Recent ucsdsom_biomarkerssymposium_2026 items

Cardiac Testing and Return-to-Exercise Guidance in Non-Fulminant Myocarditis: A Mixed-Methods Study

Tue, 19 May 2026 00:00:00 +0000

Cardiac Testing and Return-to-Exercise Guidance in Non-Fulminant Myocarditis: A Mixed-Methods Study

Oscar P. Levine, MD¹; Mark Wendle, MD¹; David Torres Barba, MD, PhD²; Ori Ben-Yehuda, MD²

Affiliations:

¹Division of General Internal Medicine, Department of Medicine, University of California San Diego

402 Dickinson St, Ste 380

San Diego, CA 92103, USA

²Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego

9434 Medical Center Drive

San Diego, CA 92037, USA

Background: Cardiac testing, including cardiac troponin levels, transthoracic echocardiography (TTE), and cardiac magnetic resonance (CMR), is central to risk stratification and guides return-to-exercise recommendations following myocarditis. However, contemporary guidelines show limited...

BNP is Selectively Produced by Amyloid-Associated Cardiomyocytes at Amyloid Border Zones in Patients with Cardiac Amyloidosis

Tue, 19 May 2026 00:00:00 +0000

BNP is Selectively Produced by Amyloid-Associated Cardiomyocytes at Amyloid Border Zones in Patients with Cardiac Amyloidosis

Beyond Acute Coronary Syndrome: Troponin Kinetics and Assay Concordance Reveal ICI-Associated Myocarditis

Tue, 19 May 2026 00:00:00 +0000

Beyond Acute Coronary Syndrome: Troponin Kinetics and Assay Concordance Reveal ICI-Associated Myocarditis

Haley Kempf¹, Nilesh Vora²

University of California Irvine, CA, USA

Long Beach Memorial Hospital, CA, USA

Background: High-sensitivity cardiac troponin has evolved from a diagnostic marker for acute coronary syndrome (ACS) to a central tool in cardio-oncology for detecting subclinical myocardial injury, risk stratification, and treatment-related toxicity. However, interpretation remains challenging in cancer patients, where elevations may reflect overlapping processes including immune-mediated inflammation, microvascular dysfunction, and extracardiac sources. Emerging evidence highlights the importance of troponin kinetics, assay-specific differences (hs-cTnI vs hs-cTnT), and integration with multimodal imaging, yet clinical frameworks remain limited—particularly in patients with...

Non-Contact Home Bed Sensing for Continuous, Personalized, Automated Detection of Clinical Events

Tue, 19 May 2026 00:00:00 +0000

Non-Contact Home Bed Sensing for Continuous, Personalized, Automated Detection of Clinical Events

Breast arterial calcification and cardiovascular risk prediction in women with and without standard modifiable risk factors

Tue, 19 May 2026 00:00:00 +0000

Breast arterial calcification and cardiovascular risk prediction in women with and without standard modifiable risk factors

Authors: Sophia Y. Xiao MD, MS¹; Richard Mantey²; Quan M. Bui, MD³; Lori B. Daniels, MD, MAS⁴

¹Department of Medicine, UC San Diego Health, San Diego, CA, USA

²Department of Applied AI and Clinical Research, CureMetrix

³Advanced Heart Failure/Transplant Cardiology, Division of Cardiology, UC San Diego Health, San Diego, CA, USA

⁴Divison of Cardiology, UC San Diego Health, San Diego, CA, USA

Background: Risk identification among women, particularly those without standard modifiable risk factors (SMuRFs) for cardiovascular disease (CVD), remains suboptimal. Breast arterial calcification (BAC), found incidentally on mammography, is a promising biomarker associated with...

