The cost of prescription medicines has recently been rising faster than other healthcare costs. This is also true for traditionally inexpensive generic medications that have long served as a fundamental healthcare safety net in the USA. These changes increasingly present challenges for individuals to obtain common medications. Owing to rising insurance co-pays, even patients who have prescription medication insurance coverage are beginning to experience challenges in this area. This document was created to help patients and their families consider various strategies and programs that exist in 2015 for reducing their out-of-pocket costs for their prescription medications. We believe that this information can also be helpful to healthcare providers when counseling patients about managing rapidly rising prescription drug costs. An effort has been made to make this document readable to patients and their families as well as to healthcare providers.