http://www.rssboard.org/rss-specification 720 https://escholarship.org/uc/ucsf/rss Recent eScholarship items from UCSF Wed, 4 Nov 2026 04:50:21 +0000 https://escholarship.org/uc/item/9kt9c6hd The Advancing Digital Health Humanities Institute: White Paper&nbsp;for National Endowment for the Humanities&nbsp;Office of Digital Humanities (Grant HT-293880-23) https://escholarship.org/uc/item/9kt9c6hd Fri, 30 Oct 2026 00:00:00 +0000 Ilieva, Polina Purcell, Sean https://escholarship.org/uc/item/3bb694qz Rethinking Linking: Effects of Cap-and-Trade Integration on Equilibrium Emissions and Welfare https://escholarship.org/uc/item/3bb694qz Fri, 30 Oct 2026 00:00:00 +0000 Larson, Thor https://escholarship.org/uc/item/4456h9xg JUUL's "smoking switching" initiative in Ghana:&nbsp; Market expansion through global health https://escholarship.org/uc/item/4456h9xg Thu, 29 Oct 2026 00:00:00 +0000 Logo, Divine Darlington, PhD Chaffee, Benjamin W, DDS, PhD, MPH Ling, Pamela M, MD, MPH Bialous, Stella A, DrPH, RN, FAAN https://escholarship.org/uc/item/9t02q3mg Abstract Neisseria gonorrhoeae, the causative agent of gonorrhea, represents an escalating global health concern because of the rapid spread of antimicrobial resistance and the continued lack of an effective vaccine. The lipooligosaccharide (LOS) epitope targeted by monoclonal antibody 2C7 is highly conserved and expressed by the majority of clinical isolates, highlighting its potential as an attractive target for therapeutic and vaccine-based interventions. To define the molecular basis for 2C7 recognition, we structurally characterized mAb 2C7 bound to an LOS-derived octasaccharide. NMR and a 1.6 Å crystal structure of the Fab 2C7–octasaccharide complex showed that mAb 2C7 recognizes the β- and γ-glycan chains through an extensive network of hydrogen-bonding and hydrophobic interactions within the Fab binding cleft. MD simulations indicated that β and γ chains form stable, specific interactions with 2C7, whereas α-chain contacts are transient. Guided by structure, we synthesized... https://escholarship.org/uc/item/9t02q3mg Tue, 27 Oct 2026 00:00:00 +0000 Tsagkarakou, Anastasia S Nieto-Fabregat, Ferran Masi, Alessandro Zhang, Yunqin Fan, Fei Shaughnessy, Jutamas Rice, Peter A Huang, Xuefei Ram, Sanjay Beernink, Peter T Silipo, Alba https://escholarship.org/uc/item/3mc871sq Gonococcal Peptide Mimetic Vaccine Antigen Forms a Beta-hairpin Structure and Binds to a Chimeric Antibody Primarily through Hydrophobic Interactions https://escholarship.org/uc/item/3mc871sq Tue, 27 Oct 2026 00:00:00 +0000 Beernink, Peter T Di Carluccio, Christina Marchetti, Roberta Beernink, BP Gulati, Sunita Shaughnessy, Jutamas Rice, PA Ram, Sanjay Silipo, Alba https://escholarship.org/uc/item/7kj8f0nw Final results of the HPTN 052 randomized controlled trial: antiretroviral therapy prevents HIV transmission https://escholarship.org/uc/item/7kj8f0nw Fri, 23 Oct 2026 00:00:00 +0000 Cohen, Myron Chen, Ying McCauley, Marybeth Gamble, Theresa Hosseinipour, Mina Kumarasamy, Nagalingeshwaran Hakim, James Kumwenda, Newton Brum, Tania Grinsztejn, Beatriz Godbole, Sheela Chariyalertsak, Suwat Santos, Breno Riegel Mayer, Kenneth Hoffman, Irving Eshleman, Susan Piwowar-Manning, Estelle Ou, San-San Cottle, Leslie Makhema, Joseph Mills, Lisa Panchia, Ravindre Badal-Faesen, Sharlaa Eron, Joseph Gallant, Joel Havlir, Diane https://orcid.org/0000-0003-0761-3136 Swindells, Susan Elharrar, Vanessa Burns, David Taha, Taha Nielsen, Karin Celentano, David Essex, Max Fleming, Thomas https://escholarship.org/uc/item/9td979xz Routine Screening for Neuroblastoma in Harlequin Syndrome Without Otherwise Known Etiology https://escholarship.org/uc/item/9td979xz Thu, 22 Oct 2026 00:00:00 +0000 Yu, Colburn https://orcid.org/0009-0007-7457-6992 El‐Haj, Nura Kim, Sunghoon https://orcid.org/0000-0002-3871-0847 Golden, Carla Agrawal, Anurag K https://escholarship.org/uc/item/9k12t8ps A Mitochondrial tRNA Mutation Causes Axonal Charcot-Marie-Tooth Disease in a Large Family from the Venezuelan Andes (2779) https://escholarship.org/uc/item/9k12t8ps Thu, 22 Oct 2026 00:00:00 +0000 Fay, Alexander Garcia, Yngo Margeta, Marta Hou, Ya-Ming Maharjan, Sunita McMahon, Tom Bassaganyas, Laia Fu, Ying-Hui Ptacek, Louis https://escholarship.org/uc/item/9cx4n0b0 Whole Slide Imaging of Peripheral Blood Smears for Diagnostic Purposes https://escholarship.org/uc/item/9cx4n0b0 Thu, 22 Oct 2026 00:00:00 +0000 Spector, Jacob Han, Lucy Balcerek, Joanna Lauw, Marietya Bhargava, Parul Brown, Laura https://orcid.org/0000-0002-9012-6680 White, Kristie Kogan, Scott https://orcid.org/0000-0002-2395-8479 Wang, Linlin https://escholarship.org/uc/item/9bg5t7w3 Whole Slide Imaging of Peripheral Blood Smears for Diagnostic Purposes https://escholarship.org/uc/item/9bg5t7w3 Thu, 22 Oct 2026 00:00:00 +0000 Spector, Jacob Han, Lucy Balcerek, Joanna Lauw, Marietya Bhargava, Parul Brown, Laura https://orcid.org/0000-0002-9012-6680 White, Kristie Kogan, Scott https://orcid.org/0000-0002-2395-8479 Wang, Linlin https://escholarship.org/uc/item/90g987qt OBJECTIVES: Understanding how obesity-associated genes function within defined neuronal subpopulations remains a major barrier to translating human genetics into pathophysiological mechanisms. Melanocortin-4 receptor-expressing (MC4R) neurons are key regulators of energy homeostasis and represent a potential site of action for these genes. Here, we investigated whether obesity-associated ciliary genes regulate body weight through MC4R neurons in vivo, using a Cre-dependent CRISPR interference (CRISPRi) strategy that enables temporal, spatial, and cell-type-specific gene repression without permanent DNA modification. METHODS: Gene repression was achieved in MC4R neurons using a Cre-dependent CRISPRi system with AAV-delivered sgRNAs, and physiological outcomes, including body weight and body composition, were assessed following gene downregulation. RESULTS: CRISPRi-mediated repression of Mc4r in adult PVN^MC4R neurons reduced transcript and protein levels and induced progressive... https://escholarship.org/uc/item/90g987qt Thu, 22 Oct 2026 00:00:00 +0000 Diener Blake, Abbey Zhang, Zhixuan Alexandre, Coralie Gorayeb, Anne Jain, Mrinaalini Liu, Qi Pattali, Rithu Bednarska, Alicja Kaur Pandher, Parleen Zhang, Sumei Yue, Xinyu Nuñez, James Vaisse, Christian https://escholarship.org/uc/item/8h75w90t Leaky Gut, Leaky Boundaries&nbsp; https://escholarship.org/uc/item/8h75w90t Thu, 22 Oct 2026 00:00:00 +0000 Khanna, Mallika https://escholarship.org/uc/item/84f0686f Acyclovir, Citizen Science, and the Reach of HIV/AIDS Activism https://escholarship.org/uc/item/84f0686f Thu, 22 Oct 2026 00:00:00 +0000 Sullivan, Mairead https://escholarship.org/uc/item/81g6p4n2 Abstract Acute promyelocytic leukemia (APL) is driven by the oncogene PML-RARA which is generated by fusion of the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes, and which strongly interferes with downstream signalling and the architecture of multiprotein structures known as PML nuclear bodies (NBs). NB disruption is a diagnostic hallmark of APL, yet the significance of this phenomenon to disease pathogenesis and treatment response remains poorly understood. The majority of APL patients can now be cured with combination therapy with arsenic trioxide (ATO) and ATRA (All Trans-Retinoic Acid), which synergize promoting re-formation of disrupted Pml NBs. To date, the importance of NB disruption has only been studied in vitro. To address this, we generated a knock-in mouse model with targeted NB disruption achieved through mutation of key zinc-binding cysteine residues (C62A/C65A) in the RING domain of Pml. Homozygous PmlC62A/C65A mice... https://escholarship.org/uc/item/81g6p4n2 Thu, 22 Oct 2026 00:00:00 +0000 Voisset, Edwige Moravcsik, Eva Stratford, Eva W Jaye, Amie Palgrave, Christopher J Hills, Robert K Salomoni, Paolo Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Solomon, Ellen Grimwade, David https://escholarship.org/uc/item/80v7z1s8 Grounding Exercises: Embodied Data and Visceralization of Online Accounts of Dissociative Experiences.&nbsp; https://escholarship.org/uc/item/80v7z1s8 Thu, 22 Oct 2026 00:00:00 +0000 Dwyer, Kaylen https://escholarship.org/uc/item/7f07f91x <p>Demographics.</p> https://escholarship.org/uc/item/7f07f91x Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/7629p8q8 <p>Data from Correlative Molecular Analysis at Various Time Points.</p> https://escholarship.org/uc/item/7629p8q8 Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/7602v8dd Abstract The classical paradigm suggests that PML/RARA fusion protein is the main driver of pathogenesis in APL. It is believed that the fusion oncogenic protein mediates this effect by potentially repressing key myeloid maturation genes involved in differentiation processes. However, the underlying mechanism is not completely understood. We recently challenged this model re-opening fundamental questions as to understand the precise contribution of the fusion protein to leukemic transformation. This knowledge on the mechanistic pathways can lead to better tailored combinatorial therapeutics. To understand the role of the PML/RARA fusion protein in leukemogenesis, we initially did a transcriptome analysis in our murine MRP8-PML/RARA APL model. Interestingly, we observed only moderate alterations in gene expression pattern of the key myeloid genes that we thought to be actively involved in differentiation processes. Of particular note, we found... https://escholarship.org/uc/item/7602v8dd Thu, 22 Oct 2026 00:00:00 +0000 Surianarayanan, Sangeetha Gaillard, Coline M Bentley, Trevor Warr, Matthew R Fitch, Briana Geng, Huimin https://orcid.org/0000-0001-5339-5446 Passegue, Emmanuelle de Thé, Hugues Kogan, Scott C https://orcid.org/0000-0002-2395-8479 https://escholarship.org/uc/item/6xq9t0wf <p>Genes assayed with a mean target coverage of 500X.</p> https://escholarship.org/uc/item/6xq9t0wf Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/6ww7q1rp BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long COVID, has emerged as a major health problem. The pathogenesis of long COVID is unknown, but among the leading hypotheses is viral persistence. We aimed to investigate whether the use of the SARS-CoV-2 antiviral nirmatrelvir-ritonavir improved long COVID symptoms. METHODS: We conducted a double-blind, placebo-controlled, randomised trial involving adults who had developed persistent symptoms (≥12 weeks) associated with three major symptom phenotypes (cognitive, autonomic, or exercise) after acute SARS-CoV-2 infection at 69 US sites. Participants were eligible if they were 18 years or older and had a previous suspected, probable, or confirmed SARS-CoV-2 infection, as defined by the Pan American Health Organization. Eligible participants were also required to have either at least two moderate symptoms from the same phenotype or one severe phenotype-associated symptom, as identified with the Cluster... https://escholarship.org/uc/item/6ww7q1rp Thu, 22 Oct 2026 00:00:00 +0000 Baden, Lindsey R Shah, Nirav S Liu, Sean TH Cohen, Jonathan Moy, James Kumar, Andre McComsey, Grace A Chen, Peter Floris-Moore, Michelle Singer, Nora G Fernandez, Inti Slandzicki, Alex J Wiley, Zanthia Kadl, Alexandra Kaminsky, David A Hsu, Harvey Walker, Tiffany A Hope, Aluko A Ostrosky-Zeichner, Luis Goldman, Jason D Peluso, Michael J Patterson, Thomas F Parthasarathy, Sairam Mullington, Janet M Bolin, Paul Jolley, Sarah E Krishnan, Jerry A Castro, Mario Hodder, Sally L Pemu, Priscilla Chu, Helen Y Risbano, Michael G Jerath, Maya R Mylonakis, Eleftherios Hurt, Ryan T Alicic, Radica Azad, Nabila S Sala, Marc A Harkins, Michelle S Parsonnet, Jeffrey Stafford, Neil Robinson, Philip Hussain, Sabiha Qiao, Xian Hawk, Sophie Two Lillestol, Michael Erdmann, Nathan Gebo, Kelly A Sudhindra, Praveen Sassine, Joseph Marshall, Gailen D Chatterjee, Tulika Morse, Caryn G Kedar, Eyal Stringer, William W Frontera, Jennifer A Jordan, Michael Blaskewicz, Caitlin Santana, Jorge L Foot, Rachel A Wongtrakool, Cherry McCarthy, Matthew William Mehari, Alem Amon, Arch Cohen, Alison K Jain, Nita Maughan, Christine Lindsay, Doug Olson, Rachel Broderick, Samuel Rowe, Pearl O’Brien, Sean M Walt, David R Levy, Bruce D Jason, Leonard A Low, Phillip A Shibao, Cyndya A Make, Barry Bateman, Lucinda Redline, Susan Knopman, David Hernandez, Adrian F Nolen, Tracy L Reist, Craig Berdan, Lisa Whitley, Richard Zimmerman, Kanecia O Abdel-Hamid, Khaled Mohammed Aberg, Judith Adhikaram, Dushmanthi Alicic, Radica Alsoubani, Majd Amon, Arch Anderson, Jordan Antonelli, Maria Arjun, Arundhati Ayache, Mirna Aylward, Laura Azad, Nabila Azola, Alba https://escholarship.org/uc/item/6p32t95q <p>Genetic and methylation analysis across timepoints.