Recent ucsdpsy_rw items

Reading the room: Children integrate multiple social factors to predict and interpret objects' locations

Wed, 6 May 2026 00:00:00 +0000

Adults infer social information from objects' locations by integrating multiple causal factors, which is often challenging for children. To test for integrated reasoning about objects' locations, 5- to 10-year-olds (N = 72; 38 girls; 62.5% White; tested 2024) viewed scenes with toys at high/low locations, in social contexts with/without competitors for toys, and inferred owners' preferences. In Experiment 2, 4- to 7-year-olds (N = 72; 27 girls; 52.8% White, tested 2023) predicted where objects would be placed, from social context and owners' preferences. Four- to 5-year-olds failed to integrate information when reasoning about objects' pre-existing locations but succeeded when predicting placement behavior. Six- to 7-year-olds succeeded in both experiments, as did adults (N = 144, 114 women, 86% White). From 4- to 7-years of age, children increasingly reason about objects' locations as the product of interacting social causes.

FACING EMOTIONAL VOCALIZATIONS AND INSTRUMENTAL SOUNDS: SIGHTED AND BLIND INDIVIDUALS SPONTANEOUSLY AND SELECTIVELY ACTIVATE FACIAL MUSCLES IN RESPONSE TO EMOTIONAL STIMULI

Thu, 26 Mar 2026 00:00:00 +0000

FACING EMOTIONAL VOCALIZATIONS AND INSTRUMENTAL SOUNDS: SIGHTED AND BLIND INDIVIDUALS SPONTANEOUSLY AND SELECTIVELY ACTIVATE FACIAL MUSCLES IN RESPONSE TO EMOTIONAL STIMULI

The role of epistemic reasoning in mutual exclusivity inferences

Thu, 26 Mar 2026 00:00:00 +0000

When encountering a novel word, adults and children as young as 12 months old often reason that it refers to a novel object rather than one with an existing name - making a 'mutual exclusivity inference.' We explored the mechanism of this inference, aiming to differentiate between three hypotheses: whether mutual exclusivity arises due to reasoning about a specific speaker's knowledge, projection of one's own egocentric knowledge, or reasoning generally about the conventionality of labels. Adults and 3.5-5-year-old children in our experiment heard a label being either taught or invented on the spot. They were then asked to decide what another label, produced by a speaker who was absent during the first label's introduction, referred to. Our results revealed that adults and older children made more mutual exclusivity inferences when the first label was taught compared to when it was invented. Additionally, they were more likely to exclude the previously-labeled object in the...

What We Have Learned About Adolescent Mental Health and Where We Are Going After a Decade with the Adolescent Brain Cognitive Development Study

Thu, 12 Mar 2026 00:00:00 +0000

This review synthesizes ten years of research utilizing data from the Adolescent Brain Cognitive Development (ABCD) Study, emphasizing how the study’s comprehensive, longitudinal design supports a multivariate understanding of adolescent mental health. We focus on studies that have examined the collective or interacting relations of multiple factors to mental health in adolescents, as this unique dataset allows for examining more complex configurations of risk factors. We highlight key findings from ABCD data that have deepened our understanding of the risk factors shaping mental health outcomes in adolescence. Findings underscore the complex interplay of biological, psychological, and/or contextual factors on adolescent mental health. We conclude with a forward-looking discussion of emerging research priorities and opportunities to further leverage the ABCD dataset to inform developmental theory, prevention, and intervention efforts.

Social Determinants of Health and Pediatric Long COVID in the US

Thu, 29 Jan 2026 00:00:00 +0000

Importance: Millions of children worldwide are experiencing prolonged symptoms after SARS-CoV-2 infection, yet social risk factors for developing long COVID are largely unknown. As child health is influenced by the environment in which they live and interact, adverse social determinants of health (SDOH) may contribute to the development of pediatric long COVID. Objective: To identify whether adverse SDOH are associated with increased odds of long COVID in school-aged children and adolescents in the US. Design, Setting, and Participants: This cross-sectional analysis of a multicenter, longitudinal, meta-cohort study encompassed 52 sites (health care and community settings) across the US. School-aged children (6-11 years; n = 903) and adolescents (12-17 years; n = 3681) with SARS-CoV-2 infection history were included. Those with an unknown date of first infection, history of multisystem inflammatory syndrome in children, or symptom surveys with less than 50% of questions completed...

How do Faces Influence Behavior? A Proposal for Distinguishing between Mechanisms that Involve Cognitive inferences, Emotional Feelings, and Unconscious Affective Reactions

Thu, 29 Jan 2026 00:00:00 +0000

Emotional stimuli – such as facial expressions, images, or text – can influence behavior, including important decisions. This influence is complex as these stimuli may engage multiple psychological and physiological processes. The processes encompass (i) perception, attention, and memory, (ii) motor patterns, (iii) central and peripheral circuitry, (iv) subjective feelings, and (v) inferences regarding the stimulus’ meaning. All these processes can shape subsequent behavior. For example, a smile may communicate permission and encouragement to explore. A smile may also lift one’s conscious mood, which, in turn, may serve as a basis for more favorable judgments. However, other mechanisms can operate without involving conscious feelings. In fact, in some studies on facial expressions, researchers observe shifts in attention, perception, and memory, changes in physiology (e.g., amygdala activation, sweating, respiration, heart rate) and behavior (e.g., approach, consumption, risky...

Nitroquinolones and nitroquinolines: syntheses and antitrypanosomal activity

Thu, 4 Dec 2025 00:00:00 +0000

Nitroaromatic small molecules are established anti-infectives, including against trypanosomal diseases. Inspired by our previously identified suicide inhibitors of Mycobacterium tuberculosis (Mtb) decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1), we report the synthesis and in vitro antitrypanosomal activity of six novel nitroquinoline derivatives (4a-4f), as well as the antitrypanosomal activity of 13 previously described nitroquinolone anti-Mtb compounds, 8a-8 m. Two compounds exhibited sub-micromolar activity (EC50 = 0.3–0.5 µM), while thirteen compounds exhibited low micromolar activity (EC50 = 1.1–8.0 µM) against Trypanosoma brucei. This study highlights nitroquinolones and nitroquinolines as a source of compounds that exhibit both antitrypanosomal and antitubercular activities.Graphical abstract

BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma

Thu, 4 Dec 2025 00:00:00 +0000

BACKGROUND: Glioblastoma (GBM) displays remarkable cell state plasticity, a major contributor to therapeutic resistance and tumor progression. While epigenetic mechanisms play a central role in driving this plasticity, the key regulators remain poorly understood, and developing effective therapeutic strategies targeting them has been challenging. METHODS: We investigated the role of BRD2, a key regulator of NF-κB mediated mesenchymal (MES) transition, using GBM patient-derived xenograft (PDX) cell lines, CRISPR-mediated knock-in/knockout approaches, RNA-seq, and in vitro and in vivo modeling. BET inhibitors were employed to target MES gene expression and sensitize GBM to radiation therapy. RESULTS: We found that PTEN loss induces RelA chromatin localization and acetylation-mediated recruitment of BRD2 to the MES gene promoters. BRD2 binding is essential for maintaining MES gene expression and phenotype. Genetic ablation or loss-of-function mutation of BRD2 bromodomains reverses...

The Development of Cardinal Extension: From Counting to Exact Equality

Thu, 20 Nov 2025 00:00:00 +0000

Numerate adults know that when two sets are equal, they should be labeled by the same number word. We explored the development of this principle-sometimes called "cardinal extension"-and how it relates to children's other numerical abilities. Experiment 1 revealed that 2- to 5-year-old children who could accurately count large sets often inferred that two equal sets should be labeled with the same number word, unlike children who could not accurately count large sets. However, not all counters made this inference, suggesting that learning to construct and label large sets may be a necessary but not sufficient step in learning how numbers represent exact quantities. Experiment 2 found that children who extended labels to equal sets were not actually sensitive to exact equality and that they often assigned two sets the same label when they were approximately equal, but differed by just one item (violating one-to-one correspondence). These results suggest a gradual, stagelike, process...

Ensemble perception of faces with naturalistic occlusions

Thu, 28 Aug 2025 00:00:00 +0000

The visual system takes advantage of redundancy in the world by extracting summary statistics, a phenomenon known as ensemble perception. Ensemble representations are formed for low-level features like orientation and size and high-level features such as facial identity and expression. Whereas recent research has shown that the visual system forms intact ensemble representations even when faces are partially occluded via solid bars, how ensemble perception is impacted with the addition of naturalistic objects such as face masks or sunglasses is largely unknown. To investigate this, we conducted a series of experiments using continuous report tasks in which faces (either varying in identity or expression) were partially occluded with a surgical mask or sunglasses and participants had to report the average face using a face wheel. We found evidence that participants could still accurately extract the average even when a significant portion of it was occluded with either face masks...

Children's Evaluations of Empathizers

Thu, 14 Aug 2025 00:00:00 +0000

Children's evaluations of empathizers were examined using vignette-based tasks (N = 159 4- to 7-year-old U.S. children, 82 girls, 52% White) between March 2023 and March 2024. Children typically evaluated empathizers positively compared to less empathic others. They rated empathic responses as more appropriate, selected empathizers as nicer, and inferred more positive relationships between empathizers and the targets of empathy. However, when empathy was contrasted with helping behavior, or directed toward an immoral actor, evaluations of empathy were more negative. Older children weighed helping and empathy more equally and shifted their evaluations more when considering responses to immoral acts. These results show children use empathy in their social evaluations, and contextual influences on these evaluations strengthen with age.

