Recent ucsd_postprints items

Seismic Analysis of the 10-Story CFS-NHERI Building

Sat, 29 Aug 2026 00:00:00 +0000

Seismic Analysis of the 10-Story CFS-NHERI Building

Exploiting the CXCR3/CXCL10 axis overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in HNSCC

Fri, 28 Aug 2026 00:00:00 +0000

Immune-suppressive tumor microenvironments (TMEs) limit the impact of checkpoint blockade in many cancers by restricting the infiltration and activation of CD8⁺ T, CD4⁺ T, and NK cells. Utilizing murine models of head and neck squamous cell carcinoma, we demonstrated that intratumoral (IT) delivery of CXCL10 drives tumor elimination and inhibits recurrence not only by recruiting these cells but by enhancing their antitumoral functions and stunting angiogenesis. CD8⁺ T cells also display enhanced activation, tumor-antigen specificity, and decreased T cell exhaustion. Despite administration of CXCL10 into tumors, CD8⁺ and CD4⁺ T cells show enhanced presence and proliferation in tumor-draining lymph nodes (TdLNs), consistent with T cell priming and trafficking between tumors and TdLNs. Together, the data suggest that CXCL10 promotes a mutually reinforcing feedback loop that reprograms the TME toward an immunologically responsive...

Indoctrination or Participation? Community Schools and the Ming State

Fri, 28 Aug 2026 00:00:00 +0000

Indoctrination or Participation? Community Schools and the Ming State

A sorghum pangenome reference improves global crop trait discovery

Fri, 28 Aug 2026 00:00:00 +0000

Although the green revolution adapted a handful of crops to homogeneous and high-input industrialized agriculture, much of the global population still relies on the local production of variable crop cultivars by low-input smallholder farms. This diversity of unhomogenized crops1, like that of the grain and bioenergy crop sorghum2, 3, 4–5, offers raw materials for genetic gain and cultivar improvement. However, breeding efforts can be constrained by highly specialized traits and breeding targets6. Here, to bridge this diversity, we constructed a 33-member pangenome reference and a diversity panel across 1,984 cultivars and landraces. We leveraged these resources to explore the complex interplay among historical contingency, ongoing adaptation and previously uncharacterized structural diversity. Specifically, our analyses conclusively demonstrated multiple nested and deeply diverged structural variants in the domestication gene SHATTERING1, which distinguish the previously established...

WIP: Empowering Teachers and Engaging Students Through Flow-Based Music Programming in K-12 CS Education

Fri, 28 Aug 2026 00:00:00 +0000

This research WIP paper explores integrating flow-based music programming (FBP) into K-12 computer science (CS) education, focusing on its impact on teachers' confidence and attitudes, and students' experience and engagement. Despite increasing research on music and CS education, limited empirical studies examine how FBP impacts novice CS teachers and student programming learning. This study investigates FBP's role in supporting teachers' confidence and pedagogical practices while fostering student experience and engagement. It employs a two-phase design: (1) Teacher workshop: A six-hour professional development workshop with ten elementary teachers used a platform for composing music through programming. It included hands-on activities and pedagogical strategies. Pre- and post-surveys measured changes in teachers' confidence, interest, and attitudes toward CS. (2) Classroom implementation: One teacher implemented the curriculum with 28 fourth-grade students. Pre-and post-surveys...

TEACHING PHYSICS THROUGH SOUND: IMPACTS OF A PROFESSIONAL DEVELOPMENT WORKSHOP INTEGRATING MUSIC AND WAVE SCIENCE

Fri, 28 Aug 2026 00:00:00 +0000

TEACHING PHYSICS THROUGH SOUND: IMPACTS OF A PROFESSIONAL DEVELOPMENT WORKSHOP INTEGRATING MUSIC AND WAVE SCIENCE

Combined effective field theory interpretation of Higgs boson, electroweak vector boson, top quark, and multijet measurements

Fri, 28 Aug 2026 00:00:00 +0000

Constraints on Wilson coefficients (WCs) corresponding to dimension-6 operators of the standard model effective field theory (SMEFT) are determined from a simultaneous fit to seven sets of CMS measurements probing Higgs boson, electroweak vector boson, top quark, and multijet production. Measurements of electroweak precision observables are also included and provide complementary constraints to those from the CMS experiment. The CMS measurements, using LHC proton-proton collision data at s=13Te$$\sqrt{s}=13\,\text {Te}\text {V} $$, corresponding to integrated luminosities of 36.3 or 138fb-1$$\,\text {fb}^{-1}$$, are chosen to provide sensitivity to a broad set of operators, for which consistent SMEFT predictions can be derived. These are primarily measurements of differential cross sections which are parameterized as functions of the WCs. In measurements targeting t(t¯)X$${\text {t}} (\bar{\textrm{t}})\text {X} $$ production, SMEFT effects are modelled at the detector level. Individual...

Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals

Fri, 28 Aug 2026 00:00:00 +0000

Cannabis is one of the most widely used drugs globally. We performed genome-wide association studies (GWASs) of lifetime (N = 131,895) and frequency (N = 73,374) of cannabis use. For lifetime cannabis use, we identified two loci, one near CADM2 (rs35827242, p = 4.63E-12) and another near GRM3 (rs12673181, p = 6.90E-09). For frequency of cannabis use, we identified one locus near CADM2 (rs4856591, p = 8.10E-09; r2 = 0.76 with rs35827242). Lifetime and frequency of cannabis use were heritable (12.88 vs. 6.63%) and genetically correlated with previous GWASs of lifetime use and cannabis use disorder (CUD), as well as other substance use and cognitive traits. Polygenic scores (PGSs) for lifetime and frequency of cannabis use predicted cannabis use phenotypes in All of Us participants. A phenome-wide association study using a PGS for lifetime cannabis use to interrogate a hospital cohort replicated prior associations with substance use and mood disorders, and uncovered novel associations...

Odorant receptor coexpression and multi-expression in the dengue mosquito

Fri, 28 Aug 2026 00:00:00 +0000

Drosophila olfactory sensory neurons tend to express a single ligand-specific receptor, following a one-receptor-per-neuron rule expected to apply broadly across insects. Recent work challenges this view by showing that some neurons in the mosquito Aedes aegypti coexpress multiple receptors. However, the full extent and nature of coexpression in Ae. aegypti remains unclear. We sequenced the transcriptomes of 46,000 female antennal neurons to resolve all olfactory neuron subtypes and identify expressed receptors. Half of all subtypes coexpress multiple receptors. However, coexpression occurs almost exclusively among receptors from the same family; cross-family coexpression of odorant receptors with ionotropic receptors is rare. We also document a phenomenon called multi-expression, wherein one receptor is expressed in multiple neuron subtypes, often alongside distant paralogs. Drosophila provides rare examples of both coexpression and multi-expression, suggesting that Drosophila...

Ludic Sonata: A Polyphonic Participatory Experience

Fri, 28 Aug 2026 00:00:00 +0000

Making music together is part of traditional rituals; it helps develop social bonds, build community, and improve mental health. Yet, in many societies, this fundamental part of human experience has been restricted to young children, with their innate sense of playfulness, and accomplished musicians. The workshop invites participants with any level of musical experience to rediscover the wonder of making music together. For this, they will engage in playful exploration of the sounds of everyday objects, digital sound transformations, and collective music-making activities inspired by Listening To Waves, a widely adopted program creating web applications and activities connecting music and STEM.

Centrifuge modeling of rocking foundations on sand improved with soil-cement columns