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    <title>Recent ucsdsom_srg_oapdeposits items</title>
    <link>https://escholarship.org/uc/ucsdsom_srg_oapdeposits/rss</link>
    <description>Recent eScholarship items from Department of Surgery - Open Access Policy Deposits</description>
    <pubDate>Wed, 24 Jun 2026 15:22:56 +0000</pubDate>
    <item>
      <title>Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy.</title>
      <link>https://escholarship.org/uc/item/07z3b7wj</link>
      <description>HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desensitization) have had inconsistent efficacy and have often failed to produce sustained reductions in anti-HLA antibodies in patients with the highest level of sensitization (calculated panel-reactive antibody score, ≥99.9%). We now report the results for the safety run-in cohort of a multicenter phase 1 clinical study evaluating the safety and efficacy of combined CD19-targeted and B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor&amp;nbsp;(CAR) T cells in eliminating the cellular sources of preformed anti-HLA antibodies (ClinicalTrials.gov number, NCT06056102). Kidney transplantation was performed in two highly sensitized candidates after desensitization with the use of dual CAR T-cell therapy.</description>
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      <pubDate>Wed, 17 Jun 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Bhoj, Vijay</name>
      </author>
      <author>
        <name>Kaminski, Mary</name>
      </author>
      <author>
        <name>Zhao, Huiwu</name>
      </author>
      <author>
        <name>Jackson, Kyle</name>
      </author>
      <author>
        <name>Wang, Wei</name>
      </author>
      <author>
        <name>Liu, Chengyang</name>
      </author>
      <author>
        <name>Montgomery, Robert</name>
      </author>
      <author>
        <name>Ali, Nicole</name>
      </author>
      <author>
        <name>Mangiola, Massimo</name>
      </author>
      <author>
        <name>Spitzer, Thomas</name>
      </author>
      <author>
        <name>Safa, Kassem</name>
      </author>
      <author>
        <name>Pattanayak, Vikram</name>
      </author>
      <author>
        <name>Taj, Raeda</name>
      </author>
      <author>
        <name>Chiu, Joy</name>
      </author>
      <author>
        <name>Bui, Thanh-Mai</name>
      </author>
      <author>
        <name>Sonnenberg, Elizabeth</name>
      </author>
      <author>
        <name>Markmann, James</name>
      </author>
      <author>
        <name>Milone, Michael</name>
      </author>
      <author>
        <name>June, Carl</name>
      </author>
      <author>
        <name>Siegel, Don</name>
      </author>
      <author>
        <name>Fraietta, Joseph</name>
      </author>
      <author>
        <name>Gonzalez, Vanessa</name>
      </author>
      <author>
        <name>Locci, Michela</name>
      </author>
      <author>
        <name>Palmer, Matthew</name>
      </author>
      <author>
        <name>Monos, Dimitri</name>
      </author>
      <author>
        <name>Hwang, Wei-Ting</name>
      </author>
      <author>
        <name>Sledge, Tina</name>
      </author>
      <author>
        <name>Bridges, Nancy</name>
      </author>
      <author>
        <name>Goldstein, Julia</name>
      </author>
      <author>
        <name>Odim, Jonah</name>
      </author>
      <author>
        <name>Sweet, Stuart</name>
      </author>
      <author>
        <name>Besharatian, Behdad</name>
      </author>
      <author>
        <name>Hussain, Sabiha</name>
      </author>
      <author>
        <name>Brown, Nicholas</name>
      </author>
      <author>
        <name>Kamoun, Malek</name>
      </author>
      <author>
        <name>Garfall, Alfred</name>
      </author>
      <author>
        <name>Naji, Ali</name>
      </author>
    </item>
    <item>
      <title>Decision-Making in Pleural Drainage Following Lung Resection in Children: A Western Pediatric Surgery Research Consortium Survey</title>
      <link>https://escholarship.org/uc/item/8hn2p25s</link>
      <description>INTRODUCTION: Studies of adults undergoing lung resection indicated that selective omission of pleural drains is safe and advantageous. Significant practice variation exists for pleural drainage practices for children undergoing lung resection. We surveyed pediatric surgeons in a 10-hospital research consortium to understand decision-making for placement of pleural drains following lung resection in children.
METHODS: Faculty surgeons at the 10 member institutions of the Western Pediatric Surgery Research Consortium completed questionnaires using a REDCap survey platform. Descriptive statistics and bivariate analyses were used to characterize responses regarding indications and management of pleural drains following lung resection in pediatric patients.
RESULTS: We received 96 responses from 109 surgeons (88&amp;nbsp;%). Most surgeons agreed that use of a pleural drain after lung resection contributes to post-operative pain, increases narcotic use, and prolongs hospitalization. Opinions...</description>
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      <pubDate>Thu, 28 May 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Schnuck, Jamie K</name>
      </author>
      <author>
        <name>Acker, Shannon N</name>
      </author>
      <author>
        <name>Kelley-Quon, Lorraine I</name>
      </author>
      <author>
        <name>Lee, Justin H</name>
      </author>
      <author>
        <name>Shew, Stephen B</name>
      </author>
      <author>
        <name>Fialkowski, Elizabeth</name>
      </author>
      <author>
        <name>Ignacio, Romeo C</name>
        <uri>https://orcid.org/0000-0001-7259-8679</uri>
      </author>
      <author>
        <name>Melhado, Caroline</name>
      </author>
      <author>
        <name>Qureshi, Faisal G</name>
      </author>
      <author>
        <name>Russell, Katie W</name>
      </author>
      <author>
        <name>Rothstein, David H</name>
      </author>
      <author>
        <name>Consortium, the Western Pediatric Surgery Research</name>
      </author>
      <author>
        <name>Cairo, Sarah</name>
      </author>
      <author>
        <name>Chao, Stephanie D</name>
      </author>
      <author>
        <name>Fenton, Stephen J</name>
      </author>
      <author>
        <name>Gollin, Gerald</name>
        <uri>https://orcid.org/0000-0002-4642-3370</uri>
      </author>
      <author>
        <name>Jensen, Aaron</name>
      </author>
      <author>
        <name>Keane, Olivia A</name>
      </author>
      <author>
        <name>Nicassio, Lauren</name>
      </author>
      <author>
        <name>Ochoa, Brielle</name>
      </author>
      <author>
        <name>Pandya, Samir</name>
      </author>
      <author>
        <name>Patwardhan, Utsav M</name>
      </author>
    </item>
    <item>
      <title>Pleural drain placement following lung resection in children: A prospective observational study of the Western Pediatric Surgery Research Consortium</title>
      <link>https://escholarship.org/uc/item/3p50r0q1</link>
      <description>PURPOSE: Pleural drains are used routinely after thoracic surgery in children despite evidence that drainage is not always necessary. The purpose of this study was to assess the necessity of intraoperative drain placement after resectional lung surgery in children, provide a contemporary characterization of the use of pleural drains, and evaluate the utility of intraoperative air leak testing.
METHODS: A multi-institutional prospective cohort study was performed at 10 free-standing children's hospitals in the United States from 2023 to 2024. Patients ≤18 years old who underwent open or thoracoscopic wedge resection or lobectomy were included. Patients undergoing operation for spontaneous pneumothorax or trauma, those on extra-corporeal life support, those undergoing bi-lobectomy or pneumonectomy, and those undergoing reoperation in the affected hemithorax were excluded. Operative parameters, intra-operative air leak, length of post-operative drain placement, and number of post-operative...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3p50r0q1</guid>
      <pubDate>Thu, 28 May 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Kahan, Anastasia M</name>
      </author>
      <author>
        <name>Kelley-Quon, Lorraine I</name>
      </author>
      <author>
        <name>Acker, Shannon N</name>
      </author>
      <author>
        <name>Vincent, Sage</name>
      </author>
      <author>
        <name>Chao, Stephanie D</name>
      </author>
      <author>
        <name>Nepomuceno, Helene</name>
      </author>
      <author>
        <name>Lee, Justin H</name>
      </author>
      <author>
        <name>Padilla, Benjamin E</name>
      </author>
      <author>
        <name>Patwardhan, Utsav M</name>
      </author>
      <author>
        <name>Gollin, Gerald</name>
      </author>
      <author>
        <name>Ignacio, Romeo C</name>
        <uri>https://orcid.org/0000-0001-7259-8679</uri>
      </author>
      <author>
        <name>Fialkowski, Elizabeth A</name>
      </author>
      <author>
        <name>Fowler, Kathryn L</name>
      </author>
      <author>
        <name>Cairo, Sarah B</name>
      </author>
      <author>
        <name>Munar, Dane</name>
      </author>
      <author>
        <name>Pandya, Samir R</name>
      </author>
      <author>
        <name>Russell, Katie W</name>
      </author>
      <author>
        <name>Fenton, Stephen J</name>
      </author>
      <author>
        <name>Lee, Steven L</name>
      </author>
      <author>
        <name>Rothstein, David H</name>
      </author>
    </item>
    <item>
      <title>Comparison of Postoperative Antibiotic Protocols for Pediatric Complicated Appendicitis: A Western Pediatric Surgery Research Consortium Study</title>
      <link>https://escholarship.org/uc/item/2v15j9s2</link>
      <description>BACKGROUND: There is no consensus on the appropriate duration of postoperative antibiotics for complicated appendicitis in children. Commonly used antibiotic endpoints include normalization of white blood cell count (WBC) or completion of a minimum number of prespecified treatment days. We compared clinical outcomes resulting from varying postoperative antibiotic protocols for complicated appendicitis in children.
METHODS: National Surgical Quality Improvement Program Pediatric (NSQIP-P) data from nine children's hospitals was used to identify a retrospective cohort of children (&amp;lt;18 years) who underwent laparoscopic appendectomy from 2021 to 2023 with intraoperative findings of complicated appendicitis. Participating hospitals were classified into four groups based on discharge protocol: 1) no discharge antibiotics, 2) oral antibiotics for elevated WBC on the day of discharge, 3) oral antibiotics to complete a minimum number of total antibiotic days, and 4) routine discharge...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2v15j9s2</guid>
      <pubDate>Thu, 28 May 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Patwardhan, Utsav M</name>
      </author>
      <author>
        <name>Kahan, Anastasia</name>
      </author>
      <author>
        <name>Eldredge, R Scott</name>
      </author>
      <author>
        <name>Russell, Katie W</name>
      </author>
      <author>
        <name>Lee, Justin</name>
      </author>
      <author>
        <name>Short, Scott S</name>
      </author>
      <author>
        <name>Padilla, Benjamin</name>
      </author>
      <author>
        <name>Cairo, Sarah B</name>
      </author>
      <author>
        <name>Acker, Shannon N</name>
      </author>
      <author>
        <name>Jensen, Aaron R</name>
      </author>
      <author>
        <name>Kelley-Quon, Lorraine I</name>
      </author>
      <author>
        <name>Rothstein, David H</name>
      </author>
      <author>
        <name>Fialkowski, Elizabeth A</name>
      </author>
      <author>
        <name>Chao, Stephanie D</name>
      </author>
      <author>
        <name>Gillory, Lauren</name>
      </author>
      <author>
        <name>Pandya, Samir</name>
      </author>
      <author>
        <name>Diaz-Miron, Jose</name>
      </author>
      <author>
        <name>Ignacio, Romeo C</name>
        <uri>https://orcid.org/0000-0001-7259-8679</uri>
      </author>
    </item>
    <item>
      <title>Developmental organization of sensory and sympathetic ganglia</title>
      <link>https://escholarship.org/uc/item/3743z3sk</link>
      <description>The neural crest generates a broad spectrum of cell types that migrate across the body plan to populate multiple tissues1. However, the relationship between lineages of neural crest derivatives remains unclear, and the extent to which neural crest cells delaminated from the neural tube have specified fates remains debated. Here, leveraging CRISPR barcoding in mice and mosaic variant barcode analysis in humans, we demonstrate robust bilateral progenitor clonal spread of neural crest progenitors along the rostrocaudal axis but limited clonal overlap between sensory and sympathetic lineages. Computational modelling of mosaic variants suggests that most neural crest cells show strong fate restriction before delamination. Real-time imaging of quail embryos further shows a fibroblast-growth-factor-dependent rostrocaudal dispersion of neural crest cells across multiple axial levels. These findings support a model in which neural crest fate bias predominantly emerges within the neural...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3743z3sk</guid>
      <pubDate>Thu, 9 Apr 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Vong, Keng Ioi</name>
      </author>
      <author>
        <name>Alvarez, Yanina D</name>
      </author>
      <author>
        <name>Zhang, Qingquan</name>
      </author>
      <author>
        <name>Weng, Jiaming</name>
      </author>
      <author>
        <name>Noel, Geoffroy</name>
        <uri>https://orcid.org/0000-0003-2192-7756</uri>
      </author>
      <author>
        <name>Barton, Scott T</name>
      </author>
      <author>
        <name>Chung, Changuk</name>
      </author>
      <author>
        <name>Howarth, Robyn</name>
      </author>
      <author>
        <name>Meave, Naomi</name>
      </author>
      <author>
        <name>Jiwani, Fiza</name>
      </author>
      <author>
        <name>Patarlapalli, Sai B</name>
      </author>
      <author>
        <name>Yao, Fenyong</name>
      </author>
      <author>
        <name>Zhu, Fugui</name>
      </author>
      <author>
        <name>Barrows, Chelsea</name>
      </author>
      <author>
        <name>Patel, Arzoo</name>
      </author>
      <author>
        <name>Wang, Jian Xiong</name>
      </author>
      <author>
        <name>Chi, Neil C</name>
      </author>
      <author>
        <name>Kingsmore, Stephen F</name>
      </author>
      <author>
        <name>White, Melanie D</name>
      </author>
      <author>
        <name>Yang, Xiaoxu</name>
      </author>
      <author>
        <name>Gleeson, Joseph G</name>
      </author>
    </item>
    <item>
      <title>War at Sea: Burn Care Challenges—Past, Present and Future</title>
      <link>https://escholarship.org/uc/item/9553d1qw</link>
      <description>Throughout history, seafarers have been exposed to potential thermal injuries during naval warfare; however, injury prevention, including advances in personal protective equipment, has saved lives. Thankfully, burn injuries have decreased over time, which has resulted in a significant clinical skills gap. Ships with only Role 1 (no surgical capability) assets have worse outcomes after burn injury compared to those with Role 2 (surgical capability) assets. To prepare for future burn care challenges during a war at sea, Military Medicine must re-learn the lessons of World War I and World War II. Burn injuries do not occur in isolation during war and are associated with concomitant traumatic injuries. To care for burn casualties at sea, there is an urgent need to increase the availability of whole blood and dried plasma, resuscitation fluids that were ubiquitous throughout the naval force during World War II for both hemorrhagic and burn shock resuscitation. Furthermore, those providing...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9553d1qw</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Tadlock, Matthew D</name>
      </author>
      <author>
        <name>Edson, Theodore D</name>
      </author>
      <author>
        <name>Cancio, Jill M</name>
      </author>
      <author>
        <name>Flieger, Dana M</name>
      </author>
      <author>
        <name>Wickard, Aaron S</name>
      </author>
      <author>
        <name>Grimsley, Bailey</name>
      </author>
      <author>
        <name>Gustafson, Corey G</name>
      </author>
      <author>
        <name>Yelon, Jay A</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Jeng, James C</name>
      </author>
      <author>
        <name>Gurney, Jennifer M</name>
      </author>
    </item>
    <item>
      <title>Management of a common hepatic artery pseudoaneurysm after blunt trauma</title>
      <link>https://escholarship.org/uc/item/75p1d14h</link>
      <description>Management of a common hepatic artery pseudoaneurysm after blunt trauma</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/75p1d14h</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Niziolek, Grace Martin</name>
      </author>
      <author>
        <name>Smith, Brian</name>
      </author>
      <author>
        <name>Cannon, Jeremy</name>
      </author>
      <author>
        <name>Yelon, Jay</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
    </item>
    <item>
      <title>From fellowship to the frontline: A survey of military trauma training experience by the Military Deployment Readiness Assessment of Fellowship Training (DRAFT) Task Force.</title>
      <link>https://escholarship.org/uc/item/6f87c2m7</link>
      <description>BACKGROUND: Military trauma/surgical critical care (T/SCC) surgeons perform both clinical "inside-the-tent" (ITT) and leadership/administrative "outside-the-tent" (OTT) responsibilities during forward deployments. Despite these demands, fellowship programs lack a standardized curriculum addressing the full spectrum of military-specific requirements. This study evaluates military T/SCC surgeons' perceptions of training quality, satisfaction, and confidence in managing deployment trauma situations, and readiness to assume leadership roles.
METHODS: A survey was distributed to all current military T/SCC fellows and attendings to evaluate their perception of ITT and OTT skill training during fellowship. Respondents reported their satisfaction with fellowship training, as well as their confidence, satisfaction, and frequency with which they practiced on ITT and OTT skills. Attendings were additionally asked how often they utilized OTT skills and assumed key OTT leadership positions,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6f87c2m7</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Dilday, Joshua</name>
      </author>
      <author>
        <name>Baird, Emily</name>
      </author>
      <author>
        <name>Miner, Jason</name>
      </author>
      <author>
        <name>Lammers, Daniel</name>
      </author>
      <author>
        <name>Eckert, Matthew</name>
      </author>
      <author>
        <name>Yelon, Jay A</name>
      </author>
      <author>
        <name>Armen, Scott</name>
      </author>
      <author>
        <name>Schreiber, Martin</name>
      </author>
      <author>
        <name>Holcomb, John B</name>
      </author>
      <author>
        <name>Flaherty, Stephen</name>
      </author>
      <author>
        <name>Tadlock, Matthew D</name>
      </author>
      <author>
        <name>Martin, Matthew J</name>
      </author>
      <author>
        <name>Gurney, Jennifer</name>
      </author>
    </item>
    <item>
      <title>Brief report on the development of hemorrhagic pericardial effusion after thoracic surgery for traumatic injuries</title>
      <link>https://escholarship.org/uc/item/5t68b07k</link>
      <description>Introduction: Hemorrhagic pericardial effusion (HPE) is a rare but life-threatening diagnosis that may occur after thoracic trauma. Previous reports have concentrated on delayed HPE in those who did not require initial surgical intervention for their traumatic injuries. In this report, we identify and characterize the phenomenon of HPE after emergent thoracic surgery for trauma.
Methods: This is a retrospective review of patients who required emergent thoracic surgery for trauma at a level 1 trauma center from 2017 to 2021. Using the institutional trauma database, demographics, injury characteristics, and outcomes were compared between patients with HPE and those without HPE after thoracic surgery for trauma.
Results: Ninety-one patients were identified who underwent emergent thoracic surgery for trauma. Most were young men who sustained a penetrating thoracic injury. Seven patients (7.7%) went on to develop HPE. Patients who developed HPE were younger (18 vs. 32 years, p=0.034),...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5t68b07k</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Niziolek, Grace Martin</name>
      </author>
      <author>
        <name>Dowzicky, Phillip</name>
      </author>
      <author>
        <name>Joergensen, Sarah</name>
      </author>
      <author>
        <name>Zone, Alea</name>
      </author>
      <author>
        <name>Brinson, Martha M</name>
      </author>
      <author>
        <name>Martin, Niels D</name>
      </author>
      <author>
        <name>Seamon, Mark J</name>
      </author>
      <author>
        <name>Raza, Shariq</name>
      </author>
      <author>
        <name>Yelon, Jay</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Cannon, Jeremy</name>
      </author>
    </item>
    <item>
      <title>REBOA in shocked penetrating abdominal trauma patients: impact on outcomes</title>
      <link>https://escholarship.org/uc/item/5kb2r8q4</link>
      <description>Introduction: The role of resuscitative endovascular balloon occlusion of the aorta (REBOA) in trauma is debated. We hypothesized that the use of REBOA for patients presenting in shock after penetrating abdominal trauma is associated with delay to laparotomy and increased mortality.