Evidence for a Decrease in Vocalizations During Bubble Burst Production in Atlantic Bottlenose Dolphins (Tursiops truncatus)

Thu, 14 Aug 2025 00:00:00 +0000

ABSTRACT: In Atlantic bottlenose dolphins, prior work has suggested that whistle vocalizations often have been observed to co‐occur with one bubble type, the bubble stream. However, vocal correlates have not been identified for another type of bubble, the bubble burst. While watching research session recordings, we serendipitously observed an absence of dolphin vocalization during bubble bursts. We formally investigated this in two studies by examining bubble bursts produced by 11 dolphins participating in various tasks with an exploratory study (n = 553) and a preregistered, confirmatory study (n = 150). In both studies, we compare the amplitude during the production of the bubble burst to the 2 s prior to its production, and the presence/absence of different vocal types. Amplitude during the bubble burst was significantly quieter than the 2 s prior, and there were significant reductions in all vocal types, especially among whistles and burst‐pulses, in both studies. Physiological...

INVESTIGATING INFANTS' EXPECTATIONS OF EMOTIONAL RESPONSES TO OWNERSHIP VIOLATIONS

Mon, 19 May 2025 00:00:00 +0000

INVESTIGATING INFANTS' EXPECTATIONS OF EMOTIONAL RESPONSES TO OWNERSHIP VIOLATIONS

Societal inferences from the physical world

Mon, 19 May 2025 00:00:00 +0000

Moffett points to humans' use of physical markers to signal group identity as crucial to human society. We characterize the developmental and cognitive bases of this capacity, arguing that it is part of an early-emerging, intuitive socio-physical interface which allows the inanimate world to encode rich social meaning about individuals' identities, and the values of the society as a whole.

Traces of Our Past: The Social Representation of the Physical World

Mon, 19 May 2025 00:00:00 +0000

How do humans build and navigate their complex social world? Standard theoretical frameworks often attribute this success to a foundational capacity to analyze other people’s appearance and behavior to make inferences about their unobservable mental states. Here we argue that this picture is incomplete. Human behavior leaves traces in our physical environment that reveal our presence, our goals, and even our beliefs and knowledge. A new body of research shows that, from early in life, humans easily detect these traces—sometimes spontaneously—and readily extract social information from the physical world. From the features and placement of inanimate objects, people make inferences about past events and how people have shaped the physical world. This capacity develops early and helps explain how people have such a rich understanding of others: by drawing not only on how others act but also on the environments they have shaped. Overall, social cognition is crucial not only to our...

Sounds of Hidden Agents: The Development of Causal Reasoning About Musical Sounds

Mon, 19 May 2025 00:00:00 +0000

Listening to music activates representations of movement and social agents. Why? We test whether causal reasoning plays a role, and find that from childhood, people can intuitively reason about how musical sounds were generated, inferring the events and agents that caused the sounds. In Experiment 1 (N = 120, pre-registered), 6-year-old children and adults inferred the presence of an unobserved animate agent from hearing musical sounds, by integrating information from the sounds' timing with knowledge of the visual context. Thus, children inferred that an agent was present when the sounds would require self-propelled movement to produce, given the current visual context (e.g., unevenly-timed notes, from evenly-spaced xylophone bars). Consistent with Bayesian causal inference, this reasoning was flexible, allowing people to make inferences not only about unobserved agents, but also the structure of the visual environment in which sounds were produced (in Experiment 2, N = 114)....

Increased Prevalence of Childhood Complex Trauma in Comorbid Posttraumatic Stress Disorder and Substance Use Disorders Compared to Either Disorder Alone: A Systematic Review

Thu, 8 May 2025 00:00:00 +0000

OBJECTIVE: Childhood complex trauma (CCT) prevalence among individuals with comorbid posttraumatic stress disorder (PTSD) and substance use disorder (SUD) is unknown. We conducted a meta-analysis to compare CCT prevalence in samples of PTSD alone, SUD alone and comorbid PTSD+SUD. METHOD: A systematic review of PTSD, CCT and SUD literature was conducted using online databases. Binary outcome meta-analytic models were fitted comparing CCT prevalence in comorbid PTSD + SUD to PTSD and SUD only. RESULTS: Seven studies were included, and estimates for CCT prevalence were higher, on average, among individuals with comorbid PTSD+SUD (35%-78%) compared to PTSD alone (4%-70%) and SUD alone (2%-65%). A meta-analysis of four studies indicated individuals with comorbid PTSD+SUD were 18% more likely to have experienced CCT compared to individuals with PTSD only (RR = 1.18, 95% CI [1.13, 1.25]) and 24% more likely compared to individuals with SUD only (RR = 1.24, 95% CI [1.20, 1.29]). CONCLUSIONS:...

Do traumatic events and substance use co‐occur during adolescence? Testing three causal etiologic hypotheses

Thu, 8 May 2025 00:00:00 +0000

BACKGROUND: Why do potentially traumatic events (PTEs) and substance use (SU) so commonly co-occur during adolescence? Causal hypotheses developed from the study of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults have not yet been subject to rigorous theoretical analysis or empirical tests among adolescents with the precursors to these disorders: PTEs and SU. Establishing causality demands accounting for various factors (e.g. genetics, parent education, race/ethnicity) that distinguish youth endorsing PTEs and SU from those who do not, a step often overlooked in previous research. METHODS: We leveraged nationwide data from a sociodemographically diverse sample of youth (N = 11,468) in the Adolescent Brain and Cognitive Development Study. PTEs and substance use prevalence were assessed annually. To account for the many pre-existing differences between youth with and without PTE/SU (i.e. confounding bias) and provide rigorous tests of causal hypotheses,...

Effort Can Have Positive, Negative, and Nonmonotonic Impacts on Outcome Value in Economic Choice

Sat, 26 Apr 2025 00:00:00 +0000

Every action demands some effort, and its level influences decision making. Existing data suggest that in some decision contexts, effort devalues outcomes, but in other contexts, effort enhances outcome valuation. Here, we describe an empirical study and propose a model that incorporates negative, positive, and mixed impacts of effort on outcomes in different decision contexts and different participants. Participants chose between money and an item associated with varying levels of stair-climbing effort. Some participants had previous direct experience with a real physical effort and made decisions about a physically present reward. For other participants, the effort and the associated reward were always purely hypothetical. Furthermore, the decisions were framed as prospective or retrospective-before or after effort exertion. The key behavioral finding was that in the "real" condition, greater effort decreased outcome value when considered prospectively, but increased outcome...

Fluency shapes evaluations: Feelings, interpretations, expectations, and goals

Sat, 26 Apr 2025 00:00:00 +0000

Fluency shapes evaluations: Feelings, interpretations, expectations, and goals

Responsible use of population neuroscience data: Towards standards of accountability and integrity

Mon, 14 Apr 2025 00:00:00 +0000

This editorial focuses on the issue of data misuse which is increasingly evidenced in social media as well as some premiere scientific journals. This issue is of critical importance to open science projects in general, and ABCD in particular, given the broad array of biological, behavioral and environmental information collected on this American sample of 12.000 youth and parents. ABCD data are already widely used with over 1000 publications and twice as many citations per year as expected (relative citation index based on year, field and journal). However, the adverse consequences of misuse of data, and inaccurate interpretation of emergent findings from this precedent setting study may have profound impact on disadvantaged populations and perpetuate biases and societal injustices.

Watching Others Mirror: Explaining the Range of Third-Party Inferences from Imitation

Thu, 13 Mar 2025 00:00:00 +0000

Abstract: Imitation is important in social life, manifesting in various forms and serving diverse functions. This chapter concerns socially oriented imitation, wherein the imitator adopts others’ arbitrary or idiosyncratic behaviors primarily for social reasons. While this form of imitation impacts dyadic interactions, it’s also observable by third parties. We review evidence concerning third-party inferences from imitation across the lifespan, spanning from infancy to adulthood. We propose that a simple concept of social affiliation, embedded within an intuitive (naïve) psychological theory, accounts for the pattern of inferences drawn from observing imitation. Essentially, observers assume that imitators, by either imitating or not, reveal whether they adopt concern for the models’ utilities, encompassing their welfare and values. Young observers typically draw positive inferences from such imitative behaviors. However, as observers mature and master understanding...

The Adolescent Brain Cognitive Development Study

Fri, 28 Feb 2025 00:00:00 +0000

The Adolescent Brain Cognitive Development (ABCD) Study was launched by the Collaborative Research on Addiction at NIH (CRAN) in 2016 and is now supported by 11 other federal agencies and centers. The six primary aims of ABCD were to: Develop national standards for normal brain development for youth ages 9-19 years; Determine individual developmental trajectories (e.g., brain, cognitive, and emotional development, academic progress), and identify factors that can influence (protectively or adversely) these developmental patterns; Examine the roles of genetic, cultural, and environmental factors in youth development, as well as their interactions; Evaluate the effects of health, physical activity, sleep, social activities, sports injuries, and other experiences on brain and developmental outcomes; Assess the onset and progression of mental health (MH) disorders and factors that influence their course and severity as well as the relations between MH and substance use (SU); Determine...