</p> https://escholarship.org/uc/item/6p32t95q Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/6jv9n9j9 Abstract The etiology of autoimmune disease is not fully understood, but disease development is believed to be due to a combination of genetic predispositions and environmental factors. Ikaros is a transcription factor that is an important regulator of hematopoiesis and critical for development of B cells. Recent genome wide association studies have found that several autoimmune diseases are associated with SNPs annotated to the Ikaros gene (IKZF1), as well as the closely related Ikaros family member Aiolos (IKZF3). Mouse models of autoimmunity are important research tools, and we recently reported the generation of two new Ikaros-mutant mice, with targeted deletions of the exons encoding the DNA-binding zinc finger 1 (ZnF1) or ZnF4 (Schjerven et al., 2013). These deletions did not abolish B-cell development, but rather illuminated differential roles of Ikaros at different stages of early B-cell development. Interestingly, we found that one of these mouse strains displayed very... https://escholarship.org/uc/item/6jv9n9j9 Thu, 22 Oct 2026 00:00:00 +0000 Schjerven, Hilde Frietze, Seth Hai, Si-Han Hermiston, Michelle https://orcid.org/0000-0003-1790-2679 Kogan, Scott https://orcid.org/0000-0002-2395-8479 Muschen, Markus https://escholarship.org/uc/item/6gx0d4ss BACKGROUND: Interest in permanent contraception has increased in the US since the 2022 Dobbs decision restricted access to abortion in many states. Despite use of the federally mandated "consent for sterilization" form HHS-687, one of every five US patients who undergo tubal sterilization subsequently reports a desire to reverse their tubal sterilization, indicating that efforts to ensure informed decision-making before permanent contraceptive procedures remain needed. OBJECTIVES: To increase access to desired contraceptive services and knowledge of long-acting contraceptive options, we developed and evaluated the efficacy of a patient-facing educational website for patients considering tubal sterilization. STUDY DESIGN: We enrolled 350 individuals considering tubal sterilization in a randomized controlled trial. Participants allocated to the intervention group reviewed the "Advancing Access" website while the "attention control" group reviewed the federal sterilization consent... https://escholarship.org/uc/item/6gx0d4ss Thu, 22 Oct 2026 00:00:00 +0000 Schwarz, Eleanor Bimla https://orcid.org/0000-0002-9912-8236 Begna, Hannah Okobi, Agatha Chiang, Amy Treder, Kelly Sudore, Rebecca L https://orcid.org/0000-0003-4436-2209 https://escholarship.org/uc/item/66x4d2sw Abstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood. While significant progress has been made in the treatment of B-ALL, the factors that influence the development of B-ALL remain poorly understood. Epidemiological studies have established a role of early childhood infections in altering leukemia risk. The focus of these studies has been on documenting the number and timing of infectious exposures; however, the role of host immune response to infections in B-ALL development is largely unknown. Low birth levels of the immunomodulatory cytokine interleukin 10 (IL-10) are associated with a 25 fold increased risk of developing childhood B-ALL. Mechanistically, IL-10 plays a critical role in controlling the neonatal immune response to infections. Together, these findings suggest that IL-10, an important regulator of host immune responsiveness, protects against childhood B-ALL. To establish whether loss... https://escholarship.org/uc/item/66x4d2sw Thu, 22 Oct 2026 00:00:00 +0000 Fitch, Briana Hermiston, Michelle L https://orcid.org/0000-0003-1790-2679 Wiemels, Joseph L Kogan, Scott C https://orcid.org/0000-0002-2395-8479 https://escholarship.org/uc/item/66h9539s Exploring Frameworks of Neurodiversity in the Digital Era https://escholarship.org/uc/item/66h9539s Thu, 22 Oct 2026 00:00:00 +0000 Padilla, Esperanza https://escholarship.org/uc/item/5vw187qw Abstract Phosphatidylinositol 3-kinase (PI3K) signaling is essential for RAS-driven transformation. To directly investigate the role of oncogenic K-Ras binding to PI3K in development and tumorigenesis, we generated KrasG12D/+,Y64G/+ mice that express, from the endogenous locus, a K-Ras oncoprotein that also contains a “second site” amino acid substitution at tyrosine 64 (Y64G) that disrupts the interaction between oncogenic K-Ras and PI3K. Surprisingly, KrasG12D,Y64G mice are viable, fertile, and phenotypically unremarkable, although they are born at a lower than expected Mendelian frequency (26% versus the expected 50% on a C57BL/6 strain background). As opposed to the enhanced proliferative rate observed in mouse embryonic fibroblasts (MEFs) from K-RasG12D mice, KrasG12D,Y64G MEFs exhibit wild-type rates of proliferation. Detailed analysis of the hematopoietic compartment in KrasG12D,Y64G mice reveals a reduced proportion of long-term hematopoietic stem cells,... https://escholarship.org/uc/item/5vw187qw Thu, 22 Oct 2026 00:00:00 +0000 Wong, Jasmine C Perez-Mancera, Pedro A Kim, Jangkyung Jen, Kuang-Yu https://orcid.org/0000-0003-2815-5912 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Firestone, Ari J Collisson, Eric A Tuveson, David A Shannon, Kevin https://escholarship.org/uc/item/5qb7f7xv Abstract The presence in mice of progenitors that can give rise selectively to B-1 or B-2 B-cells raised the possibility that B-lymphoid neoplasms may have varied developmental origins. Prior work demonstrated that murine B-1 and B-2 progenitors of mice can both be transformed by the BCR-ABL1 oncogene and that leukemias derived from B-1 progenitors initiated more quickly than leukemias derived from B-2 progenitors (J Immunol. 2014;192:5171-8). We have recently profiled the gene expression patterns of murine B-1 and B-2 progenitors using RNA-seq and have applied the observed divergences in gene expression pattern to investigate whether varied human pediatric B-cell acute lymphoblastic leukemias (B-ALLs) might arise from human B-cell progenitors with characteristics paralleling either mouse B-1 or B-2 progenitors. Underlying these analyses is the concept that pediatric ALLs might arise from progenitors present during development that may not persist into adulthood. ... https://escholarship.org/uc/item/5qb7f7xv Thu, 22 Oct 2026 00:00:00 +0000 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Geng, Huimin https://orcid.org/0000-0001-5339-5446 Roy, Ritu Montecino-Rodriguez, Encarnacion https://orcid.org/0000-0002-2826-7503 Gaillard, Coline M Hiam, Kamir Bengtsson, Henrik Casero, David Olshen, Adam B Dorshkind, Kenneth https://escholarship.org/uc/item/5d50n1gb A second site <i>Kras^G12D</i> mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis. https://escholarship.org/uc/item/5d50n1gb Thu, 22 Oct 2026 00:00:00 +0000 Wong, Jasmine C Perez-Mancera, Pedro A Kim, Jangkyung Jen, Kuang-Yu https://orcid.org/0000-0003-2815-5912 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Firestone, Ari J Collisson, Eric A Tuveson, David A Shannon, Kevin https://escholarship.org/uc/item/56c132s7 <em>Beyond the Medical Record: A Digital Archive of Immigrant Stories from Boston Harbor Island</em>. https://escholarship.org/uc/item/56c132s7 Thu, 22 Oct 2026 00:00:00 +0000 Poemape Heredia, Sisary Penner, Louise https://escholarship.org/uc/item/5651s9g9 <p>Increasingly, biomedicine has become the hegemonic paradigm under which international institutions like the WHO approach global health problems. Technocratic frameworks position doctors and biomedical academics as “experts” whose knowledge constitutes the gold standard when designing interventions. Although biomedicine constitutes global health’s “present,” history shows that there have been (and continue to be) global traditions of healing where expert knowledge is rooted in different understandings of health and illness.</p><p>Lately, international institutions like the World Health Organization (WHO) have begun acknowledging these “alternative” frameworks, which they term “traditional, complementary, and integrative medicine (TCIM).” The WHO has integrated TCIM into its policy and practice by standardizing and benchmarking systems like Ayurvedic and traditional Chinese medicine. However, this development is recent and there is little work documenting and analyzing the organization’s... https://escholarship.org/uc/item/5651s9g9 Thu, 22 Oct 2026 00:00:00 +0000 Chou, Sutina https://escholarship.org/uc/item/54x0323w Abstract Objectives. The causes of ALL are determined in part by genetic factors but less clear is the role of the environment. Temporal and demographic changes in incidence may help illuminate causes and help direct new lines of research. We sought to investigate in the US from 2000-2016, 1) the distribution of ALL incidence by race/ethnicity, 2) trend change in ALL incidence and 3) the association between ALL incidence and location of birth (US or a foreign country) among different ages and race/ethnicity groups. Methods. We used data from the population-based Surveillance, Epidemiology and End Results (SEER) Registry. Age-adjusted incidence rates (AAIRs) per 100,000 persons were calculated for people of Latino ethnicity (all races), Non-Latino (NL) White, NL Black, NL Asian and Pacific Islander (API), NL American Indian, and Alaskan Native (AIAN). Trends of ALL from 2000 to 2016 were evaluated with the annual percent change (APC) of AAIRs. We further used... https://escholarship.org/uc/item/54x0323w Thu, 22 Oct 2026 00:00:00 +0000 Feng, Qianxi Vergara-Lluri, Maria Muskens, Ivo McKean-Cowdin, Roberta Kogan, Scott https://orcid.org/0000-0002-2395-8479 Brynes, Russell de Smith, Adam Wiemels, Joseph https://escholarship.org/uc/item/4q69g3hp <p>SRC proto-oncogene, non-receptor tyrosine kinase expression in scRNAseq.