Study design: We used 2017-2021 Trauma Quality Improvement Project data to identify adult (≥16 years) penetrating abdominal trauma patients with systolic blood pressure (SBP) ≤90 mm Hg undergoing laparotomy. REBOA was defined by International Classification of Diseases-10 code, with a procedure timestamp preceding or simultaneous to laparotomy incision. We propensity score matched REBOA to non-REBOA patients on demographics, mechanism, injury characteristics and severity, solid organ injury, abdominal vascular injury, SBP, heart rate, and Glasgow Coma Scale motor score. Outcomes were time to incision, transfusion requirements, complications, and in-hospital mortality. We additionally performed a survival...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5kb2r8q4</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Hatchimonji, Justin S</name>
      </author>
      <author>
        <name>Haddad, Diane N</name>
      </author>
      <author>
        <name>Maurer, Lydia</name>
      </author>
      <author>
        <name>Dowzicky, Phillip M</name>
      </author>
      <author>
        <name>Benjamin, Andrew J</name>
      </author>
      <author>
        <name>Martin, Niels D</name>
      </author>
      <author>
        <name>Reilly, Patrick M</name>
      </author>
      <author>
        <name>Yelon, Jay</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Seamon, Mark J</name>
      </author>
    </item>
    <item>
      <title>Surgeon leadership in trauma resuscitation requires a competency-based multimodal training framework</title>
      <link>https://escholarship.org/uc/item/54w4p25v</link>
      <description>Effective leadership during trauma resuscitation is a determinant of team performance and patient outcomes, yet existing training curricula remain procedure-centric and do not explicitly address the leadership domain. A structured, competency-based framework tailored to the resuscitation context may support more consistent training, evaluation, and entrustment of emerging trauma leaders. A narrative review of the literature was conducted across MEDLINE, Embase and Scopus using terms related to trauma, leadership, non-technical skills and competency frameworks. Relevant publications were categorized into: (1) leadership theory and styles; (2) non-technical skills frameworks; (3) trauma resuscitation education and assessment and (4) high-reliability team training from allied domains. Concepts were synthesized to derive a set of core competencies for trauma resuscitation leadership. Five interdependent competencies were identified: (1) adaptive leadership style matched to clinical...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/54w4p25v</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Bass, Gary Alan</name>
      </author>
      <author>
        <name>Duffy, Caoimhe C</name>
      </author>
      <author>
        <name>Cannon, Jeremy W</name>
      </author>
      <author>
        <name>Yelon, Jay A</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Ferrada, Paula</name>
      </author>
      <author>
        <name>Evans, Susan</name>
      </author>
      <author>
        <name>Leonard, Jennifer M</name>
      </author>
      <author>
        <name>Kaplan, Lewis J</name>
      </author>
    </item>
    <item>
      <title>Percutaneous thoracostomy with thoracic lavage for traumatic hemothorax: a performance improvement initiative</title>
      <link>https://escholarship.org/uc/item/36w7h9b8</link>
      <description>Objectives: Percutaneously placed small-bore (14 Fr) catheters and pleural lavage have emerged independently as innovative approaches to hemothorax management. This report describes techniques for combining percutaneous thoracostomy with pleural lavage and presents results from a performance improvement series of patients managed with percutaneous thoracostomy with immediate lavage.
Methods: This was a prospective performance improvement series of patients treated at a level 1 trauma center with percutaneous thoracostomy and immediate lavage between April 2021 and May 2023.
Results: Percutaneous thoracostomy with immediate lavage was used to treat nine hemodynamically normal patients with acute hemothorax. Injuries included both blunt and penetrating mechanisms. 56% of patients presented immediately after injury, and 44% presented in a delayed fashion ranging from 2 to 26 days after injury. Median length of stay was 6 days (IQR 6, 9). Seven patients were discharged home in stable...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/36w7h9b8</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>McLauchlan, Nathaniel</name>
      </author>
      <author>
        <name>Ali, Ali</name>
      </author>
      <author>
        <name>Beyer, Carl A</name>
      </author>
      <author>
        <name>Brinson, Martha M</name>
      </author>
      <author>
        <name>Joergensen, Sarah M</name>
      </author>
      <author>
        <name>Yelon, Jay</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Dumas, Ryan Peter</name>
      </author>
      <author>
        <name>Vella, Michael A</name>
      </author>
      <author>
        <name>Cannon, Jeremy W</name>
      </author>
    </item>
    <item>
      <title>Venous shunting and limb outcomes in military lower extremity combined arterial and venous injuries</title>
      <link>https://escholarship.org/uc/item/23v6t9rf</link>
      <description>Introduction: Combined arterial and venous lower extremity (LE) injuries present complex management challenges. Temporary arterial shunting is widely accepted, but vein shunting is not well studied. We examined the influence of vein shunting on limb outcomes in military femoropopliteal arterial and venous combined injuries.
Methods: A retrospective cohort study of Iraq and Afghanistan LE vascular injuries from 2004-2012 was performed and combined arterial and venous femoropopliteal injuries selected. Vein shunted and non-vein shunted groups were identified and pertinent variables compared.
Results: Of 135 arteriovenous injuries, 61 (45%) had vein ligation (5 after shunting), leaving 74 injuries undergoing venous repair (37 grafts (3 synthetic), 34 local repairs, 3 patches). The vein was shunted in 16 (22%). The shunt and no shunt cohorts had similar demographics, mechanism (70% blast), and ISS (median 18, IQR 10-26). Tourniquets and fasciotomy were used equally. Venous shunts...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/23v6t9rf</guid>
      <pubDate>Thu, 26 Mar 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Choe, Lisa J</name>
      </author>
      <author>
        <name>Yelon, Jay A</name>
        <uri>https://orcid.org/0000-0001-7980-8042</uri>
      </author>
      <author>
        <name>Kauvar, David S</name>
      </author>
    </item>
    <item>
      <title>Primary Patency in Drug-Eluting Stenting versus Bypass for Femoropopliteal Occlusive Disease</title>
      <link>https://escholarship.org/uc/item/9056h9dz</link>
      <description>INTRODUCTION: Numerous studies have compared the outcomes of bypass and bare-metal stent in the management of femoropopliteal occlusive disease. However, the available evidence has become scarce since the advent of paclitaxel drug-eluting stents (DESs). This study endeavors to assess and contrast the intermediate-termS real-world results of employing DES and bypass techniques in the treatment of individuals afflicted with femoropopliteal occlusive disease.
MATERIALS AND METHODS: We identified all patients who underwent femoropopliteal revascularization at a single institution from January 2012 to December 2017. In this group, we selected all patients who received drug-eluting stents or underwent bypass using autogenous vein. We compared the primary patency, overall survival, and limb salvage at 2 y between the two groups. A comparison between the two groups within Trans-Atlantic Inter-Society Consensus (TASC) II subgroups was also performed. Multivariate Cox regression models...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9056h9dz</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Nakhaei, Pooria</name>
        <uri>https://orcid.org/0000-0002-2542-6361</uri>
      </author>
      <author>
        <name>Mathlouthi, Asma</name>
      </author>
      <author>
        <name>Khan, Maryam Ali</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>On the Independence Assumption in Meta-analyses of Registry-Derived TCAR and TFCAS Outcomes</title>
      <link>https://escholarship.org/uc/item/8md392pj</link>
      <description>On the Independence Assumption in Meta-analyses of Registry-Derived TCAR and TFCAS Outcomes</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8md392pj</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Nakhaei, Pooria</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>3. Predictors of Surgical Site Infection Following Infra-Inguinal Bypass Surgery</title>
      <link>https://escholarship.org/uc/item/89r46202</link>
      <description>3. Predictors of Surgical Site Infection Following Infra-Inguinal Bypass Surgery</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/89r46202</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Rahgozar, Shima</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Lane, John</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Outcomes After Infrainguinal Interventions For Intermittent Claudication In Patients With End Stage Renal Disease Are Poor</title>
      <link>https://escholarship.org/uc/item/5rn2d3db</link>
      <description>INTRODUCTION: Intermittent claudication (IC) interventions are predicated on safety, durability, and long-term expected benefit. Patients with end stage renal disease (ESRD) have higher risk of complications after many surgical procedures and have lower overall survival. Our goal was to assess perioperative and 1-year outcomes of IC interventions in patients with ESRD.
METHODS: The Vascular Quality Initiative was queried from 2010-2020 for peripheral vascular interventions (PVI) and infrainguinal bypasses (IIB) for IC. Demographics, comorbidities, procedural details, and outcomes were analyzed in patients with and without ESRD.
RESULTS: There were 83698 PVI (2% ESRD and 98% non-ESRD) and 10935 IIB (1.2% ESRD and 98.8% non-ESRD) performed for IC. For PVI, ESRD patients more often underwent femoropopliteal (65.1% vs. 59.5%) and infrapopliteal (26.5% vs. 10.1%), and less often iliac interventions (32.1% vs. 46.4%) (all P&amp;lt;.001). There were no differences in access site complications,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5rn2d3db</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Cheng, Thomas W</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Haqqani, Maha</name>
      </author>
      <author>
        <name>King, Elizabeth G</name>
      </author>
      <author>
        <name>Talutis, Stephanie D</name>
      </author>
      <author>
        <name>Alonso, Andrea</name>
      </author>
      <author>
        <name>Maaneb de Macedo, Khu Aten</name>
      </author>
      <author>
        <name>Hicks, Caitlin W</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Rybin, Denis</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey J</name>
      </author>
    </item>
    <item>
      <title>Artificial Intelligence and Machine Learning for Evaluation of Abdominal Aortic Aneurysm Rupture Risk.</title>
      <link>https://escholarship.org/uc/item/4mn2c53q</link>
      <description>Artificial Intelligence and Machine Learning for Evaluation of Abdominal Aortic Aneurysm Rupture Risk.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4mn2c53q</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Paraskevas, Kosmas I</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Schermerhorn, Marc L</name>
      </author>
    </item>
    <item>
      <title>Impact of Conversion from Local/Regional to General Anesthesia on Outcomes in Transcarotid Artery Revascularization</title>
      <link>https://escholarship.org/uc/item/2r6807rk</link>
      <description>Background This study evaluates impact of converting from local to general anesthesia on Transcarotid Artery Revascularization (TCAR) outcomes and identifies risk factors predictive of conversions. Methods 58,960 TCAR cases from the Vascular Quality Initiative (2018–2024) were categorized by anesthesia type: 6,831 local/regional (LRA), 51,851 general (GA), and 278 conversions from LRA to GA. In-hospital outcomes were compared using multivariate logistic regression, with stroke/death as the primary endpoint. Preoperative predictors of conversion were also assessed. Results Converted patients were oldest, more often obese, and more likely to undergo urgent procedures. Compared to LRA, conversion was associated with increased odds of in-hospital stroke/death (aOR = 3.01; 95% CI, 1.54-5.36; P &amp;lt; 0.001), stroke/death/MI (aOR = 2.92; 95% CI, 1.58-5.00; P &amp;lt; 0.001), and prolonged hospital stay (aOR = 1.38; 95% CI, 1.05-1.80; P = 0.020). Compared to GA, converted patients had higher...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2r6807rk</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Straus, Sabrina</name>
      </author>
      <author>
        <name>Patel, Nyah</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Schermerhorn, Marc</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Limited Preoperative Functionality Is Associated With Worse 30-D Mortality and Heart Failure After Carotid Artery Stenting</title>
      <link>https://escholarship.org/uc/item/2kf3z2p1</link>
      <description>INTRODUCTION: Carotid artery stenting is indicated in patients with significant carotid artery stenosis who are high risk for carotid endarterectomy. Patients who are nonambulatory before surgery are considered high risk for carotid revascularization. However, the effect of preoperative ambulatory status on outcomes has not been well established. We sought to use the Vascular Quality Initiative (VQI) multi-institutional database to evaluate the early outcomes of carotid artery stenting stratified by the preoperative ambulatory status.
METHODS: Patients included were nonemergent cases performed in participating VQI centers from 2016 to 2021. The study cohort was divided into two groups: full-functionality patients with full, light work, or self-care, and limited-functionality (LF) patients with assisted care or bed-bound. We used propensity scores by stratification matching on 29 demographic and preoperative clinical characteristics to obtain similar patient characteristics across...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2kf3z2p1</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Willie-Permor, Daniel</name>
      </author>
      <author>
        <name>Moacdieh, Munir Paul</name>
      </author>
      <author>
        <name>Herz Allah, Shatha</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Impact Of Prophylactic Postoperative Vasopressors On Outcomes Of Patients Undergoing Thoracic Endovascular Aortic Repair</title>
      <link>https://escholarship.org/uc/item/27h7859c</link>
      <description>Background Prophylactic postoperative vasopressors (PPV) are used to induce hemodynamic augmentation to prevent spinal cord ischemia (SCI) in patients undergoing thoracic endovascular aortic repair (TEVAR). However, the scientific evidence on its effectiveness and safety is limited. This study aims to investigate the safety and effectiveness of PPV in patients undergoing TEVAR in a multi-institutional real-world setting. Methods All TEVAR patients in the Society for Vascular Surgery (SVS) Vascular Quality Initiative (VQI) database between March 1, 2012, and January 28, 2023, were identified. Univariable and multivariable analyses were performed to assess the association between the use of PPV and the rates of postoperative 30-day mortality, Major Adverse Cardiovascular Events (MACE, defined as new onset of postoperative myocardial infarction (MI), congestive heart failure (CHF), dysrhythmias, or stroke), SCI, and other adverse events for patients undergoing TEVAR. Results Out...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/27h7859c</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Veranyan, Narek</name>
      </author>
      <author>
        <name>Yei, Kevin</name>
      </author>
      <author>
        <name>Ilyas, Sadia</name>
      </author>
      <author>
        <name>Wang, Sophie</name>
      </author>
      <author>
        <name>Beck, Adam W</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Expanding Access to Vascular Imaging: Preliminary Results from the Development of a Remote Surveillance Device</title>
      <link>https://escholarship.org/uc/item/0kj233w1</link>
      <description>Introduction/Objectives Patients undergoing surgical procedures for peripheral artery disease and carotid artery stenosis are recommended to undergo surveillance imaging at regular intervals. With &amp;gt; 250,000 patients undergoing interventions for both annually, the number of patients requiring interval surveillance increases in parallel, placing strain on an already overburdened health system. In this study we evaluated the performance of a novel ultrasound platform prototype built for remote ultrasound surveillance. Methods The prototype duplex ultrasound device was developed by a team of engineers and utilizes color flow images to detect the vessel for flow velocity measurements. The device was tested on 28 healthy volunteers. The results of spectral flow from the device were compared to standard of care ultrasound measurements of the CFA, SFA, ICA and CCA. Results The mean absolute difference between the prototype ultrasound and standard of care device for peak systolic velocity...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0kj233w1</guid>
      <pubDate>Wed, 25 Feb 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Perez, Sean</name>
      </author>
      <author>
        <name>Lin, Muyang</name>
      </author>
      <author>
        <name>Zhou, Sai</name>
      </author>
      <author>
        <name>Walba, Lonnie</name>
      </author>
      <author>
        <name>Frederick, Destiny</name>
      </author>
      <author>
        <name>Kistler, Erik</name>
        <uri>https://orcid.org/0000-0002-6512-4798</uri>
      </author>
      <author>
        <name>Barleben, Andrew</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Xu, Sheng</name>
      </author>
      <author>
        <name>Ross, Elsie G</name>
      </author>
    </item>
    <item>
      <title>Active Surveillance of Ductal Carcinoma In-Situ</title>
      <link>https://escholarship.org/uc/item/6v31q4sh</link>
      <description>Purpose of ReviewTailoring treatment strategies to the biological features of invasive disease and the individual needs and preference of each patient has transformed the way we manage breast cancer. This article calls for a similar shift in the management paradigm of ductal carcinoma in situ (DCIS) from a uniform treatment model toward a risk-stratified stepwise approach that aligns with the heterogeneous nature of the disease to avoid overtreatment.Recent FindingsMost DCIS lesions are hormone receptor positive, and only a subset have a risk for progression to invasive cancer. Early results from observational and clinical studies indicate that active surveillance is a safe and feasible alternative to upfront surgical treatment for low-risk DCIS. Ongoing clinical trials like RECAST will further inform and refine strategies for optimal management of this condition.SummaryThe integration of risk-adapted management strategies, endocrine risk-reducing interventions, and advanced imaging...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6v31q4sh</guid>
      <pubDate>Thu, 29 Jan 2026 00:00:00 +0000</pubDate>
      <author>
        <name>Lin, Sophie Z</name>
      </author>
      <author>
        <name>O’Keefe, Thomas J</name>
      </author>
      <author>
        <name>Jackson, Jordan E</name>
      </author>
      <author>
        <name>Hewitt, Kelly C</name>
      </author>
      <author>
        <name>Esserman, Laura J</name>
      </author>
    </item>
    <item>
      <title>Relative Effects of Brachytherapy and Beam Radiation for DCIS on Subsequent Invasive Events</title>
      <link>https://escholarship.org/uc/item/67x7m2t6</link>
      <description>&lt;b&gt;Background/Objectives:&lt;/b&gt; Patients with a diagnosis of ductal carcinoma in situ (DCIS) were poorly represented in the four trials that established the efficacy of partial relative to whole-breast irradiation. In contrast to invasive cancers, patients with DCIS are equally likely to have a subsequent ipsilateral invasive event in a different site of the breast from their initial DCIS lesion as they are at the same site. We aim to compare the efficacy of a type of partial-breast irradiation, brachytherapy, to external-beam radiation in the reduction of subsequent invasive cancers. &lt;b&gt;Methods:&lt;/b&gt; Women diagnosed with a first breast cancer of unilateral DCIS treated with breast-conserving surgery without endocrine therapy were identified in SEER. Matching was performed 1:2 from patients receiving brachytherapy to patients receiving external-beam radiation or no radiation. External-beam radiation was assumed to be whole-breast radiation for the majority of patients in this cohort...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/67x7m2t6</guid>
      <pubDate>Thu, 29 Jan 2026 00:00:00 +0000</pubDate>
      <author>
        <name>O’Keefe, Thomas J</name>
      </author>
      <author>
        <name>Prionas, Nicolas D</name>
      </author>
      <author>
        <name>Wallace, Anne M</name>
      </author>
    </item>
    <item>
      <title>Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway.</title>
      <link>https://escholarship.org/uc/item/33v304v1</link>
      <description>Pancreatic ductal adenocarcinoma (PDAC) is the deadliest major cancer and has a profoundly immunosuppressive tumor microenvironment (TME). Previous studies have shown that inhibition of the E1 enzyme, which catalyzes the small ubiquitin-like modifiers (SUMO), with the small molecule TAK-981, can reprogram the TME to enhance immune activation and suppress tumor growth. We found that the CD-155/TIGIT pathway, a key regulator of immune evasion in PDAC, is influenced by SUMOylation. We hypothesized that the combination of SUMO E1 and TIGIT inhibition would synergistically induce anti-tumor immune effects. We used a clinically relevant orthotopic mouse model that consistently develops liver metastases to study this combination therapy alone and in the perioperative setting with surgical resection. The combination of SUMO E1 and TIGIT inhibition significantly prolonged survival. Complete responders exhibited protective immunity and enhanced T cell reactivity to model-specific alloantigens....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/33v304v1</guid>
      <pubDate>Mon, 8 Dec 2025 00:00:00 +0000</pubDate>
      <author>
        <name>De la Torre Medina, Jorge</name>
      </author>
      <author>
        <name>Joshi, Utsav</name>
      </author>
      <author>
        <name>Sonowal, Himangshu</name>
        <uri>https://orcid.org/0000-0002-2977-7636</uri>
      </author>
      <author>
        <name>Kuang, Yixuan</name>
      </author>
      <author>
        <name>Ren, Tianchen</name>
      </author>
      <author>
        <name>Chen, Dai-Hua</name>
      </author>
      <author>
        <name>Tharuka, MD Neranjan</name>
      </author>
      <author>
        <name>Nguyen-Ta, Kim</name>
      </author>
      <author>
        <name>Gros, Helene L</name>
      </author>
      <author>
        <name>Mikulski, Zbigniew</name>
      </author>
      <author>
        <name>Chen, Yuan</name>
      </author>
      <author>
        <name>White, Rebekah R</name>
        <uri>https://orcid.org/0000-0003-2185-8535</uri>
      </author>
    </item>
    <item>
      <title>Effectiveness and Safety of Irreversible Electroporation When Used for the Ablation of Stage 3 Pancreatic Adenocarcinoma: Initial Results from the DIRECT Registry Study</title>
      <link>https://escholarship.org/uc/item/2p24149j</link>
      <description>BACKGROUND/OBJECTIVES: Overall survival for patients with Stage 3 pancreatic ductal adenocarcinoma (PDAC) remains limited, with a median survival of 12 to 15 months. Irreversible electroporation (IRE) is a local tumor ablation method that induces cancerous cell death by disrupting cell membrane homeostasis. The DIRECT Registry study was designed to assess the effectiveness and safety of IRE when combined with standard of care (SOC) treatment for Stage 3 PDAC versus SOC alone in a real-world setting after at least 3 months of induction chemotherapy; Methods: Patients with Stage 3 PDAC treated with IRE plus SOC or SOC alone were prospectively enrolled in a multicenter registry study. Enrollment required 3 months of active multi-agent chemotherapy with no progression before enrollment. Endpoints were 30- and 90-day mortality and adverse events (AEs).