Associations between perinatal risk and physical health in pre-adolescence in the Adolescent Brain Cognitive Development (ABCD) Study®: the unexpected relationship with sleep disruption

Mon, 17 Feb 2025 00:00:00 +0000

BackgroundTo investigate relationships among different physical health problems in a large, sociodemographically diverse sample of 9-to-10-year-old children and determine the extent to which perinatal health factors are associated with childhood physical health problems.MethodsA cross-sectional study was conducted utilizing the Adolescent Brain Cognitive Development℠ (ABCD) Study (n = 7613, ages 9-to-10-years-old) to determine the associations among multiple physical health factors (e.g., prenatal complications, current physical health problems). Logistic regression models controlling for age, sex, pubertal development, household income, caregiver education, race, and ethnicity evaluated relationships between perinatal factors and childhood physical health problems.ResultsThere were significant associations between perinatal and current physical health measures. Specifically, those who had experienced perinatal complications were more likely to have medical problems by 9-to-10...

Active vision in freely moving marmosets using head-mounted eye tracking

Thu, 13 Feb 2025 00:00:00 +0000

Our understanding of how vision functions as primates actively navigate the real-world is remarkably sparse. As most data have been limited to chaired and typically head-restrained animals, the synergistic interactions of different motor actions/plans inherent to active sensing-e.g., eyes, head, posture, movement, etc.-on visual perception are largely unknown. To address this considerable gap in knowledge, we developed an innovative wireless head-mounted eye-tracking system that performs Chair-free Eye-Recording using Backpack mounted micROcontrollers (CEREBRO) for small mammals, such as marmoset monkeys. Because eye illumination and environment lighting change continuously in natural contexts, we developed a segmentation artificial neural network to perform robust pupil tracking in these conditions. Leveraging this innovative system to investigate active vision, we demonstrate that although freely moving marmosets exhibit frequent compensatory eye movements equivalent to other...

Retrieval fluency inflates perceived preparation for difficult problems

Mon, 13 Jan 2025 00:00:00 +0000

When faced with a difficult problem, people often rely on past experiences. While remembering clearly helps us reach solutions, can retrieval also lead to misperceptions of our abilities? In three experiments, participants encountered "worst case scenarios" they likely had never experienced and that would be difficult to navigate without extensive training (e.g., bitten by snake). Learning brief tips improved problem-solving performance later, but retrieval increased feelings of preparation by an even larger margin. This gap occurred regardless of whether people thought that tips came from an expert or another participant in the study, and it did not reflect mere familiarity with the problems themselves. Instead, our results suggest that the ease experienced while remembering, or retrieval fluency, inflated feelings of preparation.

Effects of the COVID-19 Pandemic on Screen Time and Sleep in Early Adolescents

Tue, 3 Dec 2024 00:00:00 +0000

OBJECTIVE: During the COVID-19 pandemic, adolescents and families have turned to online activities and social platforms more than ever to maintain well-being, connect remotely with friends and family, and online schooling. However, excessive screen use can have negative effects on health (e.g., sleep). This study examined changes in sleep habits and recreational screen time (social media, video gaming), and their relationship, before and across the first year of the pandemic in adolescents in the Adolescent Brain Cognitive Development (ABCD) Study. METHOD: Mixed-effect models were used to examine associations between self-reported sleep and screen time using longitudinal data of 5,027 adolescents in the ABCD Study, assessed before the pandemic (10-13 years) and across six time points between May 2020 and March 2021 (pandemic). RESULTS: Time in bed varied, being higher during May-August 2020 relative to pre-pandemic, partially related to the school summer break, before declining...

Parental Knowledge/Monitoring and Adolescent Substance Use: A Causal Relationship?

Tue, 3 Dec 2024 00:00:00 +0000

OBJECTIVE: Many studies have shown that parental knowledge/monitoring is correlated with adolescent substance use, but the association may be confounded by the many preexisting differences between families with low versus high monitoring. We attempted to produce more rigorous evidence for a causal relation using a longitudinal design that took advantage of within-family fluctuations in knowledge/monitoring during the COVID-19 pandemic. METHOD: Youth (N = 8,780, age range = 10.5-15.6 years) at 21 sites across the United States completed up to seven surveys over 12 months. Youth reported on their parents' knowledge/monitoring of their activities and their substance use in the past month. Regressions were fit to within-family changes in youth-perceived knowledge/monitoring and substance use between survey waves. By analyzing within-family changes over time, we controlled for all stable, a priori differences that exist between families with low versus high levels of youth-perceived...

Pharmacokinetics, Fecal Output, and Grimace Scores in Rabbits Given Long-acting Buprenorphine or Fentanyl for Postsurgical Analgesia.

Wed, 13 Nov 2024 00:00:00 +0000

The New Zealand white rabbit (Oryctolagus cuniculus) is a frequently used surgical model. Pain management after surgery is a critical aspect of animal welfare. Recently, a long-acting buprenorphine formulation (Ethiqa XR; EXR) was approved for use in rats and mice but has not yet been investigated in rabbits. The current study aimed to determine whether a single subcutaneous dose of 0.15mg/kg of EXR could achieve and maintain therapeutic buprenorphine plasma concentrations (0.1ng/mL) for 72h in male and female rabbits. We also evaluated the safety profiles of EXR and the fentanyl patch (FP) by assessing fecal output after surgery, because opioids are known to decrease intestinal motility. Behavior and pain scores were compared for rabbits that received either EXR or the FP after undergoing an annulus puncture procedure to induce osteoarthritis. EXR at 0.15mg/kg SC provided a shorter time to onset and sustained analgesia for 72h in male and female rabbits, whereas the FP provided...

Mixing and mingling in visual working memory: Inter-item competition is feature-specific during encoding and feature-general during maintenance

Sat, 9 Nov 2024 00:00:00 +0000

Visual working memory (WM) is a central cognitive ability but is capacity-limited due to competition between remembered items. Understanding whether inter-item competition depends on the similarity of the features being remembered has important implications for determining if competition occurs in sensory or post-sensory stages of processing. Experiment 1 compared the precision of WM across homogeneous displays, where items belonged to the same feature type (e.g., colorful circles), and heterogeneous displays (e.g., colorful circles and oriented bars). Performance was better for heterogeneous displays, suggesting a feature-specific component of interference. However, Experiment 2 used a retro-cueing task to isolate encoding from online maintenance and revealed that inter-item competition during storage was not feature-specific. The data support recent models of WM in which inter-item interference – and hence capacity limits in WM – occurs in higher-order structures that receive...

Emphasizing Others’ Persistence Can Promote Unwarranted Social Inferences in Children and Adults

Sat, 9 Nov 2024 00:00:00 +0000

People often hear stories about individuals who persist to overcome their constraints. While these stories can be motivating, emphasizing others' persistence may promote unwarranted judgments about constrained individuals who do not persist. Using a developmental social inference task (Study 1a: n = 124 U.S. children, 5-12 years of age; Study 1b: n = 135 and Study 2: n = 120 U.S. adults), the present research tested whether persistence stories lead people to infer that a constrained individual who does not persist, and instead accepts the lower-quality option that is available to them, prefers it over a higher-quality option that is out of reach. Study 1 found evidence for this effect in children (1a) and adults (1b). Even persistence stories about failed outcomes, which emphasize how difficult it would have been to get the higher-quality option, had this effect. Study 2 found that the effect generalized to adults' judgments about an individual...

Mechanochemically accelerated deconstruction of chemically recyclable plastics

Thu, 26 Sep 2024 00:00:00 +0000

Plastics redesign for circularity has primarily focused on monomer chemistries enabling faster deconstruction rates concomitant with high monomer yields. Yet, during deconstruction, polymer chains interact with their reaction medium, which remains underexplored in polymer reactivity. Here, we show that, when plastics are deconstructed in reaction media that promote swelling, initial rates are accelerated by over sixfold beyond those in small-molecule analogs. This unexpected acceleration is primarily tied to mechanochemical activation of strained polymer chains; however, changes in the activity of water under polymer confinement and bond activation in solvent-separated ion pairs are also important. Together, deconstruction times can be shortened by seven times by codesigning plastics and their deconstruction processes.

Trauma’s distinctive and combined effects on subsequent substance use, mental health, and neurocognitive functioning with the NCANDA sample

Mon, 16 Sep 2024 00:00:00 +0000

PURPOSE: Traumatic brain injury (TBI) and potentially traumatic events (PTEs) contribute to increased substance use, mental health issues, and cognitive impairments. However, there's not enough research on how TBI and PTEs combined impact mental heath, substance use, and neurocognition. METHODS: This study leverages a subset of The National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) multi-site dataset with 551 adolescents to assess the combined and distinctive impacts of TBI, PTEs, and TBI+PTEs (prior to age 18) on substance use, mental health, and neurocognitive outcomes at age 18. RESULTS: TBI, PTEs, and TBI+PTEs predicted greater lifetime substance use and past-year alcohol and cannabis use. PTEs predicted greater internalizing symptoms, while TBI+PTEs predicted greater externalizing symptoms. Varying effects on neurocognitive outcomes included PTEs influencing attention accuracy and TBI+PTEs predicting faster speed in emotion tasks. PTEs predicted greater...

