri>https://orcid.org/0000-0001-8328-6806</uri>
      </author>
      <author>
        <name>Vera, Iset</name>
      </author>
      <author>
        <name>Guerra, Michelle</name>
      </author>
      <author>
        <name>Marinez, Diana I</name>
      </author>
      <author>
        <name>Gonzalez, Elma</name>
      </author>
      <author>
        <name>Rodriguez, Raymond L</name>
        <uri>https://orcid.org/0000-0002-6105-2571</uri>
      </author>
    </item>
    <item>
      <title>Multiscale transforms for signals on simplicial complexes</title>
      <link>https://escholarship.org/uc/item/1vw4k87g</link>
      <description>Our previous multiscale graph basis dictionaries/graph signal transforms—Generalized Haar-Walsh Transform (GHWT); Hierarchical Graph Laplacian Eigen Transform (HGLET); Natural Graph Wavelet Packets (NGWPs); and their relatives—were developed for analyzing data recorded on vertices of a given graph. In this article, we propose their generalization for analyzing data recorded on edges, faces (i.e., triangles), or more generally κ$$\kappa $$-dimensional simplices of a simplicial complex (e.g., a triangle mesh of a manifold). The key idea is to use the Hodge Laplacians and their variants for hierarchical partitioning of a set of κ$$\kappa $$-dimensional simplices in a given simplicial complex, and then build localized basis functions on these partitioned subsets. We demonstrate their usefulness for data representation on both illustrative synthetic examples and real-world simplicial complexes generated from a co-authorship/citation dataset and an ocean current/flow dataset.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1vw4k87g</guid>
      <pubDate>Wed, 8 May 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Saito, Naoki</name>
        <uri>https://orcid.org/0000-0001-5234-4719</uri>
      </author>
      <author>
        <name>Schonsheck, Stefan C</name>
      </author>
      <author>
        <name>Shvarts, Eugene</name>
      </author>
    </item>
    <item>
      <title>Computational complexity and 3–manifolds and zombies</title>
      <link>https://escholarship.org/uc/item/8bz0f64n</link>
      <description>Computational complexity and 3–manifolds and zombies</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8bz0f64n</guid>
      <pubDate>Wed, 24 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kuperberg, Greg</name>
      </author>
      <author>
        <name>Samperton, Eric</name>
      </author>
    </item>
    <item>
      <title>The Cartan–Hadamard conjecture and the Little Prince</title>
      <link>https://escholarship.org/uc/item/70d4c5bf</link>
      <description>The Cartan–Hadamard conjecture and the Little Prince</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/70d4c5bf</guid>
      <pubDate>Wed, 24 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kloeckner, Benoît R</name>
      </author>
      <author>
        <name>Kuperberg, Greg</name>
      </author>
    </item>
    <item>
      <title>Identifying lens spaces in polynomial time</title>
      <link>https://escholarship.org/uc/item/66h3b8md</link>
      <description>Identifying lens spaces in polynomial time</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/66h3b8md</guid>
      <pubDate>Wed, 24 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kuperberg, Greg</name>
      </author>
    </item>
    <item>
      <title>Coloring invariants of knots and links are often intractable</title>
      <link>https://escholarship.org/uc/item/5js4159f</link>
      <description>Coloring invariants of knots and links are often intractable</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5js4159f</guid>
      <pubDate>Wed, 24 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kuperberg, Greg</name>
      </author>
      <author>
        <name>Samperton, Eric</name>
      </author>
    </item>
    <item>
      <title>CANONICAL REPRESENTATIVES FOR DIVISOR CLASSES ON TROPICAL CURVES AND THE MATRIX–TREE THEOREM</title>
      <link>https://escholarship.org/uc/item/090080wv</link>
      <description>Abstract: 
Let $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}\Gamma $ be a compact tropical curve (or metric graph) of genus&amp;nbsp;$g$. Using the theory of tropical theta functions, Mikhalkin and Zharkov proved that there is a canonical effective representative (called a break divisor) for each linear equivalence class of divisors of degree $g$ on&amp;nbsp;$\Gamma $. We present a new combinatorial proof of the fact that there is a unique break divisor in each equivalence class, establishing in the process an ‘integral’ version of this result which is of independent interest. As an application, we provide a  ‘geometric proof’ of (a dual version of) Kirchhoff’s celebrated matrix–tree theorem. Indeed, we show that each weighted graph model $G$ for $\Gamma $ gives rise to a canonical polyhedral decomposition of the $g$-dimensional...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/090080wv</guid>
      <pubDate>Wed, 24 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>AN, YANG</name>
      </author>
      <author>
        <name>BAKER, MATTHEW</name>
      </author>
      <author>
        <name>KUPERBERG, GREG</name>
      </author>
      <author>
        <name>SHOKRIEH, FARBOD</name>
      </author>
    </item>
    <item>
      <title>Modeling time-varying phytoplankton subsidy reveals at-risk species in a Chilean intertidal ecosystem</title>
      <link>https://escholarship.org/uc/item/7hg208q7</link>
      <description>The allometric trophic network (ATN) framework for modeling population dynamics has provided numerous insights into ecosystem functioning in recent years. Herein we extend ATN modeling of the intertidal ecosystem off central Chile to include empirical data on pelagic chlorophyll-a concentration. This intertidal community requires subsidy of primary productivity to support its rich ecosystem. Previous work models this subsidy using a constant rate of phytoplankton input to the system. However, data shows pelagic subsidies exhibit highly variable, pulse-like behavior. The primary contribution of our work is incorporating this variable input into ATN modeling to simulate how this ecosystem may respond to pulses of pelagic phytoplankton. Our model results show that: (1) closely related sea snails respond differently to phytoplankton variability, which is explained by the underlying network structure of the food web; (2) increasing the rate of pelagic-intertidal mixing increases fluctuations...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7hg208q7</guid>
      <pubDate>Mon, 1 Apr 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Duckwall, Casey</name>
      </author>
      <author>
        <name>Largier, John L</name>
        <uri>https://orcid.org/0000-0003-4273-4443</uri>
      </author>
      <author>
        <name>Wieters, Evie A</name>
      </author>
      <author>
        <name>Valdovinos, Fernanda S</name>
      </author>
    </item>
    <item>
      <title>Markov Bases: A 25 Year Update</title>
      <link>https://escholarship.org/uc/item/96v2r876</link>
      <description>In this article, we evaluate the challenges and best practices associated with the Markov bases approach to sampling from conditional distributions. We provide insights and clarifications after 25 years of the publication of the Fundamental theorem for Markov bases by Diaconis and Sturmfels. In addition to a literature review, we prove three new results on the complexity of Markov bases in hierarchical models, relaxations of the fibers in log-linear models, and limitations of partial sets of moves in providing an irreducible Markov chain. Supplementary materials for this article are available online.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/96v2r876</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Almendra-Hernández, Félix</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Petrović, Sonja</name>
      </author>
    </item>
    <item>
      <title>The Polyhedral Geometry of Pivot Rules and Monotone Paths</title>
      <link>https://escholarship.org/uc/item/92p1f9k1</link>
      <description>Motivated by the analysis of the performance of the simplex method, we study the behavior of families of pivot rules of linear programs. We introduce normalized-weight pivot rules which are fundamental for the following reasons: First, they are memory-less, in the sense that the pivots are governed by local information encoded by an arborescence. Second, many of the most used pivot rules belong to that class, and we show this subclass is critical for understanding the complexity of all pivot rules. Finally, normalized-weight pivot rules can be parametrized in a natural continuous manner. The latter leads to the existence of two polytopes, the pivot rule polytopes and the neighbotopes, that capture the behavior of normalized-weight pivot rules on polytopes and linear programs. We explain their face structure in terms of multi-arborescences and compute upper bounds on the number of coherent arborescences, that is, vertices of our polytopes. We introduce a normalized-weight pivot...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/92p1f9k1</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Black, Alexander E</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Lütjeharms, Niklas</name>