RESULTS: Eighty-seven IRE and 27 SOC subjects were enrolled in the registry. Mean ages were 64.0 ± 8.4 and 66.4 ± 9.9 years, and mean...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2p24149j</guid>
      <pubDate>Mon, 8 Dec 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Martin, Robert CG</name>
      </author>
      <author>
        <name>White, Rebekah Ruth</name>
        <uri>https://orcid.org/0000-0003-2185-8535</uri>
      </author>
      <author>
        <name>Bilimoria, Malcolm M</name>
      </author>
      <author>
        <name>Kluger, Michael D</name>
      </author>
      <author>
        <name>Iannitti, David A</name>
      </author>
      <author>
        <name>Polanco, Patricio M</name>
      </author>
      <author>
        <name>Hammil, Chet W</name>
      </author>
      <author>
        <name>Cleary, Sean P</name>
      </author>
      <author>
        <name>Heithaus, Robert Evans</name>
      </author>
      <author>
        <name>Welling, Theodore</name>
      </author>
      <author>
        <name>Chan, Carlos HF</name>
      </author>
    </item>
    <item>
      <title>Health Policy Advocacy: Navigating Personal, Professional, and Organizational Politics</title>
      <link>https://escholarship.org/uc/item/90v6j723</link>
      <description>Health Policy Advocacy: Navigating Personal, Professional, and Organizational Politics</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/90v6j723</guid>
      <pubDate>Wed, 26 Nov 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Liepert, Amy E</name>
        <uri>https://orcid.org/0000-0002-9333-9905</uri>
      </author>
      <author>
        <name>Colosimo, Christina</name>
      </author>
    </item>
    <item>
      <title>Safely Debriefing Unexpected Simulation Death: How We Did It</title>
      <link>https://escholarship.org/uc/item/6dw8q17n</link>
      <description>PURPOSE: Medical students feel inadequately prepared to cope with patient death. Simulation training may provide learners with the opportunity to experience death in a safe environment with a structured debriefing.
METHODS: Nineteen fourth-year medical students who matched into surgical specialties participated in a 2-week surgical intern preparatory course. During an individual surgical decision-making simulation, 6 learners experienced unexpected patient death at the hands of a facilitator who deviated from the simulation script. Subjectively, these learners displayed high anxiety before the debriefing. Objectively, their self-reported anxiety after the structured debriefing was similar to the self-reported anxiety of learners who did not experience simulation death.
RESULTS: We formalized a bi-directional debriefing instrument using the Gather Analyze Summarize (GAS) model as a framework. We recognized that learners who experienced simulation death need to debrief on 2 aspects...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6dw8q17n</guid>
      <pubDate>Wed, 26 Nov 2025 00:00:00 +0000</pubDate>
      <author>
        <name>L'Huillier, Joseph C</name>
      </author>
      <author>
        <name>Ulrich, Sasha M</name>
      </author>
      <author>
        <name>Jung, Sarah A</name>
      </author>
      <author>
        <name>O'Rourke, Ann P</name>
      </author>
      <author>
        <name>Liepert, Amy E</name>
        <uri>https://orcid.org/0000-0002-9333-9905</uri>
      </author>
    </item>
    <item>
      <title>Differential change in extraocular muscle volume after teprotumumab for thyroid eye disease</title>
      <link>https://escholarship.org/uc/item/1rh8s5x9</link>
      <description>PURPOSE: To evaluate the effects of teprotumumab on individual extraocular muscle (EOM) volume and proptosis in thyroid eye disease (TED).
METHODS: A retrospective review was performed using exophthalmometry, clinical activity score (CAS), and orbital imaging before and after teprotumumab treatment. The lateral rectus (LR), medial rectus (MR), superior rectus (SR), inferior rectus (IR) muscles, and the globe were manually segmented individually. Individual and total EOM volumes were calculated and compared between pre- and post-treatment magnetic resonance imaging (MRI).
RESULTS: Mean proptosis reduction after teprotumumab treatment was 3.69 mm (95% CI: 2.82, 4.17, &lt;i&gt;p&lt;/i&gt; &amp;lt; 0.001), with an improvement in all orbits. Significant muscle volume reductions occurred in the MR (-20%, &lt;i&gt;p&lt;/i&gt; &amp;lt; 0.001) and IR (-28%, &lt;i&gt;p&lt;/i&gt; = 0.002) but not the LR (-11%, &lt;i&gt;p&lt;/i&gt; = 0.063) or SR (-19%, &lt;i&gt;p&lt;/i&gt; = 0.053). Total EOM volume decreased by 20%, while globe volume remained unchanged....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1rh8s5x9</guid>
      <pubDate>Thu, 6 Nov 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Richkind, Hanna</name>
      </author>
      <author>
        <name>Shoji, Marissa K</name>
      </author>
      <author>
        <name>Walker, Evan</name>
      </author>
      <author>
        <name>Routzong, Megan R</name>
      </author>
      <author>
        <name>Kikkawa, Don O</name>
        <uri>https://orcid.org/0000-0002-3738-3864</uri>
      </author>
      <author>
        <name>Granet, David</name>
        <uri>https://orcid.org/0000-0001-8011-2480</uri>
      </author>
      <author>
        <name>Rudell, Jolene</name>
        <uri>https://orcid.org/0000-0003-3022-4649</uri>
      </author>
    </item>
    <item>
      <title>The Predictors of Prolonged Length of Stay Following Elective Aortobifemoral Bypass for Aortoiliac Occlusive Disease</title>
      <link>https://escholarship.org/uc/item/9sk66430</link>
      <description>The Predictors of Prolonged Length of Stay Following Elective Aortobifemoral Bypass for Aortoiliac Occlusive Disease</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9sk66430</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Nakhaei, Pooria</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
      </author>
    </item>
    <item>
      <title>Comparative analysis of stroke-related disability and mortality after carotid endarterectomy and carotid artery stenting using the modified Rankin Scale</title>
      <link>https://escholarship.org/uc/item/9n0618hp</link>
      <description>OBJECTIVE: Although previous studies have compared stroke risk after different carotid revascularization procedures, limited evidence exists on whether the magnitude of stroke is procedure-dependent. This study aims to quantify and compare the severity of strokes after carotid endarterectomy (CEA), transcarotid artery revascularization (TCAR), and transfemoral carotid artery stenting (TFCAS) using the modified Rankin Scale (mRS). By evaluating functional outcomes, we provide insights into debilitating and fatal consequences of strokes across these procedures.
METHODS: The Vascular Quality Initiative database was queried from September 2016 to August 2024 for patients who suffered a postoperative stroke after their carotid revascularization procedure. The magnitude of the stroke was quantified using mRS 0 to 6 (0 = stroke with no symptoms; 6 = stroke leading to death). Patients who did not experience stroke after the index procedure were excluded. A severe stroke was defined as...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9n0618hp</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Motaganahalli, Raghu L</name>
      </author>
      <author>
        <name>Kashyap, Vikram</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Impact of Preoperative Smoking Cessation on Outcomes of Elective Suprainguinal Bypasses in Patients With Aortoiliac Occlusive Disease: A Propensity Score-matched Analysis</title>
      <link>https://escholarship.org/uc/item/99b260dt</link>
      <description>The Impact of Preoperative Smoking Cessation on Outcomes of Elective Suprainguinal Bypasses in Patients With Aortoiliac Occlusive Disease: A Propensity Score-matched Analysis</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/99b260dt</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Gaffey, Ann</name>
      </author>
      <author>
        <name>Abou-Zamzam, Ahmed M</name>
      </author>
      <author>
        <name>Lane, John</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
      </author>
    </item>
    <item>
      <title>Reintervention Rates and Costs Following Dialysis Access Placement: Insights from the Vascular Quality Initiative Database</title>
      <link>https://escholarship.org/uc/item/9790v05s</link>
      <description>Reintervention Rates and Costs Following Dialysis Access Placement: Insights from the Vascular Quality Initiative Database</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9790v05s</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Sim, Dong-Jin Kang</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Ross, Elsie</name>
        <uri>https://orcid.org/0000-0002-9366-0109</uri>
      </author>
    </item>
    <item>
      <title>Using Machine Learning Algorithms to Predict the Safest and Most Effective Carotid Revascularization Procedure Based on Patient-specific Factors</title>
      <link>https://escholarship.org/uc/item/9462j4dp</link>
      <description>Using Machine Learning Algorithms to Predict the Safest and Most Effective Carotid Revascularization Procedure Based on Patient-specific Factors</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/9462j4dp</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Sim, Dong-Jin Kang</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
      </author>
    </item>
    <item>
      <title>Transcarotid Artery Revascularization Versus Carotid Endarterectomy With and Without High-Risk Criteria: A National Target Trial.</title>
      <link>https://escholarship.org/uc/item/8g65g6g3</link>
      <description>OBJECTIVE: We sought to evaluate outcomes associated with transcarotid artery revascularization with flow reversal(TCAR) versus carotid endarterectomy(CEA) for carotid artery stenosis(CAS), emulating a randomized controlled trial.
SUMMARY BACKGROUND DATA: The introduction of TCAR has revolutionized management of CAS. While this approach has been demonstrated to yield reduced morbidity relative to transfemoral carotid artery stenting, a comparison of outcomes with gold-standard CEA remains lacking.
METHODS: We identified all records entailing CEA or TCAR for CAS within the 2021-2022 Nationwide Readmissions Database. We conducted a target trial emulation using doubly robust inverse probability-weighted regression analysis to evaluate the adjusted hazard of 90-day composite morbidity, comprised of in-hospital stroke, myocardial infarction, or death. Patients were further stratified as high- or low-risk based on Centers for Medicare and Medicaid Services(CMS) criteria.
RESULTS: We...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8g65g6g3</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Sakowitz, Sara</name>
      </author>
      <author>
        <name>Vadlakonda, Amulya</name>
      </author>
      <author>
        <name>Bakhtiyar, Syed Shahyan</name>
      </author>
      <author>
        <name>Sanaiha, Yas</name>
      </author>
      <author>
        <name>Coaston, Troy</name>
      </author>
      <author>
        <name>deVirgilio, Christian</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Benharash, Peyman</name>
      </author>
    </item>
    <item>
      <title>Comparison of Bypass and Endovascular Treatment of Isolated Popliteal Artery Occlusive Disease in Patients With Chronic Limb-threatening Ischemia: An Analysis of Vascular Quality Initiative Data</title>
      <link>https://escholarship.org/uc/item/88r6z4px</link>
      <description>Comparison of Bypass and Endovascular Treatment of Isolated Popliteal Artery Occlusive Disease in Patients With Chronic Limb-threatening Ischemia: An Analysis of Vascular Quality Initiative Data</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/88r6z4px</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Patel, Rohini</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Conte, Michael S</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Impact of Preoperative Smoking Cessation on Outcomes of Elective Suprainguinal Bypasses in Patients With Aortoiliac Occlusive Disease: A Propensity Score-matched Analysis</title>
      <link>https://escholarship.org/uc/item/8548m4sc</link>
      <description>The Impact of Preoperative Smoking Cessation on Outcomes of Elective Suprainguinal Bypasses in Patients With Aortoiliac Occlusive Disease: A Propensity Score-matched Analysis</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8548m4sc</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Gaffey, Ann</name>
      </author>
      <author>
        <name>Abou-Zamzam, Ahmed M</name>
      </author>
      <author>
        <name>Lane, John</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Assessing the Impact of Distal ICA Tortuosity on Outcomes of Carotid Revascularization: A Comparative Analysis of Transcarotid Artery Revascularization and Transfemoral Carotid Artery Stenting</title>
      <link>https://escholarship.org/uc/item/7sw8v7mp</link>
      <description>Assessing the Impact of Distal ICA Tortuosity on Outcomes of Carotid Revascularization: A Comparative Analysis of Transcarotid Artery Revascularization and Transfemoral Carotid Artery Stenting</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7sw8v7mp</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Straus, Sabrina</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey J</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Effect of mannitol administration on outcomes of open abdominal aortic aneurysm repair</title>
      <link>https://escholarship.org/uc/item/7cx6v7vw</link>
      <description>OBJECTIVE: Mannitol, a hyperosmolar solution widely administered for renal protection, may also have cardioprotective effects. Although its benefits in chronic kidney disease patients undergoing vascular surgery are documented, the impact of mannitol on all patients undergoing open abdominal aortic aneurysm (AAA) repair, including patients without chronic kidney disease, remains unclear. This study aimed to evaluate the effect of intraoperative mannitol on mortality, renal protection, and other postoperative outcomes in patients undergoing open AAA repair.
METHODS: We conducted a retrospective analysis using data from the Society for Vascular Surgery Vascular Quality Initiative database, covering patients who underwent open AAA repair from 2003 to 2021. The study population was divided into two groups based on intraoperative mannitol use, stratified by proximal clamp location (suprarenal vs infrarenal). Baseline characteristics, comorbidities, and perioperative details were compared...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7cx6v7vw</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Willie-Permor, Daniel</name>
      </author>
      <author>
        <name>Paul Moacdieh, Munir</name>
      </author>
      <author>
        <name>Straus, Sabrina</name>
      </author>
      <author>
        <name>Rahgozar, Shima</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
        <uri>https://orcid.org/0000-0002-9366-0109</uri>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Predictors of Prolonged Length of Stay Following Elective Aortobifemoral Bypass for Aortoiliac Occlusive Disease</title>
      <link>https://escholarship.org/uc/item/76z8d3md</link>
      <description>The Predictors of Prolonged Length of Stay Following Elective Aortobifemoral Bypass for Aortoiliac Occlusive Disease</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/76z8d3md</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Nakhaei, Pooria</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
        <uri>https://orcid.org/0000-0002-9366-0109</uri>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Outcomes in American Indian/Alaska Native Patients After Peripheral Vascular Intervention</title>
      <link>https://escholarship.org/uc/item/6t9883mg</link>
      <description>Outcomes in American Indian/Alaska Native Patients After Peripheral Vascular Intervention</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6t9883mg</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Gierok, Sarah M</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Winters, Kathryn</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Role of Pedal Access as an Adjunct to Femoral Access For Challenging Lesions in Chronic Limb-threatening Ischemia.</title>
      <link>https://escholarship.org/uc/item/6q03t10z</link>
      <description>The Role of Pedal Access as an Adjunct to Femoral Access For Challenging Lesions in Chronic Limb-threatening Ischemia.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6q03t10z</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Menard, Matthew T</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Evaluating the management of intermittent claudication before and after publication of the Society of Vascular Surgery's Appropriate Use Criteria</title>
      <link>https://escholarship.org/uc/item/6m71953p</link>
      <description>OBJECTIVE: In April 2022, the Society for Vascular Surgery (SVS) published the Appropriate Use Criteria (AUC) for the management of intermittent claudication (IC). Our goal was to compare practice patterns before and after publication of the AUC to identify changes.
METHODS: The Vascular Quality Initiative (VQI) peripheral vascular intervention (PVI) and suprainguinal and infrainguinal bypass registries were analyzed for interventions for IC. Relevant patient and intervention characteristics pre-AUC (2018-2019) and post-AUC (May 2022-December 2023) were compared. Key points of the AUC that are analyzable from the VQI include claudication severity, use of optimal medical therapy (OMT), smoking status, high-risk comorbid conditions (as indicators of operative risk), operative management of complex aortoiliac and femoropopliteal disease (TASC II C/D), common femoral artery (CFA) PVIs, and infrapopliteal procedures.
RESULTS: There were 15,892 PVI, 2352 suprainguinal bypass, and 3480...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6m71953p</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Alonso, Andrea</name>
      </author>
      <author>
        <name>Kobzeva-Herzog, Anna</name>
      </author>
      <author>
        <name>Dalton-Petillo, Stephen</name>
      </author>
      <author>
        <name>Haqqani, Maha</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>King, Elizabeth G</name>
      </author>
      <author>
        <name>Hicks, Cailtin W</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Garg, Karan</name>
      </author>
      <author>
        <name>Osborne, Nicholas</name>
      </author>
      <author>
        <name>Simons, Jessica P</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey J</name>
      </author>
    </item>
    <item>
      <title>Upper Extremity Arteriovenous Grafts are Less Likely to be Abandoned Compared to Autogenous Fistulas Despite a Higher Reintervention Rate</title>
      <link>https://escholarship.org/uc/item/6jk00207</link>
      <description>BACKGROUND: Upper-extremity arteriovenous (AV) access often requires reintervention. However, the frequency of reinterventionsand subsequent access failure is not well-characterized. Our goal was to evaluate the frequency and type of reinterventions, risk-factors, and outcomes after AV access creation.
METHODS: We performed a retrospective review of index upper extremity AV access creations (2017-2019) within the VQI Medicare-linked Vascular Implant Surveillance and Interventional Outcomes Network dataset for patients on hemodialysis (HD). Reinterventionswere defined as open or endovascular procedures on the access occurring at 1 day or more after access creation. Access abandonment was defined as any new access creation, peritoneal dialysis, kidney transplant, or death following index access creation. Univariable, multivariable, Kaplan-Meier, and Cox regression analyses were performed.