Comprehensive Social Trait Judgments From Faces in Autism Spectrum Disorder

Mon, 16 Sep 2024 00:00:00 +0000

Processing social information from faces is difficult for individuals with autism spectrum disorder (ASD). However, it remains unclear whether individuals with ASD make high-level social trait judgments from faces in the same way as neurotypical individuals. Here, we comprehensively addressed this question using naturalistic face images and representatively sampled traits. Despite similar underlying dimensional structures across traits, online adult participants with self-reported ASD showed different judgments and reduced specificity within each trait compared with neurotypical individuals. Deep neural networks revealed that these group differences were driven by specific types of faces and differential utilization of features within a face. Our results were replicated in well-characterized in-lab participants and partially generalized to more controlled face images (a preregistered study). By investigating social trait judgments in a broader population, including individuals...

Covert Attention Increases the Gain of Stimulus-Evoked Population Codes

Thu, 5 Sep 2024 00:00:00 +0000

Covert spatial attention has a variety of effects on the responses of individual neurons. However, relatively little is known about the net effect of these changes on sensory population codes, even though perception ultimately depends on population activity. Here, we measured the EEG in human observers (male and female), and isolated stimulus-evoked activity that was phase-locked to the onset of attended and ignored visual stimuli. Using an encoding model, we reconstructed spatially selective population tuning functions from the pattern of stimulus-evoked activity across the scalp. Our EEG-based approach allowed us to measure very early visually evoked responses occurring ∼100 ms after stimulus onset. In Experiment 1, we found that covert attention increased the amplitude of spatially tuned population responses at this early stage of sensory processing. In Experiment 2, we parametrically varied stimulus contrast to test how this effect scaled with stimulus contrast. We found that...

Beyond the Features: The Role of Consistency in Impressions of Trust

Thu, 29 Aug 2024 00:00:00 +0000

Beyond the Features: The Role of Consistency in Impressions of Trust

Identifying high school risk factors that forecast heavy drinking onset in understudied young adults

Mon, 5 Aug 2024 00:00:00 +0000

Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults who enrolled in 4-year residential college programs (4YCP) even though most high school graduates join the workforce, military, or community colleges. We examined 106 of these understudied young adults (USYA) and 453 4YCPs from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) by longitudinally following their drinking patterns for 8 years from adolescence to young adulthood. All participants were no-to-low drinkers during high school. Whereas 4YCP individuals were more likely to initiate heavy drinking during college years, USYA participants did so later. Using mental health metrics recorded during high school, machine learning forecasted individual-level risk for initiating heavy drinking after leaving high school. The risk factors differed between demographically...

Comparison of online, offline, and hybrid hypotheses of motor sequence learning using a quantitative model that incorporate reactive inhibition

Sat, 3 Aug 2024 00:00:00 +0000

Two hypotheses have been advanced for when motor sequence learning occurs: offline between bouts of practice or online concurrently with practice. A third possibility is that learning occurs both online and offline. A complication for differentiating between those hypotheses is a process known as reactive inhibition, whereby performance worsens over consecutively executed sequences, but dissipates during breaks. We advance a new quantitative modeling framework that incorporates reactive inhibition and in which the three learning accounts can be implemented. Our results show that reactive inhibition plays a far larger role in performance than is appreciated in the literature. Across four groups of participants in which break times and correct sequences per trial were varied, the best overall fits were provided by a hybrid model. The version of the offline model that does not account for reactive inhibition, which is widely assumed in the literature, had the worst fits. We discuss...

Changing the landscape of mental health among college students: a community case study of a course on learning sustainable well-being

Thu, 25 Jul 2024 00:00:00 +0000

Our society is facing an unprecedented mental health crisis, with nearly one in two people being affected by mental health issues over their lifespan. This trend is especially noticeable among college students, who undergo significant shifts in social, familial, and academic responsibilities. Exacerbating the mental health crisis is the fact that students are facing other societal crises (e.g., climate change). And, in a reciprocal fashion, students experiencing poor mental health are less likely to feel resilient enough to tackle these other crises. In response to these colliding societal crises, we need a comprehensive solution that goes beyond the current models of college mental health services. We propose an alternative preventative mental health approach, which aims to prevent the onset of mental health concerns and build resilience in the face of colliding crises. Specifically, we argue that colleges can aid in building mental health resilience by creating for-credit...

The Confidence Database

Sun, 21 Jul 2024 00:00:00 +0000

Understanding how people rate their confidence is critical for the characterization of a wide range of perceptual, memory, motor and cognitive processes. To enable the continued exploration of these processes, we created a large database of confidence studies spanning a broad set of paradigms, participant populations and fields of study. The data from each study are structured in a common, easy-to-use format that can be easily imported and analysed using multiple software packages. Each dataset is accompanied by an explanation regarding the nature of the collected data. At the time of publication, the Confidence Database (which is available at https://osf.io/s46pr/) contained 145 datasets with data from more than 8,700 participants and almost 4 million trials. The database will remain open for new submissions indefinitely and is expected to continue to grow. Here we show the usefulness of this large collection of datasets in four different analyses that provide precise estimations...

How do people build up visual memory representations from sensory evidence? Revisiting two classic models of choice

Sat, 20 Jul 2024 00:00:00 +0000

In many decision tasks, we have a set of alternative choices and are faced with the problem of how to use our latent beliefs and preferences about each alternative to make a single choice. Cognitive and decision models typically presume that beliefs and preferences are distilled to a scalar latent strength for each alternative, but it is also critical to model how people use these latent strengths to choose a single alternative. Most models follow one of two traditions to establish this link. Modern psychophysics and memory researchers make use of signal detection theory, assuming that latent strengths are perturbed by noise, and the highest resulting signal is selected. By contrast, many modern decision theoretic modeling and machine learning approaches use the softmax function (which is based on Luce's choice axiom; Luce, 1959) to give some weight to non-maximal-strength alternatives. Despite the prominence of these two theories of choice, current approaches rarely address the...

The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function

Thu, 6 Jun 2024 00:00:00 +0000

The brain’s primary circadian pacemaker, the suprachiasmatic nucleus (SCN), is required to translate day-length and circadian rhythms into neuronal, hormonal, and behavioral rhythms. Here, we identify the homeodomain transcription factor ventral anterior homeobox 1 (Vax1) as required for SCN development, vasoactive intestinal peptide expression, and SCN output. Previous work has shown that VAX1 is required for gonadotropin-releasing hormone (GnRH/LHRH) neuron development, a neuronal population controlling reproductive status. Surprisingly, the ectopic expression of a Gnrh-Cre allele (Gnrhcre) in the SCN confirmed the requirement of both VAX1 (Vax1flox/flox:Gnrhcre, Vax1Gnrh-cre) and sine oculis homeobox protein 6 (Six6flox/flox:Gnrhcre, Six6Gnrh-cre) in SCN function in adulthood. To dissociate the role of Vax1 and Six6 in GnRH neuron and SCN function, we used another Gnrh-cre allele that targets GnRH neurons, but not the SCN (Lhrhcre). Both Six6Lhrh-cre and Vax1Lhrh-cre were infertile,...

Asymmetric Activation of ON and OFF Pathways in the Degenerated Retina

Mon, 27 May 2024 00:00:00 +0000

Retinal prosthetics are one of the leading therapeutic strategies to restore lost vision in patients with retinitis pigmentosa and age-related macular degeneration. Much work has described patterns of spiking in retinal ganglion cells (RGCs) in response to electrical stimulation, but less work has examined the underlying retinal circuitry that is activated by electrical stimulation to drive these responses. Surprisingly, little is known about the role of inhibition in generating electrical responses or how inhibition might be altered during degeneration. Using whole-cell voltage-clamp recordings during subretinal electrical stimulation in the rd10 and wild-type (wt) retina, we found electrically evoked synaptic inputs differed between ON and OFF RGC populations, with ON cells receiving mostly excitation and OFF cells receiving mostly inhibition and very little excitation. We found that the inhibition of OFF bipolar cells limits excitation in OFF RGCs, and a majority...

How Do Anger and Impulsivity Impact Fast-Food Consumption in Transitional Age Youth?

Mon, 22 Apr 2024 00:00:00 +0000

Introduction: Consumption of fast food has been linked to psychiatric distress, violent behaviors, and impulsivity in adolescents. The relationship between eating fast food, anger, and impulsivity has not been widely investigated. The National Consortium on Alcohol and Neurodevelopment in Adolescence community-based cohort consists of 831 youth, half at elevated risk factors for substance use disorders during adolescence, followed annually. Methods: Impulsivity using Urgency, Premeditation, Perseverance, and Sensation Seeking Impulsive Behavior scale from annual assessments was examined in relation to self-reported fast-food consumption frequency and mobile application questions of anger. This study tested the hypotheses that youth anger may be predicted by fast-food consumption frequency and impulsivity using multiple regression, in addition to whether adolescent fast-food consumption frequency may be predicted by anger and impulsivity. Results: Among youth, higher anger levels...

A quantitative model of ensemble perception as summed activation in feature space

Mon, 15 Apr 2024 00:00:00 +0000

Ensemble perception is a process by which we summarize complex scenes. Despite the importance of ensemble perception to everyday cognition, there are few computational models that provide a formal account of this process. Here we develop and test a model in which ensemble representations reflect the global sum of activation signals across all individual items. We leverage this set of minimal assumptions to formally connect a model of memory for individual items to ensembles. We compare our ensemble model against a set of alternative models in five experiments. Our approach uses performance on a visual memory task for individual items to generate zero-free-parameter predictions of interindividual and intraindividual differences in performance on an ensemble continuous-report task. Our top-down modelling approach formally unifies models of memory for individual items and ensembles and opens a venue for building and comparing models of distinct memory processes and representations.