Threshold and Kinetic Differences Between Fifth- and Sixth-Generation High-Sensitivity Cardiac Troponin T in Routine Clinical Care Testing

Tue, 19 May 2026 00:00:00 +0000

Threshold and Kinetic Differences Between Fifth- and Sixth-Generation High-Sensitivity Cardiac Troponin T in Routine Clinical Care Testing

Megan Palacio^1*, Lori B. Daniels^2,Nolan R. Martin², Spencer Seely¹, Ronald W. McLawhon¹, Robert L. Fitzgerald¹, Raymond T. Suhandynata^1,3

¹Department of Pathology, University of California San Diego, San Diego, CA, USA

²Division of Cardiovascular Medicine, University of California San Diego, San Diego, CA, USA

³Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA

*Author for correspondence

Center for Advanced Laboratory Medicine

University of California San Diego

10300 Campus Point Dr.

San Diego, CA 92121

mepalacio@health.ucsd.edu

Background: High-sensitivity cardiac...

Association between Triglyceride-Glucose Index and Heart Failure Risk by Body MassIndex in a Multi-Ethnic Cohort

Tue, 19 May 2026 00:00:00 +0000

Association between Triglyceride- Glucose Index and Heart Failure Risk by Body Mass Index in a Multi-Ethnic Cohort

Nandan Thakkar, MD, MSc¹; Kimberly Hong, MD, MHSA²; Michael D. Shapiro, DO, MCR³; Alain G. Bertoni, MD, MPH⁴; Harpreet S. Bhatia, MD, MAS, FACC²¹ Department of Medicine, University of California San Diego, La Jolla, CA² Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA³ Center for Preventive Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC⁴ Department of Internal Medicine and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NCBackground: Insulin resistance contributes to heart failure (HF) through metabolic dysregulation, systemic inflammation, and adverse myocardial remodeling. However, commonly used measures of cardiometabolic risk, such as body-mass-index (BMI), may not capture...

Comparison of Gen5 and Gen6 high-sensitivity cardiac troponin T in a real-world setting

Tue, 19 May 2026 00:00:00 +0000

Comparison of Gen5 and Gen6 high-sensitivity cardiac troponin T in a real-world setting

Nolan R. Martin, Megan Woelkers, Megan Palacio, Raymond T. Suhandynata, Robert L. Fitzgerald, Lori B. Daniels

Background: Accuracy and precision are crucial characteristics of cardiac troponin T (cTnT) assays, since results are instrumental in managing patients in acute care settings. We examined discrepancies between the Gen5 and Gen6 cTnT assays in paired analyses of real-world cases.

Methods: This retrospective analysis compared same-specimen Gen5 and Gen6 assay results from 1,847 encounters at a single center. Cases were classified by peak cTnT (based on sex-specific 99^th percentile upper reference limit [URL]) and time-to-peak cTnT. Cases with discordance in peak or time-to-peak cTnT were categorized into four groups: Gen5 normal/Gen6 positive (+), Gen5+/Gen6 normal, concordant but...

Rilonacept Reduces Pericarditis Recurrence Risk, Hospitalizations, and ED visits: Outcomes from the RESONANCE Patient Registry

Tue, 19 May 2026 00:00:00 +0000

RILONACEPT REDUCES PERICARDITIS RECURRENCE RISK, HOSPITALIZATIONS, AND ED VISITS: OUTCOMES FROM THE RESONANCE PATIENT REGISTRY

Paul C. Cremer, MD¹, Michael S. Garshick, MD^2,3, Sushil A. Luis, MBBS, PhD⁴, Ajit Raisinghani, MD⁵, Brittany Weber, MD, PhD⁶,MohamedAl-Kazaz, MD¹, Tracy Hagerty, MD⁷, John J. Ryan, MD⁸, Jonathan R. Salik, MD⁹, Taylor Corey¹⁰, Vidhya Parameswaran, MPH¹⁰, Allan L. Klein, MD¹¹, John F. Paolini,MD, PhD¹⁰, on behalf of the RESONANCE Study Group.

Presenter: Corina Grancorvitz¹⁰

*Corresponding author:

Vidhya Parameswaran, MPH

Kiniksa Pharmaceuticals

100 Hayden Ave. Lexington, MA 02421

+1 7814319100

vparameswaran@kiniksa.com

¹Bluhm Cardiovascular Institute,...