RESULTS: There were 2,551 patients with an index AV graft (AVG) (19.5%) or AV fistula (AVF)...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6jk00207</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Patel, Nyah</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>King, Elizabeth</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Alonso, Andrea</name>
      </author>
      <author>
        <name>Chitalia, Vipul</name>
      </author>
      <author>
        <name>Lotfollahzadeh, Saran</name>
      </author>
      <author>
        <name>Columbo, Jesse A</name>
      </author>
      <author>
        <name>Goodney, Philip P</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey J</name>
      </author>
      <author>
        <name>Initiative, Vascular Implant Surveillance and Interventional Outcomes Network Vascular Quality</name>
      </author>
    </item>
    <item>
      <title>The Impact of Preoperative Beta-Blocker Use on Outcomes of Lower Extremity Bypass in Patients With Chronic Limb-threatening Ischemia</title>
      <link>https://escholarship.org/uc/item/6cn1h0bh</link>
      <description>The Impact of Preoperative Beta-Blocker Use on Outcomes of Lower Extremity Bypass in Patients With Chronic Limb-threatening Ischemia</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6cn1h0bh</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Farhoud, Dana J</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Impact of Postoperative Stroke and Myocardial Infarction on One-Year Survival Following Carotid Revascularization Using the VQI Database</title>
      <link>https://escholarship.org/uc/item/6971j6bn</link>
      <description>BACKGROUND: Postoperative stroke and myocardial infarction (MI) are associated with devastating postoperative morbidity and mortality, therefore limiting the protective effect of carotid revascularization procedures. Moreover, there seems to be a relationship between the severity of stroke and the type of carotid revascularization technique. We aim to investigate the impact of in-hospital stroke or MI on 1-year survival following carotid endarterectomy (CEA), transfemoral carotid artery stenting (TFCAS), and transcarotid artery revascularization (TCAR).
METHODS: This is a retrospective analysis of patients undergoing CEA, TFCAS, and TCAR in the vascular quality initiative (VQI) database (2016-2023). Our primary outcome was 1-year mortality in patients who developed in-hospital stroke or MI following carotid revascularization. Kaplan-Meier survival estimate and multivariable Cox regression analysis were applied to calculate hazard ratios (HRs) after adjusting for potential confounders....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6971j6bn</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdalla, Mohamed</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Columbo, Jesse A</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Long-term beta blocker use lowers postoperative mortality while initiating beta blockers preoperatively does not improve outcomes in thoracic endovascular aortic repair</title>
      <link>https://escholarship.org/uc/item/65m2k9g1</link>
      <description>OBJECTIVE: Beta-blockers play a pivotal role in reducing perioperative cardiac complications; however, their impact on outcomes following thoracic endovascular aortic repair (TEVAR) remains unknown. Utilizing the Vascular Quality Initiative database, our study aims to uncover the impact and determine the optimal timeframe for initiating beta-blocker therapy prior to TEVAR.
METHODS: A total of 4724 TEVAR patients (2016-2023) were grouped as follows: non-beta-blocker users (NBB), beta-blocker initiators ≤30 days prior to procedure (I30), and long-term beta-blocker users for &amp;gt;30 days prior to procedure (L30). Primary outcomes were in-hospital death, stroke, myocardial infarction, and spinal cord ischemia. Secondary outcomes included pulmonary complications, cardiac complications, bowel ischemia, leg ischemia, and prolonged length of stay (≥2 days). A subanalysis was conducted to assess the influence of beta-blocker use by TEVAR indication: type B aortic dissection and thoracic...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/65m2k9g1</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Straus, Sabrina</name>
      </author>
      <author>
        <name>Farah, Marc</name>
      </author>
      <author>
        <name>Yin, Kanhua</name>
      </author>
      <author>
        <name>Gaffey, Ann</name>
      </author>
      <author>
        <name>Schermerhorn, Marc</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Bypass Versus Endovascular Therapy for Elective Infrapopliteal Interventions in Chronic Limb-threatening Ischemia</title>
      <link>https://escholarship.org/uc/item/5w6022c9</link>
      <description>OBJECTIVE: We used multi-institutional data from the Vascular Quality Initiative (VQI) to compare outcomes following revascularization in infrapopliteal chronic limb-threatening ischemia (CLTI).
BACKGROUND: The choice between bypass and endovascular therapy (ET) in patients with CLTI is controversial, particularly when the distal target is within the infrapopliteal region.
METHODS: We used VQI data (2018-2023) to compare bypass with single-segment great saphenous vein (SSGSV) versus ET and bypass with an alternative conduit (AC) versus ET in patients presenting with CLTI who underwent first-time elective infrapopliteal-only or femorotibial revascularizations. We performed 2 one-to-one propensity score matchings (PSM) in patients who had at least one follow-up. Two pairs of matched cohorts were created: SSGSV versus ET and AC versus ET. PSMs were conducted based on demographics, insurance status, smoking status, comorbidities, prior procedures, type of CLTI, and preoperative and...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5w6022c9</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Mills, Joseph L</name>
      </author>
      <author>
        <name>Conte, Michael S</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Mortality and amputation outcomes of infrainguinal bypass versus endovascular therapy based on body mass index</title>
      <link>https://escholarship.org/uc/item/58j3z628</link>
      <description>OBJECTIVE: Obese patients have higher rates of cardiovascular disease and associated risk factors, but lower rates of peripheral artery disease and better outcomes after revascularization. This results in an obesity paradox, where obese patients have the lowest risk of adverse outcomes following treatment, while underweight and morbidly obese patients are at the highest risk. No previous studies have compared outcomes of endovascular vs open bypass within each body mass index (BMI) group. Our study aims to compare outcomes of peripheral vascular intervention (PVI) with infrainguinal bypass (IIB) stratified by patient BMI group.
METHODS: The Vascular Quality Initiative database was queried for patients presenting with claudication or chronic limb-threatening ischemia (CLTI) undergoing PVI or IIB (using the great saphenous vein) from 2012 to 2023. Patients were categorized into five BMI groups: underweight (BMI ≤ 18.5 kg/m&lt;sup&gt;2&lt;/sup&gt;), normal weight (BMI 18.5-24.9 kg/m&lt;sup&gt;2&lt;/sup&gt;),...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/58j3z628</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Kricfalusi, Mikayla</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Hart, Joseph P</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Outcomes in Fenestrated and Branched Endovascular Aortic Repair Comparing Patients with Narrow Flow Lumen versus Standard Flow Lumen of the Paravisceral Aortic Segment</title>
      <link>https://escholarship.org/uc/item/56w6f8m2</link>
      <description>BACKGROUND: Fenestrated/branched endovascular aortic repair (F/BEVAR) with commercially available devices require a paravisceral segment &amp;gt;20 mm. We compared commercial and physician-modified F/BEVAR outcomes in a narrowed flow lumen (NFL, &amp;lt;20 mm) to a standard flow lumen (SFL, ≥20 mm).
METHODS: We conducted a retrospective review of F/BEVAR repairs between 2016 and 2024. Primary outcome was technical success, and secondary endpoints were target vessel stability, type 1/3 endoleaks requiring reintervention, and major adverse events (MAEs).
RESULTS: A total of 136 patients underwent 138 repairs (75% male, 74 ± 10 years), 35 repairs (25%) were in NFL and 103 (75%) in SFL. Median visceral segment diameter was 24 mm (interquartile range [IQR] 19-29; 16 mm, IQR 15-18 in NFL; 28 mm, IQR 23-30 in SFL, P &amp;lt; 0.001). We observed 99% technical success. Mean fenestrations per repair was higher in NFL (3.1 vs. 1.5, P &amp;lt; 0.001), and mean branches was higher in SFL (2.1 vs. 0.7, P &amp;lt;...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/56w6f8m2</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>DiLosa, Kathryn</name>
      </author>
      <author>
        <name>Patel, Rohini J</name>
      </author>
      <author>
        <name>Mathlouthi, Asma</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Al-Nouri, Omar</name>
      </author>
      <author>
        <name>Barleben, Andrew</name>
      </author>
    </item>
    <item>
      <title>The future in the management of patients with asymptomatic carotid artery stenosis.</title>
      <link>https://escholarship.org/uc/item/4wk309qx</link>
      <description>INTRODUCTION: The optimal management of patients with asymptomatic (AsxCS) and symptomatic carotid stenosis (SxCS) is still debatable. The present article will discuss emerging technological advances for the diagnosis and management of patients with AsxCS.
EVIDENCE ACQUISITION: PubMed/MedLine was searched until December 31, 2024 for studies in English discussing emerging technological advances in the diagnosis and management of patients with AsxCS.
EVIDENCE SYNTHESIS: Several technological advances have recently been reported, among others, nanoplastics and microplastics, artificial intelligence and machine learning in predictive analytics for stroke prevention, digital twins for personalized monitoring, electronic tattoos for continuous non-invasive monitoring, stroke risk prediction through plaque morphology and late-phase contrast-enhanced ultrasound. A brief overview of each technological advance is presented and discussed.
CONCLUSIONS: The technological advances discussed...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4wk309qx</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Paraskevas, Kosmas I</name>
      </author>
      <author>
        <name>Sultan, Sherif A</name>
      </author>
      <author>
        <name>Aburahma, Ali F</name>
      </author>
      <author>
        <name>Moore, Wesley S</name>
      </author>
      <author>
        <name>Blecha, Matthew</name>
      </author>
      <author>
        <name>Myrcha, Piotr</name>
      </author>
      <author>
        <name>Zeebregts, Clark J</name>
      </author>
      <author>
        <name>Blinc, Ales</name>
      </author>
      <author>
        <name>Davies, Alun H</name>
      </author>
      <author>
        <name>D'Oria, Mario</name>
      </author>
      <author>
        <name>Gargiulo, Mauro</name>
      </author>
      <author>
        <name>Poredos, Pavel</name>
      </author>
      <author>
        <name>Svetlikov, Alexei</name>
      </author>
      <author>
        <name>Perler, Bruce A</name>
      </author>
      <author>
        <name>Chaturvedi, Seemant</name>
      </author>
      <author>
        <name>Sufali, Gemmi</name>
      </author>
      <author>
        <name>Saba, Luca</name>
      </author>
      <author>
        <name>Eldrup-Jorgensen, Jens</name>
      </author>
      <author>
        <name>Lyden, Sean P</name>
      </author>
      <author>
        <name>Setacci, Carlo</name>
      </author>
      <author>
        <name>DI Lazzaro, Vincenzo</name>
      </author>
      <author>
        <name>Reiff, Tilman</name>
      </author>
      <author>
        <name>Sawicka, Agnieszka</name>
      </author>
      <author>
        <name>Liapis, Christos D</name>
      </author>
      <author>
        <name>Lanza, Gaetano</name>
      </author>
      <author>
        <name>Spinetti, Gaia</name>
      </author>
      <author>
        <name>Bruno, Antonino</name>
      </author>
      <author>
        <name>Nicolaides, Andrew N</name>
      </author>
      <author>
        <name>Thapar, Ankur</name>
      </author>
      <author>
        <name>Uyttenboogaart, Maarten</name>
      </author>
      <author>
        <name>Jawien, Arkadiusz</name>
      </author>
      <author>
        <name>Mikhailidis, Dimitri P</name>
      </author>
      <author>
        <name>Spinelli, Francesco</name>
      </author>
      <author>
        <name>Stilo, Francesco</name>
      </author>
      <author>
        <name>Musialek, Piotr</name>
      </author>
      <author>
        <name>Gurevich, Victor</name>
      </author>
      <author>
        <name>Silvestrini, Mauro</name>
      </author>
      <author>
        <name>Erben, Young M</name>
      </author>
      <author>
        <name>Schneider, Peter A</name>
      </author>
      <author>
        <name>Lip, Gregory Y</name>
      </author>
      <author>
        <name>White, Christopher J</name>
      </author>
      <author>
        <name>Dardik, Alan</name>
      </author>
      <author>
        <name>Meschia, James F</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Gloviczki, Peter</name>
      </author>
      <author>
        <name>Schermerhorn, Marc L</name>
      </author>
      <author>
        <name>Mansilha, Armando</name>
      </author>
    </item>
    <item>
      <title>Low-Profile Endografts Are Associated With Increased Risk of Type I/III Endoleaks At Midterm Follow-up Of 1220 Physician-Modified Fenestrated, Branched Endovascular Repairs For Complex Abdominal and Thoracoabdominal Aortic Aneurysms</title>
      <link>https://escholarship.org/uc/item/4rj3m7fj</link>
      <description>OBJECTIVE: Physician-modified endografts (PMEGs) are widely used for complex abdominal and thoracoabdominal aortic repairs, offering versatility in patient-specific stent graft configurations. Low-profile (LP) endografts improve deliverability and decrease access site complications compared with standard-profile (SP) devices. However, concerns have been raised about the long-term durability of certain LP devices. Although LP devices have been incorporated into PMEGs at many centers, data on their impact on outcomes are limited. Therefore, this study compared outcomes of LP and SP endografts used with PMEGs using an international multicenter database.
METHODS: A retrospective analysis of data on patients who received PMEGs at 19 international centers from 2009 to 2022 was conducted. Patients were grouped by LP or SP aortic endografts used for modification. Baseline patient characteristics, aortic pathologies, modification techniques, and outcomes were compared. Primary outcomes...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4rj3m7fj</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Han, Sukgu M</name>
      </author>
      <author>
        <name>Melo, Ryan Gouveia</name>
      </author>
      <author>
        <name>Beck, Adam</name>
      </author>
      <author>
        <name>Schermerhorn, Marc</name>
      </author>
      <author>
        <name>Kölbel, Tilo</name>
      </author>
      <author>
        <name>Sweet, Matthew</name>
      </author>
      <author>
        <name>Barleban, Andrew</name>
      </author>
      <author>
        <name>Adam, Donald</name>
      </author>
      <author>
        <name>Farber, Mark</name>
      </author>
      <author>
        <name>Mendes, Bernardo</name>
      </author>
      <author>
        <name>Oderich, Gustavo</name>
      </author>
      <author>
        <name>Tsilimparis, Nikolaos</name>
      </author>
      <author>
        <name>Group, International Multicenter PMEG Study</name>
      </author>
      <author>
        <name>Scali, Salvatore</name>
      </author>
      <author>
        <name>Magee, Gregory</name>
      </author>
      <author>
        <name>Pyun, Alyssa</name>
      </author>
      <author>
        <name>Swerdlow, Nicholas</name>
      </author>
      <author>
        <name>Juszczak, Maciej</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Panuccio, Giuseppe</name>
      </author>
      <author>
        <name>Zetterval, Sara</name>
      </author>
      <author>
        <name>Josph, George</name>
      </author>
      <author>
        <name>Branzan, Daniela</name>
      </author>
      <author>
        <name>Chochennec, Frederic</name>
      </author>
      <author>
        <name>Becquemin, Jean Pierre</name>
      </author>
      <author>
        <name>Cannonge, Jennifer</name>
      </author>
      <author>
        <name>Timaran, Carlos</name>
      </author>
      <author>
        <name>Tenorio, Emanuel R</name>
      </author>
      <author>
        <name>Bertoglio, Luca</name>
      </author>
      <author>
        <name>Cieri, Enrico</name>
      </author>
      <author>
        <name>Giordano, Antonino</name>
      </author>
      <author>
        <name>Verzini, Fabio</name>
      </author>
      <author>
        <name>Pedro, Luis Mendes</name>
      </author>
    </item>
    <item>
      <title>The Effect of Smoking Cessation on Outcomes of Thoracic Endovascular Aortic Repair</title>
      <link>https://escholarship.org/uc/item/4mr105m3</link>
      <description>BACKGROUND: Smoking is known to be a strong predictive factor for deleterious outcomes after surgical procedures; however, there is limited research that has focused on the effect of smoking cessation on the outcomes of thoracic endovascular aortic repair (TEVAR). Using a multi-institutional database, we aimed to determine if smoking cessation was associated with improved outcomes following TEVAR.
METHODS: Patients undergoing thoracic endovascular aortic repair in Vascular Quality Initiative from 2013 to 2023 were categorized into three groups: never smokers (NS), those who quit smoking (QS) &amp;gt;30 days prior, or current smokers (CS) who quit ≤30 days prior or never quit. Primary outcomes include perioperative death, stroke, myocardial infarction, and spinal cord ischemia. Secondary outcomes include cardiac and pulmonary complications, prolonged length of stay (≥2 days), and leg and bowel ischemia. A multivariate logistic regression analysis was conducted to control for confounding...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4mr105m3</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Farah, Marc</name>
      </author>
      <author>
        <name>Straus, Sabrina</name>
      </author>
      <author>
        <name>Wang, Grace</name>
      </author>
      <author>
        <name>Gaffey, Ann</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Strokes Occurring After Transfemoral Carotid Artery Stenting Are the Most Lethal and Disabling: A Comparative Analysis of Rankin Scores</title>
      <link>https://escholarship.org/uc/item/46b8z0q7</link>
      <description>Strokes Occurring After Transfemoral Carotid Artery Stenting Are the Most Lethal and Disabling: A Comparative Analysis of Rankin Scores</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/46b8z0q7</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Motaganahalli, Raghu</name>
      </author>
      <author>
        <name>Kashyap, Vikram</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Outcomes of Retroperitoneal vs Transperitoneal Approach for Open Abdominal Aortic Aneurysm Repair Stratified by Aortic Cross-Clamping Site.</title>
      <link>https://escholarship.org/uc/item/4283v3hp</link>
      <description>BACKGROUND: The approach for open infrarenal abdominal aortic aneurysm (AAA) repair is mainly surgeon driven based on experience and previous training. Although the midline transperitoneal (TP) approach remains the most common, the retroperitoneal (RP) approach is usually used in more complex cases where suprarenal cross-clamping is necessary. As previous literature is conflicting on optimal outcomes between the 2 approaches, we aimed to compare RP vs TP outcomes stratified by aortic clamp level.
STUDY DESIGN: The Vascular Quality Initiative database was queried for all patients who underwent open AAA repair from January 2012 to February 2024. Patients were stratified according to aortic cross-clamp site: infrarenal, interrenal, suprarenal, and supraceliac. We used multivariate logistic regression to analyze the outcomes of RP vs TP within each clamp site while adjusting for baseline and clinically relevant variables.