      </author>
      <author>
        <name>Sanyal, Raman</name>
      </author>
    </item>
    <item>
      <title>Convexity in (Colored) Affine Semigroups</title>
      <link>https://escholarship.org/uc/item/75c5j84r</link>
      <description>In this paper, we explore affine semigroup versions of the convex geometry theorems of Helly, Tverberg, and Carathéodory. Additionally, we develop a new theory of colored affine semigroups, where the semigroup generators each receive a color and the elements of the semigroup take into account the colors used (the classical theory of affine semigroups coincides with the case in which all generators have the same color). We prove an analog of Tverberg’s theorem and colorful Helly’s theorem for semigroups, as well as a version of colorful Carathéodory’s theorem for cones. We also demonstrate that colored numerical semigroups are particularly rich by introducing a colored version of the Frobenius number.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/75c5j84r</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>O’Neill, Christopher</name>
      </author>
      <author>
        <name>Wang, Chengyang</name>
      </author>
    </item>
    <item>
      <title>Average behavior of minimal free resolutions of monomial ideals</title>
      <link>https://escholarship.org/uc/item/6p3161d7</link>
      <description>We show that, under a natural probability distribution, random monomial ideals will almost always have minimal free resolutions of maximal length; that is, the projective dimension will almost always be n, where n is the number of variables in the polynomial ring. As a consequence we prove that Cohen.Macaulayness is a rare property. We characterize when a random monomial ideal is generic/strongly generic, and when it is Scarf.i.e., when the algebraic Scarf complex of M S = k[x1, . . . , xn] gives a minimal free resolution of S/M. It turns out, outside of a very specific ratio of model parameters, random monomial ideals are Scarf only when they are generic. We end with a discussion of the average magnitude of Betti numbers.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6p3161d7</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Hoşten, Serkan</name>
      </author>
      <author>
        <name>Krone, Robert</name>
      </author>
      <author>
        <name>Silverstein, Lily</name>
      </author>
    </item>
    <item>
      <title>On the Length of Monotone Paths in Polyhedra</title>
      <link>https://escholarship.org/uc/item/6mk1d53m</link>
      <description>Motivated by the problem of bounding the number of iterations of the simplex algorithm, we investigate the possible lengths of monotone paths followed inside the oriented graphs of polyhedra (oriented by the objective function). We consider both the shortest and the longest monotone paths and estimate the monotone diameter and height of polyhedra. Our analysis applies to transportation polytopes, matroid polytopes, matching polytopes, shortest-path polytopes, and the traveling salesman polytope, among others. We begin by showing that combinatorial cubes have monotone diameter and Bland simplex height upper bounded by their dimension and that in fact all monotone paths of zonotopes are no larger than the number of edge directions of the zonotope. We later use this to show that several polytopes have polynomial-size monotone diameter. In contrast, we show that for many well-known combinatorial polytopes, the height is at least exponential. Surprisingly, for some famous pivot rules,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6mk1d53m</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Blanchard, Moïse</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Louveaux, Quentin</name>
      </author>
    </item>
    <item>
      <title>Random monomial ideals</title>
      <link>https://escholarship.org/uc/item/6b25c1h0</link>
      <description>Inspired by the study of random graphs and simplicial complexes, and motivated by the need to understand average behavior of ideals, we propose and study probabilistic models of random monomial ideals. We prove theorems about the probability distributions, expectations and thresholds for events involving monomial ideals with given Hilbert function, Krull dimension, and first graded Betti numbers, and show that our models generalize several well-known random simplicial complex models. Finally we present several experimentally-backed conjectures about regularity, projective dimension, strong genericity, and Cohen–Macaulayness of random monomial ideals.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6b25c1h0</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Petrović, Sonja</name>
      </author>
      <author>
        <name>Silverstein, Lily</name>
      </author>
      <author>
        <name>Stasi, Despina</name>
      </author>
      <author>
        <name>Wilburne, Dane</name>
      </author>
    </item>
    <item>
      <title>Data-driven algorithm selection and tuning in optimization and signal processing</title>
      <link>https://escholarship.org/uc/item/5kt2c509</link>
      <description>Machine learning algorithms typically rely on optimization subroutines and are well known to provide very effective outcomes for many types of problems. Here, we flip the reliance and ask the reverse question: can machine learning algorithms lead to more effective outcomes for optimization problems? Our goal is to train machine learning methods to automatically improve the performance of optimization and signal processing algorithms. As a proof of concept, we use our approach to improve two popular data processing subroutines in data science: stochastic gradient descent and greedy methods in compressed sensing. We provide experimental results that demonstrate the answer is “yes”, machine learning algorithms do lead to more effective outcomes for optimization problems, and show the future potential for this research direction. In addition to our experimental work, we prove relevant Probably Approximately Correct (PAC) learning theorems for our problems of interest. More precisely,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5kt2c509</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Haddock, Jamie</name>
      </author>
      <author>
        <name>Ma, Anna</name>
      </author>
      <author>
        <name>Needell, Deanna</name>
      </author>
    </item>
    <item>
      <title>Monotone Paths on Cross-Polytopes</title>
      <link>https://escholarship.org/uc/item/5cz296g3</link>
      <description>In the early 1990s, Billera and Sturmfels introduced the monotone path polytope (MPP), an important case of the general theory of fiber polytopes, which has led to remarkable combinatorics. Given a pair (P, φ) of a polytope P and a linear functional φ , the MPP is obtained from averaging the fibers of the projection φ(P) . They also showed that MPPs of (regular) simplices and hyper-cubes are combinatorial cubes and permutahedra respectively. As a natural follow-up we investigate the monotone paths of cross-polytopes for a generic linear functional φ . We show the face lattice of the MPP of the cross-polytope is isomorphic to the lattice of intervals in the sign poset from oriented matroid theory. We also describe its f-vector, some geometric realizations, an irredundant inequality description, the 1-skeleton and we compute its diameter. In contrast to the case of simplices and hyper-cubes, monotone paths on cross-polytopes are not always coherent.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5cz296g3</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Black, Alexander E</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
    </item>
    <item>
      <title>Tverberg-Type Theorems with Altered Intersection Patterns (Nerves)</title>
      <link>https://escholarship.org/uc/item/5b6972vn</link>
      <description>Tverberg’s theorem says that a set with sufficiently many points in Rd can always be partitioned into m parts so that the (m- 1) -simplex is the (nerve) intersection pattern of the convex hulls of the parts. The main results of our paper demonstrate that Tverberg’s theorem is just a special case of a more general situation, where other simplicial complexes must always arise as nerve complexes, as soon as the number of points is large enough. We prove that, given a set with sufficiently many points, all trees and all cycles can also be induced by at least one partition of the point set. We also discuss how some simplicial complexes can never be achieved this way, even for arbitrarily large sets of points.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5b6972vn</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Hogan, Thomas A</name>
      </author>
      <author>
        <name>Oliveros, Deborah</name>
      </author>
      <author>
        <name>Yang, Dominic</name>
      </author>
    </item>
    <item>
      <title>The lattice of cycles of an undirected graph</title>