Cell dispersal by localized degradation of a chemoattractant

Fri, 12 Apr 2024 00:00:00 +0000

Chemotaxis, the guided motion of cells by chemical gradients, plays a crucial role in many biological processes. In the social amoeba Dictyostelium discoideum, chemotaxis is critical for the formation of cell aggregates during starvation. The cells in these aggregates generate a pulse of the chemoattractant, cyclic adenosine 3',5'-monophosphate (cAMP), every 6 min to 10 min, resulting in surrounding cells moving toward the aggregate. In addition to periodic pulses of cAMP, the cells also secrete phosphodiesterase (PDE), which degrades cAMP and prevents the accumulation of the chemoattractant. Here we show that small aggregates of Dictyostelium can disperse, with cells moving away from instead of toward the aggregate. This surprising behavior often exhibited oscillatory cycles of motion toward and away from the aggregate. Furthermore, the onset of outward cell motion was associated with a doubling of the cAMP signaling period. Computational modeling suggests that...

Aesthetic Motivation Impacts Judgments of Others’ Prosociality and Mental Life

Fri, 12 Apr 2024 00:00:00 +0000

The ability to infer others' prosocial vs. antisocial behavioral tendencies from minimal information is core to social reasoning. Aesthetic motivation (the value or appreciation of aesthetic beauty) is linked with prosocial tendencies, raising the question of whether this factor is used in interpersonal reasoning and in the attribution of mental capacities. We propose and test a model of this reasoning, predicting that evidence of others' aesthetic motivations should impact judgments of others' prosocial (and antisocial) tendencies by signaling a heightened capacity for emotional experience. In a series of four pre-registered experiments (total N = 1440), participants saw pairs of characters (as photos/vignettes), and judged which in each pair showed more of a mental capacity of interest. Distractor items prevented participants from guessing the hypothesis. For one critical pair of characters, both characters performed the same activity (music listening, painting, cooking,...

From Commitment to Action

Fri, 12 Apr 2024 00:00:00 +0000

From Commitment to Action

Interpersonal utility and children's social inferences from shared preferences

Fri, 12 Apr 2024 00:00:00 +0000

Similarity of behaviors or attributes is often used to infer social affiliation and prosociality. Does this reflect reasoning using a simple expectation of homophily, or more complex reasoning about shared utility? We addressed this question by examining the inferences children make from similar choices when this similarity does or does not cause competition over a zero-sum resource. Four- to six-year-olds (N = 204) saw two vignettes, each featuring three characters (a target plus two others) choosing between two types of resources. In all stories, each character expressed a preference: one 'other' chose the same resource as the target, while a second 'other' chose the different resource. In one condition there were enough resources for all the characters; in the other condition, one type of resource was limited, with only one available (inducing potential competition between the target and the similar-choice other). Children then judged which of the two 'other' characters...

Dissociable Neural Mechanisms Underlie the Effects of Attention on Visual Appearance and Response Bias

Sat, 30 Mar 2024 00:00:00 +0000

A prominent theoretical framework spanning philosophy, psychology, and neuroscience holds that selective attention penetrates early stages of perceptual processing to alter the subjective visual experience of behaviorally relevant stimuli. For example, searching for a red apple at the grocery store might make the relevant color appear brighter and more saturated compared with seeing the exact same red apple while searching for a yellow banana. In contrast, recent proposals argue that data supporting attention-related changes in appearance reflect decision- and motor-level response biases without concurrent changes in perceptual experience. Here, we tested these accounts by evaluating attentional modulations of EEG responses recorded from male and female human subjects while they compared the perceived contrast of attended and unattended visual stimuli rendered at different levels of physical contrast. We found that attention enhanced the amplitude of the P1 component, an early...

Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents

Tue, 12 Mar 2024 00:00:00 +0000

STUDY OBJECTIVES: Adolescence is characterized by significant brain development, accompanied by changes in sleep timing and architecture. It also is a period of profound psychosocial changes, including the initiation of alcohol use; however, it is unknown how alcohol use affects sleep architecture in the context of adolescent development. We tracked developmental changes in polysomnographic (PSG) and electroencephalographic (EEG) sleep measures and their relationship with emergent alcohol use in adolescents considering confounding effects (e.g. cannabis use). METHODS: Adolescents (n = 94, 43% female, age: 12-21 years) in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study had annual laboratory PSG recordings across 4-years. Participants were no/low drinkers at baseline. RESULTS: Linear mixed effect models showed developmental changes in sleep macrostructure and EEG, including a decrease in slow wave sleep and slow wave (delta) EEG activity with...

Instrumental lying by parents in the US and China

Fri, 1 Mar 2024 00:00:00 +0000

The practice of lying to one's children to encourage behavioral compliance was investigated among parents in the US (N = 114) and China (N = 85). The vast majority of parents (84% in the US and 98% in China) reported having lied to their children for this purpose. Within each country, the practice most frequently took the form of falsely threatening to leave a child alone in public if he or she refused to follow the parent. Crosscultural differences were seen: A larger proportion of the parents in China reported that they employed instrumental lie-telling to promote behavioral compliance, and a larger proportion approved of this practice, as compared to the parents in the US. This difference was not seen on measures relating to the practice of lying to promote positive feelings, or on measures relating to statements about fantasy characters such as the tooth fairy. Findings are discussed with reference to sociocultural values and certain parenting-related challenges that extend...

Children’s Reputation Management: Learning to Identify What Is Socially Valued and Acting Upon It

Fri, 1 Mar 2024 00:00:00 +0000

Much of what people do is motivated by a concern with social evaluation. We argue that the process of figuring out what others value and making effective use of this information presents significant cognitive challenges. These challenges include reasoning about the relevance of different forms of information and making inferences about the mental lives of others. They also include modifying one's behavior in light of whatever personal qualities appear to be valued in an effort to appeal to different audiences. We argue that the foundations of many of the important skills needed to meet these challenges are already in place early during childhood, but that the challenges themselves persist well into adulthood.

Parenting by Lying

Fri, 1 Mar 2024 00:00:00 +0000

Parenting by lying is a practice in which parents lie to their children to influence their emotions or behavior. Recently, researchers have tried to document the nature of this phenomenon and to understand its causes and consequences. The present research provides an overview of the research in the emerging field, describes some key theoretical and methodological challenges in studying this topic, and proposes a theoretical framework for understanding parenting by lying and for guiding future research to advance our knowledge about this understudied parenting practice.

Brain structural covariance network features are robust markers of early heavy alcohol use

Tue, 27 Feb 2024 00:00:00 +0000

BACKGROUND AND AIMS: Recently, we demonstrated that a distinct pattern of structural covariance networks (SCN) from magnetic resonance imaging (MRI)-derived measurements of brain cortical thickness characterized young adults with alcohol use disorder (AUD) and predicted current and future problematic drinking in adolescents relative to controls. Here, we establish the robustness and value of SCN for identifying heavy alcohol users in three additional independent studies. DESIGN AND SETTING: Cross-sectional and longitudinal studies using data from the Pediatric Imaging, Neurocognition and Genetics (PING) study (n = 400, age range = 14-22 years), the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) (n = 272, age range = 17-22 years) and the Human Connectome Project (HCP) (n = 375, age range = 22-37 years). CASES: Cases were defined based on heavy alcohol use patterns or former alcohol use disorder (AUD) diagnoses: 50, 68 and 61 cases were identified. Controls...

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Fri, 23 Feb 2024 00:00:00 +0000

OBJECTIVE: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. METHOD: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. RESULTS: The meta-analysis of overall internalizing symptoms (INT_overall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, n_effective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of...

Parallel developmental changes in children’s production and recognition of line drawings of visual concepts

Tue, 13 Feb 2024 00:00:00 +0000

Childhood is marked by the rapid accumulation of knowledge and the prolific production of drawings. We conducted a systematic study of how children create and recognize line drawings of visual concepts. We recruited 2-10-year-olds to draw 48 categories via a kiosk at a children’s museum, resulting in >37K drawings. We analyze changes in the category-diagnostic information in these drawings using vision algorithms and annotations of object parts. We find developmental gains in children’s inclusion of category-diagnostic information that are not reducible to variation in visuomotor control or effort. Moreover, even unrecognizable drawings contain information about the animacy and size of the category children tried to draw. Using guessing games at the same kiosk, we find that children improve across childhood at recognizing each other’s line drawings. This work leverages vision algorithms to characterize developmental changes in children’s drawings and suggests that these changes...

Assessing cross-lagged associations between depression, anxiety, and binge drinking in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study

Tue, 13 Feb 2024 00:00:00 +0000

BACKGROUND: Between 20 % and 30 % of teens suffer from depression or anxiety before reaching adulthood, and up to half also use or misuse alcohol. Although theories suggest bidirectional links between harmful alcohol use (e.g., binge drinking) and internalizing symptoms (i.e., depression and anxiety), empirical evidence to-date has been mixed. Systematic reviews have attributed mixed findings to limitations in study design, such as the utilization of between-person analyses and the focus on unidirectional effects. The goal of this study was to address these limitations by assessing bidirectional within-person associations between internalizing symptoms and binge drinking over the course of 5 years in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) sample, a large cohort recruited at ages 12-21 and followed annually on substance use and psychiatric functioning. METHODS: We used latent curve models with structured residuals to examine within-person...