RESULTS: A total of 8,842 patients were included. Compared...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4283v3hp</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Kricfalusi, Mikayla</name>
      </author>
      <author>
        <name>Brooke, Benjamin S</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Evaluating the management of intermittent claudication before and after publication of the Society of Vascular Surgery's Appropriate Use Criteria Presented at the Thirty-eighth Annual Meeting of the Eastern Vascular Society, Charleston, South Carolina, September 19-22, 2024.</title>
      <link>https://escholarship.org/uc/item/3th1v4mz</link>
      <description>Evaluating the management of intermittent claudication before and after publication of the Society of Vascular Surgery's Appropriate Use Criteria Presented at the Thirty-eighth Annual Meeting of the Eastern Vascular Society, Charleston, South Carolina, September 19-22, 2024.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3th1v4mz</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Alonso, Andrea</name>
      </author>
      <author>
        <name>Kobzeva-Herzog, Anna</name>
      </author>
      <author>
        <name>Dalton-Petillo, Stephen</name>
      </author>
      <author>
        <name>Haqqani, Maha</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>King, Elizabeth G</name>
      </author>
      <author>
        <name>Hicks, Cailtin W</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Garg, Karan</name>
      </author>
      <author>
        <name>Osborne, Nicholas</name>
      </author>
      <author>
        <name>Simons, Jessica P</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey J</name>
      </author>
    </item>
    <item>
      <title>Real-World Outcomes of Open Surgical Repair vs Endovascular Aortic Repair in Ruptured Abdominal Aortic Aneurysms: Does Neck Anatomy Make a Difference?</title>
      <link>https://escholarship.org/uc/item/3r902609</link>
      <description>Real-World Outcomes of Open Surgical Repair vs Endovascular Aortic Repair in Ruptured Abdominal Aortic Aneurysms: Does Neck Anatomy Make a Difference?</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3r902609</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Fallentine, Joshua</name>
      </author>
      <author>
        <name>Yei, Kevin</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
        <uri>https://orcid.org/0000-0002-9366-0109</uri>
      </author>
      <author>
        <name>Lee, Jason</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Impact of Insulin Therapy on Revascularization Outcomes in the BEST-CLI</title>
      <link>https://escholarship.org/uc/item/2b44v5pn</link>
      <description>Impact of Insulin Therapy on Revascularization Outcomes in the BEST-CLI</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2b44v5pn</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Chaar, Cassius Iyad Ochoa</name>
      </author>
      <author>
        <name>Alameddine, Dana</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Doros, Gheorghe</name>
      </author>
      <author>
        <name>Conte, Michael</name>
      </author>
      <author>
        <name>Kenneth, Rosenfield</name>
      </author>
      <author>
        <name>Strong, Michael</name>
      </author>
      <author>
        <name>Menard, Mathew</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Hamdan, Allen</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>The Impact of Preoperative Beta-Blocker Use on Outcomes of Lower Extremity Bypass in Patients With Chronic Limb-threatening Ischemia</title>
      <link>https://escholarship.org/uc/item/29d832ks</link>
      <description>The Impact of Preoperative Beta-Blocker Use on Outcomes of Lower Extremity Bypass in Patients With Chronic Limb-threatening Ischemia</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/29d832ks</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Farhoud, Dana J</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Using Machine Learning Algorithms to Predict the Safest and Most Effective Carotid Revascularization Procedure Based on Patient-specific Factors</title>
      <link>https://escholarship.org/uc/item/22p8g6d6</link>
      <description>Using Machine Learning Algorithms to Predict the Safest and Most Effective Carotid Revascularization Procedure Based on Patient-specific Factors</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/22p8g6d6</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Sim, Dong-Jin Kang</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Insulin Therapy and Outcomes of Revascularization Procedures for Chronic Limb Threatening Ischemia in the Best-CLI Trial</title>
      <link>https://escholarship.org/uc/item/21w297bw</link>
      <description>OBJECTIVE: Diabetes mellitus (DM) is a major risk factor for amputation in patients with chronic limb-threatening ischemia (CLTI) undergoing lower extremity revascularization. Observational studies comparing patients with DM based on insulin therapy have reported inconsistent findings. This study compares the outcomes of patients with insulin-requiring DM (IRDM) and non-IRDM (NIRDM) based on high-quality prospective data.
METHODS: Characteristics and outcomes of patients with IRDM and NIRDM enrolled in the BEST-CLI (Best Endovascular vs Best Surgical Therapy in Patients with CLTI) trial were compared. A Cox regression model was used to determine the association between insulin requirement and outcomes.
RESULTS: The analysis included 1229 patients with DM, among whom 67.7% (N = 832) had IRDM. The mean age was 66.7 ± 9.9 years, with the IRDM group being younger (65.8 vs 68.6 years, P &amp;lt; .001) and more likely to be Hispanic (19% vs 13.1%, P = .01). Patients with IRDM were more...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/21w297bw</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Alameddine, Dana</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Doros, Gheorghe</name>
      </author>
      <author>
        <name>Conte, Michael S</name>
      </author>
      <author>
        <name>Rosenfield, Kenneth</name>
      </author>
      <author>
        <name>Strong, Michael B</name>
      </author>
      <author>
        <name>Menard, Matthew T</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Hamdan, Allen</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Ochoa Chaar, Cassius Iyad</name>
      </author>
    </item>
    <item>
      <title>Strokes Occurring After Transfemoral Carotid Artery Stenting Are the Most Lethal and Disabling: A Comparative Analysis of Rankin Scores</title>
      <link>https://escholarship.org/uc/item/1076n777</link>
      <description>Strokes Occurring After Transfemoral Carotid Artery Stenting Are the Most Lethal and Disabling: A Comparative Analysis of Rankin Scores</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1076n777</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Motaganahalli, Raghu</name>
      </author>
      <author>
        <name>Kashyap, Vikram</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Real-World Outcomes of Open Surgical Repair vs Endovascular Aortic Repair in Ruptured Abdominal Aortic Aneurysms: Does Neck Anatomy Make a Difference?</title>
      <link>https://escholarship.org/uc/item/081008nk</link>
      <description>Real-World Outcomes of Open Surgical Repair vs Endovascular Aortic Repair in Ruptured Abdominal Aortic Aneurysms: Does Neck Anatomy Make a Difference?</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/081008nk</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Fallentine, Joshua</name>
      </author>
      <author>
        <name>Yei, Kevin</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
      </author>
      <author>
        <name>Lee, Jason</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Impact of embolic protection methods versus access types on outcomes of carotid artery stenting</title>
      <link>https://escholarship.org/uc/item/01s9p3j6</link>
      <description>OBJECTIVE: Carotid artery stenting (CAS) is commonly performed through transfemoral or transcarotid access. Neurologic protection methods utilized during the procedure include distal embolic protection (DEP) and flow reversal devices. Multiple studies demonstrated more favorable outcomes associated with transcarotid artery revascularization with flow reversal (TCAR) in comparison to transfemoral carotid artery stenting with DEP (TFCAS-DEP). However, not many studies compared TCAR with transcarotid artery stenting with DEP (TCAS-DEP) or TFCAS with flow arrest by proximal balloon occlusion (TFCAS-PBO). We aimed to compare the effect of access types and embolic protection methods on the outcomes of CAS.
METHODS: All patients undergoing CAS between September 2016 and August 2024 were identified in the Vascular Quality Initiative database. Inverse probability of treatment weighting based on propensity scores was used to compare outcomes of TFCAS-DEP, TFCAS-PBO, and TCAS-DEP with TCAR....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/01s9p3j6</guid>
      <pubDate>Thu, 9 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Kang Sim, Dong-Jin E</name>
      </author>
      <author>
        <name>Vootukuru, Nishita R</name>
      </author>
      <author>
        <name>Vielma-Garcia, Jocelyn</name>
      </author>
      <author>
        <name>Gaffey, Ann C</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Serially-Connected Soft Continuum Robots for Endovascular Emergencies</title>
      <link>https://escholarship.org/uc/item/42f2d455</link>
      <description>Endovascular surgeries generally rely on push-based catheters and guidewires, which require significant training to master and can still result in high stress being exerted on the anatomy, especially in tortuous paths. Because these procedures are so technically challenging to perform, many patients have limited access to high-quality treatment. Although various robotic systems have been developed to enhance navigation capabilities, they can also apply high stresses due to sliding against the vascular walls, impeding movement and raising the risk of vascular damage. Soft growing robots offer a promising alternative since their method of movement via eversion minimizes interaction forces with the environment and enables follow-the-leader navigation through tortuous paths. However, reliable steering of small-scale growing robots remains a significant challenge. We propose a robot architecture that combines a hydraulically-actuated, soft growing robot with a soft, tendon-driven notched...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/42f2d455</guid>
      <pubDate>Mon, 6 Oct 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Mangan, Aedan</name>
      </author>
      <author>
        <name>Kim, Sukjun</name>
        <uri>https://orcid.org/0000-0001-7154-8872</uri>
      </author>
      <author>
        <name>Jones, Noah</name>
      </author>
      <author>
        <name>Brandel, Michael G</name>
      </author>
      <author>
        <name>Heit, Jeremy J</name>
      </author>
      <author>
        <name>Norbash, Alexander</name>
      </author>
      <author>
        <name>Hwang, John T</name>
      </author>
      <author>
        <name>Hawkes, Elliot</name>
      </author>
      <author>
        <name>Morimoto, Tania K</name>
        <uri>https://orcid.org/0000-0001-5319-8995</uri>
      </author>
    </item>
    <item>
      <title>Meconium-related obstruction: Contemporary experience in a multi-institutional consortium</title>
      <link>https://escholarship.org/uc/item/3qp0v2f1</link>
      <description>PURPOSE: Neonatal bowel obstruction secondary to inspissated meconium has been historically associated with cystic fibrosis. Increasingly, meconium-related obstruction (MRO) has been observed in preterm infants. We conducted a multicenter mixed-methods study to better characterize the contemporary experience with MRO.
METHODS: A retrospective cohort study of infants with MRO was performed at seven children's hospitals from 2018 to 2022. Chi-squared tests, Kruskal-Wallis tests, and logistic regression were used to assess the association of cystic fibrosis, Hirschsprung disease, and prematurity with treatment strategies and clinical outcomes of MRO. Providers were surveyed regarding their management of MRO of prematurity.
RESULTS: We identified 105 infants treated for MRO, including 54 (51 %) with MRO of prematurity, 16 (15 %) with Hirschsprung disease, 6 (6 %) with cystic fibrosis, and 29 (28 %) with MRO of the term infant. Overall, 32 % (n = 34) received glycerin suppositories,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3qp0v2f1</guid>
      <pubDate>Wed, 24 Sep 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Rook, Jordan M</name>
      </author>
      <author>
        <name>Anderson, Jamie E</name>
        <uri>https://orcid.org/0000-0002-8259-4062</uri>
      </author>
      <author>
        <name>Kramer, Katelin P</name>
        <uri>https://orcid.org/0000-0001-7280-0558</uri>
      </author>
      <author>
        <name>Royse, Caitlin</name>
      </author>
      <author>
        <name>Evans, Michele</name>
      </author>
      <author>
        <name>West, Erin</name>
      </author>
      <author>
        <name>Ismail, Adnan</name>
      </author>
      <author>
        <name>Guner, Yigit S</name>
      </author>
      <author>
        <name>Lee, Henry C</name>
        <uri>https://orcid.org/0000-0001-8383-1720</uri>
      </author>
      <author>
        <name>Bai-Tong, Shiyu</name>
      </author>
      <author>
        <name>Lusk, Leslie</name>
      </author>
      <author>
        <name>Bautista, Geoanna M</name>
        <uri>https://orcid.org/0000-0003-0245-9272</uri>
      </author>
      <author>
        <name>Lee, Hanmin</name>
      </author>
      <author>
        <name>Uy, Cherry</name>
      </author>
      <author>
        <name>Calkins, Kara L</name>
      </author>
      <author>
        <name>Kling, Karen M</name>
      </author>
      <author>
        <name>DeUgarte, Daniel A</name>
      </author>
      <author>
        <name>Consortium, the University of California Fetal</name>
      </author>
    </item>
    <item>
      <title>Genetic and pharmacological targeting of nicotinic acetylcholine receptor action blocks tumor progression in mouse models of breast cancer</title>
      <link>https://escholarship.org/uc/item/5fr2h9w6</link>
      <description>Effective small molecule therapies are a major unmet need in triple-negative breast cancer. Therefore, we examined the mechanism of action of a novel cancer therapeutic target in preclinical mouse models focusing on the α7 nicotinic acetylcholine receptor (CHRNA7). E0771 breast tumor cells were implanted into CHRNA7KO mice to determine the role of CHRNA7, which is expressed in tumor-associated myeloid immune cells. We observed that tumor-bearing CHRNA7KO mice had decreased survival and increased tumor burden linked to a CHRNA7-mediated reduction in immune cell activation. Based on the tumor permissive phenotype of CHRNA7KO mice, we tested the effect of a small molecule agonist of CHRNA7, AR-R17779, in several mouse models of breast cancer. For example, in both the E0771 tumor model and PyMT tumor models, treatment with AR-R17779 increased survival. In the 4T1 breast tumor model, treatment with AR-R17779 also increased survival, with a well-defined reduction in primary tumor burden...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5fr2h9w6</guid>
      <pubDate>Thu, 31 Jul 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Heard, Matthew A</name>
      </author>
      <author>
        <name>Qian, Jin</name>
      </author>
      <author>
        <name>Sayeed, Sakeef</name>
      </author>
      <author>
        <name>Mechlowicz, Sereena</name>
      </author>
      <author>
        <name>Zhang, Qingyang</name>
      </author>
      <author>
        <name>Yeluri, Sudha</name>
      </author>
      <author>
        <name>Pool, Katie</name>
      </author>
      <author>
        <name>Yamane, Ryan</name>
      </author>
      <author>
        <name>Morris, Gerald P</name>
        <uri>https://orcid.org/0000-0002-1097-4453</uri>
      </author>
      <author>
        <name>Eliceiri, Brian P</name>
        <uri>https://orcid.org/0000-0003-1811-1916</uri>
      </author>
    </item>
    <item>
      <title>The new bridge to hernia surgery: achieving preoperative weight optimization with GLP-1 receptor agonists for abdominal wall hernia repair</title>
      <link>https://escholarship.org/uc/item/37g35660</link>
      <description>BackgroundObesity is a risk factor for complications after abdominal hernia repair. Glucagon-like-peptide-1 (GLP-1) receptor agonists are effective weight loss medications that may help patients reach weight loss goals for surgery. In this study, we examine our outcomes utilizing GLP-1 agonists for preoperative weight loss in obese patients undergoing elective hernia repair.  MethodsA retrospective review identified obese patients who were prescribed GLP-1 agonists for weight loss in addition to lifestyle changes before elective hernia repair from 2021 to 2024. Patients were managed by a multidisciplinary team and asked to achieve a body mass index (BMI) ≤ 33&amp;nbsp;kg/m2 before surgery. Primary outcomes were preoperative mean percentage total weight loss (%TWL), mean BMI reduction, and time from GLP-1 agonist initiation to surgery. Secondary outcomes were 30-day morbidity and 30-day reoperation rates, hernia recurrence, and postoperative weight changes.ResultsA total of 70 patients...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/37g35660</guid>
      <pubDate>Thu, 17 Jul 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Spurzem, Graham J</name>
      </author>
      <author>
        <name>Broderick, Ryan C</name>
      </author>
      <author>
        <name>Ruiz-Cota, Patricia</name>
      </author>
      <author>
        <name>Rocha, Amanda</name>
      </author>
      <author>
        <name>Reyes, Edgardo</name>
      </author>
      <author>
        <name>Fontaine-Nicola, Andres</name>
      </author>
      <author>
        <name>Altolaguirre, Agustina</name>
      </author>
      <author>
        <name>Hollandsworth, Hannah M</name>
      </author>
      <author>
        <name>Sandler, Bryan J</name>
      </author>
      <author>
        <name>Grunvald, Eduardo</name>
        <uri>https://orcid.org/0000-0001-9332-7069</uri>
      </author>
      <author>
        <name>Jacobsen, Garth R</name>
      </author>
    </item>
    <item>
      <title>Adenosine accumulation in the blood of newborn mice weakens antimicrobial host defenses</title>
      <link>https://escholarship.org/uc/item/4mx557w9</link>
      <description>Pediatric intensive care patients are particularly susceptible to severe bacterial infections because of ineffective neutrophil responses. The reasons why neutrophils of newborns are less responsive than those of adults are not clear. Because adenosine triphosphate and adenosine tightly regulate neutrophils, we studied whether the adenosine triphosphate and adenosine levels in the blood of newborn mice could impair the function of their neutrophils. We observed significant changes in plasma adenosine triphosphate and adenosine levels throughout the lifespan of mice. Adenosine levels in newborns were significantly higher than in older mice, while adenosine triphosphate levels were significantly lower. These changes were particularly striking in newborn and juvenile mice with adenosine triphosphate and adenosine levels of about 80 and 600 nM in newborns vs 130 and 190 nM in juveniles, respectively. The ratios of the adenosine triphosphate vs adenosine levels of newborns were (with...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4mx557w9</guid>
      <pubDate>Thu, 5 Jun 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Ledderose, Carola</name>
      </author>
      <author>
        <name>Valsami, Eleftheria-Angeliki</name>
      </author>
      <author>
        <name>Elevado, Mark</name>
      </author>
      <author>
        <name>Stevenson, Ava</name>
      </author>
      <author>
        <name>Abutabikh, Reem</name>
      </author>
      <author>
        <name>Curatolo, Julian</name>
      </author>
      <author>
        <name>Junger, Wolfgang G</name>
      </author>
    </item>
    <item>
      <title>Factors Associated with Postoperative Opioid Use in Adolescents</title>
      <link>https://escholarship.org/uc/item/1n29w85w</link>
      <description>BACKGROUND: We aimed to identify factors associated with postoperative prescription opioid use in adolescents.
METHODS: Adolescents aged 13-20 years undergoing surgery were prospectively recruited from a children's hospital. Adolescent-parent dyads completed a preoperative survey, measuring clinical and sociodemographic factors, and two postoperative surveys evaluating self-reported opioid use at 30- and 90-days. Poisson regression analysis identified factors associated with the number of pills used within 90-days, adjusting for age, gender, race/ethnicity, surgery type, and pain at discharge.
RESULTS: We enrolled 119 adolescents who reported postoperative opioid use following posterior spinal fusion (PSF) (50&amp;nbsp;%), arthroscopy (23&amp;nbsp;%), pectus excavatum repair (11&amp;nbsp;%), tonsillectomy (8&amp;nbsp;%), and hip reconstruction (7&amp;nbsp;%). Overall, 81&amp;nbsp;% of adolescents reported unused opioids. The median pain score at discharge was 7 (IQR:5-8). Adolescents reported using a...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1n29w85w</guid>
      <pubDate>Mon, 14 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Odegard, Marjorie</name>
      </author>
      <author>
        <name>Ourshalimian, Shadassa</name>
      </author>
      <author>
        <name>Hijaz, Donia</name>
      </author>
      <author>
        <name>Goldstein, Rachel Y</name>
      </author>
      <author>
        <name>Ignacio, Romeo C</name>
        <uri>https://orcid.org/0000-0001-7259-8679</uri>
      </author>
      <author>
        <name>Chen, Stephanie Y</name>
      </author>
      <author>
        <name>Kim, Eugene</name>
      </author>
      <author>
        <name>Kim, Eugene S</name>
      </author>
      <author>
        <name>Kelley-Quon, Lorraine I</name>
      </author>
    </item>
    <item>
      <title>Factors Associated With 30-Day Readmission in Hand Surgery Patients.</title>
      <link>https://escholarship.org/uc/item/7780n4rg</link>
      <description>BACKGROUND: Surgical patient hospital readmissions are costly to the health care system. The Affordable Care Act Hospital Readmissions Reduction Program introduced penalties for high hospital readmission rates. We performed a retrospective study evaluating factors associated with readmission in hand surgical inpatients.
METHODS: We performed a retrospective chart review on 566 patients admitted to a level 1 trauma center for hand trauma or infection from January 1, 2016, to December 31, 2019. Data included demographics, social history, medical problems, comorbidities, procedure details, and admission and readmission details. A multivariable regression analysis was performed to identify factors associated with hospital readmission within 30 days.