      <link>https://escholarship.org/uc/item/20f776vg</link>
      <description>We study bases of the lattice generated by the cycles of an undirected graph, defined as the integer linear combinations of the 0/1-incidence vectors of cycles. We prove structural results for this lattice, including explicit formulas for its dimension and determinant, and we present efficient algorithms to construct lattice bases, using only cycles as generators, in quadratic time. By algebraic considerations, we relate these results to the more general setting with coefficients from an arbitrary Abelian group. Our results generalize classical results for the vector space of cycles of a graph over the binary field to the case of an arbitrary field.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/20f776vg</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Averkov, G</name>
      </author>
      <author>
        <name>Chavez, A</name>
      </author>
      <author>
        <name>De Loera, JA</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Gillespie, B</name>
      </author>
    </item>
    <item>
      <title>The Minimum Euclidean-Norm Point in a Convex Polytope: Wolfe's Combinatorial Algorithm is Exponential</title>
      <link>https://escholarship.org/uc/item/1c97d268</link>
      <description>The complexity of Philip Wolfe's method for the minimum Euclidean-norm point problem over a convex polytope has remained unknown since he proposed the method in 1974. The method is important because it is used as a subroutine for one of the most practical algorithms for submodular function minimization. We present the first example that Wolfe's method takes exponential time. Additionally, we improve previous results to show that linear programming reduces in strongly polynomial time to the minimum norm point problem over a simplex.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1c97d268</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Haddock, Jamie</name>
      </author>
      <author>
        <name>Rademacher, Luis</name>
      </author>
    </item>
    <item>
      <title>A Model for Birdwatching and other Chronological Sampling Activities</title>
      <link>https://escholarship.org/uc/item/18m013dq</link>
      <description>In many real life situations one has m types of random events happening in chronological order within a time interval and one wishes to predict various milestones about these events or their subsets. An example is birdwatching. Suppose we can observe up to m different types of birds during a season. At any moment a bird of type i is observed with some probability. There are many natural questions a birdwatcher may have: how many observations should one expect to perform before recording all types of birds? Is there a time interval where the researcher is most likely to observe all species? Or, what is the likelihood that several species of birds will be observed at overlapping time intervals? Our paper answers these questions using a new model based on random interval graphs. This model is a natural follow up to the famous coupon collector’s problem.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/18m013dq</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Jaramillo-Rodriguez, Edgar</name>
      </author>
      <author>
        <name>Oliveros, Deborah</name>
      </author>
      <author>
        <name>Torres, Antonio J</name>
      </author>
    </item>
    <item>
      <title>Enumerative problems for arborescences and monotone paths on polytope graphs</title>
      <link>https://escholarship.org/uc/item/0j6380qq</link>
      <description>Every generic linear functional (Formula presented.) on a convex polytope (Formula presented.) induces an orientation on the graph of (Formula presented.). From the resulting directed graph one can define a notion of (Formula presented.) -arborescence and (Formula presented.) -monotone path on (Formula presented.), as well as a natural graph structure on the vertex set of (Formula presented.) -monotone paths. These concepts are important in geometric combinatorics and optimization. This paper bounds the number of (Formula presented.) -arborescences, the number of (Formula presented.) -monotone paths, and the diameter of the graph of (Formula presented.) -monotone paths for polytopes (Formula presented.) in terms of their dimension and number of vertices or facets.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0j6380qq</guid>
      <pubDate>Wed, 27 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Athanasiadis, Christos A</name>
      </author>
      <author>
        <name>De Loera, Jesús A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Zhang, Zhenyang</name>
      </author>
    </item>
    <item>
      <title>A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle</title>
      <link>https://escholarship.org/uc/item/8x36h534</link>
      <description>The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the 'Hernandez-Hernandez model', of electrical and Ca&lt;sup&gt;2+&lt;/sup&gt; signaling in arterial myocytes based on new experimental data indicating sex-specific differences in male and female arterial myocytes from murine resistance arteries. The model suggests the fundamental ionic mechanisms underlying membrane potential and intracellular Ca&lt;sup&gt;2+&lt;/sup&gt; signaling during the development of myogenic tone in arterial blood vessels. Although experimental data suggest that K&lt;sub&gt;V&lt;/sub&gt;1.5 channel currents have similar amplitudes, kinetics, and voltage dependencies in male and female myocytes, simulations suggest that the K&lt;sub&gt;V&lt;/sub&gt;1.5 current is the dominant current regulating membrane potential in male myocytes. In female cells, which have larger...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8x36h534</guid>
      <pubDate>Tue, 26 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Hernandez-Hernandez, Gonzalo</name>
      </author>
      <author>
        <name>O'Dwyer, Samantha C</name>
      </author>
      <author>
        <name>Yang, Pei-Chi</name>
        <uri>https://orcid.org/0000-0002-5753-1131</uri>
      </author>
      <author>
        <name>Matsumoto, Collin</name>
      </author>
      <author>
        <name>Tieu, Mindy</name>
      </author>
      <author>
        <name>Fong, Zhihui</name>
      </author>
      <author>
        <name>Lewis, Timothy J</name>
      </author>
      <author>
        <name>Santana, L Fernando</name>
      </author>
      <author>
        <name>Clancy, Colleen E</name>
      </author>
    </item>
    <item>
      <title>PrestoCell: A persistence-based clustering approach for rapid and robust segmentation of cellular morphology in three-dimensional data</title>
      <link>https://escholarship.org/uc/item/1qs1c3nk</link>
      <description>Light microscopy methods have continued to advance allowing for unprecedented analysis of various cell types in tissues including the brain. Although the functional state of some cell types such as microglia can be determined by morphometric analysis, techniques to perform robust, quick, and accurate measurements have not kept pace with the amount of imaging data that can now be generated. Most of these image segmentation tools are further burdened by an inability to assess structures in three-dimensions. Despite the rise of machine learning techniques, the nature of some biological structures prevents the training of several current day implementations. Here we present PrestoCell, a novel use of persistence-based clustering to segment cells in light microscopy images, as a customized Python-based tool that leverages the free multidimensional image viewer Napari. In evaluating and comparing PrestoCell to several existing tools, including 3DMorph, Omipose, and Imaris, we demonstrate...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1qs1c3nk</guid>
      <pubDate>Tue, 12 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Wu, Yue</name>
      </author>
      <author>
        <name>Brust-Mascher, Ingrid</name>
        <uri>https://orcid.org/0000-0001-7733-4410</uri>
      </author>
      <author>
        <name>Gareau, Melanie G</name>
        <uri>https://orcid.org/0000-0001-6008-6975</uri>
      </author>
      <author>
        <name>De Loera, Jesus A</name>
        <uri>https://orcid.org/0000-0002-9556-1112</uri>
      </author>
      <author>
        <name>Reardon, Colin</name>
        <uri>https://orcid.org/0000-0003-2204-8091</uri>
      </author>
    </item>
    <item>
      <title>Transitions between Distinct Compaction Regimes in Complexes of Multivalent Cationic Lipids and DNA</title>
      <link>https://escholarship.org/uc/item/88p5f00z</link>