Multimodal pathways to joint attention in infants with a familial history of autism

Tue, 6 Feb 2024 00:00:00 +0000

Joint attention (JA) is an early-developing behavior that allows caregivers and infants to share focus on an object. Deficits in JA, as measured through face-following pathways, are a defining feature of autism spectrum disorder (ASD) and are observable as early as 12 months of age in infants later diagnosed with ASD. However, recent evidence suggests that JA may be achieved through hand-following pathways by children with and without ASD. Development of JA through multimodal pathways has yet to be studied in infants with an increased likelihood of developing ASD. The current study investigated how 6-, 9- and 12-month-old infants with (FH+) and without (FH-) a family history of ASD engaged in JA. Parent-infant dyads played at home while we recorded the interaction over Zoom and later offline coded for hand movements and gaze. FH+ and FH- infants spent similar amounts of time in JA with their parents, but the cues available before JA were different. Parents of FH+ infants...

Fluency, prediction and motivation: how processing dynamics, expectations and epistemic goals shape aesthetic judgements

Sat, 20 Jan 2024 00:00:00 +0000

What psychological mechanisms underlie aesthetic judgements? An influential account known as the Hedonic Marking of Fluency, later developed into a Processing Fluency Theory of Aesthetic Pleasure, posits that ease of processing elicits positive feelings and thus enhances stimulus evaluations. However, the theory faces empirical and conceptual challenges. In this paper, we extend it by integrating insights from predictive processing frameworks (PPF) and the epistemic motivation model (EMM). We propose four extensions. First, fluency of a stimulus depends on perceivers' expectations-their internal model of the world. Second, perceivers also form expectations about fluency itself and thus can experience surprising fluency. These expectations can come from the individual's history, their current task and their environment. Third, perceivers can value fluency but also disfluency, reflecting their non-directional epistemic goals. Fourth, perceivers also have directional epistemic goals,...

What latent variable underlies confidence in lineup rejections?

Thu, 18 Jan 2024 00:00:00 +0000

What latent variable underlies confidence in lineup rejections?

Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach

Sat, 13 Jan 2024 00:00:00 +0000

Cortical thickness changes dramatically during development and is associated with adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the underlying spatially heterogeneous effects of alcohol. In this study, adolescents (n = 657; 12–22 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study who endorsed little to no alcohol use at baseline were assessed with structural magnetic resonance imaging and followed longitudinally at four yearly intervals. Seven unique spatial patterns of covarying cortical thickness were obtained from the baseline scans by applying an unsupervised machine learning method called non-negative matrix factorization (NMF). The cortical thickness maps of all participants’ longitudinal scans were projected onto vertex-level cortical patterns to obtain participant-specific coefficients for...

Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study

Sun, 24 Dec 2023 00:00:00 +0000

Neurodevelopment continues through adolescence, with notable maturation of white matter tracts comprising regional fiber systems progressing at different rates. To identify factors that could contribute to regional differences in white matter microstructure development, large samples of youth spanning adolescence to young adulthood are essential to parse these factors. Recruitment of adequate samples generally relies on multi-site consortia but comes with the challenge of merging data acquired on different platforms. In the current study, diffusion tensor imaging (DTI) data were acquired on GE and Siemens systems through the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA), a multi-site study designed to track the trajectories of regional brain development during a time of high risk for initiating alcohol consumption. This cross-sectional analysis reports baseline Tract-Based Spatial Statistic (TBSS) of regional fractional anisotropy (FA), mean diffusivity...

Animal model of methylphenidate's long-term memory-enhancing effects

Sun, 24 Dec 2023 00:00:00 +0000

Methylphenidate (MPH), introduced more than 60 years ago, accounts for two-thirds of current prescriptions for attention deficit hyperactivity disorder (ADHD). Although many studies have modeled MPH's effect on executive function, almost none have directly modeled its effect on long-term memory (LTM), even though improvement in LTM is a critical target of therapeutic intervention in ADHD. We examined the effects of a wide range of doses of MPH (0.01-10 mg/kg, i.p.) on Pavlovian fear learning, a leading model of memory. MPH's effects were then compared to those of atomoxetine (0.1-10 mg/kg, i.p.), bupropion (0.5-20 mg/kg, i.p.), and citalopram (0.01-10 mg/kg, i.p.). At low, clinically relevant doses, MPH enhanced fear memory; at high doses it impaired memory. MPH's memory-enhancing effects were not confounded by its effects on locomotion or anxiety. Further, MPH-induced memory enhancement seemed to require both dopamine and norepinephrine transporter inhibition. Finally, the addictive...

Probabilistic and rich individual working memories revealed by a betting game.

Mon, 18 Dec 2023 00:00:00 +0000

When asked to remember a color, do people remember a point estimate (e.g., a particular shade of red), a point estimate plus an uncertainty estimate, or are memory representations rich probabilistic distributions over feature space? We asked participants to report the color of a circle held in working memory. Rather than collecting a single report per trial, we had participants place multiple bets to create trialwise uncertainty distributions. Bet dispersion correlated with performance, indicating that internal uncertainty guided bet placement. While the first bet was on average the most precisely placed, the later bets systematically shifted the distribution closer to the target, resulting in asymmetrical distributions about the first bet. This resulted in memory performance improvements when averaging across bets, and overall suggests that memory representations contain more information than can be conveyed by a single response. The later bets contained target information even...

Many Ways to Be Lonely: Fine-Grained Characterization of Loneliness and Its Potential Changes in COVID-19.

Sat, 9 Dec 2023 00:00:00 +0000

Many Ways to Be Lonely: Fine-Grained Characterization of Loneliness and Its Potential Changes in COVID-19.

Orbitofrontal cortex populations are differentially recruited to support actions

Wed, 15 Nov 2023 00:00:00 +0000

The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press durations to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the encoding of ongoing press durations but did not disrupt the use of prior action information to guide future action performance. In contrast, a chronic functional loss of lOFC circuit activity resulted in increased reliance on recently executed lever-press...

Children’s Reasoning About Empathy and Social Relationships

Wed, 15 Nov 2023 00:00:00 +0000

Across the lifespan, empathic and counter-empathic emotions are shaped by social relationships. Here we test the hypothesis that this connection is encoded in children's intuitive theory of psychology, allowing them to predict when others will feel empathy versus counter-empathy and to use vicarious emotion information to infer relationships. We asked 4- to 7-year-old children (N = 79) to make emotion predictions or relationship inferences in response to stories featuring two characters, an experiencer and an observer, and either a positive or negative outcome for the experiencer. In the context of positive outcomes, we found that children engaged in robust joint reasoning about relationships and vicarious emotions. When given information about the characters' relationship, children predicted empathy from a friendly observer and counter-empathy from a rival observer. When given information about the observer's response to the experiencer, children inferred positive and negative...

Using transitional information in sign and gesture perception

Mon, 23 Oct 2023 00:00:00 +0000

For sign languages, transitional movements of the hands are fully visible and may be used to predict upcoming linguistic input. We investigated whether and how deaf signers and hearing nonsigners use transitional information to detect a target item in a string of either pseudosigns or grooming gestures, as well as whether motor imagery ability was related to this skill. Transitional information between items was either intact (Normal videos), digitally altered such that the hands were selectively blurred (Blurred videos), or edited to only show the frame prior to the transition which was frozen for the entire transition period, removing all transitional information (Static videos). For both pseudosigns and gestures, signers and nonsigners had faster target detection times for Blurred than Static videos, indicating similar use of movement transition cues. For linguistic stimuli (pseudosigns), only signers made use of transitional handshape information, as evidenced by faster target...

How (and why) does iconicity effect lexical access: An electrophysiological study of American sign language

Mon, 23 Oct 2023 00:00:00 +0000

Prior research has found that iconicity facilitates sign production in picture-naming paradigms and has effects on ERP components. These findings may be explained by two separate hypotheses: (1) a task-specific hypothesis that suggests these effects occur because visual features of the iconic sign form can map onto the visual features of the pictures, and (2) a semantic feature hypothesis that suggests that the retrieval of iconic signs results in greater semantic activation due to the robust representation of sensory-motor semantic features compared to non-iconic signs. To test these two hypotheses, iconic and non-iconic American Sign Language (ASL) signs were elicited from deaf native/early signers using a picture-naming task and an English-to-ASL translation task, while electrophysiological recordings were made. Behavioral facilitation (faster response times) and reduced negativities were observed for iconic signs (both prior to and within the N400 time window), but only in...

The Importance of Considering Model Choices When Interpreting Results in Computational Neuroimaging

Sun, 22 Oct 2023 00:00:00 +0000

Model-based analyses open exciting opportunities for understanding neural information processing. In a commentary published in eNeuro, Gardner and Liu (2019) discuss the role of model specification in interpreting results derived from complex models of neural data. As a case study, they suggest that one such analysis, the inverted encoding model (IEM), should not be used to assay properties of "stimulus representations" because the ability to apply linear transformations at various stages of the analysis procedure renders results "arbitrary." Here, we argue that the specification of all models is arbitrary to the extent that an experimenter makes choices based on current knowledge of the model system. However, the results derived from any given model, such as the reconstructed channel response profiles obtained from an IEM analysis, are uniquely defined and are arbitrary only in the sense that changes in the model can predictably change results. IEM-based channel response...