Association of Lipoprotein(a) with ASCVD Risk in Women by Menopausal Status: the UK Biobank

Tue, 19 May 2026 00:00:00 +0000

Title: Association of Lipoprotein(a) with ASCVD Risk in Women by Menopausal Status: the UK Biobank

Author names: Mikaila P. Reyes¹, Alexander C. Razavi², Harpreet S. Bhatia³

Affiliations:

¹University of California San Diego School of Medicine, San Diego, CA, USA; mpr006@health.ucsd.edu

²Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA; alexander.c.razavi@emory.edu

³Division of Cardiovascular Medicine, University of California San Diego, CA, USA; hsbhatia@health.ucsd.edu

ABSTRACT

Introduction: Lipoprotein(a) [Lp(a)] is a predominantly genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD); however, menopause is one of the few conditions that can lead to an increase in Lp(a). We aimed to investigate...

Nocturnal Respiratory Rate: a Stable, Heritable Trait that Predicts All-Cause Mortality

Tue, 19 May 2026 00:00:00 +0000

Nocturnal Respiratory Rate: a Stable, Heritable Trait that Predicts All-Cause Mortality

Raimon Padrós-Valls, MS1,2, Mijia Ma, MS3, Keshav Gupta, MBBS, MS1, Nicholas Harrington, PhD1, Jeremy E. Orr, MD4, Robert L. Owens, MD4, Rany Salem, PhD5, Kevin R. King, MD, PhD1,6

1.Department of Bioengineering, Jacobs School of Engineering, UC San Diego; 2.Bioinformatics and Systems Biology Graduate Program, UC San Diego; 3.Department of Biostatistics, Harvard T.H. Chan School of Public Health; 4.Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego; 5.Herbert Wertheim School of Public Health and Longevity Science, UC San Diego; 6.Department of Medicine, Division of Cardiovascular Medicine, UC San Diego.

Abstract:

Respiratory rate is a fundamental vital sign controlled by brainstem circuits, yet its determinants and prognostic potential remain poorly defined....

Trends and Disparities in Cardiac Magnetic Resonance Utilization During Index Hospitalization for Myocarditis (2015–2025)

Tue, 19 May 2026 00:00:00 +0000

Trends and Disparities in Cardiac Magnetic Resonance Utilization During Index Hospitalization for Myocarditis (2015–2025)

Oscar P. Levine, MD¹; Ido Avivi²; Mattheus Ramsis²; Ori Ben-Yehuda, MD²

Affiliations:

¹Division of General Internal Medicine, Department of Medicine, University of California San Diego

402 Dickinson St, Ste 380

San Diego, CA 92103, USA

²Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego

9434 Medical Center Drive

San Diego, CA 92037, USA

Background: Cardiac magnetic resonance (CMR) is a key tool in the diagnosis of myocarditis and provides valuable prognostic information. However, real-world utilization and variation in access remain incompletely characterized. We sought to evaluate temporal...

Early Rise in Urinary TIMP-2 and IGF-BP7 and Prediction of Contrast-Associated Acute Kidney Injury after Invasive Angiography

Tue, 12 May 2026 00:00:00 +0000

Early Rise in Urinary TIMP-2 and IGF-BP7 and Prediction of Contrast-Associated Acute Kidney Injury after Invasive Angiography

Authors: Megan Woelkers, Melody Sedighi, Harini Rangarajan, Alekhya Pushadapu, Srusti Acharya, Saiharinath Nerella, Elizabeth Tabornal, Lori B. Daniels, MD, MAS

Division of Cardiovascular Medicine, University of California, San Diego, La Jolla, CA

Background: Contrast-associated acute kidney injury (CA-AKI) occurs in approximately 12% of patients following exposure to iodinated contrast media during angiography and is associated with increased morbidity and mortality; reported mortality approaches 20% in some cohorts. Early detection of CA-AKI is essential in mitigating long-term complications and improving outcomes, yet current diagnosis relies largely on serum creatinine (sCr) which typically rises 24-48h after contrast exposure. Tissue inhibitor of metalloproteinases-2 (TIMP-2)...