      <description>Cationic lipids (CLs) have found widespread use as nonviral gene carriers (vectors), including applications in clinical trials of gene therapy. However, their observed transfection efficiencies (TEs) are inferior to those of viral vectors, providing a strong incentive for a detailed understanding of CL-DNA complex behavior. In recent systematic studies employing monovalent as well as newly synthesized multivalent lipids (MVLs), the membrane cationic charge density has been identified as a key parameter governing the TE of lamellar CL-DNA complexes. In this work, we use x-ray scattering and molecular simulations to investigate the structural properties of complexes containing MVLs. At low mole fraction of neutral lipids (NLs), Phi(NL), the complexes show dramatic DNA compaction, down to essentially close-packed DNA arrays with a DNA interaxial spacing d(DNA) = 25 A. A gradual increase in Phi(NL) does not lead to a continuous increase in d(DNA) as observed for DNA complexes of monovalent...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/88p5f00z</guid>
      <pubDate>Mon, 4 Mar 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Farago, Oded</name>
      </author>
      <author>
        <name>Ewert, Kai</name>
        <uri>https://orcid.org/0000-0002-4861-8278</uri>
      </author>
      <author>
        <name>Ahmad, Ayesha</name>
      </author>
      <author>
        <name>Evans, Heather M</name>
      </author>
      <author>
        <name>Grønbech-Jensen, Niels</name>
      </author>
      <author>
        <name>Safinya, Cyrus R</name>
      </author>
    </item>
    <item>
      <title>Tps: A new way to find good vertex-search order for exact subgraph matching</title>
      <link>https://escholarship.org/uc/item/9nd3z1hq</link>
      <description>Tps: A new way to find good vertex-search order for exact subgraph matching</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9nd3z1hq</guid>
      <pubDate>Wed, 28 Feb 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Ma, Yixing</name>
      </author>
      <author>
        <name>Xu, Baomin</name>
      </author>
      <author>
        <name>Yin, Hongfeng</name>
      </author>
    </item>
    <item>
      <title>A Lieb–Robinson bound for quantum spin chains with strong on-site impurities</title>
      <link>https://escholarship.org/uc/item/8b84q5nd</link>
      <description>We consider a quantum spin chain with nearest neighbor interactions and sparsely distributed on-site impurities. We prove commutator bounds for its Heisenberg dynamics which incorporate the coupling strengths of the impurities. The impurities are assumed to satisfy a minimum spacing, and each impurity has a non-degenerate spectrum. Our results are proven in a broadly applicable setting, both in finite volume and in thermodynamic limit. We apply our results to improve Lieb–Robinson bounds for the Heisenberg spin chain with a random, sparse transverse field drawn from a heavy-tailed distribution.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8b84q5nd</guid>
      <pubDate>Wed, 14 Feb 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Gebert, Martin</name>
      </author>
      <author>
        <name>Moon, Alvin</name>
      </author>
      <author>
        <name>Nachtergaele, Bruno</name>
        <uri>https://orcid.org/0000-0002-7835-3776</uri>
      </author>
    </item>
    <item>
      <title>Promotion for fans of Dyck paths</title>
      <link>https://escholarship.org/uc/item/9cc3r49r</link>
      <description>We construct an injection from the set of r-fans of Dyck paths of length n into the set of chord diagrams on [n] that intertwines promotion and rotation. This is done in two different ways, namely as fillings of promotion matrices and in terms of Fomin growth diagrams. Our analysis uses the fact that r-fans of Dyck paths can be viewed as highest weight elements of weight zero in crystals of type Br, which in turn can be analyzed using virtual crystals. On the level of Fomin growth diagrams, the virtualization process corresponds to the Roby–Krattenthaler blow up construction. Our construction generalizes to vacillating tableaux as well. We give a cyclic sieving phenomenon on r-fans of Dyck paths using the promotion action.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9cc3r49r</guid>
      <pubDate>Wed, 31 Jan 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Pappe, J</name>
      </author>
      <author>
        <name>Pfannerer, S</name>
      </author>
      <author>
        <name>Schilling, A</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Simone, MC</name>
      </author>
    </item>
    <item>
      <title>STRUCTURAL STABILITY OF MEANDERING-HYPERBOLIC GROUP ACTIONS</title>
      <link>https://escholarship.org/uc/item/2rr2620j</link>
      <description>Abstract: 

	  In his 1985 paper, Sullivan sketched a proof of his structural stability theorem for differentiable group actions satisfying certain expansion-hyperbolicity axioms. In this paper, we relax Sullivan’s axioms and introduce a notion of meandering hyperbolicity for group actions on geodesic metric spaces. This generalization is substantial enough to encompass actions of certain nonhyperbolic groups, such as actions of uniform lattices in semisimple Lie groups on flag manifolds. At the same time, our notion is sufficiently robust, and we prove that meandering-hyperbolic actions are still structurally stable. We also prove some basic results on meandering-hyperbolic actions and give other examples of such actions.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2rr2620j</guid>
      <pubDate>Wed, 31 Jan 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Kapovich, Michael</name>
        <uri>https://orcid.org/0000-0001-5475-8755</uri>
      </author>
      <author>
        <name>Kim, Sungwoon</name>
      </author>
      <author>
        <name>Lee, Jaejeong</name>
      </author>
    </item>
    <item>
      <title>Tracking Mechanical Stress and Cell Migration with Inexpensive Polymer Thin‐Film Sensors</title>
      <link>https://escholarship.org/uc/item/1n09z7cb</link>
      <description>Polydiacetylene (PDA) Langmuir films are well known for their blue to red chromatic transitions in response to a variety of stimuli, including UV light, heat, bio-molecule bindings and mechanical stress. In this work, we detail the ability to tune PDA Langmuir films to exhibit discrete chromatic transitions in response to applied mechanical stress. Normal and shear-induced transitions were quantified using the Surface Forces Apparatus and established to be binary and tunable as a function of film formation conditions. Both monomer alkyl tail length and metal cations were used to manipulate the chromatic transition force threshold to enable discrete force sensing from ~50 to ~500 nN μm&lt;sup&gt;-2&lt;/sup&gt; for normal loading and ~2 to ~40 nN μm&lt;sup&gt;-2&lt;/sup&gt; for shear-induced transitions, which are appropriate for biological cells. The utility of PDA thin-film sensors was demonstrated with the slime mold &lt;i&gt;Physarum polycephalum&lt;/i&gt;. The fluorescence readout of the films enabled: the area...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1n09z7cb</guid>
      <pubDate>Wed, 24 Jan 2024 00:00:00 +0000</pubDate>
      <author>
        <name>Finney, Tanner J</name>
      </author>
      <author>
        <name>Frank, Skye L</name>
      </author>
      <author>
        <name>Bull, Michael R</name>
      </author>
      <author>
        <name>Guy, Robert D</name>
        <uri>https://orcid.org/0000-0002-0602-7015</uri>
      </author>
      <author>
        <name>Kuhl, Tonya L</name>
        <uri>https://orcid.org/0000-0002-6069-0205</uri>
      </author>
    </item>
    <item>
      <title>On Viazovska’s modular form inequalities</title>
      <link>https://escholarship.org/uc/item/34g5h9zs</link>
      <description>Viazovska proved that the [Formula: see text] lattice sphere packing is the densest sphere packing in [Formula: see text] dimensions. Her proof relies on two inequalities between functions defined in terms of modular and quasimodular forms. We give a direct proof of these inequalities that does not rely on computer calculations.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/34g5h9zs</guid>
      <pubDate>Wed, 15 Nov 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Romik, Dan</name>
      </author>
    </item>
    <item>
      <title>Common population codes produce extremely nonlinear neural manifolds</title>
      <link>https://escholarship.org/uc/item/7vt037gp</link>
      <description>Populations of neurons represent sensory, motor, and cognitive variables via patterns of activity distributed across the population. The size of the population used to encode a variable is typically much greater than the dimension of the variable itself, and thus, the corresponding neural population activity occupies lower-dimensional subsets of the full set of possible activity states. Given population activity data with such lower-dimensional structure, a fundamental question asks how close the low-dimensional data lie to a linear subspace. The linearity or nonlinearity of the low-dimensional structure reflects important computational features of the encoding, such as robustness and generalizability. Moreover, identifying such linear structure underlies common data analysis methods such as Principal Component Analysis (PCA). Here, we show that for data drawn from many common population codes the resulting point clouds and manifolds are exceedingly nonlinear, with the dimension...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7vt037gp</guid>