</p> https://escholarship.org/uc/item/4q69g3hp Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/364484gn Neural crest cells, a multipotent vertebrate stem cell population, undergo a tightly regulated epithelial-mesenchymal transition (EMT) to delaminate from the neural tube and initiate migration. Neural crest EMT is controlled by a transient pulse of <i>Draxin</i>, which acts as a molecular rheostat of canonical Wnt signaling, and is then rapidly downregulated by unknown mechanisms. To address this, here we use in vivo reporter assays and live RNA imaging to show that <i>Draxin</i> mRNA is rapidly degraded posttranscriptionally via its 3' untranslated region. We found that <i>Draxin</i> transcripts are targeted to cytoplasmic processing bodies (P-bodies), which are membrane-less sites of RNA processing and decay. Disruption of P-bodies by CRISPR/Cas9-mediated depletion of the RNA helicase DDX6 prevented posttranscriptional downregulation of <i>Draxin</i> and impaired neural crest EMT in vivo. These findings parallel observations in human patients carrying <i>DDX6</i> mutations,... https://escholarship.org/uc/item/364484gn Thu, 22 Oct 2026 00:00:00 +0000 Rajan, Arvind Arul Nambi Piacentino, Michael L Bronner, Marianne E Hutchins, Erica J https://orcid.org/0000-0002-4316-0333 https://escholarship.org/uc/item/35k1k5k3 Here, we present a protocol for assessing endolysosomal chloride channel function in mammalian cells using the endolysosomal patch-clamp technique. We describe steps for vesicle enlargement, fabrication and fire-polishing of high-resistance pipettes, and mechanical dissection and isolation of enlarged vesicles. We then detail procedures for giga-seal formation and configuration to whole-endolysosome modes. For complete details on the use and execution of this protocol, please refer to Wang et al.¹. https://escholarship.org/uc/item/35k1k5k3 Thu, 22 Oct 2026 00:00:00 +0000 Wang, Yayu Jan, Lily Yeh https://escholarship.org/uc/item/2rb1q5h8 Not available. https://escholarship.org/uc/item/2rb1q5h8 Thu, 22 Oct 2026 00:00:00 +0000 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 https://escholarship.org/uc/item/2jv3q2rz Objective: To describe trends in the prevalence of tubal sterilization and subsequent desire for reversal among US women and identify sociodemographic factors associated with desires for reversal. Design: Nationally representative data were collected from US women between 2006 and 2023 in a series of six cross-sectional waves of the National Survey of Family Growth. We employed weighted logistic regression models to assess associations between sociodemographic variables and outcomes of interest. Subjects: Nationally representative samples of US women aged 15<b>-</b>49 surveyed between 2006 and 2023. Exposure: Sociodemographic variables including age at interview, race and ethnicity, health insurance status, poverty level, education, marital status, parity, and timing of sterilization. Main Outcome Measures: Tubal sterilization, desire for tubal reversal surgery, and experience with tubal reversal surgery. Results: In 2022-2023, 21.3% of US individuals who had undergone tubal sterilization... https://escholarship.org/uc/item/2jv3q2rz Thu, 22 Oct 2026 00:00:00 +0000 Chiang, Amy Yunyu Gariepy, Aileen M Leon-Martinez, Daisy Treder, Kelly M Schwarz, Eleanor Bimla https://orcid.org/0000-0002-9912-8236 https://escholarship.org/uc/item/25k0k054 <p>Qualitative and Quantitative Summary of Abnormal Peripheral Blood and Bone Marrow Findings.</p> https://escholarship.org/uc/item/25k0k054 Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/1pv0z75v Abstract Background: Epidemiologic evidence points to a role for infection and immune development in childhood acute lymphoblastic leukemia (ALL). Emerging evidence suggests that in utero immunosuppressive processes, along with immaturity at birth, cause immune hyporesponsiveness to commensal microbes and susceptibility to early childhood infections. A key regulator of active immunosuppression within the neonatal environment is arginase 2, which is produced by CD71+ erythroid cells and myeloid-derived suppressor cells. Arginase-dependent arginine depletion is suspected to aggravate both infections and tumor growth (the latter in adult settings) due to suppressed T-cell function by downregulation of TCR-CD3ζ. Studies have shown that immune vulnerability of the preterm neonate is critically related to arginase-dependent arginine depletion, but none have investigated this neonatal immunosuppression in relation to ALL. Methods: Children were identified... https://escholarship.org/uc/item/1pv0z75v Thu, 22 Oct 2026 00:00:00 +0000 Nielsen, Amalie B Zhou, Mi Smith, Adam de McCoy, Lucie Hansen, Helen Bracci, Paige Morimoto, Libby Kogan, Scott https://orcid.org/0000-0002-2395-8479 Metayer, Catherine Ma, Xiaomei Wiemels, Joseph https://escholarship.org/uc/item/0xx7v1c4 <p>Changes in MIB binding ordered by p value (unpaired t-tests of log2LFQ).</p> https://escholarship.org/uc/item/0xx7v1c4 Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/0wf21407 Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with T lineage ALL (T-ALL) accounting for approximately 20% of cases. Many T-ALL patients present with high risk clinical features, and receive aggressive multi-agent genotoxic therapies that pose a substantial risk of long-term adverse health effects. Glucocorticoids (GCs) are an integral part of current treatment strategies for T-ALL and other lymphoid cancers. Despite decades of clinical use, the molecular mechanisms underlying GC efficacy and resistance are incompletely understood. Limited initial response to GCs correlates with poor outcome, and secondary GC resistance is frequently observed in relapsed patients. Thus, identifying drugs that either enhance initial responses or prevent resistance to GCs could significantly improve the treatment of T-ALL and other lymphoid malignancies. Our laboratory performed retroviral insertional mutagenesis (RIM) in wild-type (KrasWT) and... https://escholarship.org/uc/item/0wf21407 Thu, 22 Oct 2026 00:00:00 +0000 Wandler, Anica M Huang, Benjamin https://orcid.org/0000-0001-6996-0833 Scacchetti, Alessandro Craig, Jeff Yan, Hannah Monsalve, Gabriela Li, Qing Dail, Monique Wong, Jasmine C Nakitandwe, Joy Weinberg, Olga Hasserjian, Robert P Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Sampath, Deepak Downing, James R Yamamoto, Keith Taylor, Barry S Aster, Jon C Zhang, Jinghui Shannon, Kevin https://escholarship.org/uc/item/0v20s690 <p>Representativeness of Study Participants.</p> https://escholarship.org/uc/item/0v20s690 Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/0kg1b0pr 37.1 Untangling Symptom Spaghetti: Examining the Overlap Between Rating Scales for Impulsive Aggression and Diagnostic Criteria https://escholarship.org/uc/item/0kg1b0pr Thu, 22 Oct 2026 00:00:00 +0000 Langfus, Joshua https://escholarship.org/uc/item/03m3q3pg <p>Adverse events, grade 3+ with attribution of possible, probable, or definite.</p> https://escholarship.org/uc/item/03m3q3pg Thu, 22 Oct 2026 00:00:00 +0000 Stieglitz, Elliot https://orcid.org/0000-0001-7032-4623 Lee, Alex G https://orcid.org/0000-0003-0107-5920 Angus, Steven P https://orcid.org/0000-0002-7655-657X Davis, Christopher https://orcid.org/0009-0004-7226-3819 Barkauskas, Donald A https://orcid.org/0000-0002-2339-719X Hall, David https://orcid.org/0000-0003-1257-2316 Kogan, Scott C https://orcid.org/0000-0002-2395-8479 Meyer, Julia https://orcid.org/0000-0001-5945-9885 Rhodes, Steven D https://orcid.org/0000-0002-6551-8631 Tasian, Sarah K https://orcid.org/0000-0003-1327-1662 Xuei, Xiaoling https://orcid.org/0000-0002-4143-2024 Shannon, Kevin https://orcid.org/0000-0003-4299-1773 Loh, Mignon L https://orcid.org/0000-0003-4099-4700 Fox, Elizabeth https://orcid.org/0000-0002-9998-5326 Weigel, Brenda J https://orcid.org/0000-0003-1080-1402 https://escholarship.org/uc/item/62k7c755 Families in unincorporated communities in Southern California’s Eastern Coachella Valley (ECV) increasingly experience the burden of repeat wildfires and smoke. This study describes their lived wildfire and smoke experiences, health impacts, unique community-level inequities that compound wildfire risk and air quality effects, communication preferences, and resource needs for future wildfire preparedness. A wildfire community vulnerability framework informed the focus group discussion guide, exploring individual, community, and local government level factors that potentially influence community response and mitigation behaviors to repeat wildfire and smoke. Ten focus groups with 118 participants occurred in spring 2023 with four communities in ECV, California. Findings center on narratives of acute wildfire-related experiences, including evacuation and burned trailer homes, acute and chronic self report physical and mental health impacts of wildfires and smoke, daily life disruptions,... https://escholarship.org/uc/item/62k7c755 Wed, 21 Oct 2026 00:00:00 +0000 Hopfer, Suellen https://orcid.org/0000-0003-3232-9743 Jiao, Anqi Li, Mengyi Vargas, Anna Lisa Wu, Jun https://orcid.org/0000-0002-2693-7112 https://escholarship.org/uc/item/3c3783rt Macrolide antibiotics are a class of structurally diverse polyketides including essential medicines like erythromycin and azithromycin. Structurally minimal macrolides such as narbomycin lack much of the functionality common to other members of the class and exhibit a distinct mode of action wherein they completely inhibit bacterial growth despite only moderate inhibition of global protein synthesis. Unfortunately, lack of availability of these natural products has prevented a thorough investigation of their unusual mechanisms of action. Here we report a 10-step synthesis of narbomycin enabled by a Liebeskind-Srogl fragment coupling, a novel macrolactonization by direct displacement of an Evans auxiliary, and a stereoselective late-stage enone reduction. In addition to accessing the natural product, the route enables access to C8,19-unsaturated variants which could in principle serve as useful precursors for late-stage functionalization by conjugate addition. https://escholarship.org/uc/item/3c3783rt Wed, 21 Oct 2026 00:00:00 +0000 Edmondson, Quinn Panfil, Cecilia Keyes, Jasmine K Ecker, Andrew K Settineri, Nicholas S Seiple, Ian B https://escholarship.org/uc/item/1k3887t5 Understanding factors associated with wildfire risk perception and preferences for risk communication strategies is crucial for promoting individual risk reduction behaviors and enhancing educational campaigns. Given a lack of research focusing on disadvantaged communities with low socioeconomic status, we administered an in-person survey from February to April 2023 in four unincorporated communities in Eastern Coachella Valley to collect information on wildfire experiences and community preparedness. We used multivariate logistic regressions to identify potential predictors of wildfire risk perception, such as sociodemographic characteristics, previous wildfire experiences, and social participation. We performed Chi-square or Fisher's exact tests to examine whether preferences for risk communication varied across sociodemographic groups. Among 115 participants with wildfire experiences, 113 (98.3&nbsp;%) were self-identified as Hispanic/Latino and 69 (60.0&nbsp;%) had an annual... https://escholarship.org/uc/item/1k3887t5 Wed, 21 Oct 2026 00:00:00 +0000 Jiao, Anqi Vargas, Anna Lisa Gluhova, Yuliya D Headon, Kathryne Rangel, Lilia Abdallah, Sara Ramsey, Erika C Truong, Keira Chal, Aiden M Hopfer, Suellen https://orcid.org/0000-0003-3232-9743 Wu, Jun https://orcid.org/0000-0002-2693-7112 https://escholarship.org/uc/item/0k92s1k0 OBJECTIVE: While most people in the United States obtain abortion care in outpatient settings, such facilities may limit care for some individuals because of a variety of conditions. The situations when abortion care cannot be obtained in the outpatient setting