RESULTS: Cigarette smoking (&lt;i&gt;P&lt;/i&gt; = .048), bite wound (&lt;i&gt;P&lt;/i&gt; = .038), laceration wound (&lt;i&gt;P&lt;/i&gt; = .028), laceration repair (&lt;i&gt;P&lt;/i&gt; &amp;lt; .01), open reduction internal fixation (&lt;i&gt;P&lt;/i&gt; = .041), and disposition to a skilled nursing...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7780n4rg</guid>
      <pubDate>Sat, 12 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Sendek, Gabriela</name>
      </author>
      <author>
        <name>Benyamein, Paige</name>
      </author>
      <author>
        <name>Segal, Rachel</name>
      </author>
      <author>
        <name>Reghunathan, Meera</name>
      </author>
      <author>
        <name>Abrams, Reid</name>
        <uri>https://orcid.org/0000-0003-0388-6348</uri>
      </author>
    </item>
    <item>
      <title>Comparing Neurodevelopmental Outcomes in Infants With Patent Ductus Arteriosus Stenting Versus Blalock-Taussig-Thomas Shunt: A Pilot Study</title>
      <link>https://escholarship.org/uc/item/7162f9mm</link>
      <description>Background: Patent ductus arteriosus stenting (PDAS) is a nonsurgical alternative to Blalock-Taussig-Thomas shunt (BTTS) for infants with ductal-dependent congenital heart disease. In this single-center study, we aimed to compare neurodevelopmental outcomes in children who underwent BTTS as initial palliation versus PDAS.
Methods: Bayley Scales of Infant and Toddler Development Screening Test (Bayley-III) reports and mode of feeding data were collected for any patient who underwent PDAS or BTTS at Rady Children's Hospital from 2013 to 2021. We also prospectively administered the Parents' Evaluation of Development Status questionnaire (PEDS) to parents of children aged 2-8 years in this patient population.
Results: Of the 99 patients, 64 received a Bayley-III assessment and/or PEDS screen. Of the 35 who had a Bayley-III, there was a higher proportion of patients with PDAS who scored as developmentally appropriate compared with BTTS. PEDS screen showed that a higher proportion of...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7162f9mm</guid>
      <pubDate>Fri, 11 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>El-Said, Howaida</name>
      </author>
      <author>
        <name>Hussein, Amira</name>
      </author>
      <author>
        <name>Price, Katherine</name>
      </author>
      <author>
        <name>Heibel, Jessica</name>
      </author>
      <author>
        <name>Haley, Jessica</name>
      </author>
      <author>
        <name>Haldeman, Shylah</name>
      </author>
      <author>
        <name>Boulil, Zeinab</name>
      </author>
      <author>
        <name>Brigger, Matthew</name>
        <uri>https://orcid.org/0000-0002-3528-1696</uri>
      </author>
      <author>
        <name>Rao, Aparna</name>
      </author>
      <author>
        <name>Ganta, Srujan</name>
      </author>
      <author>
        <name>Rao, Rohit</name>
      </author>
      <author>
        <name>Nigro, John</name>
      </author>
      <author>
        <name>Sweeney, Nathaly</name>
      </author>
    </item>
    <item>
      <title>Upper Extremity Arteriovenous Grafts Are Less Likely to Be Abandoned Compared With Autogenous Fistulas Despite a Higher Reintervention Rate</title>
      <link>https://escholarship.org/uc/item/7828z3x6</link>
      <description>Upper Extremity Arteriovenous Grafts Are Less Likely to Be Abandoned Compared With Autogenous Fistulas Despite a Higher Reintervention Rate</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7828z3x6</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Patel, Nyah</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>King, Elizabeth</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Chitalia, Vipul</name>
      </author>
      <author>
        <name>Columbo, Jesse</name>
      </author>
      <author>
        <name>Goodney, Phillip</name>
      </author>
      <author>
        <name>Siracuse, Jeffrey</name>
      </author>
    </item>
    <item>
      <title>The impact of postoperative dual antiplatelet therapy on outcomes of endovascular therapies in patients with chronic limb-threatening ischemia in the Vascular Quality Initiative–Medicare-linked database</title>
      <link>https://escholarship.org/uc/item/62j4d2fq</link>
      <description>OBJECTIVE: The beneficial effects of dual antiplatelet therapy (DAPT) compared with single antiplatelet therapy (SAPT) have been well-established in coronary and carotid endovascular interventions; however, no consensus exists to the role of DAPT in lower extremity endovascular therapies (ETs). We aimed to investigate the impact of postoperative DAPT after ET in patients presenting with chronic limb-threatening ischemia (CLTI) in the Vascular Quality Initiative-Medicare-Linked (Vascular Implant Surveillance and Interventional Outcomes Network) database.
METHODS: The study was a multicenter retrospective analysis of prospectively collected Vascular Quality Initiative-Medicare-linked data. The Vascular Implant Surveillance and Interventional Outcomes Network database was queried for all ETs performed for infrainguinal occlusive disease between 2011 and 2019. The patients were stratified by discharge antiplatelet regimen (DAPT vs SAPT). SAPT patients received either aspirin or P2Y12...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/62j4d2fq</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Moacdieh, Munir P</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Gaffey, Ann C</name>
      </author>
    </item>
    <item>
      <title>Outcomes of Thoracic Endovascular Aortic Repair in Dialysis Patients</title>
      <link>https://escholarship.org/uc/item/4b09714q</link>
      <description>Outcomes of Thoracic Endovascular Aortic Repair in Dialysis Patients</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4b09714q</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Elsayed, Nadin</name>
      </author>
      <author>
        <name>Unkart, Jonathan</name>
      </author>
      <author>
        <name>Dodo-Williams, Taiwo</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Safety and Efficacy of Carotid Artery Dissection Management With Transfemoral Carotid Artery Stent&amp;nbsp;and Transcarotid Artery Revascularization: Multi-institutional Study</title>
      <link>https://escholarship.org/uc/item/2t32w5w9</link>
      <description>Safety and Efficacy of Carotid Artery Dissection Management With Transfemoral Carotid Artery Stent&amp;nbsp;and Transcarotid Artery Revascularization: Multi-institutional Study</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2t32w5w9</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Abdelkarim, Ahmed</name>
      </author>
      <author>
        <name>Kricfalusi, Mikayla</name>
      </author>
      <author>
        <name>Zarrintan, Sina</name>
      </author>
      <author>
        <name>Ross, Elsie</name>
      </author>
      <author>
        <name>Malas, Mahmoud</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
    </item>
    <item>
      <title>Operative and Long-term Outcomes of Combined and Staged Carotid Endarterectomy and Coronary Bypass: A Medicare-linked VQI/VISION Analysis</title>
      <link>https://escholarship.org/uc/item/1ts0j04q</link>
      <description>Operative and Long-term Outcomes of Combined and Staged Carotid Endarterectomy and Coronary Bypass: A Medicare-linked VQI/VISION Analysis</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1ts0j04q</guid>
      <pubDate>Thu, 10 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Haywood, Nathan S</name>
      </author>
      <author>
        <name>Ratcliffe, Sarah J</name>
      </author>
      <author>
        <name>Zheng, Xinyan</name>
      </author>
      <author>
        <name>Mao, Jialin</name>
      </author>
      <author>
        <name>Farivar, Behzad</name>
      </author>
      <author>
        <name>Tracci, Margaret C</name>
      </author>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Goodney, Philip P</name>
      </author>
      <author>
        <name>Clouse, W Darrin</name>
      </author>
    </item>
    <item>
      <title>Examining the cost burden of dietary supplements in older adults: an analysis from the AAA longroad study</title>
      <link>https://escholarship.org/uc/item/57q891vz</link>
      <description>BackgroundThe use of dietary supplements (DS) has steadily increased over the last several decades, particularly among older adults, contributing to the growth of the multibillion-dollar DS industry. The cost of prescription medication is a known contributor to medication nonadherence, yet the cost burden of DS among older adults is not well understood.MethodsUsing medication data from the 5-year multicenter longitudinal cohort AAA LongROAD study of older adults who drive, DS were identified and categorized. Cost estimates were based on prices obtained from a popular online marketplace, using dosing and frequency recommendations from the National Institutes of Health Office of Dietary Supplements database. ANOVA was used to explore associations between demographics and DS cost burden.ResultsOf the 2,990 participants at baseline, 2068 (69%) followed up through year 5. The number of DS users ranged from 70.4 to 82.7% of the participants from baseline to year 5. Among the 160 supplement...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/57q891vz</guid>
      <pubDate>Fri, 4 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Baird, Sara</name>
      </author>
      <author>
        <name>Moran, Ryan</name>
        <uri>https://orcid.org/0000-0002-2219-5502</uri>
      </author>
      <author>
        <name>Hacker, Sarah</name>
      </author>
      <author>
        <name>Lawton, Dylan</name>
      </author>
      <author>
        <name>Hill, Linda</name>
      </author>
    </item>
    <item>
      <title>Outcomes of Kidney Transplantation From Donors on Renal Replacement Therapy</title>
      <link>https://escholarship.org/uc/item/3ns1p9xr</link>
      <description>Background: The increasing demand for organs has pushed transplant providers to expand kidney acceptance criteria. The use of kidneys from donors with AKI has been shown to provide good long-term graft survival. We aim to evaluate and compare the outcomes of deceased donor kidney transplantation from donors with acute kidney injury (AKI), either with or without renal replacement therapy (AKI-RRT) before donation.
Methods: A single-center retrospective review of all patients who underwent deceased donor kidney transplantation from AKI donors between 2009 and 2020 was performed. AKI donors were defined on the basis of donor terminal creatinine ≥2.0 mg/dL or use of RRT before donation. We compared the outcomes of recipients receiving a kidney from a donor with AKI versus AKI-RRT. Data are presented as medians (interquartile ranges) and numbers (percentages).
Results: Four hundred ninety-six patients were identified, of whom 300 (60.4%) were men with a median age of 57 y at transplantation....</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3ns1p9xr</guid>
      <pubDate>Thu, 3 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Goussous, Naeem</name>
        <uri>https://orcid.org/0000-0002-5642-7252</uri>
      </author>
      <author>
        <name>Alghannam, Karima</name>
      </author>
      <author>
        <name>Than, Peter A</name>
      </author>
      <author>
        <name>Wang, Aileen X</name>
      </author>
      <author>
        <name>Chen, Ling-Xin</name>
      </author>
      <author>
        <name>Alexopoulos, Sophoclis P</name>
      </author>
      <author>
        <name>Sageshima, Junichiro</name>
        <uri>https://orcid.org/0000-0002-5703-4936</uri>
      </author>
      <author>
        <name>Perez, Richard V</name>
      </author>
    </item>
    <item>
      <title>Modulation of tumor inflammatory signaling and drug sensitivity by CMTM4</title>
      <link>https://escholarship.org/uc/item/76q7837p</link>
      <description>Although inflammation has been widely associated with cancer development, how it affects the outcomes of immunotherapy and chemotherapy remains incompletely understood. Here, we show that CKLF-like MARVEL transmembrane domain-containing member 4 (CMTM4) is highly expressed in multiple human and murine cancer types including Lewis lung carcinoma, triple-negative mammary cancer and melanoma. In lung carcinoma, loss of CMTM4 significantly reduces tumor growth and impairs NF-κB, mTOR, and PI3K/Akt pathway activation. Furthermore, we demonstrate that CMTM4 can regulate epidermal growth factor (EGF) signaling post-translationally by promoting EGFR recycling and preventing its Rab-dependent degradation. Consequently, CMTM4 knockout sensitizes human lung tumor cells to EGFR inhibitors. In addition, CMTM4 knockout tumors stimulated with EGF show a decreased ability to produce inflammatory cytokines including granulocyte colony-stimulating factor (G-CSF), leading to decreased recruitment...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/76q7837p</guid>
      <pubDate>Wed, 2 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Xu, Yitian</name>
      </author>
      <author>
        <name>Kang, Kyeongah</name>
      </author>
      <author>
        <name>Coakley, Brian A</name>
      </author>
      <author>
        <name>Eisenstein, Samuel</name>
        <uri>https://orcid.org/0000-0002-2646-0625</uri>
      </author>
      <author>
        <name>Parveen, Arshiya</name>
      </author>
      <author>
        <name>Mai, Sunny</name>
      </author>
      <author>
        <name>Wang, Yuan Shuo</name>
      </author>
      <author>
        <name>Zheng, Junjun</name>
      </author>
      <author>
        <name>Boral, Debasish</name>
      </author>
      <author>
        <name>Mai, Junhua</name>
      </author>
      <author>
        <name>Pan, William</name>
      </author>
      <author>
        <name>Zhang, Licheng</name>
      </author>
      <author>
        <name>Aaronson, Stuart A</name>
      </author>
      <author>
        <name>Fang, Bingliang</name>
      </author>
      <author>
        <name>Divino, Celia</name>
      </author>
      <author>
        <name>Zhang, Bin</name>
      </author>
      <author>
        <name>Song, Won-Min</name>
      </author>
      <author>
        <name>Hung, Mien-Chie</name>
      </author>
      <author>
        <name>Pan, Ping-Ying</name>
      </author>
      <author>
        <name>Chen, Shu-Hsia</name>
      </author>
    </item>
    <item>
      <title>Fluid Flow Measurements in Nanoslits Using Holographic Microscopy</title>
      <link>https://escholarship.org/uc/item/1gt2250s</link>
      <description>To understand the mechanisms driving fluid flow behavior in nanofluidics so that they may be used for on-chip biomedical and chemical applications, the fluid's motion itself needs to be observable and measurable, a difficult challenge at these small scales. We present a new method for measuring both slow and fast flows in nanofluidics using high-speed digital holographic microscopy. We measure the evaporation-driven flow in 25 and 7 nm tall nanoslit channels, showing that the consequent flow speed is about 15 times slower than open atmospheric evaporation due to the confinement of the nanoslit channel. We also measured the surface acoustic wave-driven flow in the 25 nm channel, showing flow at a speed of 0.12 m/s from acoustic wave propagation at 39.7 MHz interacting with the fluid in the channel. A process to eliminate the many sources of noise to produce these results is provided, showing that─in particular─spatial averaging is useful to determine the fluid flow and the dewetting...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/1gt2250s</guid>
      <pubDate>Wed, 2 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Yu, Siyang</name>
      </author>
      <author>
        <name>Orosco, Jeremy</name>
      </author>
      <author>
        <name>Friend, James</name>
        <uri>https://orcid.org/0000-0003-0416-2165</uri>
      </author>
    </item>
    <item>
      <title>Approaches for optimizing venous thromboembolism prevention in injured patients: Findings from the consensus conference to implement optimal venous thromboembolism prophylaxis in trauma</title>
      <link>https://escholarship.org/uc/item/0x72d12h</link>
      <description>ABSTRACT: Venous thromboembolism (VTE) is a major issue in trauma patients. Without prophylaxis, the rate of deep venous thrombosis approaches 60% and even with chemoprophylaxis may be nearly 30%. Advances in VTE reduction are imperative to reduce the burden of this issue in the trauma population. Novel approaches in VTE prevention may include new medications, dosing regimens, and extending prophylaxis to the postdischarge phase of care. Standard dosing regimens of low-molecular-weight heparin are insufficient in trauma, shifting our focus toward alternative dosing strategies to improve prophylaxis. Mixed data suggest that anti-Xa-guided dosage, weight-based dosing, and thromboelastography are among these potential strategies. The concern for VTE in trauma does not end upon discharge, however. The risk for VTE in this population extends well beyond hospitalization. Variable extended thromboprophylaxis regimens using aspirin, low-molecular-weight heparin, and direct oral anticoagulants...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/0x72d12h</guid>
      <pubDate>Wed, 2 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Teichman, Amanda L</name>
      </author>
      <author>
        <name>Cotton, Bryan A</name>
      </author>
      <author>
        <name>Byrne, James</name>
      </author>
      <author>
        <name>Dhillon, Navpreet K</name>
      </author>
      <author>
        <name>Berndtson, Allison E</name>
      </author>
      <author>
        <name>Price, Michelle A</name>
      </author>
      <author>
        <name>Johns, Tracy J</name>
      </author>
      <author>
        <name>Ley, Eric J</name>
      </author>
      <author>
        <name>Costantini, Todd</name>
      </author>
      <author>
        <name>Haut, Elliott R</name>
      </author>
    </item>
    <item>
      <title>CDK1-loaded extracellular vesicles promote cell cycle to reverse impaired wound healing in diabetic obese mice</title>
      <link>https://escholarship.org/uc/item/7x16x80k</link>
      <description>Small extracellular vesicles (sEVs) mediate intercellular signaling to coordinate the proliferation of cell types that promote re-epithelialization of skin following injury. Cyclin-dependent kinase 1 (CDK1) drives cell division and is a key regulator of entry to the cell cycle. To understand the potential of sEV-mediated delivery of CDK1 to reverse impaired wound healing, we generated CDK1-loaded sEVs (CDK1-sEVs) and evaluated their ability to mediate cell proliferation, re-epithelialization, and downstream signaling responses in the wound bed. We found that treatment of human keratinocytes with CDK1-sEVs increased phosphorylation of the CDK1 target, eukaryotic translation inhibition factor 4E-binding protein 1 (4E-BP1), and histone H3 within 24&amp;nbsp;h via AKT and ERK phosphorylation, driving increased proliferation and cell migration. Treatment of the wound bed of diabetic obese mice, a model of delayed wound healing, with a single dose of CDK1-sEVs accelerated wound closure,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7x16x80k</guid>
      <pubDate>Tue, 1 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Choi, Wooil</name>
        <uri>https://orcid.org/0000-0001-7311-8171</uri>
      </author>
      <author>
        <name>Park, Dong Jun</name>
      </author>
      <author>
        <name>Dorschner, Robert A</name>
      </author>
      <author>
        <name>Nakatsutsumi, Keita</name>
      </author>
      <author>
        <name>Yi, Michelle</name>
      </author>
      <author>
        <name>Eliceiri, Brian P</name>
        <uri>https://orcid.org/0000-0003-1811-1916</uri>
      </author>
    </item>
    <item>
      <title>The Impact of Complication Timing on the Outcomes of Implant-based Breast Reconstruction</title>
      <link>https://escholarship.org/uc/item/3cr1j35w</link>
      <description>Background: The National Surgical Quality Improvement Program (NSQIP) database provides an important resource for determining complication rates and risk factors for surgical procedures. However, NSQIP is limited to 30-day follow-up, and it is unclear whether this is reliable for evaluating prosthetic breast reconstruction outcomes.
Methods: A single-institution, cross-sectional, retrospective review was performed for patients undergoing mastectomy with immediate, prepectoral tissue expander reconstruction. Timing of complications was stratified as early (within 30 days of operation) versus late (after 30 days). Categorical variables were compared using χ&lt;sup&gt;2&lt;/sup&gt; (or Fisher exact) tests, and continuous variables were analyzed using Kruskal-Wallis or Wilcoxon rank-sum tests.