An Adaptive Perspective on Visual Working Memory Distortions

Fri, 13 Oct 2023 00:00:00 +0000

When holding multiple items in visual working memory, representations of individual items are often attracted to, or repelled from, each other. While this is empirically well-established, existing frameworks do not account for both types of distortions, which appear to be in opposition. Here, we demonstrate that both types of memory distortion may confer functional benefits under different circumstances. When there are many items to remember and subjects are near their capacity to accurately remember each item individually, memories for each item become more similar (attraction). However, when remembering smaller sets of highly similar but discernible items, memory for each item becomes more distinct (repulsion), possibly to support better discrimination. Importantly, this repulsion grows stronger with longer delays, suggesting that it dynamically evolves in memory and is not just a differentiation process that occurs during encoding. Furthermore, both attraction and repulsion...

A comparison between a rate-them-all simultanous lineup procedure vs. standard simultaneous and showup procedures

Thu, 5 Oct 2023 00:00:00 +0000

A comparison between a rate-them-all simultanous lineup procedure vs. standard simultaneous and showup procedures

The Reveal Procedure: A Way to Enhance Evidence of Innocence From Police Lineups

Thu, 5 Oct 2023 00:00:00 +0000

OBJECTIVE: Recent work has established that high-confidence identifications (IDs) from a police lineup can provide compelling evidence of guilt. By contrast, when a witness rejects the lineup, it may offer only limited evidence of innocence. Moreover, confidence in a lineup rejection often provides little additional information beyond the rejection itself. Thus, although lineups are useful for incriminating the guilty, they are less useful for clearing the innocent of suspicion. Here, we test predictions from a signal-detection-based model of eyewitness ID to create a lineup that is capable of increasing information about innocence. HYPOTHESES: Our model-based simulations suggest that high-confidence rejections should exonerate many more innocent suspects and do so with higher accuracy if, after a witness rejects a lineup but before they report their confidence, they are shown the suspect and asked, "How sure are you that this person is not the perpetrator?" METHOD: Participants...

The Latent Decision Variable Underlying Confidence in Lineup Rejections

Thu, 5 Oct 2023 00:00:00 +0000

The Latent Decision Variable Underlying Confidence in Lineup Rejections

The Scientific Principles of Memory versus the Federal Rules of Evidence

Thu, 5 Oct 2023 00:00:00 +0000

Eyewitness misidentifications have contributed to many wrongful convictions. However, despite expressing high confidence at trial, eyewitnesses often make inconclusive misidentifications on the first test conducted early in a police investigation. According to a new scientific consensus, it is important to focus on the results of the first test because, if the perpetrator is not in the lineup, the test itself leaves a memory trace of the innocent suspect in the witness’s brain. Thus, all subsequent tests of the witness’s memory for the same suspect constitute tests of contaminated memory. Unfortunately, when evidence of an initial inconclusive identification is introduced at trial, the rules of evidence provide a witness with an opportunity to explain their prior inconsistent statement. In response, witnesses often provide an opinion about why they did not confidently identify the suspect on the initial test despite doing so now (e.g., “I was nervous on the first test”).However,...

Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples

Mon, 25 Sep 2023 00:00:00 +0000

Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12-21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10-18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala...

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

Thu, 21 Sep 2023 00:00:00 +0000

The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data is a resource of unprecedented scale and depth for studying typical and atypical development. The aim of this manuscript is to describe the baseline neuroimaging processing and subject-level analysis methods used by ABCD. Processing and analyses include modality-specific...

There Is no Theory-Free Measure of “Swaps” in Visual Working Memory Experiments

Sat, 16 Sep 2023 00:00:00 +0000

Abstract Visual working memory is highly limited, and its capacity is tied to many indices of cognitive function. For this reason, there is much interest in understanding its architecture and the sources of its limited capacity. As part of this research effort, researchers often attempt to decompose visual working memory errors into different kinds of errors, with different origins. One of the most common kinds of memory error is referred to as a “swap,” where people report a value that closely resembles an item that was not probed (e.g., an incorrect, non-target item). This is typically assumed to reflect confusions, like location binding errors, which result in the wrong item being reported. Capturing swap rates reliably and validly is of great importance because it permits researchers to accurately decompose different sources of memory errors and elucidate the processes that give rise to them. Here, we ask whether different visual working memory models yield robust and consistent...

Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals

Fri, 15 Sep 2023 00:00:00 +0000

Some of the most widely studied variants in psychiatric genetics include variable number tandem repeat variants (VNTRs) in SLC6A3, DRD4, SLC6A4, and MAOA. While initial findings suggested large effects, their importance with respect to psychiatric phenotypes is the subject of much debate with broadly conflicting results. Despite broad interest, these loci remain absent from the largest available samples, such as the UK Biobank, limiting researchers’ ability to test these contentious hypotheses rigorously in large samples. Here, using two independent reference datasets, we report out-of-sample imputation accuracy estimates of >0.96 for all four VNTR variants and one modifying SNP, depending on the reference and target dataset. We describe the imputation procedures of these candidate variants in 486,551 UK Biobank individuals, and have made the imputed variant data available to UK Biobank researchers. This resource, provided to the scientific community, will allow the most rigorous...

Independent predictors of mortality in adolescents ascertained for conduct disorder and substance use problems, their siblings and community controls

Fri, 15 Sep 2023 00:00:00 +0000

BACKGROUND AND AIMS: Adolescents with conduct and substance use problems are at increased risk for premature mortality, but the extent to which these risk factors reflect family- or individual-level differences and account for shared or unique variance is unknown. This study examined common and independent contributions to mortality hazard in adolescents ascertained for conduct disorder (CD) and substance use disorder (SUD), their siblings and community controls, hypothesizing that individual differences in CD and SUD severity would explain unique variation in mortality risk beyond that due to clinical/control status and demographic factors. DESIGN: Mortality analysis in a prospective study (Genetics of Antisocial Drug Dependence Study) that began in 1993. SETTING: Multi-site sample recruited in San Diego, California and Denver, Colorado, USA. PARTICIPANTS: A total of 1463 clinical probands were recruited through the juvenile correctional system, court-mandated substance abuse...

Retrospective Self-Reported Childhood Experiences in Enriched Environments Uniquely Predict Prosocial Behavior and Personality Traits in Adulthood

Tue, 5 Sep 2023 00:00:00 +0000

What features of people's childhood environments go on to shape their prosocial behavior during adulthood? Past studies linking childhood environment to adult prosocial behavior have focused primarily on adverse features, thereby neglecting the possible influence of exposure to enriched environments (e.g., access to material resources, experiences with rich cooperative relationships, and interactions with morally exemplary role models). Here, we expand the investigation of childhood environmental quality to include consideration of enriching childhood experiences and their relation to adult prosociality. In two cross-sectional studies, we found promising evidence that enriched childhood environments are associated with adult moral behavior. In study 1 (N = 1,084 MTurk workers), we adapted an existing measure of enriched childhood environmental quality for retrospective recall of childhood experiences and found that subjects' recollections of their enriched childhood experiences...

Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity

Mon, 4 Sep 2023 00:00:00 +0000

Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are implicated in balancing goal-directed and habitual control over actions and show disruption in disorders with compulsive, inflexible behaviors, including AUD. However, whether there is a causal link between disrupted premotor activity and altered action control is unknown. Here, we find that mice chronically exposed to alcohol (chronic intermittent ethanol [CIE]) showed impaired ability to use recent action information to guide subsequent actions. Prior CIE exposure resulted in aberrant increases in the calcium activity of premotor cortex (M2) neurons that project to the dorsal medial striatum (M2-DMS) during action control. Chemogenetic reduction of this CIE-induced hyperactivity in M2-DMS neurons rescued goal-directed action control. This suggests a direct, causal relationship between chronic alcohol...

Genetic association study of childhood aggression across raters, instruments, and age

Sat, 2 Sep 2023 00:00:00 +0000

Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E–06), PCDH7 (P = 2.0E–06), and IPO13 (P = 2.5E–06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively...

Defending Against Medical Error: Personal Reflections on the Legacy of John Senders

Fri, 1 Sep 2023 00:00:00 +0000

OBJECTIVE: To honor the legacy of John Senders, a distinguished member of the Human Factors and Ergonomics Society, by a short, personal history of him, but then to honor his legacy by extending it through our own professional opinions, with an emphasis on the study of human error and its implications for healthcare systems-two topics in which he excelled. BACKGROUND: The authors are familiar with the topic and subject matter. One was a friend of Senders for over 50 years. Another was a collaborator and joint author with Senders (as well as his stepdaughter). All three authors have extensive publications in the topic areas. METHOD, RESULTS, AND CONCLUSION: The authors used personal accounts of interactions with Senders at conferences, experiences living and working with him, and a brief review of his most personal, notable publications in healthcare. The reflections indicate a strong resonance on Senders' contributions to system design that are relevant today in healthcare's...

The neurobiology of vocal communication in marmosets

Thu, 31 Aug 2023 00:00:00 +0000

An increasingly popular animal model for studying the neural basis of social behavior, cognition, and communication is the common marmoset (Callithrix jacchus). Interest in this New World primate across neuroscience is now being driven by their proclivity for prosociality across their repertoire, high volubility, and rapid development, as well as their amenability to naturalistic testing paradigms and freely moving neural recording and imaging technologies. The complement of these characteristics set marmosets up to be a powerful model of the primate social brain in the years to come. Here, we focus on vocal communication because it is the area that has both made the most progress and illustrates the prodigious potential of this species. We review the current state of the field with a focus on the various brain areas and networks involved in vocal perception and production, comparing the findings from marmosets to other animals, including humans.