have not been evaluated, leaving a deficit in understanding the need for hospital-based abortion care. METHODS: We obtained outpatient abortion facility care protocols from the Society of Family Planning #We Count project, which, in January 2024, invited participating organizations with outpatient physical facilities to share their protocols for determining when patients were unable to be cared for in their facility(ies). Using summative content analysis, we identified health conditions for which a patient could be deemed ineligible, organizing individual conditions thematically and, as appropriate, by organ system. RESULTS: We analyzed 20 unique protocols. Protocols delineated ineligibility for temporary conditions (e.g.,... https://escholarship.org/uc/item/0k92s1k0 Wed, 21 Oct 2026 00:00:00 +0000 Kimport, Katrina https://orcid.org/0000-0001-7472-3074 Chen, Melissa J https://orcid.org/0000-0002-4569-5614 Creinin, Mitchell D https://orcid.org/0000-0001-5967-8180 https://escholarship.org/uc/item/7zc7m06g Cannabis as a Nicotine Cessation Aid: Prevalence of Use and Potential Consequences in a Survey of US Adults https://escholarship.org/uc/item/7zc7m06g Thu, 15 Oct 2026 00:00:00 +0000 Halliday, Deanna M Wu, Stephanie Nguyen, Nhung Hoggatt, Katherine J Keyhani, Salomeh Cohen, Beth E https://escholarship.org/uc/item/8xq069kh Gene-Environment Interaction in Nonfamilial Corticobasal Syndrome in Monozygotic Twins With Differential Occupational Exposure https://escholarship.org/uc/item/8xq069kh Tue, 13 Oct 2026 00:00:00 +0000 Chen, Yu https://orcid.org/0000-0001-5863-7002 Pham, Hieu Rabkina, Liya Weigand, Alexandra J Lane-Donovan, Courtney Snyder, Allison Ljubenkov, Peter Alexander Rojas, Julio C Lee, Suzee E Rabinovici, Gil Dan https://orcid.org/0000-0002-3626-4265 Yokoyama, Jennifer S https://orcid.org/0000-0001-7274-2634 Dratch, Laynie Mcmillan, Corey T Suh, Eunran Van Deerlin, Vivianna M Irwin, David John Ulugut, Hulya Tee, Boon Lead Rankin, Katherine P https://orcid.org/0000-0002-3611-0848 Seeley, William W Gorno-Tempini, Maria Luisa Rosen, Howard J https://orcid.org/0000-0001-9281-7402 Miller, Bruce L https://orcid.org/0000-0002-2152-4220 Boxer, Adam L VandeVrede, Lawren https://orcid.org/0000-0002-8304-6711 https://escholarship.org/uc/item/7ct8121j Background: At the University of California, San Francisco (UCSF), college students in the Patient Support Corps learn by helping patients navigate their care. This report focuses on how Patient Support Corps students help patients whose primary care physicians referred them to UCSF’s Integrated Behavioral Health program. We summarize the disposition of these primary care physician referrals. We also describe programmatic efforts to assure that UCSF connects all referrals to behavioral health care, whether at UCSF or externally. Methods: We counted the referrals to UCSF’s Integrated Behavioral Health program between August 2025 and May 2026. Then we determined the number of patients scheduled for care at UCSF, along with the barriers to successful scheduling. We ascertained what support the program’s staff and student navigators were able to provide patients not scheduled for care at UCSF. Student navigators also reflected on their efforts to promote equitable access to behavioral... https://escholarship.org/uc/item/7ct8121j Tue, 13 Oct 2026 00:00:00 +0000 Belkora, Jeff https://orcid.org/0000-0002-0719-4325 Duaybis, Daniel Davila Escorza, Suzette Phan, Catherine Chun, Leo Santos, Virly Zhou, Yingyi Ramos, Joshua Saldana, Emily LoCicero, Zoe Perez Maldonado, Kimberly Arroyo Reyes, Lizeth Atadaini, John Aguilar Ortiz, Damaris Wang, Evelyn Tacla, Janbrylle Rios-Savanapridi, Shavalee Duong, Tammy https://escholarship.org/uc/item/1960g0mp Right Care at the Right Time: Student Healthcare Navigators Reduce Patient Wait Times for Behavioral Healthcare https://escholarship.org/uc/item/1960g0mp Tue, 13 Oct 2026 00:00:00 +0000 Duaybis, Daniel Tacla, J Davila Escorza, S Reyes, D Ramos, J Perez Maldonado, K LoCicero, Z Saldana, E Chun, L Phan, C Aguilar Ortiz, D Atadaini, J Nguyen, C Zhou, Yingyi Santos, Virly Brody, Helen Rios-Savanapridi, S Duong, Tammy Belkora, Jeff https://escholarship.org/uc/item/49m4f2zn Antimicrobial resistance poses an urgent threat to global health. The development of new antimicrobials is crucial. Synthetic copolymers are attractive as a potential tool because they can be produced at scale and designed to mimic antimicrobial peptides and act as broad-spectrum antimicrobials capable of evading resistance mechanisms. This work leverages a cross-molecular machine learning pipeline, trained on antimicrobial peptides, to develop potent antimicrobial polymers—which were then synthesized and validated experimentally—to combat Escherichia coli. Crucially, all polymers predicted by the active learning pipeline during exploitation sampling exhibited impressive antimicrobial activity. One candidate copolymer was further characterized and shown to permeabilize the bacterial membrane, which is associated with decreased resistance. Furthermore, this copolymer demonstrated remarkable synergy in eradicating biofilm-associated E. coli when combined with a clinical drug regimen.... https://escholarship.org/uc/item/49m4f2zn Mon, 12 Oct 2026 00:00:00 +0000 Williams, Shoshana C https://orcid.org/0000-0001-5669-6340 Makar-Limanov, Anna Greenstein, Gabriel Liu, Xinyu Fragasso, Alessio Ganesh, Priya Eckman, Noah Prossnitz, Alexander N Dong, Changxin Jacobs-Wagner, Christine Cegelski, Lynette Hernandez, Hector Lopez Appel, Eric A https://escholarship.org/uc/item/5t72d7v3 Collaborative Care Goes Global https://escholarship.org/uc/item/5t72d7v3 Fri, 9 Oct 2026 00:00:00 +0000 Acharya,, Bibhav https://escholarship.org/uc/item/4qx1s12n Therapeutic Efficacy of NSI-189 against Diabetic Neuropathy and Encephalopathy in Mice https://escholarship.org/uc/item/4qx1s12n Fri, 9 Oct 2026 00:00:00 +0000 Jolivalt, Corinne G https://orcid.org/0000-0003-4391-1341 Marquez, Alex Anaya, Carlos Kifle, Betelhem Muttalib, Nabeel Hefferan, Michael Johe, Karl Calcutt, Nigel A https://orcid.org/0000-0001-8458-8195 https://escholarship.org/uc/item/9903s4f9 In this narrative medicine essay, the author discusses the inaccuracies of generational stereotypes and unfounded criticisms about trainees, and the problems that faculty members who voice these criticisms can cause among physicians. https://escholarship.org/uc/item/9903s4f9 Thu, 8 Oct 2026 00:00:00 +0000 Dhaliwal, Gurpreet https://escholarship.org/uc/item/7hf4g216 The Supporting Our Ladies And Reducing Stress to prevent preterm birth (SOLARS) Feasibility Study utilized three strategies to recruit Black and Latina/x women in a biospecimen study: individual (warm hand-off from community partner); group (attend group sessions to discuss study), and tabling (setting up a table at a clinic or community event). Additionally, we combined individual&nbsp;+&nbsp;group and individual&nbsp;+&nbsp;group&nbsp;+&nbsp;tabling strategies. Using these strategies, 35 women were recruited, where 32 completed survey and biospecimen at two timepoints across their pregnancies. Findings from our study support that using a reproductive justice framework is an effective strategy to build trust and increase participation in biospecimen studies among communities of color. https://escholarship.org/uc/item/7hf4g216 Thu, 8 Oct 2026 00:00:00 +0000 Chambers Butcher, Brittany D Arabia, Silvia E Arcara, Jennet Arega, Helen A Delgado, Ana Bell, Amber Camara, Tanefer Carrasco, Zoe Clary, Chakiya Robertson, Kellye Craig Flowers, Elena Henderson, Jaontra Jackson, Andrea V Kitt, Bonita Kober, Kord M https://orcid.org/0000-0001-9732-3321 McKenzie-Sampson, Safyer Mitchell, Alexandra Negrete, Gabriela Oseguera, Talita Wells Taylor, Brianne Scott, Karen A Stanley, Darcy Sucher, Anatol Waters, Sonia Spellen, Solaire A Cobbins, Alexis McLemore, Monica R Gomez, Anu Manchikanti https://orcid.org/0000-0002-9461-4411 https://escholarship.org/uc/item/66n920m4 As quality metrics become more tightly linked to reimbursement and reputation, medical educators face the growing challenge of teaching clinical medicine in the context of policy-driven mandates. The Centers for Medicare and Medicaid Services sepsis bundle (SEP-1) requires physicians to execute time-bound interventions with little flexibility, while clinicians’ professional duty compels them to individualize care based on evidence, comorbidities, and evolving best practices. This perspective explores how educators can prepare trainees to recognize when clinical actions are grounded in evidence-based practice, professional judgment, or the demands of a protocol. Teachers should become skilled at narrating the moments when clinical care and compliance overlap, diverge, or conflict. Post hoc reflection plays a critical role in consolidating these lessons, allowing trainees to explore trade-offs and question assumptions. Medical educators must guide learners through today’s system... https://escholarship.org/uc/item/66n920m4 Thu, 8 Oct 2026 00:00:00 +0000 Zapata, Josué Dhaliwal, Gurpreet https://escholarship.org/uc/item/4x30w8gj The DEAD-box ATPase Dhh1 (DDX6 in humans) is a general activator of 5'-3' mRNA decay that acts between the deadenylation and decapping steps of the pathway, although the exact mechanism of its action remains unclear. Dhh1 has been shown to interact with the MIF4G domain of the central scaffold protein of the Ccr4-Not deadenylase complex, Not1, as well as the decapping activator Edc3. Although structures have been published of Dhh1 in complex with Not1MIF4G or an Edc3 peptide, the impact of these interactions on the catalytic cycle of Dhh1 are unknown. Here, we show that cEdc3 enhances ATP and RNA binding by Dhh1, whereas Not1MIF4G promotes the catalytic step of ATP hydrolysis. Additionally, the modulation of Dhh1 activity by Edc3 requires a more extensive set of interaction motifs and interfaces than was previously recognized. While the effect of either Not1MIF4G or Edc3 on the ATPase activity of Dhh1 is modest, together both proteins increase Dhh1 activity over 200-fold. The... https://escholarship.org/uc/item/4x30w8gj Thu, 8 Oct 2026 00:00:00 +0000 Braun, Gabriel A Kumar, Rakesh Hinnebusch, Alan G Gross, John D https://escholarship.org/uc/item/3k59m102 INTRODUCTION: The United States is a global anomaly in its lack of postpartum care. Community midwives' scope of practice generally includes maternal and infant care until 6 weeks after birth, although research on community midwifery postpartum care in the United States has been limited. The purpose of this analysis was to further describe community midwifery postpartum care using a national quantitative data set. METHODS: This analysis uses data from the Midwives Alliance of North America Statistics Project, birth years 2004 to 2009. The data include 20,720 pregnancies, with home or birth center as the planned place of birth at the onset of labor. We used standard descriptive statistics. The main variables of interest to characterize postpartum care were the number of postpartum care visits and the number of weeks of postpartum care. We used Kruskal-Wallis tests to assess whether number of visits or number of weeks of postpartum care varied by subgroup. RESULTS: Breastfeeding... https://escholarship.org/uc/item/3k59m102 Thu, 8 Oct 2026 00:00:00 +0000 Thompson‐Lastad, Ariana Bovbjerg, Marit L Harrison, Jessica M Taiwo, Tanya Khemet Erickson, Elise Cheyney, Melissa https://escholarship.org/uc/item/38v337v2 Abstract Introduction