      <pubDate>Wed, 4 Oct 2023 00:00:00 +0000</pubDate>
      <author>
        <name>De, Anandita</name>
      </author>
      <author>
        <name>Chaudhuri, Rishidev</name>
        <uri>https://orcid.org/0000-0003-2301-3261</uri>
      </author>
    </item>
    <item>
      <title>An insertion algorithm for diagram algebras</title>
      <link>https://escholarship.org/uc/item/8pc9k0cv</link>
      <description>We generalize the Robinson–Schensted–Knuth algorithm to the insertion of two row arrays of multisets. This generalization leads to an algorithm from partition diagrams to pairs of a standard tableau and a standard multiset tableau of the same shape, which has the remarkable property that it is well-behaved with respect to restricting a representation to a subalgebra. This insertion algorithm matches recent representation-theoretic results of Halverson and Jacobson.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8pc9k0cv</guid>
      <pubDate>Wed, 27 Sep 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Colmenarejo, L</name>
      </author>
      <author>
        <name>Orellana, R</name>
      </author>
      <author>
        <name>Saliola, F</name>
      </author>
      <author>
        <name>Schilling, A</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Zabrocki, M</name>
      </author>
    </item>
    <item>
      <title>Promotion and growth diagrams for fans of Dyck paths and vacillating tableaux</title>
      <link>https://escholarship.org/uc/item/0d16p9f7</link>
      <description>Promotion and growth diagrams for fans of Dyck paths and vacillating tableaux</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0d16p9f7</guid>
      <pubDate>Wed, 30 Aug 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Pappe, Joseph</name>
      </author>
      <author>
        <name>Pfannerer, Stephan</name>
      </author>
      <author>
        <name>Schilling, Anne</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
      <author>
        <name>Simone, Mary Claire</name>
      </author>
    </item>
    <item>
      <title>Unexpected Stein fillings, rational surface singularities and plane curve arrangements</title>
      <link>https://escholarship.org/uc/item/0229d5mp</link>
      <description>Unexpected Stein fillings, rational surface singularities and plane curve arrangements</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0229d5mp</guid>
      <pubDate>Wed, 30 Aug 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Plamenevskaya, Olga</name>
      </author>
      <author>
        <name>Starkston, Laura</name>
      </author>
    </item>
    <item>
      <title>Mixing time for Markov chain on linear extensions</title>
      <link>https://escholarship.org/uc/item/5pn742dt</link>
      <description>We provide a general framework for computing mixing times of finite Markov chains when its minimal ideal is left zero. Our analysis is based on combining results by Brown and Diaconis with our previous work on stationary distributions of finite Markov chains. We introduce a new Markov chain on linear extensions of a poset with n vertices, which is a variant of the promotion Markov chain of Ayyer, Klee and the last author, and show that it has a mixing time O(n log n).</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5pn742dt</guid>
      <pubDate>Wed, 16 Aug 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Rhodes, J</name>
      </author>
      <author>
        <name>Schilling, A</name>
        <uri>https://orcid.org/0000-0002-2601-7340</uri>
      </author>
    </item>
    <item>
      <title>Using machine learning to detect coronaviruses potentially infectious to humans</title>
      <link>https://escholarship.org/uc/item/5x3516hh</link>
      <description>Establishing the host range for novel viruses remains a challenge. Here, we address the challenge of identifying non-human animal coronaviruses that may infect humans by creating an artificial neural network model that learns from spike protein sequences of alpha and beta coronaviruses and their binding annotation to their host receptor. The proposed method produces a human-Binding Potential (h-BiP) score that distinguishes, with high accuracy, the binding potential among coronaviruses. Three viruses, previously unknown to bind human receptors, were identified: Bat coronavirus BtCoV/133/2005 and Pipistrellus abramus bat coronavirus HKU5-related (both MERS related viruses), and Rhinolophus affinis coronavirus isolate LYRa3 (a SARS related virus). We further analyze the binding properties of BtCoV/133/2005 and LYRa3 using molecular dynamics. To test whether this model can be used for surveillance of novel coronaviruses, we re-trained the model on a set that excludes SARS-CoV-2 and...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5x3516hh</guid>
      <pubDate>Tue, 18 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Gonzalez-Isunza, Georgina</name>
      </author>
      <author>
        <name>Jawaid, M Zaki</name>
      </author>
      <author>
        <name>Liu, Pengyu</name>
      </author>
      <author>
        <name>Cox, Daniel L</name>
      </author>
      <author>
        <name>Vazquez, Mariel</name>
        <uri>https://orcid.org/0000-0001-8328-6806</uri>
      </author>
      <author>
        <name>Arsuaga, Javier</name>
      </author>
    </item>
    <item>
      <title>A Note on Cumulant Technique in Random Matrix Theory</title>
      <link>https://escholarship.org/uc/item/1888k21h</link>
      <description>We discuss the cumulant approach to spectral properties of large random matrices. In particular, we study in detail the joint cumulants of high traces of large unitary random matrices and prove Gaussian fluctuation for pair-counting statistics with non-smooth test functions.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1888k21h</guid>
      <pubDate>Tue, 18 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Soshnikov, Alexander</name>
      </author>
      <author>
        <name>Wu, Chutong</name>
      </author>
    </item>
    <item>
      <title>SPARCoC: A New Framework for Molecular Pattern Discovery and Cancer Gene Identification</title>
      <link>https://escholarship.org/uc/item/8fd81054</link>
      <description>It is challenging to cluster cancer patients of a certain histopathological type into molecular subtypes of clinical importance and identify gene signatures directly relevant to the subtypes. Current clustering approaches have inherent limitations, which prevent them from gauging the subtle heterogeneity of the molecular subtypes. In this paper we present a new framework: SPARCoC (Sparse-CoClust), which is based on a novel Common-background and Sparse-foreground Decomposition (CSD) model and the Maximum Block Improvement (MBI) co-clustering technique. SPARCoC has clear advantages compared with widely-used alternative approaches: hierarchical clustering (Hclust) and nonnegative matrix factorization (NMF). We apply SPARCoC to the study of lung adenocarcinoma (ADCA), an extremely heterogeneous histological type, and a significant challenge for molecular subtyping. For testing and verification, we use high quality gene expression profiling data of lung ADCA patients, and identify...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8fd81054</guid>
      <pubDate>Thu, 13 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Ma, Shiqian</name>
        <uri>https://orcid.org/0000-0003-1967-1069</uri>
      </author>
      <author>
        <name>Johnson, Daniel</name>
      </author>
      <author>
        <name>Ashby, Cody</name>
      </author>
      <author>
        <name>Xiong, Donghai</name>
      </author>
      <author>
        <name>Cramer, Carole L</name>
      </author>
      <author>
        <name>Moore, Jason H</name>
      </author>
      <author>
        <name>Zhang, Shuzhong</name>
      </author>
      <author>
        <name>Huang, Xiuzhen</name>
      </author>
    </item>
    <item>
      <title>SparRec: An effective matrix completion framework of missing data imputation for GWAS</title>
      <link>https://escholarship.org/uc/item/84p05992</link>
      <description>Genome-wide association studies present computational challenges for missing data imputation, while the advances of genotype technologies are generating datasets of large sample sizes with sample sets genotyped on multiple SNP chips. We present a new framework SparRec (Sparse Recovery) for imputation, with the following properties: (1) The optimization models of SparRec, based on low-rank and low number of co-clusters of matrices, are different from current statistics methods. While our low-rank matrix completion (LRMC) model is similar to Mendel-Impute, our matrix co-clustering factorization (MCCF) model is completely new. (2) SparRec, as other matrix completion methods, is flexible to be applied to missing data imputation for large meta-analysis with different cohorts genotyped on different sets of SNPs, even when there is no reference panel. This kind of meta-analysis is very challenging for current statistics based methods. (3) SparRec has consistent performance and achieves...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/84p05992</guid>
