© 2016 Elsevier Ltd The US DOE-funded National Risk Assessment Partnership (NRAP) has developed an integrated assessment model (NRAP-IAM-CS) that can be used to simulate carbon dioxide (CO2) injection, migration, and associated impacts at a geologic carbon storage site. The model, NRAP-IAM-CS, incorporates a system-modeling-based approach while taking into account the full subsurface system from the storage reservoir to groundwater aquifers and the atmosphere. The approach utilizes reduced order models (ROMs) that allow fast computations of entire system performance even for periods of hundreds to thousands of years. The ROMs are run in Monte Carlo mode allowing estimation of uncertainties of the entire system without requiring long computational times. The NRAP-IAM-CS incorporates ROMs that realistically represent several key processes and properties of storage reservoirs, wells, seals, and groundwater aquifers. Results from the NRAP-IAM-CS model are used to quantify risk profiles for selected parameter distributions of reservoir properties, seal properties, numbers of wells, well properties, thief zones, and groundwater aquifer properties. A series of examples is used to illustrate how the risk under different storage conditions evolves over time, both during injection, in the near-term post injection period, and over the long term. It is also shown how results from NRAP-IAM-CS can be used to investigate the importance of different parameters on risk of leakage and risk of groundwater contamination under different storage conditions.