SARS-CoV-2-CoV-2 infection is known to induce autoantibodies across a wide range of targets, including immune modulatory proteins and pro-thrombotic factors. It is not known if vaccination with SARS-CoV-2 mRNA vaccines would induce a similar autoantibody profile, or whether prior vaccination would protect recipients from autoantibody production upon SARS-CoV-2 infection. Methods Our group followed a cohort of over 65,000 blood donors across repeat donations in the COVID-19 era. We identified SARS-CoV-2 naïve donors who were infected without prior vaccination (n = 150) or were vaccinated then became infected (n = 100). We tested samples from the naïve time point and 6-10 weeks after infection (2 paired samples) or naïve then vaccination then infection (three samples) using a T7 bacteriophage array displaying 731,724 peptides (49 amino acids each) spanning the human proteome. Data were partitioned into five random groups and peptide comparisons between groups... https://escholarship.org/uc/item/38v337v2 Thu, 8 Oct 2026 00:00:00 +0000 Norris, Philip https://orcid.org/0000-0003-0526-2088 Zheng, Jiashun Bodansky, Aaron Grebe, Eduard Sulaeman, Hasan Deng, Xutao Kleinman, Steven Spencer, Bryan Reese, Sarah Di Germanio, Clara Stone, Mars Busch, Michael DeRisi, Joseph https://orcid.org/0000-0002-4611-9205 https://escholarship.org/uc/item/2c9689fr BACKGROUND: Synthetic biology involves combining different DNA fragments, each containing functional biological parts, to address specific problems. Fundamental gene-function research often requires cloning and propagating DNA fragments, such as those from the iGEM Parts Registry or Addgene, typically distributed as circular plasmids. Addgene's repository alone offers around 150,000 plasmids. To ensure data integrity, cryptographic checksums can be calculated for the sequences. Each sequence has a unique checksum, making checksums useful for validation and quick lookups of associated annotations. For example, the SEGUID checksum uniquely identifies protein sequences with a 27-character string. OBJECTIVES: The original SEGUID, while effective for protein sequences and single-stranded DNA (ssDNA), is not suitable for circular DNA since there is no natural starting position nor for double-stranded DNA (dsDNA) since two separate sequences are present. Challenges include how to uniquely... https://escholarship.org/uc/item/2c9689fr Thu, 8 Oct 2026 00:00:00 +0000 Pereira, Humberto Silva, Paulo César Davis, M Wayne Abraham, Louis Babnigg, György Bengtsson, Henrik Johansson, Björn https://escholarship.org/uc/item/1m90m4x9 An 81-year-old man with a history of high-grade urothelial carcinoma of the bladder and ureter on treatment with atezolizumab and tiragolumab presented to the emergency department with 5 months of malaise, generalized weakness, and fatigue and 2 weeks of subjective fevers. One month prior to presentation, he received an empiric 9-day course of levofloxacin for possible epididymitis based on&nbsp;scrotal pain and an ultrasound showing mild bilateral epididymal prominence. Blood and urine cultures were negative. His constitutional symptoms persisted, and he developed a subjective fever 2 weeks prior to presentation. He was admitted for further evaluation. https://escholarship.org/uc/item/1m90m4x9 Thu, 8 Oct 2026 00:00:00 +0000 Roudsari, Hadi Dhaliwal, Gurpreet Jagannath, Anand D Baik, Alan H https://orcid.org/0000-0001-8840-8825 Brondfield, Sam https://escholarship.org/uc/item/20n73861 Background: Parental feeding practices are thought to influence children's weight status, through children's eating behavior and nutritional intake. However, because most studies have been cross-sectional, the direction of influence is unclear. Moreover, although obesity rates are high among Latino children, few studies of parental feeding practices have focused on this population. Methods: This 2-year longitudinal study examined mutual influences over time between parental feeding practices and children's weight status, in Mexican American families with children 18 years old at baseline. Mothers (n = 322) and fathers (n = 182) reported on their feeding practices at baseline, 1-year follow-up, and 2-year follow-up. Weight status, defined by waist-height ratio (WHtR) and body mass index (BMI), was ascertained at all assessments. Cross-lagged panel models were used to examine the mutual influences of parental feeding practices and child weight status over time, controlling for covariates.... https://escholarship.org/uc/item/20n73861 Tue, 6 Oct 2026 00:00:00 +0000 Tschann, JM Martinez, SM https://orcid.org/0000-0001-7864-1391 Penilla, C https://orcid.org/0000-0002-2212-5432 Gregorich, SE Pasch, LA de Groat, CL Flores, E Deardorff, J Greenspan, LC Butte, NF https://escholarship.org/uc/item/530551c0 Aggressive-variant prostate cancer (AVPC) is characterized by several high-risk features and is typically treated with chemotherapy. In this study, we evaluated the outcomes of patients with AVPC who received prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT). <b>Methods</b>: This retrospective study included patients with AVPC with metastatic castration-resistant prostate cancer who received PSMA RLT at 3 academic centers. Patients with AVPC were further stratified into 2 subcategories: AVPC-C (clinicopathologic), referring to patients who met AVPC on the basis of clinical or pathologic features, and AVPC-MS (molecular signature), referring to patients who met AVPC criteria on the basis of genomic alterations. Prostate-specific antigen (PSA) response was calculated in the overall cohort, and PSA progression-free survival and overall survival (OS) were calculated in the paired cohort. In the segmentation cohort, SUV_mean and total tumor volume... https://escholarship.org/uc/item/530551c0 Mon, 5 Oct 2026 00:00:00 +0000 Moradpour, Moein Moradi Tuchayi, Abuzar Yadav, Surekha Jiang, Fei https://orcid.org/0000-0001-6244-7877 Burger, Irene A Pop, Sabin George Surasi, Devaki Shilpa Hussein, Akram Arora, Ishan Aparicio, Ana de Kouchkovsky, Ivan Flavell, Robert R https://orcid.org/0000-0002-8694-1199 Hope, Thomas A https://escholarship.org/uc/item/0mt4w6jj Pre-Health Students Help Patients in their Search for Living Kidney Donors https://escholarship.org/uc/item/0mt4w6jj Thu, 1 Oct 2026 00:00:00 +0000 Camarena, Alondra https://orcid.org/0009-0003-8742-8674 Shabbir, zain Pham, Han Carpio Sandoval, Nelson Webber, Allison Sood, Puneet Mello, Anna Light, Carolyn Adey, Deborah Brar, Amarpali Whelan, Adrian Oveyssi, Justin Martinez, Brianna David, Kaelin Bolanos Lopez, Ricardo Salazar, Darleen Huang, Heidi Addo, Ohemaa Lam, Calista Bareng, Jaiden Barrera, Julieta Chen, Angela Fontao, Adrian Nijagal, Senna Zantua, Brysbaine Ku, Elaine Freise, Chris Belkora, Jeff https://escholarship.org/uc/item/23n146vz Despite decades of evidence supporting methadone as a life-saving treatment for opioid use disorder, its delivery in the US has been stymied by stigmatizing dispensation policies that are neither evidence-based nor person-centered. Implementation failures and regulatory challenges have resulted in a significant treatment gap in the US and less than 30% of people with OUD enter and remain in treatment. In this article, we provide a historical overview of the methadone treatment (MT) system in the US and outline why it requires de-implementation. We present the COVID-19 public health emergency as a naturalistic experiment in de-implementation, outline evidence from this period on how COVID-19 related flexibilities influenced treatment outcomes and patient experiences and present a de-implementation framework to contextualize these changes while imagining further expansion of de-implementation efforts to support sustained change. We highlight how patient advocacy can shape further... https://escholarship.org/uc/item/23n146vz Wed, 30 Sep 2026 00:00:00 +0000 Roberts, Kate https://orcid.org/0000-0001-7021-2920 Goodman, Andrew Ferguson, Aaron Kaminski, Axl Spellman, Tamika Luba, Rachel https://escholarship.org/uc/item/9tt8v6qc BACKGROUND: The impact of depressive symptoms and anxiety on rural patients' decisions to seek care for worsening heart failure (HF) symptoms remains unknown. The purposes of this study were (1) to describe rural patients' reasons for delay in seeking care for HF, and (2) to determine whether depressive symptoms or anxiety was associated with patients' reasons for delay in seeking medical care for worsening symptoms. METHODS: A total of 611 rural HF patients were included. Data on reasons for patient delay in seeking medical care (The Reasons for Delay Questionnaire), depressive symptoms (PHQ-9), and anxiety (BSI-ANX) were collected. Statistical analyses included chi-square and multiple regression. RESULTS: A total of 85.4% of patients reported at least 1 reason for delay. Patients with higher levels of depressive symptoms were more likely to cite embarrassment, problems with transportation, and financial concerns as a reason for delay. Patients with anxiety not only cited nonsymptom-related... https://escholarship.org/uc/item/9tt8v6qc Tue, 29 Sep 2026 00:00:00 +0000 Lin, Chin‐Yen Dracup, Kathleen Pelter, Michele M Biddle, Martha J Moser, Debra K https://escholarship.org/uc/item/33r1w8wr Introduction: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp). Methods: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD&nbsp;=&nbsp;0 [<i>N</i>&nbsp;=&nbsp;101]; prodromal: 0.5 [<i>N</i>&nbsp;=&nbsp;49]; symptomatic ≥1 [<i>N</i>&nbsp;=&nbsp;51]; not measured [<i>N</i>&nbsp;=&nbsp;13]) were asked to complete ALLFTD-mApp tests on their smartphone three times within 12 days. They completed smartphone familiarity and participation experience surveys. Results: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered... https://escholarship.org/uc/item/33r1w8wr Tue, 29 Sep 2026 00:00:00 +0000 Taylor, Jack Carson Heuer, Hilary W Clark, Annie L Wise, Amy B Manoochehri, Masood Forsberg, Leah Mester, Carly Rao, Meghana Brushaber, Daniell Kramer, Joel Welch, Ariane E Kornak, John https://orcid.org/0000-0002-0089-0619 Kremers, Walter Appleby, Brian Dickerson, Bradford C Domoto‐Reilly, Kimiko Fields, Julie A Ghoshal, Nupur Graff‐Radford, Neill Grossman, Murray Hall, Matthew GH Huey, Edward D Irwin, David Lapid, Maria I Litvan, Irene https://orcid.org/0000-0002-3485-3445 Mackenzie, Ian R Masdeu, Joseph C Mendez, Mario F Nevler, Naomi Onyike, Chiadi U Pascual, Belen Pressman, Peter Rankin, Katherine P https://orcid.org/0000-0002-3611-0848 Ratnasiri, Buddhika Rojas, Julio C Tartaglia, Maria Carmela Wong, Bonnie Gorno‐Tempini, Maria Luisa Boeve, Bradley F Rosen, Howard J https://orcid.org/0000-0001-9281-7402 Boxer, Adam L Staffaroni, Adam M https://escholarship.org/uc/item/2db2p1k7 The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations... https://escholarship.org/uc/item/2db2p1k7 Tue, 29 Sep 2026 00:00:00 +0000 Thompson, Paul M Stein, Jason L Medland, Sarah E Hibar, Derrek P Vasquez, Alejandro Arias Renteria, Miguel E Toro, Roberto Jahanshad, Neda Schumann, Gunter Franke, Barbara Wright, Margaret J Martin, Nicholas G Agartz, Ingrid Alda, Martin Alhusaini, Saud Almasy, Laura Almeida, Jorge Alpert, Kathryn Andreasen, Nancy C Andreassen, Ole A Apostolova, Liana G Appel, Katja Armstrong, Nicola J Aribisala, Benjamin Bastin, Mark E Bauer, Michael Bearden, Carrie E Bergmann, Ørjan Binder, Elisabeth B Blangero, John Bockholt, Henry J Bøen, Erlend Bois, Catherine Boomsma, Dorret I Booth, Tom Bowman, Ian J Bralten, Janita Brouwer, Rachel M Brunner, Han G Brohawn, David