      <pubDate>Thu, 13 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Jiang, Bo</name>
      </author>
      <author>
        <name>Ma, Shiqian</name>
        <uri>https://orcid.org/0000-0003-1967-1069</uri>
      </author>
      <author>
        <name>Causey, Jason</name>
      </author>
      <author>
        <name>Qiao, Linbo</name>
      </author>
      <author>
        <name>Hardin, Matthew Price</name>
      </author>
      <author>
        <name>Bitts, Ian</name>
      </author>
      <author>
        <name>Johnson, Daniel</name>
      </author>
      <author>
        <name>Zhang, Shuzhong</name>
      </author>
      <author>
        <name>Huang, Xiuzhen</name>
      </author>
    </item>
    <item>
      <title>Dynamic anticrack propagation in snow</title>
      <link>https://escholarship.org/uc/item/82w626rd</link>
      <description>Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem. Here, on the basis of a new elastoplasticity model for porous cohesive materials and a large strain hybrid Eulerian-Lagrangian numerical method, we accurately reproduced the onset and propagation dynamics of anticracks observed in snow fracture experiments. The key ingredient consists of a modified strain-softening plastic flow rule that captures the complexity of porous materials under mixed-mode loading accounting for the interplay between cohesion loss and volumetric collapse. Our unified model represents a significant step forward as it simulates solid-fluid phase transitions in geomaterials which is of paramount importance to mitigate and forecast gravitational...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/82w626rd</guid>
      <pubDate>Mon, 10 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Gaume, J</name>
      </author>
      <author>
        <name>Gast, T</name>
      </author>
      <author>
        <name>Teran, J</name>
      </author>
      <author>
        <name>van Herwijnen, A</name>
      </author>
      <author>
        <name>Jiang, C</name>
      </author>
    </item>
    <item>
      <title>Random Recurrent Networks Near Criticality Capture the Broadband Power Distribution of Human ECoG Dynamics.</title>
      <link>https://escholarship.org/uc/item/4x27q585</link>
      <description>Brain electric field potentials are dominated by an arrhythmic broadband signal, but the underlying mechanism is poorly understood. Here we propose that broadband power spectra characterize recurrent neural networks of nodes (neurons or clusters of neurons), endowed with an effective balance between excitation and inhibition tuned to keep the network on the edge of dynamical instability. These networks show a fast mode reflecting local dynamics and a slow mode emerging from distributed recurrent connections. Together, the 2 modes produce power spectra similar to those observed in human intracranial EEG (i.e., electrocorticography, ECoG) recordings. Moreover, such networks convert spatial input correlations across nodes into temporal autocorrelation of network activity. Consequently, increased independence between nodes reduces low-frequency power, which may explain changes observed during behavioral tasks. Lastly, varying network coupling causes activity changes that resemble...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4x27q585</guid>
      <pubDate>Mon, 10 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chaudhuri, Rishidev</name>
        <uri>https://orcid.org/0000-0003-2301-3261</uri>
      </author>
      <author>
        <name>He, Biyu J</name>
      </author>
      <author>
        <name>Wang, Xiao-Jing</name>
      </author>
    </item>
    <item>
      <title>A diversity of localized timescales in network activity</title>
      <link>https://escholarship.org/uc/item/3ct2p6gk</link>
      <description>Neurons show diverse timescales, so that different parts of a network respond with disparate temporal dynamics. Such diversity is observed both when comparing timescales across brain areas and among cells within local populations; the underlying circuit mechanism remains unknown. We examine conditions under which spatially local connectivity can produce such diverse temporal behavior. In a linear network, timescales are segregated if the eigenvectors of the connectivity matrix are localized to different parts of the network. We develop a framework to predict the shapes of localized eigenvectors. Notably, local connectivity alone is insufficient for separate timescales. However, localization of timescales can be realized by heterogeneity in the connectivity profile, and we demonstrate two classes of network architecture that allow such localization. Our results suggest a framework to relate structural heterogeneity to functional diversity and, beyond neural dynamics, are generally...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3ct2p6gk</guid>
      <pubDate>Mon, 10 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chaudhuri, Rishidev</name>
        <uri>https://orcid.org/0000-0003-2301-3261</uri>
      </author>
      <author>
        <name>Bernacchia, Alberto</name>
      </author>
      <author>
        <name>Wang, Xiao-Jing</name>
      </author>
    </item>
    <item>
      <title>A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex</title>
      <link>https://escholarship.org/uc/item/17b7g47x</link>
      <description>We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual versus somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish a circuit mechanism for "temporal receptive windows" that are progressively enlarged along the cortical hierarchy, suggest an extension of time integration in decision making from local to large circuits, and should...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/17b7g47x</guid>
      <pubDate>Mon, 10 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chaudhuri, Rishidev</name>
        <uri>https://orcid.org/0000-0003-2301-3261</uri>
      </author>
      <author>
        <name>Knoblauch, Kenneth</name>
      </author>
      <author>
        <name>Gariel, Marie-Alice</name>
      </author>
      <author>
        <name>Kennedy, Henry</name>
      </author>
      <author>
        <name>Wang, Xiao-Jing</name>
      </author>
    </item>
    <item>
      <title>Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy</title>
      <link>https://escholarship.org/uc/item/6511p95j</link>
      <description>Mice are the most commonly used model animals for itch research and for development of anti-itch drugs. Most laboratories manually quantify mouse scratching behavior to assess itch intensity. This process is labor-intensive and limits large-scale genetic or drug screenings. In this study, we developed a new system, Scratch-AID (&lt;b&gt;A&lt;/b&gt;utomatic &lt;b&gt;I&lt;/b&gt;tch &lt;b&gt;D&lt;/b&gt;etection), which could automatically identify and quantify mouse scratching behavior with high accuracy. Our system included a custom-designed videotaping box to ensure high-quality and replicable mouse behavior recording and a convolutional recurrent neural network trained with frame-labeled mouse scratching behavior videos, induced by nape injection of chloroquine. The best trained network achieved 97.6% recall and 96.9% precision on previously unseen test videos. Remarkably, Scratch-AID could reliably identify scratching behavior in other major mouse itch models, including the acute cheek model, the histaminergic...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6511p95j</guid>
      <pubDate>Sat, 8 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Yu, Huasheng</name>
      </author>
      <author>
        <name>Xiong, Jingwei</name>
      </author>
      <author>
        <name>Ye, Adam Yongxin</name>
      </author>
      <author>
        <name>Cranfill, Suna Li</name>
      </author>
      <author>
        <name>Cannonier, Tariq</name>
      </author>
      <author>
        <name>Gautam, Mayank</name>
      </author>
      <author>
        <name>Zhang, Marina</name>
      </author>
      <author>
        <name>Bilal, Rayan</name>
      </author>
      <author>
        <name>Park, Jong-Eun</name>
      </author>
      <author>
        <name>Xue, Yuji</name>
      </author>
      <author>
        <name>Polam, Vidhur</name>
      </author>
      <author>
        <name>Vujovic, Zora</name>
      </author>
      <author>
        <name>Dai, Daniel</name>
      </author>
      <author>
        <name>Ong, William</name>
      </author>
      <author>
        <name>Ip, Jasper</name>
      </author>
      <author>
        <name>Hsieh, Amanda</name>
      </author>
      <author>
        <name>Mimouni, Nour</name>
      </author>
      <author>
        <name>Lozada, Alejandra</name>
      </author>
      <author>
        <name>Sosale, Medhini</name>
      </author>
      <author>
        <name>Ahn, Alex</name>
      </author>
      <author>
        <name>Ma, Minghong</name>
      </author>
      <author>
        <name>Ding, Long</name>
      </author>
      <author>
        <name>Arsuaga, Javier</name>
      </author>
      <author>
        <name>Luo, Wenqin</name>
      </author>