Moving thoughts: emotion concepts from the perspective of context dependent embodied simulation

Thu, 3 Aug 2023 00:00:00 +0000

Moving thoughts: emotion concepts from the perspective of context dependent embodied simulation

From spatial navigation via visual construction to episodic memory and imagination

Sat, 22 Jul 2023 00:00:00 +0000

This hybrid of review and personal essay argues that models of visual construction are essential to extend spatial navigation models to models that link episodic memory and imagination. The starting point is the TAM–WG model, combining the Taxon Affordance Model and the World Graph model of spatial navigation. The key here is to reject approaches in which memory is restricted to unanalyzed views from familiar places, and their later recall. Instead, we will seek mechanisms for imagining truly novel scenes and episodes. We thus introduce a specific variant of schema theory and VISIONS, a cooperative computation model of visual scene understanding in which a scene is represented by an assemblage of schema instances with links to lower-level “patches” of relevant visual data. We sketch a new conceptual framework for future modeling, Visual Integration of Diverse Multi-Modal Aspects, by extending VISIONS from static scenes to episodes combining agents, actions and objects and assess...

Computational challenges of evolving the language-ready brain

Thu, 20 Jul 2023 00:00:00 +0000

Computational challenges of evolving the language-ready brain

Tooling and Construction: From Nut-Cracking and Stone-Tool Making to Bird Nests and Language

Thu, 20 Jul 2023 00:00:00 +0000

Tooling and Construction: From Nut-Cracking and Stone-Tool Making to Bird Nests and Language

The comparative neuroprimatology 2018 (CNP-2018) road map for research on How the Brain Got Language

Thu, 20 Jul 2023 00:00:00 +0000

The comparative neuroprimatology 2018 (CNP-2018) road map for research on How the Brain Got Language

Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Wed, 19 Jul 2023 00:00:00 +0000

Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood–brain barrier in non-human primates. Here we report on AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques, which has improved delivery efficiency in the brains of multiple non-human primate species: marmoset, rhesus macaque and green monkey. CAP-Mac is neuron biased in infant Old World primates, exhibits broad tropism in adult rhesus macaques and is vasculature biased in adult marmosets. We demonstrate applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for Brainbow-like labelling throughout the macaque brain, circumventing the...

Pandemic-Related Changes in the Prevalence of Early Adolescent Alcohol and Drug Use, 2020–2021: Data From a Multisite Cohort Study

Mon, 17 Jul 2023 00:00:00 +0000

PURPOSE: Evaluate changes in early adolescent substance use from May 2020 to May 2021 during the coronavirus disease 2019 pandemic using data from a prospective nationwide cohort: the Adolescent Brain Cognitive Development Study. METHODS: In 2018-2019, 9,270 youth aged 11.5-13.0 completed a prepandemic assessment of past-month alcohol and drug use, then up to seven during-pandemic assessments between May 2020 and May 2021. We compared the prevalence of substance use among same-age youth across these eight timepoints. RESULTS: Pandemic-related decreases in the past-month prevalence of alcohol use were detectable in May 2020, grew larger over time, and remained substantial in May 2021 (0.3% vs. 3.2% prepandemic, p <.001). Pandemic-related increases in inhalant use (p = .04) and prescription drug misuse (p < .001) were detectable in May 2020, shrunk over time, and were smaller but still detectable in May 2021(0.1%-0.2% vs. 0% pre-pandemic). Pandemic-related increases...

Visual hindsight bias for abnormal mammograms in radiologists

Mon, 17 Jul 2023 00:00:00 +0000

Purpose: Hindsight bias-where people falsely believe they can accurately predict something once they know about it-is a pervasive decision-making phenomenon, including in the interpretation of radiological images. Evidence suggests it is not only a decision-making phenomenon but also a visual perception one, where prior information about an image enhances our visual perception of the contents of that image. The current experiment investigates to what extent expert radiologists perceive mammograms with visual abnormalities differently when they know what the abnormality is (a visual hindsight bias), above and beyond being biased at a decision level. Approach: experienced mammography readers were presented with a series of unilateral abnormal mammograms. After each case, they were asked to rate their confidence on a 6-point scale that ranged from confident mass to confident calcification. We used the random image structure evolution method, where the images repeated in an unpredictable...

High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Sat, 8 Jul 2023 00:00:00 +0000

Flexibility of behavior and the ability to rapidly switch actions is critical for adaptive living in humans. It is well established that the right-inferior frontal gyrus (R-IFG) is recruited during outright action-stopping, relating to increased beta (12-30 Hz) power. It has also been posited that inhibiting incorrect response tendencies and switching is central to motor flexibility. However, it is not known if the commonly reported R-IFG beta signature of response inhibition in action-stopping is also recruited during response conflict, which would suggest overlapping networks for stopping and switching. In the current study, we analyzed high precision magnetoencephalography (hpMEG) data recorded with multiple within subject recording sessions (trials n > 10,000) from 8 subjects during different levels of response conflict. We hypothesized that a R-IFG-triggered network for response inhibition is domain general and therefore also involved in mediating response...

Expectancy Effects Threaten the Inferential Validity of Synchrony-Prosociality Research

Sat, 8 Jul 2023 00:00:00 +0000

Many studies argue that synchronized movement increases prosocial attitudes and behavior. We reviewed meta-analytic evidence that reported effects of synchrony may be driven by experimenter expectancy, leading to experimenter bias; and participant expectancy, otherwise known as placebo effects. We found that a majority of published studies do not adequately control for experimenter bias and that multiple independent replication attempts with added controls have failed to find the original effects. In a preregistered experiment, we measured participant expectancy directly, asking whether participants have a priori expectations about synchrony and prosociality that match the findings in published literature. Expectations about the effects of synchrony on prosocial attitudes directly mirrored previous experimental findings (including both positive and null effects)-despite the participants not actually engaging in synchrony. On the basis of this evidence, we propose an alternative...

Substance use patterns in 9 to 13-year-olds: Longitudinal findings from the Adolescent Brain Cognitive Development (ABCD) study

Fri, 7 Jul 2023 00:00:00 +0000

Background: Though largely substance-naïve at enrollment, a proportion of the youth in the Adolescent Brain Cognitive Development (ABCD) Study are expected to initiate substance use (SU) as they transition into later adolescence. With annual data from youth 9-13 years-old, this study aims to describe their SU patterns over time. Here, prevalence rates of use are reported, along with predicted odds of use while analyzing common risk-factors associated with youth SU. Methods: The ABCD Study^® enrolled 11,876 participants at Baseline (ages 9-10) and has followed them annually. Data through half of the third follow-up visit are available (ages 12-13; n = 6,251). SU descriptives for al psychoactive substances over time are outlined. General estimating equations (GEEs) assessed whether sociodemographic factors, internalizing and externalizing symptoms, and parental SU problems were associated with SU between Baseline and Y2 follow-up. Results: Across time, alcohol and...

Measuring memory is harder than you think: How to avoid problematic measurement practices in memory research

Fri, 7 Jul 2023 00:00:00 +0000

We argue that critical areas of memory research rely on problematic measurement practices and provide concrete suggestions to improve the situation. In particular, we highlight the prevalence of memory studies that use tasks (like the “old/new” task: “have you seen this item before? yes/no”) where quantifying performance is deeply dependent on counterfactual reasoning that depends on the (unknowable) distribution of underlying memory signals. As a result of this difficulty, different literatures in memory research (e.g., visual working memory, eyewitness identification, picture memory, etc.) have settled on a variety of fundamentally different metrics to get performance measures from such tasks (e.g., A′, corrected hit rate, percent correct, d′, diagnosticity ratios, K values, etc.), even though these metrics make different, contradictory assumptions about the distribution of latent memory signals, and even though all of their assumptions are frequently incorrect. We suggest that...

Dynamics Are the Only Constant in Working Memory

Fri, 7 Jul 2023 00:00:00 +0000

In this short perspective, we reflect upon our tendency to use oversimplified and idiosyncratic tasks in a quest to discover general mechanisms of working memory. We discuss how the work of Mark Stokes and collaborators has looked beyond localized, temporally persistent neural activity and shifted focus toward the importance of distributed, dynamic neural codes for working memory. A critical lesson from this work is that using simplified tasks does not automatically simplify the neural computations supporting behavior (even if we wish it were so). Moreover, Stokes' insights about multidimensional dynamics highlight the flexibility of the neural codes underlying cognition and have pushed the field to look beyond static measures of working memory.

You Cannot “Count” How Many Items People Remember in Visual Working Memory: The Importance of Signal Detection–Based Measures for Understanding Change Detection Performance

Thu, 6 Jul 2023 00:00:00 +0000

Change detection tasks are commonly used to measure and understand the nature of visual working memory capacity. Across three experiments, we examine whether the nature of the memory signals used to perform change detection are continuous or all-or-none and consider the implications for proper measurement of performance. In Experiment 1, we find evidence from confidence reports that visual working memory is continuous in strength, with strong support for an equal variance signal detection model with no guesses or lapses. Experiments 2 and 3 test an implication of this, which is that K should confound response criteria and memory. We found K values increased by roughly 30% when criteria are shifted despite no change in the underlying memory signals. Overall, our data call into question a large body of work using threshold measures, like K, to analyze change detection data. This metric confounds response bias with memory performance and is inconsistent with...