G Buckner, Randy L Buitelaar, Jan Bulayeva, Kazima Bustillo, Juan R Calhoun, Vince D Cannon, Dara M Cantor, Rita M Carless, Melanie A Caseras, Xavier Cavalleri, Gianpiero L Chakravarty, M Mallar Chang, Kiki D Ching, Christopher RK Christoforou, Andrea Cichon, Sven Clark, Vincent P Conrod, Patricia Coppola, Giovanni https://orcid.org/0000-0003-2105-1061 Crespo-Facorro, Benedicto Curran, Joanne E Czisch, Michael Deary, Ian J de Geus, Eco JC den Braber, Anouk Delvecchio, Giuseppe Depondt, Chantal de Haan, Lieuwe de Zubicaray, Greig I Dima, Danai Dimitrova, Rali Djurovic, Srdjan Dong, Hongwei Donohoe, Gary Duggirala, Ravindranath Dyer, Thomas D Ehrlich, Stefan Ekman, Carl Johan Elvsåshagen, Torbjørn Emsell, Louise Erk, Susanne Espeseth, Thomas Fagerness, Jesen Fears, Scott Fedko, Iryna Fernández, Guillén Fisher, Simon E Foroud, Tatiana Fox, Peter T Francks, Clyde Frangou, Sophia Frey, Eva Maria Frodl, Thomas Frouin, Vincent Garavan, Hugh Giddaluru, Sudheer Glahn, David C Godlewska, Beata Goldstein, Rita Z Gollub, Randy L Grabe, Hans J https://escholarship.org/uc/item/96p6t5f2 Introduction: In January 2025, the United States government froze most foreign assistance and issued a 90-day stop-work order affecting many global health, education, and nutrition programs. Methods: Using a qualitative case study approach, we examined perceptions about experiences around how this abrupt funding disruption affected HIV care in one county in Kenya through in-depth interviews with women and men living with HIV and with healthcare providers. Results: Participants described immediate and severe antiretroviral therapy (ART) rationing and broader, cascading effects across the HIV care continuum, including missed visits, interrupted monitoring, and heightened anxiety about treatment continuity. Respondents also reported that rapid integration of HIV and primary care services-implemented amid the funding shock-undermined confidentiality in clinical settings, intensifying stigma concerns and discouraging care seeking among people living with HIV. Discussion: These findings... https://escholarship.org/uc/item/96p6t5f2 Fri, 25 Sep 2026 00:00:00 +0000 Sedlander, Erica Lawson, Kyla Wairimu, Njeri Werner, Kalin Mutai, Sharon Mwai, Daniel Gandhi, Monica Ngure, Kenneth https://escholarship.org/uc/item/9s74k97w BACKGROUND: Derangements of the renin-angiotensin-aldosterone system may contribute to circulatory dysfunction in cirrhosis. We hypothesized that renin is elevated in patients undergoing liver transplantation (LT) and is associated with vasopressor requirements and postoperative organ dysfunction. METHODS: We collected serum from 138 patients before LT and measured renin by enzyme-linked immunosorbent assay. Eligible patients were adults with cirrhosis undergoing LT from a deceased or living donor. Detailed clinical data were obtained from a perioperative data warehouse. The primary outcome was vasopressor dosage during the dissection phase of LT. The secondary outcomes were postoperative acute kidney injury (AKI) and early allograft dysfunction. RESULTS: Renin was elevated up to 100-fold above normal and strongly correlated with Model for End-Stage Liver Disease sodium. A 10-fold increase in renin was associated with a 0.03 µg/kg/min (95% confidence interval [CI], 0.01-0.05)... https://escholarship.org/uc/item/9s74k97w Thu, 24 Sep 2026 00:00:00 +0000 St Hilaire, Liam Tran, Amy Kothari, Rishi P Adelmann, Dieter Hellman, Judith Bokoch, Michael P https://orcid.org/0000-0003-1387-9547 https://escholarship.org/uc/item/91f2b8p2 BACKGROUND: Psilocybin, a serotonergic psychedelic found in hallucinogenic mushrooms, is metabolized to psilocin, the compound responsible for its psychoactive effects. Psilocybin has demonstrated therapeutic potential for neuropsychiatric conditions. While recent trials have primarily used orally administered synthetic psilocybin, alternative formulations and delivery methods may offer therapeutic advantages, yet the effects of these approaches remain poorly characterized. AIMS: To compare the pharmacodynamic profiles and tolerability of oral psilocybin, oral psilocin, and sublingual psilocin derived from whole-mushroom extracts in healthy adults. METHODS: In this randomized, within-subject, crossover trial, 20 healthy adults (10 men, 10 women; mean age 40.1 ± 5.9 years) completed up to four drug administration sessions involving botanical oral psilocybin (25 mg), oral psilocin (17.5 mg), or sublingual psilocin (2.18, 4.36, or 8 mg). All sessions included therapeutic support... https://escholarship.org/uc/item/91f2b8p2 Thu, 24 Sep 2026 00:00:00 +0000 Tai, Marlene L Szigeti, Balázs Downey, Amanda E Aday, Jacob S Fredenburg, Lisa Sakai, Kimberly Molina, Cesar Fernandes-Osterhold, Gisele Bradley, Ellen R Pantoni, Maddie Moss, Ryan Lightburn, Benjamin Plessow, Franziska O'Donovan, Aoife Woolley, Josh D https://escholarship.org/uc/item/7rp382gn Paroxysmal cold hemoglobinuria (PCH) is an acquired intravascular hemolytic anemia of young children that is usually self-limited. Two patients with PCH have previously been described in the medical literature to have received complement inhibition with eculizumab, an inhibitor of complement C5, and in both cases, the drug was given in the setting of organ failure. No criterion defines when the use of complement inhibition is warranted. We report a previously healthy 23-month-old boy with postviral PCH whose hemoglobin nadir of 2.7 g/dL, undetectable total hemolytic complement (CH50), and elevated soluble C5b-9 represent the most severe anemia among the three reported patients. Despite this laboratory severity, he remained hemodynamically stable with preserved renal function, never requiring vasoactive support or dialysis, and recovered with warmed transfusion and thermal protection after eculizumab was deferred. Our experience suggests that organ failure, rather than anemia or... https://escholarship.org/uc/item/7rp382gn Thu, 24 Sep 2026 00:00:00 +0000 Yu, Colburn https://orcid.org/0009-0007-7457-6992 Rane, Zachary Nedelcu, Elena https://orcid.org/0000-0001-5981-9633 Matsunaga, Alison https://escholarship.org/uc/item/6r730425 Finding Diastole: Palliative Care Fellows, Transformative Learning Theory, and a Narrative Medicine Curriculum https://escholarship.org/uc/item/6r730425 Thu, 24 Sep 2026 00:00:00 +0000 Kuruvilla, Pramita Oyakhire, Adeoluwa https://escholarship.org/uc/item/54j8q8v9 Until there is a cure for amyotrophic lateral sclerosis (ALS), it is imperative that everyone facing this devastating illness receives care to alleviate symptoms and suffering and improve quality of life. Emerging evidence has demonstrated benefits of palliative care for people with ALS, but palliative care is not yet widely available or accessed by people with ALS throughout the disease course. The Palliative Care for ALS Working Group was formed within the International Neuropalliative Care Society, consisting of interprofessional ALS and palliative care clinicians, researchers, advocates, and patients and care partner representatives who are committed to improving palliative care for people living with ALS. The group engaged in a strategic planning process to determine what is needed to advance palliative care for people with ALS over the next 3-5 years. This report outlines the core recommendations from that strategic planning process. Recommendations are divided into five... https://escholarship.org/uc/item/54j8q8v9 Thu, 24 Sep 2026 00:00:00 +0000 Bischoff, Kara E Leavell, Yaowaree L Besbris, Jessica M Lero, Christi Noble, Kelsey Grouls, Astrid Kurent, Jerome Kluger, Benzi M Pantilat, Steven Z https://orcid.org/0000-0003-1004-7892 Mehta, Ambereen K Group, the International Neuropalliative Care Society's Palliative Care for ALS Working https://escholarship.org/uc/item/4b19n3fd Femoral artery stenosis is a rare but serious complication of arterial puncture in neonates, and surgical revascularization is challenging due to small vessel size. We report the case of a premature newborn with limb-threatening ischemia from femoral artery stenosis treated using the native umbilical artery as an autologous bypass graft. The umbilical artery was mobilized, tunneled, and anastomosed distal to the stenosis, restoring perfusion. Postoperative Doppler confirmed graft patency and resolution of ischemia. The patient later died from unrelated respiratory complications. This case highlights the technical feasibility of umbilical artery bypass for neonatal limb salvage and underscores the vulnerability of premature infants. https://escholarship.org/uc/item/4b19n3fd Thu, 24 Sep 2026 00:00:00 +0000 Jin, Flora Jarrin Lopez, Alberto Kim, Sunghoon https://orcid.org/0000-0002-3871-0847 Betts, James https://escholarship.org/uc/item/4326c78d Importance: Approximately 47 million individuals in the US experience food insecurity. Food insecurity adversely impacts treatment and prevention of diet-related health conditions (DRHCs). Health systems are increasingly screening for food insecurity and referring individuals with food insecurity to food assistance. Many people experiencing food insecurity seek care in Health Resources and Services Administration (HRSA) health centers. Objectives: To evaluate the frequency of referrals to food assistance from HRSA health centers and to examine the demographic, socioeconomic, and clinical characteristics of patients who received them. Design, Setting, and Participants: This cross-sectional survey study used data from the 2022 HRSA Healthcare Patient Survey, which included 3616 English- or Spanish-speaking adult patients with at least 1 visit to a HRSA health center from 2021 to 2022; this weighted sample represented 19.6 million patients. Analyses were conducted from August to... https://escholarship.org/uc/item/4326c78d Thu, 24 Sep 2026 00:00:00 +0000 Rohatgi, Karthik Warke https://orcid.org/0000-0003-3207-0145 Fernandez, Alicia Seligman, Hilary Kessler https://escholarship.org/uc/item/3kq257cs Navigating the Emotional Landscape of Kidney Allograft Failure: Patient and Provider Perspectives. https://escholarship.org/uc/item/3kq257cs Thu, 24 Sep 2026 00:00:00 +0000 Yerram, Preethi Brazie, Marc Edwards, Dawn P Howard, Andrew Landry, Daniel McCowan, Precious Sam, Ramin https://orcid.org/0000-0002-4016-6676 Sledge, Renata Baliker, Mary https://escholarship.org/uc/item/1mf026kp PURPOSE: Coaching is an emerging pedagogical strategy in health professions education, aimed at enhancing learners' growth and competency through self-reflection, self-regulated learning, and lifelong learning skills. Coaching programs are resource-intensive due to the training and support required for clinician educators. Through the lens of actor-oriented transfer theory, this study seeks to understand the broader value of coaching programs beyond benefits for learners by investigating how medical student coaches apply coaching skills beyond their direct coaching relationships and the impacts of this skill transfer. METHOD: Using a qualitative interpretivist approach, individual semi-structured interviews were conducted with 11 medical student coaches at UCSF School of Medicine in 2024-2025. The interviews, guided by literature on coaching and actor-oriented transfer, were analyzed inductively using template analysis. RESULTS: Participants described applying coaching skills... https://escholarship.org/uc/item/1mf026kp Thu, 24 Sep 2026 00:00:00 +0000 Hitchner, Lily Kuruvilla, Pramita Hauer, Karen E O’Brien, Bridget C https://escholarship.org/uc/item/14p6p074 