    </item>
    <item>
      <title>TAaCGH Suite for Detecting Cancer—Specific Copy Number Changes Using Topological Signatures</title>
      <link>https://escholarship.org/uc/item/5hx0g9vd</link>
      <description>Copy number changes play an important role in the development of cancer and are commonly associated with changes in gene expression. Persistence curves, such as Betti curves, have been used to detect copy number changes; however, it is known these curves are unstable with respect to small perturbations in the data. We address the stability of lifespan and Betti curves by providing bounds on the distance between persistence curves of Vietoris-Rips filtrations built on data and slightly perturbed data in terms of the bottleneck distance. Next, we perform simulations to compare the predictive ability of Betti curves, lifespan curves (conditionally stable) and stable persistent landscapes to detect copy number aberrations. We use these methods to identify significant chromosome regions associated with the four major molecular subtypes of breast cancer: Luminal A, Luminal B, Basal and HER2 positive. Identified segments are then used as predictor variables to build machine learning...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5hx0g9vd</guid>
      <pubDate>Mon, 3 Jul 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Aslam, Jai</name>
      </author>
      <author>
        <name>Ardanza-Trevijano, Sergio</name>
      </author>
      <author>
        <name>Xiong, Jingwei</name>
      </author>
      <author>
        <name>Arsuaga, Javier</name>
      </author>
      <author>
        <name>Sazdanovic, Radmila</name>
      </author>
    </item>
    <item>
      <title>Use of machine-learning algorithms to aid in the early detection of leptospirosis in dogs</title>
      <link>https://escholarship.org/uc/item/0481k543</link>
      <description>Leptospirosis is a life-threatening, zoonotic disease with various clinical presentations, including renal injury, hepatic injury, pancreatitis, and pulmonary hemorrhage. With prompt recognition of the disease and treatment, 90% of infected dogs have a positive outcome. Therefore, rapid, early diagnosis of leptospirosis is crucial. Testing for &lt;i&gt;Leptospira&lt;/i&gt;-specific serum antibodies using the microscopic agglutination test (MAT) lacks sensitivity early in the disease process, and diagnosis can take &amp;gt;2 wk because of the need to demonstrate a rise in titer. We applied machine-learning algorithms to clinical variables from the first day of hospitalization to create machine-learning prediction models (MLMs). The models incorporated patient signalment, clinicopathologic data (CBC, serum chemistry profile, and urinalysis = blood work [BW] model), with or without a MAT titer obtained at patient intake (=BW + MAT model). The models were trained with data from 91 dogs with confirmed...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0481k543</guid>
      <pubDate>Fri, 30 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Reagan, Krystle L</name>
        <uri>https://orcid.org/0000-0003-3426-6352</uri>
      </author>
      <author>
        <name>Deng, Shaofeng</name>
      </author>
      <author>
        <name>Sheng, Junda</name>
      </author>
      <author>
        <name>Sebastian, Jamie</name>
      </author>
      <author>
        <name>Wang, Zhe</name>
      </author>
      <author>
        <name>Huebner, Sara N</name>
      </author>
      <author>
        <name>Wenke, Louise A</name>
      </author>
      <author>
        <name>Michalak, Sarah R</name>
      </author>
      <author>
        <name>Strohmer, Thomas</name>
      </author>
      <author>
        <name>Sykes, Jane E</name>
        <uri>https://orcid.org/0000-0002-6814-9835</uri>
      </author>
    </item>
    <item>
      <title>Vaping discussion in the COVID-19 pandemic: An observational study using Twitter data</title>
      <link>https://escholarship.org/uc/item/54m060th</link>
      <description>BACKGROUND: With the spread of COVID-19, significant concerns have been raised about the potential increased risk for electronic cigarette (e-cigarette) users for COVID-19 infection and related syndromes. Social media is an increasingly popular source for health information dissemination and discussion, and can affect health outcomes.
OBJECTIVE: This study aims to identify the topics in the public vaping discussion in COVID-19-related Twitter posts in order to get insight into public vaping-related perceptions, attitudes and concerns, and to discern possible misinformation and misconceptions around vaping in the COVID-19 pandemic.
METHODS: Using the tweets ID database maintained by Georgia State University's Panacea Lab, we downloaded the tweets related to COVID-19 from March 11, 2020, when the World Health Organization declared COVID-19 a pandemic, to February 12, 2021. We used R to analyze the tweets that contained a list of 79 keywords related to vaping. After removing duplicates...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/54m060th</guid>
      <pubDate>Tue, 27 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Lyu, Joanne Chen</name>
      </author>
      <author>
        <name>Luli, Garving K</name>
        <uri>https://orcid.org/0000-0002-9630-1750</uri>
      </author>
      <author>
        <name>Ling, Pamela M</name>
        <uri>https://orcid.org/0000-0001-6166-9347</uri>
      </author>
    </item>
    <item>
      <title>Ion-dependent DNA configuration in bacteriophage capsids</title>
      <link>https://escholarship.org/uc/item/5kz0w6hh</link>
      <description>Bacteriophages densely pack their long double-stranded DNA genome inside a protein capsid. The conformation of the viral genome inside the capsid is consistent with a hexagonal liquid crystalline structure. Experiments have confirmed that the details of the hexagonal packing depend on the electrochemistry of the capsid and its environment. In this work, we propose a biophysical model that quantifies the relationship between DNA configurations inside bacteriophage capsids and the types and concentrations of ions present in a biological system. We introduce an expression for the free energy that combines the electrostatic energy with contributions from bending of individual segments of DNA and Lennard-Jones-type interactions between these segments. The equilibrium points of this energy solve a partial differential equation that defines the distributions of DNA and the ions inside the capsid. We develop a computational approach that allows us to simulate much larger systems&amp;nbsp;than...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5kz0w6hh</guid>
      <pubDate>Fri, 23 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Liu, Pei</name>
      </author>
      <author>
        <name>Arsuaga, Javier</name>
      </author>
      <author>
        <name>Calderer, M Carme</name>
      </author>
      <author>
        <name>Golovaty, Dmitry</name>
      </author>
      <author>
        <name>Vazquez, Mariel</name>
        <uri>https://orcid.org/0000-0001-8328-6806</uri>
      </author>
      <author>
        <name>Walker, Shawn</name>
      </author>
    </item>
    <item>
      <title>Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model</title>
      <link>https://escholarship.org/uc/item/62r8g6w6</link>
      <description>State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a sodium channel blocker is thought to depend on the characteristics of its rate-dependent block, the mechanisms linking these two attributes are unclear. Furthermore, how specific properties of rate-dependent block arise from the binding kinetics of a particular drug is poorly understood. Here, we examine the rate-dependent effects of the sodium channel blocker lidocaine by constructing and analyzing a novel drug-channel interaction model. First, we identify the predominant mode of lidocaine binding in a 24 variable Markov model for lidocaine-sodium channel interaction by Moreno et al. Specifically, we find that (1) the vast majority of lidocaine bound to sodium channels is in the neutral form, i.e., the binding of charged lidocaine to sodium channels is negligible,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/62r8g6w6</guid>
      <pubDate>Thu, 22 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Docken, Steffen S</name>
      </author>
      <author>
        <name>Clancy, Colleen E</name>
      </author>
      <author>
        <name>Lewis, Timothy J</name>
      </author>
    </item>
    <item>
      <title>Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment</title>
      <link>https://escholarship.org/uc/item/6zw6x3vt</link>