Results: There were 301 patients (509 reconstructed breasts) included with a median follow-up time of 11 months. Of them, 176 patients (58%) experienced a postoperative complication-140 patients (47%) experienced...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3cr1j35w</guid>
      <pubDate>Tue, 1 Apr 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Alnaseri, Tahera</name>
      </author>
      <author>
        <name>Prabhu, Shamit</name>
      </author>
      <author>
        <name>Anderson, Lexy</name>
      </author>
      <author>
        <name>Kwan, Lorna</name>
      </author>
      <author>
        <name>Demirjian, Maral</name>
      </author>
      <author>
        <name>Kwok, Alvin</name>
      </author>
      <author>
        <name>Reid, Christopher</name>
      </author>
      <author>
        <name>Hollenbeck, Scott</name>
      </author>
      <author>
        <name>DeLong, Michael R</name>
      </author>
    </item>
    <item>
      <title>Astrocyte glypican 5 regulates synapse maturation and stabilization</title>
      <link>https://escholarship.org/uc/item/5bs985x6</link>
      <description>The maturation and stabilization of appropriate synaptic connections is a vital step in neural circuit development; however, the molecular signals underlying these processes are not fully understood. We show that astrocytes, through production of glypican 5 (GPC5), are required for maturation and refinement of synapses in the mouse cortex during the critical period. In the absence of astrocyte GPC5, thalamocortical synapses show structural immaturity, including smaller presynaptic terminals, decreased postsynaptic density area, and presence of more postsynaptic partners at multisynaptic connections. This structural immaturity is accompanied by a delay in developmental incorporation of GLUA2-containing AMPARs at intracortical synapses. The functional impact of this is that mice lacking astrocyte GPC5 exhibit increased levels of ocular dominance plasticity in adulthood. This demonstrates that astrocyte GPC5 is necessary for maturation and stabilization of synaptic connections, which...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/5bs985x6</guid>
      <pubDate>Fri, 28 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Bosworth, Alexandra P</name>
      </author>
      <author>
        <name>Contreras, Minerva</name>
      </author>
      <author>
        <name>Sancho, Laura</name>
      </author>
      <author>
        <name>Salas, Isabel H</name>
      </author>
      <author>
        <name>Paumier, Adrien</name>
      </author>
      <author>
        <name>Novak, Sammy Weiser</name>
      </author>
      <author>
        <name>Manor, Uri</name>
        <uri>https://orcid.org/0000-0002-9802-1955</uri>
      </author>
      <author>
        <name>Allen, Nicola J</name>
      </author>
    </item>
    <item>
      <title>Material Scrunching Enables Working Channels in Miniaturized Vine-Inspired Robots</title>
      <link>https://escholarship.org/uc/item/2jt677r0</link>
      <description>A new subclass of soft robot, known as tip-extending or "vine" robots, consists of long inflatable devices that move through the environment by extending from the tip. A key requirement for many applications of these robots is a working channel-a hollow tube through the core of the robot for passing tools, sensors, fluids, etc. While working channels have been proposed in a few vine robots, it remains an open challenge to create miniaturized vine robots (diameter &amp;lt; 1 cm) with working channels that enable continuous access through the core. In this paper, we analyze the growth models of current vine robot designs and show that the working channel greatly increases required pressure to grow at small scales due to internal friction. Based on this insight, we propose the concept of storing scrunched material at the tip of the vine robot to circumvent this frictional force. We validate our models and demonstrate this concept via prototypes down to diameters of 2.3 mm. Overall, this...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2jt677r0</guid>
      <pubDate>Thu, 20 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Girerd, Cdric</name>
      </author>
      <author>
        <name>Alvarez, Anna</name>
      </author>
      <author>
        <name>Hawkes, Elliot W</name>
      </author>
      <author>
        <name>Morimoto, Tania K</name>
        <uri>https://orcid.org/0000-0001-5319-8995</uri>
      </author>
    </item>
    <item>
      <title>Predictors of Mortality, Withdrawal of Life-Sustaining Measures, and Discharge Disposition in Octogenarians with Subdural Hematomas</title>
      <link>https://escholarship.org/uc/item/6h6628jr</link>
      <description>OBJECTIVE: Risk factors for mortality in patients with subdural hematoma (SDH) include poor Glasgow Coma Scale (GCS) score, pupil nonreactivity, and hemodynamic instability on presentation. Little is published regarding prognosticators of SDH in the elderly. This study aims to examine risk factors for hospital mortality and withdrawal of life-sustaining measures in an octogenarian population presenting with SDH.
METHODS: A prospectively collected multicenter database of 3279 traumatic brain injury admissions to 45 different U.S. trauma centers between 2017 and 2019 was queried to identify patients aged &amp;gt;79 years old presenting with SDH. Factors collected included baseline demographic data, past medical history, antiplatelet/anticoagulant use, and clinical presentation (GCS, pupil reactivity, injury severity scale [ISS]). Primary outcome data included hospital mortality/discharge to hospice care and withdrawal of life-sustaining measures. Multivariate logistic regression analyses...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6h6628jr</guid>
      <pubDate>Tue, 18 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Kashkoush, Ahmed</name>
      </author>
      <author>
        <name>Petitt, Jordan C</name>
      </author>
      <author>
        <name>Ladhani, Husayn</name>
      </author>
      <author>
        <name>Ho, Vanessa P</name>
      </author>
      <author>
        <name>Kelly, Michael L</name>
      </author>
      <author>
        <name>Group, the American Association for the Surgery of Trauma GERI-TBI Study</name>
      </author>
      <author>
        <name>Ghneim, Mira</name>
      </author>
      <author>
        <name>Albrecht, Jennifer S</name>
      </author>
      <author>
        <name>Brasel, Karen</name>
      </author>
      <author>
        <name>Livaris, Anna</name>
      </author>
      <author>
        <name>Watras, Jill B</name>
      </author>
      <author>
        <name>Michetti, Christopher P</name>
      </author>
      <author>
        <name>Haan, James M</name>
      </author>
      <author>
        <name>Lightwine, Kelly</name>
      </author>
      <author>
        <name>Winfield, Robert D</name>
      </author>
      <author>
        <name>Adams, Sasha D</name>
      </author>
      <author>
        <name>Podbielski, Jeanette M</name>
      </author>
      <author>
        <name>Armen, Scott B</name>
      </author>
      <author>
        <name>Zacko, J Christopher</name>
      </author>
      <author>
        <name>Nasrallah, Fady S</name>
      </author>
      <author>
        <name>Schaffer, Kathryn B</name>
      </author>
      <author>
        <name>Dunn, Julie</name>
      </author>
      <author>
        <name>Widdel, Lars</name>
      </author>
      <author>
        <name>Schroeppel, Thomas J</name>
      </author>
      <author>
        <name>Stillman, Zachery</name>
      </author>
      <author>
        <name>Cooper, Zara</name>
      </author>
      <author>
        <name>Stein, Deborah</name>
      </author>
      <author>
        <name>Adams, Charles</name>
      </author>
      <author>
        <name>Lueckel, Stephanie</name>
      </author>
      <author>
        <name>Murry, Jason</name>
      </author>
      <author>
        <name>Patel, Nikita</name>
      </author>
      <author>
        <name>Hsu, Cindy</name>
      </author>
      <author>
        <name>Bhatti, Umer F</name>
      </author>
      <author>
        <name>Lissauer, Matthew E</name>
      </author>
      <author>
        <name>LaFonte, Marc</name>
      </author>
      <author>
        <name>Najafi, Kaveh</name>
      </author>
      <author>
        <name>Lewandowski, Karen</name>
      </author>
      <author>
        <name>Mukherjee, Kaushik</name>
      </author>
      <author>
        <name>Imperio-Lagabon, Kristelle J</name>
      </author>
      <author>
        <name>Martin, Niels D</name>
      </author>
      <author>
        <name>Hirsch, Kathleen</name>
      </author>
      <author>
        <name>Berry, Cherisse</name>
      </author>
      <author>
        <name>Freitas, Derek</name>
      </author>
      <author>
        <name>Cullinane, Daniel</name>
      </author>
      <author>
        <name>Ramawi, Roshini</name>
      </author>
      <author>
        <name>Truitt, Michael</name>
      </author>
      <author>
        <name>Pearcy, Chris</name>
      </author>
      <author>
        <name>Hashimi, Habiba</name>
      </author>
      <author>
        <name>Kaups, Krista</name>
      </author>
      <author>
        <name>Claridge, Jeffrey</name>
      </author>
      <author>
        <name>Hartwell, Jennifer L</name>
      </author>
      <author>
        <name>Ballou, Jessica</name>
      </author>
      <author>
        <name>Croce, Martin</name>
      </author>
      <author>
        <name>Markle, Stephanie</name>
      </author>
      <author>
        <name>Osserwaarde, Sally</name>
      </author>
      <author>
        <name>Posluszny, Joseph</name>
      </author>
      <author>
        <name>Stocker, Benjamin</name>
      </author>
      <author>
        <name>Hranjec, Tjasa</name>
      </author>
      <author>
        <name>Solomon, Rachele</name>
      </author>
      <author>
        <name>Martinek, Lucy</name>
      </author>
      <author>
        <name>Gupta, Alok</name>
      </author>
      <author>
        <name>Grabo, Daniel J</name>
      </author>
      <author>
        <name>Khan, Uzer</name>
      </author>
      <author>
        <name>Tatum, Danielle</name>
      </author>
      <author>
        <name>Jacome, Tomas</name>
      </author>
      <author>
        <name>Gates, Jonathan</name>
      </author>
      <author>
        <name>Jawani, Alisha</name>
      </author>
      <author>
        <name>Berndtson, Allison E</name>
      </author>
      <author>
        <name>Curry, Terry G</name>
      </author>
      <author>
        <name>Bala, Miklosh</name>
      </author>
      <author>
        <name>Dultz, Linda A</name>
      </author>
      <author>
        <name>Houshmand, Natasha N</name>
      </author>
      <author>
        <name>Pieri, Paola</name>
      </author>
      <author>
        <name>Zielinski, Martin D</name>
      </author>
      <author>
        <name>Hughes, Joy D</name>
      </author>
      <author>
        <name>Hartwell, Jennifer</name>
      </author>
      <author>
        <name>Malhotra, Ajai K</name>
      </author>
      <author>
        <name>Lee, Tim</name>
      </author>
      <author>
        <name>Petrone, Patrizio</name>
      </author>
      <author>
        <name>Joseph, D'andrea</name>
      </author>
      <author>
        <name>Marshall, Gary T</name>
      </author>
      <author>
        <name>Carrick, Matthew M</name>
      </author>
      <author>
        <name>Pathak, Abhijit</name>
      </author>
      <author>
        <name>Van Zandt, Andrea</name>
      </author>
      <author>
        <name>Glass, Nina</name>
      </author>
      <author>
        <name>Livingston, David</name>
      </author>
      <author>
        <name>Gregg, Shea</name>
      </author>
      <author>
        <name>Webb, Travis</name>
      </author>
      <author>
        <name>Drumheller, Byron</name>
      </author>
      <author>
        <name>Kozar, Rosemary</name>
      </author>
      <author>
        <name>Barraco, Robert</name>
      </author>
      <author>
        <name>Joseph, Bellal</name>
      </author>
    </item>
    <item>
      <title>A heterogenous population of extracellular vesicles mobilize to the alveoli postinjury</title>
      <link>https://escholarship.org/uc/item/46159444</link>
      <description>BACKGROUND: Acute lung injury and subsequent resolution following severe injury are coordinated by a complex lung microenvironment that includes extracellular vesicles (EVs). We hypothesized that there is a heterogenous population of EVs recruited to the alveoli postinjury and that we could identify specific immune-relevant mediators expressed on bronchoalveolar lavage (BAL) EVs as candidate biomarkers of injury and injury resolution.
METHODS: Mice underwent 30% TBSA burn injury and BAL fluid was collected 4 hours postinjury and compared with sham. Extracellular vesicles were purified and single vesicle flow cytometry (vFC) was performed using fluorescent antibodies to quantify the expression of specific cell surface markers on individual EVs. Next, we evaluated human BAL specimens from injured patients to establish translational relevance of the mouse vFC analysis. Human BAL was collected from intubated patients following trauma or burn injury, EVs were purified, then subjected...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/46159444</guid>
      <pubDate>Tue, 18 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Costantini, Todd W</name>
      </author>
      <author>
        <name>Park, Dong Jun</name>
        <uri>https://orcid.org/0000-0002-4209-0302</uri>
      </author>
      <author>
        <name>Johnston, William</name>
      </author>
      <author>
        <name>Nakatsutsumi, Keita</name>
      </author>
      <author>
        <name>Kezios, Jenny</name>
      </author>
      <author>
        <name>Weaver, Jessica L</name>
      </author>
      <author>
        <name>Coimbra, Raul</name>
      </author>
      <author>
        <name>Eliceiri, Brian P</name>
        <uri>https://orcid.org/0000-0003-1811-1916</uri>
      </author>
    </item>
    <item>
      <title>Robotic repair of traumatic bronchial disruption: A minimally invasive and multi-disciplinary approach to a complex constellation of injuries</title>
      <link>https://escholarship.org/uc/item/2bj5b9dv</link>
      <description>Bronchial disruption is a catastrophic consequence of blunt thoracic trauma with high pre-hospital lethality. This injury is classically managed through a large thoracotomy incision to facilitate adequate exposure for open repair. Here, we describe a case of complete bronchus intermedius disruption following a motor vehicle accident that was repaired via robotic thoracoscopy. The patient sustained multi-system trauma, including a grade III liver laceration, an innominate artery pseudoaneurysm, and femoral condyle fracture, all of which required systematic intervention and multi-disciplinary coordination to best facilitate this patient's care. This patient recovered well from his multiple injuries and was discharged after an uneventful post-operative course.</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2bj5b9dv</guid>
      <pubDate>Tue, 18 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Marshall, W Aaron</name>
      </author>
      <author>
        <name>Robles, Julie N</name>
      </author>
      <author>
        <name>Adams, Laura M</name>
      </author>
      <author>
        <name>Potenza, Bruce M</name>
      </author>
      <author>
        <name>Kobayashi, Leslie M</name>
      </author>
    </item>
    <item>
      <title>Factors associated with receipt of intracranial pressure monitoring in older adults with traumatic brain injury</title>
      <link>https://escholarship.org/uc/item/6nr3z6z5</link>
      <description>BACKGROUND: The Brain Trauma Foundation (BTF) Guidelines for the Management of Severe Traumatic Brain Injury (TBI) include intracranial pressure monitoring (ICPM), yet very little is known about ICPM in older adults. Our objectives were to characterize the utilization of ICPM in older adults and identify factors associated with ICPM in those who met the BTF guidelines.
METHODS: We analyzed data from the American Association for the Surgery of Trauma Geriatric TBI Study, a registry study conducted among individuals with isolated, CT-confirmed TBI across 45 trauma centers. The analysis was restricted to those aged ≥60. Independent factors associated with ICPM for those who did and did not meet the BTF guidelines were identified using logistic regression.
RESULTS: Our sample was composed of 2303 patients, of whom 66 (2.9%) underwent ICPM. Relative to Glasgow Coma Scale (GCS) score of 13 to 15, GCS score of 9 to 12 (OR 10.2; 95% CI 4.3 to 24.4) and GCS score of &amp;lt;9 (OR 15.0; 95%...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6nr3z6z5</guid>
      <pubDate>Mon, 17 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Ghneim, Mira</name>
      </author>
      <author>
        <name>Albrecht, Jennifer</name>
      </author>
      <author>
        <name>Brasel, Karen</name>
      </author>
      <author>
        <name>Knight, Ariel</name>
      </author>
      <author>
        <name>Liveris, Anna</name>
      </author>
      <author>
        <name>Watras, Jill</name>
      </author>
      <author>
        <name>Michetti, Christopher P</name>
      </author>
      <author>
        <name>Haan, James</name>
      </author>
      <author>
        <name>Lightwine, Kelly</name>
      </author>
      <author>
        <name>Winfield, Robert D</name>
      </author>
      <author>
        <name>Adams, Sasha D</name>
      </author>
      <author>
        <name>Podbielski, Jeanette</name>
      </author>
      <author>
        <name>Armen, Scott</name>
      </author>
      <author>
        <name>Zacko, J Christopher</name>
      </author>
      <author>
        <name>Nasrallah, Fady S</name>
      </author>
      <author>
        <name>Schaffer, Kathryn B</name>
      </author>
      <author>
        <name>Dunn, Julie A</name>
      </author>
      <author>
        <name>Smoot, Brittany</name>
      </author>
      <author>
        <name>Schroeppel, Thomas J</name>
      </author>
      <author>
        <name>Stillman, Zachery</name>
      </author>
      <author>
        <name>Cooper, Zara</name>
      </author>
      <author>
        <name>Stein, Deborah M</name>
      </author>
      <author>
        <name>Adams, Charles</name>
      </author>
      <author>
        <name>Lueckel, Stephanie</name>
      </author>
      <author>
        <name>Murry, Jason</name>
      </author>
      <author>
        <name>Hsu, Cindy</name>
      </author>
      <author>
        <name>Bhatti, Umer F</name>
      </author>
      <author>
        <name>Lissauer, Matthew E</name>
      </author>
      <author>
        <name>LaFonte, Marc</name>
      </author>
      <author>
        <name>Najafi, Kaveh</name>
      </author>
      <author>
        <name>Lewandowski, Karen</name>
      </author>
      <author>
        <name>Mukherjee, Kaushik</name>
      </author>
      <author>
        <name>Imperio-Lagabon, Kristelle J</name>
      </author>
      <author>
        <name>Martin, Niels D</name>
      </author>
      <author>
        <name>Hirsch, Kathleen</name>
      </author>
      <author>
        <name>Berry, Cherisse</name>
      </author>
      <author>
        <name>Freitas, Derek</name>
      </author>
      <author>
        <name>Cullinane, Daniel</name>
      </author>
      <author>
        <name>Ramawani, Roshini</name>
      </author>
      <author>
        <name>Truitt, Michael</name>
      </author>
      <author>
        <name>Pearcy, Chris</name>
      </author>
      <author>
        <name>Hashimi, Habiba</name>
      </author>
      <author>
        <name>Kaups, Krista</name>
      </author>
      <author>
        <name>Claridge, Jeffry</name>
      </author>
      <author>
        <name>Ladhani, Husayn</name>
      </author>
      <author>
        <name>Hartwell, Jennifer L</name>
      </author>
      <author>
        <name>Ballou, Jessica</name>
      </author>
      <author>
        <name>Croce, Martin</name>
      </author>
      <author>
        <name>Markle, Stephanie</name>
      </author>
      <author>
        <name>Osserwaarde, Sally</name>
      </author>
      <author>
        <name>Posluszny, Joseph</name>
      </author>
      <author>
        <name>Stocker, Benjamin</name>
      </author>
      <author>
        <name>Hranjec, Tjasa</name>
      </author>
      <author>
        <name>Solomon, Rachele</name>
      </author>
      <author>
        <name>Martinek, Lucy</name>
      </author>
      <author>
        <name>Gupta, Alok</name>
      </author>
      <author>
        <name>Grabo, Daniel J</name>
      </author>
      <author>
        <name>Khan, Uzer</name>
      </author>
      <author>
        <name>Tatum, Danielle</name>
      </author>
      <author>
        <name>Jacome, Tomas</name>
      </author>
      <author>
        <name>Gates, Jonathan</name>
      </author>
      <author>
        <name>Jawani, Alisha</name>
      </author>
      <author>
        <name>Berndtson, Allison E</name>
      </author>
      <author>
        <name>Curry, Terry G</name>
      </author>
      <author>
        <name>Bala, Miklosh</name>
      </author>
      <author>
        <name>Dultz, Linda A</name>
      </author>
      <author>
        <name>Houshmand, Natasha N</name>
      </author>
      <author>
        <name>Pieri, Paola</name>
      </author>
      <author>
        <name>Zielinski, Martin D</name>
      </author>
      <author>
        <name>Hughes, Joy D</name>
      </author>
      <author>
        <name>Hartwell, Jennifer</name>
      </author>
      <author>
        <name>Malhotra, Ajai K</name>
      </author>
      <author>
        <name>Lee, Tim</name>
      </author>
      <author>
        <name>Petrone, Patrizio</name>
      </author>
      <author>
        <name>Joseph, D'andrea</name>
      </author>
      <author>
        <name>Marshall, Gary T</name>
      </author>
      <author>
        <name>Carrick, Matthew M</name>
      </author>
      <author>
        <name>Pathak, Abhijit</name>
      </author>
      <author>
        <name>Van Zandt, Andrea</name>
      </author>
      <author>
        <name>Glass, Nina</name>
      </author>
      <author>
        <name>Livingston, David</name>
      </author>
      <author>
        <name>Gregg, Shea</name>
      </author>
      <author>
        <name>Webb, Travis</name>
      </author>
      <author>
        <name>Drumheller, Byron</name>
      </author>
      <author>
        <name>Kozar, Rosemary</name>
      </author>
      <author>
        <name>Barraco, Robert</name>
      </author>
      <author>
        <name>Joseph, Bellal</name>
      </author>
    </item>
    <item>
      <title>Laboratory measures of coagulation among trauma patients on NOAs: results of the AAST-MIT</title>
      <link>https://escholarship.org/uc/item/55j638mj</link>
      <description>BACKGROUND: Warfarin is associated with poor outcomes after trauma, an effect correlated with elevations in the international normalized ratio (INR). In contrast, the novel oral anticoagulants (NOAs) have no validated laboratory measure to quantify coagulopathy. We sought to determine if use of NOAs was associated with elevated activated partial thromboplastin time (aPTT) or INR levels among trauma patients or increased clotting times on thromboelastography (TEG).