Antiarrhythmic drugs can be an important treatment option for patients with heart rhythm disorders, but not all patients and scenarios are represented in trials related to antiarrhythmic drug use. This Heart Rhythm Society scientific statement identifies common clinical scenarios for which little guidance exists, at least partly because they are understudied. It also provides as much practical advice as possible, sourcing available evidence and the clinical proficiency of a diverse group of experienced clinicians, and provides the rationale for each recommendation. https://escholarship.org/uc/item/14p6p074 Thu, 24 Sep 2026 00:00:00 +0000 Morin, Daniel P https://orcid.org/0000-0002-9637-9507 Kaufman, Elizabeth S Campbell, Kristen Bova Epstein, Andrew E Goldberger, Zachary D Görenek, Bülent Hendriks, Jeroen ML Kannankeril, J Tamirisa, Kamala P Valdés, Santiago O Zeitler, Emily P Pothineni, Naga Venkata K https://escholarship.org/uc/item/12q7796j The human cortex is complex and heterogeneous, undergoing extensive expansion during development1,2. Our&nbsp;prior study of neurogenesis, including radial glia (RG), intermediate progenitor cells, excitatory neurons and interneurons demonstrated that chromatin looping underlies transcriptional regulation for lineage-specific genes, shedding light on how non-coding genetic variants contribute to neuropsychiatric disorders by means of cell-type-specific gene regulation3. RG have a crucial role in generating cellular diversity through both neurogenesis and gliogenesis and can be further classified into ventricular RG (vRG) and outer RG (oRG)4,5. Given their significance in cortical development, we conducted a comprehensive three-dimensional (3D) epigenomic analysis of four main glial populations, including vRG, oRG, oligodendrocyte precursor cells and microglia, from the mid-gestational human neocortex. By integrating gene expression, chromatin accessibility, DNA methylation and... https://escholarship.org/uc/item/12q7796j Thu, 24 Sep 2026 00:00:00 +0000 Jones, Ian R Wang, Li Kosicki, Michael https://orcid.org/0000-0001-7173-8852 Battle, Stephanie L Narayan, Vivek JJ Bi, Qiuli Gemenes, Kaila Liu, Yuxi Zhou, Lingbo Song, Mengyi White, Matthew Olson, Wendy Beuchat, Gabriel Dickel, Diane Li, Yun Pennacchio, Len A https://orcid.org/0000-0002-8748-3732 Hawkins, R David Kriegstein, Arnold Shen, Yin https://escholarship.org/uc/item/0b78p0kh Using Serum Lactate Concentration to Correct for the Anion Gap. https://escholarship.org/uc/item/0b78p0kh Thu, 24 Sep 2026 00:00:00 +0000 Sam, Ramin https://orcid.org/0000-0002-4016-6676 https://escholarship.org/uc/item/8dc562x2 Newly Diagnosed Breast Cancer Patient Informational Needs Across Visits: Using AI to Mine Question Lists https://escholarship.org/uc/item/8dc562x2 Tue, 22 Sep 2026 00:00:00 +0000 Camarena, Alondra https://orcid.org/0009-0003-8742-8674 Barkin, Joshua Garza, Venezia Montoya, Daisy Duflock, Annabelle Pama, Alyssa Prashanth, Pranati Li, Thomas Choi, Michael Park, Chaelee Cooper, Olivia Dela Pena, Leila Malekzadeh, Sam Krasnegor, Simona Smith, Emily Juan, Kylie Choi, Sarah De Las Alas, Francesca Belkora, Jeff https://escholarship.org/uc/item/88r80088 Introduction In 2016, UCSF implemented an electronic health record (EHR) based tool, the Supportive Care Needs Survey (SCNS), to systematically identify psychosocial concerns and connect patients with appropriate resources. The American College of Surgeons Commission on Cancer Standard 5.2 mandates direct outreach to patients endorsing moderate distress, substantially increasing social work workload. UCSF partnered with Patient Support Corps (PSC) students to conduct outreach and streamline referrals to social work. PSC is a four-year co-op internship in which pre-health college students earn academic credit while working as healthcare navigators. For this evaluation, we reviewed data collected in 2025 to report on program reach. Design At the start of each of their weekly half-day shifts, students review an EHR report showing all patients who have upcoming appointments in 14 participating cancer clinics. Each student messages up to 40 of these patients per shift via the patient... https://escholarship.org/uc/item/88r80088 Tue, 22 Sep 2026 00:00:00 +0000 Camarena, Alondra https://orcid.org/0009-0003-8742-8674 Sumra, Saffanat Martin, Joshua Duaybis, Daniel Velazquez, Rosa Vichuaco Abary, Princess Macko, Elena Kosoff, Alexander Iuitz, Nathaly Kaur, Gurleen Pham, Rachel Coria Alvarez, Jesus Kaur, Sunit Belkora, Jeff https://escholarship.org/uc/item/6731823v Must Care Be Earned? The Normalization of Sacrifice in Post-Disenhancement Ethics https://escholarship.org/uc/item/6731823v Tue, 22 Sep 2026 00:00:00 +0000 Black, Valerie Hunt, Maya https://escholarship.org/uc/item/2f75p0bm Adenoviral-vectored vaccines are licensed for prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus, but, for bacterial proteins, expression in a eukaryotic cell may affect the antigen's localization and conformation or lead to unwanted glycosylation. Here, we investigated the potential use of an adenoviral-vectored vaccine platform for capsular group B meningococcus (MenB). Vector-based candidate vaccines expressing MenB antigen factor H binding protein (fHbp) were generated, and immunogenicity was assessed in mouse models, including the functional antibody response by serum bactericidal assay (SBA) using human complement. All adenovirus-based vaccine candidates induced high antigen-specific antibody and T cell responses. A single dose induced functional serum bactericidal responses with titers superior or equal to those induced by two doses of protein-based comparators, as well as longer persistence and a similar breadth. The fHbp transgene... https://escholarship.org/uc/item/2f75p0bm Tue, 22 Sep 2026 00:00:00 +0000 Dold, Christina Marsay, Leanne Wang, Nelson Silva-Reyes, Laura Clutterbuck, Elizabeth Paterson, Gavin K Sharkey, Kelsey Wyllie, David Beernink, Peter T Hill, Adrian V Pollard, Andrew J Rollier, Christine S https://escholarship.org/uc/item/28t8j9d6 The Neisseria meningitidis serogroup B (MenB) polysaccharide, α(2-8) polysialic acid (polySia), is essential for resistance to complement-mediated bacteriolysis and inhibition of opsonophagocytosis. The monoclonal antibody SEAM 3 binds de-N-acetyl polySia (dPSA) but not polySia, yet still recognizes encapsulated MenB, indicating the capsule contains dPSA derivatives. Since SEAM 3 also recognizes other pathogens as well as human cancers, we have explored its biological role and mapped the SEAM 3 epitope. We compared binding of N-acetylated and de-N-acetylated polySia and ganglioside GD3 derivatives to sialic-acid-binding immunoglobulin-like lectins (Siglecs) on leukocytes. Siglec-9 showed higher affinity for dPSA and de-N-acetyl GD3 (K_D ∼2.6-3.1 nM) than for their acetylated counterparts, while Siglec-5 bound polySia and GD3 derivatives with similar and moderate (K_D∼40-60 nM and 7.9 nM, respectively) affinity. Siglecs-2, -3, -7, -10, and -11 showed negligible... https://escholarship.org/uc/item/28t8j9d6 Tue, 22 Sep 2026 00:00:00 +0000 Moe, Gregory R Agirre, Jon Beernink, Peter T https://escholarship.org/uc/item/9hh9k18m Objective: The number of missed school days attributable to secondhand smoke (SHS) exposure at home among U.S. children has not been quantified. We estimated the association between SHS exposure at home and school absenteeism and derived national estimates of SHS-attributable missed school days. Methods: We analyzed data from the 2016-2024 National Survey of Children's Health for U.S. children aged 6-11&nbsp;years. Propensity score weighting and two-part models were used to estimate the association between SHS exposure at home and school absenteeism. National estimates of SHS-attributable missed school days were derived by combining model-based attributable fractions with national public school enrollment data. Results: SHS exposure at home was associated with both a higher likelihood of missing school and a greater number of missed school days among children with any absence. In 2024, an estimated 266,008 (95% CI: 139,627, 392,390) missed school days were attributable to SHS... https://escholarship.org/uc/item/9hh9k18m Fri, 18 Sep 2026 00:00:00 +0000 Wang, Yingning Sung, Hai-Yen Max, Wendy Halpern-Felsher, Bonnie Gu, Dian Planche, Sarah Wang, Chunxia https://escholarship.org/uc/item/7px8n0qv Background: Patients with schizophrenia experience gaps in the human immunodeficiency virus (HIV) care continuum. We examined the impact of dual enrollment in Medicare upon HIV testing and retention among Medicaid-enrolled patients with schizophrenia. Methods: Using Medicaid Analytic eXtract and Medicare files from 2008 to 2012, we examined adult participants with schizophrenia enrolled in Medicaid or dually enrolled in Medicare and Medicaid. Our outcomes were (a) HIV testing probability among participants without HIV and (b) retention in HIV care among people living with HIV (PLWH) (two HIV viral loads or CD4+ counts &gt;90&nbsp;days apart and within 1&nbsp;year). Results: The average annual HIV testing probability was 4.9% among dually enrolled and 7.4% among Medicaid-enrolled patients (<i>p</i>&nbsp;&lt;&nbsp;0.001). Compared to Medicaid-only, HIV testing for dually enrolled patients were highest among those with opioid use disorder or sexually transmitted infection (STI);... https://escholarship.org/uc/item/7px8n0qv Thu, 17 Sep 2026 00:00:00 +0000 Murphy, Karly https://orcid.org/0000-0001-5576-8859 Thomas, Marilyn D https://orcid.org/0000-0003-3245-6363 Alonso‐Fraire, Paola Bazazi, Alexander R Dahiya, Priya Olfson, Mark Cournos, Francine Arnold, Emily Dilley, James Wesson, Paul Hermida, Richard Walkup, James Crystal, Stephen Mangurian, Christina https://escholarship.org/uc/item/49j0g5m9 What sustains us—our bodies, our communities, our sense of who we are? In this inaugural volume of the <em>University of California Health Humanities Review</em>, writers, artists, scholars, clinicians, and students from across the University of California explore <strong>Sustenance</strong> in its many forms. Through essays, poetry, art, and creative nonfiction, contributors consider nourishment not simply as food, but as memory, language, caregiving, community, resilience, and human connection. Together, these works illuminate the cultural, historical, social, and ecological dimensions of health, while engaging urgent questions of justice, identity, migration, technology, and healing. Bringing creative expression into conversation with critical inquiry, this volume invites readers to consider what enables individuals and communities not only to survive, but to flourish. https://escholarship.org/uc/item/49j0g5m9 Tue, 15 Sep 2026 00:00:00 +0000 Dolan, Brian Bucknor, Matthew Whang, Audrey https://escholarship.org/uc/item/2wf404xb BackgroundGeneral medicine (GM) research fellowships facilitate health care professionals to obtain the skills and mentored research experience needed for a research career. Yet, little is known about the experience and outcomes of recent graduates of GM fellowships.ObjectiveTo survey (1) GM research fellows and recent graduates and (2) program directors to learn about the opportunities and challenges facing GM research fellowships.DesignCross-sectional retrospective survey study.ParticipantsIndividuals who were enrolled in or completed a GM research fellowship (identified through prior fellow lists, advertising from the Society of General Internal Medicine, and fellowship program