      <description>Dense innervation of the heart by the sympathetic nervous system (SNS) allows cardiac output to respond appropriately to the needs of the body under varying conditions, but occasionally the abrupt onset of SNS activity can trigger cardiac arrhythmias. Sympathetic activity leads to the release of norepinephrine (NE) onto cardiomyocytes, activating β&lt;sub&gt;1&lt;/sub&gt;-adrenergic receptors (β&lt;sub&gt;1&lt;/sub&gt;-ARs) and leading to the production of the second messenger cyclic AMP (cAMP). Upon sudden activation of β&lt;sub&gt;1&lt;/sub&gt;-ARs in experiments, intracellular cAMP can transiently rise to a high concentration before converging to a steady state level. Although changes to cellular cAMP concentration are important in modulating the overall cardiovascular response to sympathetic tone, the underlying mechanisms of the cAMP transients and the parameters that control their magnitude are unclear. We reduce a detailed computational model of the β&lt;sub&gt;1&lt;/sub&gt;-adrenergic signaling cascade to a system of...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6zw6x3vt</guid>
      <pubDate>Mon, 19 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Meyer, Emily E</name>
      </author>
      <author>
        <name>Clancy, Colleen E</name>
      </author>
      <author>
        <name>Lewis, Timothy J</name>
      </author>
    </item>
    <item>
      <title>Emerging roles for R-loop structures in the management of topological stress</title>
      <link>https://escholarship.org/uc/item/4c89d66p</link>
      <description>R-loop structures are a prevalent class of alternative non-B DNA structures that form during transcription upon invasion of the DNA template by the nascent RNA. R-loops form universally in the genomes of organisms ranging from bacteriophages, bacteria, and yeasts to plants and animals, including mammals. A growing body of work has linked these structures to both physiological and pathological processes, in particular to genome instability. The rising interest in R-loops is placing new emphasis on understanding the fundamental physicochemical forces driving their formation and stability. Pioneering work in &lt;i&gt;Escherichia coli&lt;/i&gt; revealed that DNA topology, in particular negative DNA superhelicity, plays a key role in driving R-loops. A clear role for DNA sequence was later uncovered. Here, we review and synthesize available evidence on the roles of DNA sequence and DNA topology in controlling R-loop formation and stability. Factoring in recent developments in R-loop modeling and...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4c89d66p</guid>
      <pubDate>Wed, 7 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chedin, Frederic</name>
        <uri>https://orcid.org/0000-0002-1306-5335</uri>
      </author>
      <author>
        <name>Benham, Craig J</name>
      </author>
    </item>
    <item>
      <title>Synchronization of Electrically Coupled Resonate-and-Fire Neurons.</title>
      <link>https://escholarship.org/uc/item/8336q2bs</link>
      <description>Electrical coupling between neurons is broadly present across brain areas and is typically assumed to synchronize network activity. However, intrinsic properties of the coupled cells can complicate this simple picture. Many cell types with electrical coupling show a diversity of post-spike subthreshold fluctuations, often linked to subthreshold resonance, which are transmitted through electrical synapses in addition to action potentials. Using the theory of weakly coupled oscillators, we explore the effect of both subthreshold and spike-mediated coupling on synchrony in small networks of electrically coupled resonate-and-fire neurons, a hybrid neuron model with damped subthreshold oscillations and a range of post-spike voltage dynamics. We calculate the phase response curve using an extension of the adjoint method that accounts for the discontinuous post-spike reset rule. We find that both spikes and subthreshold fluctuations can jointly promote synchronization. The subthreshold...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8336q2bs</guid>
      <pubDate>Fri, 2 Jun 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chartrand, Thomas</name>
      </author>
      <author>
        <name>Goldman, Mark S</name>
        <uri>https://orcid.org/0000-0002-8257-2314</uri>
      </author>
      <author>
        <name>Lewis, Timothy J</name>
      </author>
    </item>
    <item>
      <title>Monogenic wavelet scattering network for texture image classification</title>
      <link>https://escholarship.org/uc/item/4jh2n56b</link>
      <description>Monogenic wavelet scattering network for texture image classification</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4jh2n56b</guid>
      <pubDate>Wed, 24 May 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Chak, Wai Ho</name>
      </author>
      <author>
        <name>Saito, Naoki</name>
        <uri>https://orcid.org/0000-0001-5234-4719</uri>
      </author>
    </item>
    <item>
      <title>Computing trisections of 4-manifolds</title>
      <link>https://escholarship.org/uc/item/24060234</link>
      <description>We describe an algorithm to compute trisections of orientable four-manifolds using arbitrary triangulations as input. This results in explicit complexity bounds for the trisection genus of a 4-manifold in terms of the number of pentachora (4-simplices) in a triangulation.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/24060234</guid>
      <pubDate>Tue, 23 May 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Bell, Mark</name>
      </author>
      <author>
        <name>Hass, Joel</name>
        <uri>https://orcid.org/0000-0002-9019-4464</uri>
      </author>
      <author>
        <name>Rubinstein, Joachim Hyam</name>
      </author>
      <author>
        <name>Tillmann, Stephan</name>
      </author>
    </item>
    <item>
      <title>Highly accurate model for prediction of lung nodule malignancy with CT scans</title>
      <link>https://escholarship.org/uc/item/61d0q7sw</link>
      <description>Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve performance comparable to experienced radiologists. Here we present NoduleX, a systematic approach to predict lung nodule malignancy from CT data, based on deep learning convolutional neural networks (CNN). For training and validation, we analyze &amp;gt;1000 lung nodules in images from the LIDC/IDRI cohort. All nodules were identified and classified by four experienced thoracic radiologists who participated in the LIDC project. NoduleX achieves high accuracy for nodule malignancy classification, with an AUC of ~0.99. This is commensurate with the analysis of the dataset by experienced radiologists. Our approach, NoduleX, provides an effective framework for highly accurate nodule malignancy prediction with the model trained on a large patient population....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/61d0q7sw</guid>
      <pubDate>Sat, 20 May 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Causey, Jason L</name>
      </author>
      <author>
        <name>Zhang, Junyu</name>
      </author>
      <author>
        <name>Ma, Shiqian</name>
        <uri>https://orcid.org/0000-0003-1967-1069</uri>
      </author>
      <author>
        <name>Jiang, Bo</name>
      </author>
      <author>
        <name>Qualls, Jake A</name>
      </author>
      <author>
        <name>Politte, David G</name>
      </author>
      <author>
        <name>Prior, Fred</name>
      </author>
      <author>
        <name>Zhang, Shuzhong</name>
      </author>
      <author>
        <name>Huang, Xiuzhen</name>
      </author>
    </item>
    <item>
      <title>Flagellar swimming in viscoelastic fluids: role of fluid elastic stress revealed by simulations based on experimental data</title>
      <link>https://escholarship.org/uc/item/6564692m</link>
      <description>Many important biological functions depend on microorganisms' ability to move in viscoelastic fluids such as mucus and wet soil. The effects of fluid elasticity on motility remain poorly understood, partly because the swimmer strokes depend on the properties of the fluid medium, which obfuscates the mechanisms responsible for observed behavioural changes. In this study, we use experimental data on the gaits of &lt;i&gt;Chlamydomonas reinhardtii&lt;/i&gt; swimming in Newtonian and viscoelastic fluids as inputs to numerical simulations that decouple the swimmer gait and fluid type in order to isolate the effect of fluid elasticity on swimming. In viscoelastic fluids, cells employing the Newtonian gait swim faster but generate larger stresses and use more power, and as a result the viscoelastic gait is more efficient. Furthermore, we show that fundamental principles of swimming based on viscous fluid theory miss important flow dynamics: fluid elasticity provides an elastic memory effect that...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6564692m</guid>
      <pubDate>Mon, 15 May 2023 00:00:00 +0000</pubDate>
      <author>
        <name>Li, Chuanbin</name>
      </author>
      <author>
        <name>Qin, Boyang</name>
      </author>
      <author>
        <name>Gopinath, Arvind</name>
      </author>
      <author>
        <name>Arratia, Paulo E</name>
      </author>
      <author>
        <name>Thomases, Becca</name>
        <uri>https://orcid.org/0000-0001-8502-8915</uri>
      </author>
      <author>
        <name>Guy, Robert D</name>
        <uri>https://orcid.org/0000-0002-0602-7015</uri>
      </author>
    </item>
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