METHODS: This was a post-hoc analysis of a prospective observational study across 16 trauma centers. Patients on dabigatran, rivaroxaban, or apixaban were included. Laboratory data were collected at admission and after reversal. Admission labs were compared between medication groups. Traditional measures of coagulopathy were compared with TEG results using Spearman's rank coefficient for correlation. Labs before and after reversal were also analyzed between medication groups.
RESULTS: 182 patients were enrolled between...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/55j638mj</guid>
      <pubDate>Sat, 15 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Kobayashi, Leslie M</name>
      </author>
      <author>
        <name>Brito, Alexandra</name>
      </author>
      <author>
        <name>Barmparas, Galinos</name>
      </author>
      <author>
        <name>Bosarge, Patrick</name>
      </author>
      <author>
        <name>Brown, Carlos V</name>
      </author>
      <author>
        <name>Bukur, Marko</name>
      </author>
      <author>
        <name>Carrick, Matthew M</name>
      </author>
      <author>
        <name>Catalano, Richard D</name>
      </author>
      <author>
        <name>Holly-Nicolas, Jan</name>
      </author>
      <author>
        <name>Inaba, Kenji</name>
      </author>
      <author>
        <name>Kaminski, Stephen</name>
      </author>
      <author>
        <name>Klein, Amanda L</name>
      </author>
      <author>
        <name>Kopelman, Tammy</name>
      </author>
      <author>
        <name>Ley, Eric J</name>
      </author>
      <author>
        <name>Martinez, Ericca M</name>
      </author>
      <author>
        <name>Moore, Forrest O</name>
      </author>
      <author>
        <name>Murry, Jason</name>
      </author>
      <author>
        <name>Nirula, Raminder</name>
      </author>
      <author>
        <name>Paul, Douglas</name>
      </author>
      <author>
        <name>Quick, Jacob</name>
      </author>
      <author>
        <name>Rivera, Omar</name>
      </author>
      <author>
        <name>Schreiber, Martin</name>
      </author>
      <author>
        <name>Coimbra, Raul</name>
      </author>
    </item>
    <item>
      <title>Improving life expectancy: A ‘broken neck’ doesn’t have to be a terminal diagnosis for the elderly</title>
      <link>https://escholarship.org/uc/item/2rp3v98s</link>
      <description>BACKGROUND: Elderly patients with cervical spine fractures require optimal care. Treatment with a cervical collar or halo instead of surgical fixation may increase mortality. This investigation intends to describe the life expectancy after injury and evaluate the impact of surgical intervention on mortality.
METHODS: Patients ≥65 years, with traumatic cervical spine fractures without cord injury were identified in the 1995-2009 California Office of Statewide Health and Planning database. Those with halo placement or surgical spine fixation were identified. Primary outcome was death, studied at the initial admission, 30 days, 1 year, and the entire study period. Univariate and multivariate regressions were performed to identify predictors of death. Kaplan-Meier survival curves were used to describe life expectancy after injury.
RESULTS: 10 938 patients were identified. Mortality rate was 10% during the initial admission, 28% at 1 year and 50% during the entire study period. A halo...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2rp3v98s</guid>
      <pubDate>Fri, 14 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Godat, Laura N</name>
      </author>
      <author>
        <name>Kobayashi, Leslie M</name>
      </author>
      <author>
        <name>Chang, David C</name>
      </author>
      <author>
        <name>Coimbra, Raul</name>
      </author>
    </item>
    <item>
      <title>Migraine headaches are associated with motor vehicle crashes and driving habits among older drivers: Prospective cohort study</title>
      <link>https://escholarship.org/uc/item/8vz2z1rg</link>
      <description>BACKGROUND: Migraine headache is common in older adults, often causing symptoms that may affect driving safety. This study examined associations of migraine with motor vehicle crashes (MVCs) and driving habits in older drivers and assessed modification of associations by medication use.
METHODS: In a multi-site, prospective cohort study of active drivers aged 65-79 (53% female), we assessed prevalent migraine (i.e., ever had migraine, reported at enrollment), incident migraine (diagnosis first reported at a follow-up visit), and medications typically used for migraine prophylaxis and treatment. During 2-year follow-up, we recorded self-reported MVCs and measured driving habits using in-vehicle GPS devices. Associations of prevalent migraine with driving outcomes were estimated in multivariable mixed models. Using a matched design, associations of incident migraine with MVCs in the subsequent year were estimated with conditional logistic regression. Interactions between migraine...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/8vz2z1rg</guid>
      <pubDate>Mon, 10 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>DiGuiseppi, Carolyn G</name>
      </author>
      <author>
        <name>Johnson, Rachel L</name>
      </author>
      <author>
        <name>Betz, Marian E</name>
      </author>
      <author>
        <name>Hill, Linda L</name>
      </author>
      <author>
        <name>Eby, David W</name>
      </author>
      <author>
        <name>Jones, Vanya C</name>
      </author>
      <author>
        <name>Mielenz, Thelma J</name>
      </author>
      <author>
        <name>Molnar, Lisa J</name>
      </author>
      <author>
        <name>Strogatz, David</name>
      </author>
      <author>
        <name>Li, Guohua</name>
      </author>
    </item>
    <item>
      <title>From Peril to Protection: an evaluation of regulations impacting eScooter injuries</title>
      <link>https://escholarship.org/uc/item/85p665zd</link>
      <description>Background: The use of standing electric motorized scooters (eScooters) has skyrocketed since its first release in 2016. This quickly popularized form of transportation has been associated with significant injury and even death. These eScooter-related traumatic injuries led to local advocacy efforts, resulting in safety restrictions including speed limit geofencing, sidewalk restrictions, and limiting the number of eScooter providers in high-density population areas. We hypothesized that these local safety restrictions decreased the number of eScooter-related injuries presenting to our trauma center. .
Methods: This is a retrospective cohort study of eScooter-crash patients presenting to our Level 1 trauma center from July 2018 to June 2023. Variables included patient demographics, injury severity score (ISS), and mortality. The primary outcome was the rate of eScooter patients presenting over time in relation to the implementation of local-regional safety regulations.
Results:...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/85p665zd</guid>
      <pubDate>Mon, 3 Mar 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Black, Kendra M</name>
      </author>
      <author>
        <name>Santorelli, Jarrett E</name>
      </author>
      <author>
        <name>Costantini, Todd W</name>
      </author>
      <author>
        <name>Kobayashi, Leslie M</name>
      </author>
      <author>
        <name>Doucet, Jay J</name>
      </author>
      <author>
        <name>Haines, Laura N</name>
      </author>
    </item>
    <item>
      <title>Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal</title>
      <link>https://escholarship.org/uc/item/4w51v72k</link>
      <description>Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic inflammation in many disease contexts. Cells experiencing mtDNA stress caused by depletion of the mtDNA-packaging protein, transcription factor A, mitochondrial (TFAM) or during herpes simplex virus-1 infection exhibit elongated mitochondria, enlargement of nucleoids (mtDNA–protein complexes) and activation of cGAS–STING innate immune signalling via mtDNA released into the cytoplasm. However, the relationship among aberrant mitochondria and nucleoid dynamics, mtDNA release and cGAS–STING activation remains unclear. Here we show that, under a variety of mtDNA replication stress conditions and during herpes simplex virus-1 infection,...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/4w51v72k</guid>
      <pubDate>Mon, 17 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Newman, Laura E</name>
      </author>
      <author>
        <name>Weiser Novak, Sammy</name>
      </author>
      <author>
        <name>Rojas, Gladys R</name>
      </author>
      <author>
        <name>Tadepalle, Nimesha</name>
      </author>
      <author>
        <name>Schiavon, Cara R</name>
        <uri>https://orcid.org/0000-0002-9311-2145</uri>
      </author>
      <author>
        <name>Grotjahn, Danielle A</name>
      </author>
      <author>
        <name>Towers, Christina G</name>
      </author>
      <author>
        <name>Tremblay, Marie-Ève</name>
      </author>
      <author>
        <name>Donnelly, Matthew P</name>
      </author>
      <author>
        <name>Ghosh, Sagnika</name>
      </author>
      <author>
        <name>Medina, Michaela</name>
      </author>
      <author>
        <name>Rocha, Sienna</name>
      </author>
      <author>
        <name>Rodriguez-Enriquez, Ricardo</name>
      </author>
      <author>
        <name>Chevez, Joshua A</name>
      </author>
      <author>
        <name>Lemersal, Ian</name>
      </author>
      <author>
        <name>Manor, Uri</name>
        <uri>https://orcid.org/0000-0002-9802-1955</uri>
      </author>
      <author>
        <name>Shadel, Gerald S</name>
      </author>
    </item>
    <item>
      <title>Implementation of an electronic health record-integrated instant messaging system in an academic health system</title>
      <link>https://escholarship.org/uc/item/3sc9t353</link>
      <description>OBJECTIVES: Effective communication amongst healthcare workers simultaneously promotes optimal patient outcomes when present and is deleterious to outcomes when absent. The advent of electronic health record (EHR)-embedded secure instantaneous messaging systems has provided a new conduit for provider communication. This manuscript describes the experience of one academic medical center with deployment of one such system (Secure Chat).
METHODS: Data were collected on Secure Chat message volume from June 2017 to April 2023. Significant perideployment events were reviewed chronologically.
RESULTS: After the first coronavirus disease 2019 lockdown in March 2020, messaging use increased by over 25 000 messages per month, with 1.2 million messages sent monthly by April 2023. Comparative features of current communication modalities in healthcare were summarized, highlighting the many advantages of Secure Chat.
CONCLUSIONS: While EHR-embedded secure instantaneous messaging systems represent...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/3sc9t353</guid>
      <pubDate>Fri, 14 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Kwan, Brian</name>
        <uri>https://orcid.org/0000-0002-5835-0631</uri>
      </author>
      <author>
        <name>Bell, John F</name>
        <uri>https://orcid.org/0000-0003-3116-1774</uri>
      </author>
      <author>
        <name>Longhurst, Christopher A</name>
      </author>
      <author>
        <name>Goldhaber, Nicole H</name>
        <uri>https://orcid.org/0000-0002-3847-3634</uri>
      </author>
      <author>
        <name>Clay, Brian</name>
      </author>
    </item>
    <item>
      <title>Ultrasound-guided Percutaneous Cryoneurolysis for the Treatment of Pain after Traumatic Rib Fracture: A Randomized, Active-controlled, Participant- and Observer-masked Study</title>
      <link>https://escholarship.org/uc/item/43b1q2t1</link>
      <description>BACKGROUND: Traumatic rib fractures are associated with pain lasting weeks to months and a decreased ability to inspire deeply or cough to clear secretions. Ultrasound-guided percutaneous cryoneurolysis involves reversibly ablating peripheral nerve(s) using exceptionally low temperature with a transdermal probe, resulting in a prolonged nerve block with a duration measured in months. The authors hypothesized that cryoneurolysis would improve analgesia and inspired volume after rib fracture.
METHODS: Adults with one to six traumatic rib fractures were randomized to either active cryoneurolysis and sham peripheral nerve block or sham cryoneurolysis and active peripheral nerve block in a participant/observer-masked fashion. The primary endpoint was the maximum inspired volume the day after the procedure as measured with an incentive spirometer.
RESULTS: The day after the procedure, the unadjusted median [interquartile range] maximum inspired volume for participants who received cryoneurolysis...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/43b1q2t1</guid>
      <pubDate>Thu, 13 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Finneran, John J</name>
      </author>
      <author>
        <name>Kobayashi, Leslie</name>
      </author>
      <author>
        <name>Costantini, Todd W</name>
      </author>
      <author>
        <name>Weaver, Jessica L</name>
      </author>
      <author>
        <name>Berndtson, Allison E</name>
      </author>
      <author>
        <name>Haines, Laura</name>
      </author>
      <author>
        <name>Doucet, Jay J</name>
      </author>
      <author>
        <name>Adams, Laura</name>
      </author>
      <author>
        <name>Santorelli, Jarrett E</name>
      </author>
      <author>
        <name>Lee, Jeanne</name>
      </author>
      <author>
        <name>Trescot, Andrea M</name>
      </author>
      <author>
        <name>Donohue, Michael C</name>
      </author>
      <author>
        <name>Schaar, Adam</name>
      </author>
      <author>
        <name>Ilfeld, Brian M</name>
        <uri>https://orcid.org/0000-0002-6144-3273</uri>
      </author>
    </item>
    <item>
      <title>Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial</title>
      <link>https://escholarship.org/uc/item/7nf02000</link>
      <description>BACKGROUND: Chronic limb-threatening ischemia (CLTI) in patients with chronic kidney disease (CKD) has a high risk of poor outcomes. We aimed to compare the outcomes of lower extremity revascularization in patients with CLTI stratified by CKD severity in patients enrolled in the prospective, randomized Best Endovascular vs Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial.
METHODS: The BEST-CLI trial dataset was queried to categorize patients into three groups according to CKD stage. Group A includes non-CKD and CKD stages&amp;nbsp;&amp;lt;3; group B includes stage 3 and stage 4 CKD patients; and group C includes stage 5 CKD and dialysis-dependent patients. Furthermore, spline modeling was performed across the range of estimated glomerular filtration rate (eGFR, mL/min/1.73&amp;nbsp;m&lt;sup&gt;2&lt;/sup&gt;) observed in study participants to identify a threshold eGFR that impacted the primary trial outcomes: major adverse limb events (MALEs; defined as above-ankle amputation or major reintervention)...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/7nf02000</guid>
      <pubDate>Wed, 12 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Malas, Mahmoud B</name>
        <uri>https://orcid.org/0000-0002-2865-4079</uri>
      </author>
      <author>
        <name>Hamouda, Mohammed</name>
      </author>
      <author>
        <name>Farber, Alik</name>
      </author>
      <author>
        <name>Menard, Matthew T</name>
      </author>
      <author>
        <name>Conte, Michael S</name>
      </author>
      <author>
        <name>Rosenfield, Kenneth</name>
      </author>
      <author>
        <name>Strong, Michael B</name>
      </author>
      <author>
        <name>Doros, Gheorghe</name>
      </author>
      <author>
        <name>Powell, Richard J</name>
      </author>
      <author>
        <name>Mena-Hurtado, Carlos</name>
      </author>
      <author>
        <name>Gasper, Warren</name>
      </author>
      <author>
        <name>Schermerhorn, Marc L</name>
      </author>
      <author>
        <name>Allievi, Sara</name>
      </author>
      <author>
        <name>Smolderen, Kim G</name>
      </author>
      <author>
        <name>Dake, Michael D</name>
      </author>
      <author>
        <name>Rymer, Jennifer A</name>
      </author>
      <author>
        <name>Tuttle, Katherine R</name>
      </author>
    </item>
    <item>
      <title>Sex-Based Differences in IBD Surgical Outcomes</title>
      <link>https://escholarship.org/uc/item/6vz9k7ch</link>
      <description>BACKGROUND: Although there are discrepancies in the development and progression of IBD based on biologic sex, little is known about differences in postoperative outcomes between men and women undergoing surgery for this condition.
OBJECTIVE: To compare rates of anastomotic leaks, wound complications, and serious adverse events between men and women undergoing surgery for IBD.
DESIGN: This was a retrospective cohort study.
SETTINGS: Data were obtained from the American College of Surgeons National Surgical Quality Improvement Program IBD Collaborative database, which includes 15 high-volume IBD surgery centers.
PATIENTS: All adult patients undergoing surgery for IBD were included. Participants with missing data for exposure or outcome variables were excluded.
MAIN OUTCOME MEASURES: Rates of anastomotic leaks, wound complications, and serious adverse events were compared between women and men.
RESULTS: A total of 3143 patients were included. There was a significant association between...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/6vz9k7ch</guid>
      <pubDate>Wed, 5 Feb 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Sundel, Margaret H</name>
      </author>
      <author>
        <name>Newland, John J</name>
      </author>
      <author>
        <name>Blackburn, Kyle W</name>
      </author>
      <author>
        <name>Vesselinov, Roumen M</name>
      </author>
      <author>
        <name>Eisenstein, Samuel</name>
        <uri>https://orcid.org/0000-0002-2646-0625</uri>
      </author>
      <author>
        <name>Bafford, Andrea C</name>
      </author>
      <author>
        <name>Collaborative, On Behalf of the NSQIP-IBD</name>
      </author>
    </item>
    <item>
      <title>Wearable, noninvasive, pulsed shortwave (radiofrequency) therapy for postoperative analgesia: A randomized, double‐masked, sham‐controlled pilot study</title>
      <link>https://escholarship.org/uc/item/2c73v2p8</link>
      <description>BACKGROUND: Nonthermal, pulsed shortwave (radiofrequency) therapy (PSWT) is a nonpharmacologic, noninvasive modality that limited evidence suggests provides analgesia. Its potential favorable risk-benefit ratio stems from its lack of side effects and significant medical risks, applicability to any anatomic location, long treatment duration, and ease of application by simply affixing it with tape. Even with a relatively small treatment effect, PSWT might contribute to a multimodal analgesic regimen, similar to acetaminophen. However, widespread clinical use is hindered by a lack of systematic evidence. The current randomized, controlled pilot study was undertaken to determine the feasibility and optimize the protocol for a subsequent definitive investigation and estimate the treatment effect of PSWT on postoperative pain and opioid consumption.
METHODS: Within the recovery room following primary knee and hip arthroplasty, cholecystectomy, hernia repair, and non-mastectomy breast...</description>
      <guid isPermaLink="true">https://escholarship.org/uc/item/2c73v2p8</guid>
      <pubDate>Thu, 30 Jan 2025 00:00:00 +0000</pubDate>
      <author>
        <name>Ilfeld, Brian M</name>
        <uri>https://orcid.org/0000-0002-6144-3273</uri>
      </author>
      <author>
        <name>Finneran, John J</name>
      </author>
      <author>
        <name>Said, Engy T</name>
        <uri>https://orcid.org/0000-0002-7897-1670</uri>
      </author>
      <author>
        <name>Ball, Scott T</name>
      </author>
      <author>
        <name>Wallace, Anne M</name>
      </author>
      <author>
        <name>Broderick, Ryan C</name>
      </author>
      <author>
        <name>Sandler, Bryan J</name>
      </author>
      <author>
        <name>Doucet, Jay J</name>
      </author>
      <author>
        <name>Hu, Sandy R</name>
      </author>
      <author>
        <name>J., Brannon</name>
      </author>
      <author>
        <name>Murthy, Adhithi Narayana</name>
      </author>
      <author>
        <name>Abdullah, Baharin</name>
      </author>
    </item>
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