directors) between 2012 and 2022 in which ≥ 50% of effort was devoted to training and conducting research; 2022 program directors were recruited separately.Main MeasuresRespondents were asked to rate factors motivating them to pursue a research fellowship and their experiences during fellowship and to... https://escholarship.org/uc/item/2wf404xb Tue, 15 Sep 2026 00:00:00 +0000 Maruthur, Nisa M Ryskina, Kira L Weerahandi, Himali Block, Lauren Cordasco, Kristina M Gilliam, Elizabeth A Kwolek, Deborah Gomez Nelson, Karin Paasche-Orlow, Michael K Schwarz, Eleanor Bimla https://orcid.org/0000-0002-9912-8236 Windish, Donna M Schonberg, Mara A https://escholarship.org/uc/item/1fq951g2 Purpose To assess image quality and detection performance of 0.55-T MRI for common lung pathologies in a multireader study. Materials and Methods Twenty-eight participants were prospectively enrolled at a tertiary academic medical center between January 1, 2023, and August 31, 2023, and underwent same-day chest CT and 0.55-T MRI with respiratory-triggered T2-weighted axial BLADE and T1-weighted ultrashort echo time sequences. Six radiologists evaluated the quality of the MRI using a Likert-type scale and assessed common lung abnormalities. Sensitivity was calculated as the proportion of CT-confirmed lesions detected on MRI and was compared between readers by training status using the Kruskal-Wallis test. Fleiss κ values were calculated for interreader agreement. Nodule measurements were compared between modalities using the Pearson correlation coefficient. Results Twenty-eight participants (mean age ± SD, 59 years ± 19; 17 female) were included. The overall quality of 80% (134... https://escholarship.org/uc/item/1fq951g2 Tue, 15 Sep 2026 00:00:00 +0000 Tang, Felicia Chen, Timothy Ebrahimzadeh, Sayedomid Fields, Brandon KK https://orcid.org/0000-0002-1727-2091 Lee, Yoo Jin Liu, Jonathan Yen, Adam Bowers, Kiara Schonour, Richard B Su, Pan Itriago Leon, Pedro Darwish, Omar Larson, Peder Yang, Yang Sohn, Jae Ho https://escholarship.org/uc/item/1c01465f Background and Objectives: Uterine fibroids are common in women and can lead to symptoms of abnormal uterine bleeding, pelvic pain and bulk symptoms. Treatment can be medical or surgical. This study aims to describe characteristics and outcomes of women undergoing combined laparoscopic radiofrequency ablation (lap-RFA) and laparoscopic myomectomy (lap-MYO) to treat symptomatic uterine fibroids. Methods: This is a multicenter prospective cohort study including both academic centers and private practices. Women in the Uterine Leiomyoma Treatment by Radiofrequency Ablation (ULTRA) Study who were scheduled to undergo surgical management of fibroids underwent a combined lap-RFA and lap-MYO. We assessed quality of life and sexual function changes from before to 12 months after surgery using validated questionnaires. Results: Of the 480 participants in ULTRA, 49 underwent a combined lap-RFA and lap-MYO procedure between 2014 and 2022. The mean number of fibroids treated was 3.6 (standard... https://escholarship.org/uc/item/1c01465f Tue, 15 Sep 2026 00:00:00 +0000 Sendukas, Emily A Shields, Jessica K Kho, Kimberly A Latham, Marisa Jacoby, Vanessa Schembri, Michael Waetjen, L Elaine https://escholarship.org/uc/item/104905t3 INTRODUCTION: The authors' objective was to assess knowledge of and perceived access to long-acting reversible contraceptives (LARC) among individuals in the United States considering tubal sterilization. METHODS: Using online convenience sampling through social media advertisements, the authors recruited 442 US-born individuals considering tubal sterilization for this cross-sectional study. Eligibility criteria included age 21-45 years, female sex, premenopausal, desire to avoid future pregnancy, and no history of tubal sterilization, hysterectomy, or infertility treatment. After confirming eligibility, participants completed a 45-item online survey assessing sociodemographic characteristics, contraceptive and pregnancy history, and awareness of LARC. Chi-square tests and multivariate linear regression were used to identify sociodemographic variables associated with knowledge of and perceived access to LARC. RESULTS: Among these diverse (39% Black, 36% White, 10% Hispanic and... https://escholarship.org/uc/item/104905t3 Tue, 15 Sep 2026 00:00:00 +0000 Treder, Kelly Chiang, Amy Okobi, Agatha Schwarz, Eleanor Bimla https://orcid.org/0000-0002-9912-8236 https://escholarship.org/uc/item/4z9515xw BACKGROUND: Despite increasing incidence of stroke among younger adults, the associations of social determinants of health (SDOH) and stroke among younger adults are not well known. This study investigates the associations between SDOH from early adulthood and stroke in a prospective longitudinal cohort. METHODS: We studied participants enrolled in the CARDIA study (Coronary Artery Risk Development in Young Adults). Participants aged 18 to 30 years were enrolled in 1985 and followed through 2022. We investigated longitudinal, time-varying measures of SDOH classified into 5 distinct domains: economic (6 measures), education (1 measure), healthcare (4 measures), neighborhood (2 measures), and social/community (5 measures). The outcome was incident stroke or transient ischemic attack. We evaluated associations between individual SDOH and stroke using unadjusted Cox models. We then evaluated whether a greater cumulative number of adverse SDOH domains (each represented by 1 exposure... https://escholarship.org/uc/item/4z9515xw Mon, 14 Sep 2026 00:00:00 +0000 Fleming, Nathaniel https://orcid.org/0000-0001-8130-9189 Dintica, Christina https://orcid.org/0000-0001-8186-8140 Arynchyn, Alexander Lloyd-Jones, Donald M Lackland, Daniel Yaffe, Kristine https://escholarship.org/uc/item/5kp6n177 Background: The European Bone and Joint Infection Society (EBJIS)/Musculoskeletal Infection Society (MSIS) criteria provide a framework for diagnosing hip periprosthetic joint infection, yet daily clinical application lacks a standardized algorithm. Since these criteria rely heavily on synovial fluid markers, surgeons encounter 2 primary dilemmas: the reliability of aspiration techniques (ultrasound vs fluoroscopy) and the economic trade-off between higher-cost proprietary assays and standard institutional laboratories. This cost-effectiveness analysis was conducted to identify the diagnostic pathway that maximizes clinical benefit while minimizing expenditure within the EBJIS/MSIS framework. Methods: A decision tree model simulated the diagnostic workup of a 67-year-old patient with suspected hip periprosthetic joint infection. Ten strategies were evaluated, comparing aspiration modality and laboratory method (institutional, point-of-care, and third-party analysis). The model... https://escholarship.org/uc/item/5kp6n177 Sat, 12 Sep 2026 00:00:00 +0000 Diaz-Ledezma, Claudio Zedan, Ahmad M Xiao, Angel Barber, Thomas https://escholarship.org/uc/item/5344n2jm Background Osteoporosis is a well-established risk factor for early femoral failure following cementless total hip arthroplasty (THA). The performance of cementless collared triple-taper stems (CTTSs) in patients with a confirmed diagnosis of osteoporosis remains poorly defined. This study aimed to evaluate early clinico-radiographic outcomes of CTTS in osteoporotic patients undergoing elective THA. Methods We retrospectively reviewed 96 patients (87.5% women; mean age 69.5 ± 7.4 years) who underwent elective THA with a CTTS between 2018 and 2025. Osteoporosis was confirmed by either dual-energy x-ray absorptiometry T-score ≤ −2.5 or history of fragility fracture. Preoperative morphology and postoperative canal fill ratios, alignment, and subsidence (&gt;3 mm) were assessed. Femoral failure was defined as periprosthetic fracture or aseptic loosening. Results Preoperative morphology demonstrated a predominance of wide canals (Dorr B: 67.5%, Dorr C: 26%) and a mean morphological... https://escholarship.org/uc/item/5344n2jm Sat, 12 Sep 2026 00:00:00 +0000 Zedan, Ahmad M Abrolat, Jessica L Diaz, Maithily Zhong, Alan Barry, Jeffrey J Hansen, Erik N Bini, Stefano A Diaz-Ledezma, Claudio https://escholarship.org/uc/item/9zt439nr Comment sections on social media websites such as YouTube provide a unique venue to observe contemporaneous audience interpretation and discussion of entertainment television content. While entertainment-education research has largely examined whether and how exposure to television content influences viewer knowledge, attitudes, and beliefs, analyzing comment sections provides an opportunity to observe how audiences interpret and discuss these plotlines in an organic setting. We examined comments posted to YouTube clips of entertainment television abortion plotlines to document how these comments explicitly discussed the plotlines depicted and what themes emerged in these discussions. We identified 15 YouTube clips of abortion plotlines posted between 2018 and 2023 on official network accounts. We used thematic analysis techniques to qualitatively assess the top 20 comments and replies for each video (n = 162). Twenty-six percent of all comments referenced the content of the clip.... https://escholarship.org/uc/item/9zt439nr Fri, 11 Sep 2026 00:00:00 +0000 Herold, Stephanie https://orcid.org/0000-0003-2592-3883 Narendorf, Piper Hoffman, Beth https://escholarship.org/uc/item/6qp8s2dz Importance: Afghans are one of the world's largest refugee populations. Afghan women face compounded health risks due to sociocultural restrictions, low literacy, forced displacement, and limited health care access, yet little is known about their experiences with health care after resettlement in the US. Objective: To explore health and health care access issues of Afghan refugee women in the US. Design, Setting, and Participants: This qualitative study was part of an ongoing community-based participatory research project started in July 2020. Bilingual investigators conducted semistructured interviews with Afghan refugee women in Dari or English. Dari interviews were interpreted to English by a fluent bilingual investigator, validated by a separate bilingual investigator, and then reviewed with an Afghan immigrant community member for accuracy. Transcribed interviews were analyzed using grounded theory from July 2023 to July 2024. Participants who self-identified as Afghan,... https://escholarship.org/uc/item/6qp8s2dz Fri, 11 Sep 2026 00:00:00 +0000 Kandahari, Nazineen Kayhani, Nilufar N Zada, Fareha Moulana Kayhani, Zahra Noor, Zarin Nelson, Nicholas Ivey, Susan L https://orcid.org/0000-0002-8921-7032 https://escholarship.org/uc/item/52q0s9rb Analyzing a growing body of epidemiological research that considers coronavirus disease 2019 (COVID-19) as an occupational disease situates teaching (eg, pre-kindergarten, elementary, secondary) among the more vulnerable occupations. Teachers have experienced a higher risk of COVID-19 infection, hospitalization, death, and Long COVID than people from many other occupations. More research attending to occupational patterns and risk mitigation is needed. Taking an occupational epidemiology approach for teachers can inform a wide array of policy solutions, including school environment improvements that can support infection control, like air cleaning and ventilation, as well as supporting teachers experiencing disproportionate burdens of COVID-19, including those living with Long COVID. https://escholarship.org/uc/item/52q0s9rb Fri, 11 Sep 2026 00:00:00 +0000 Cohen, Alison K Bartlett, Lora