Concomitant inhibition of multiple cancer-driving kinases is an established strategy to improve the durability of clinical responses to targeted therapies. The difficulty of discovering kinase inhibitors with an appropriate multitarget profile has, however

By analyzing a data set of 2.92 fb$^{-1}$ of $e^+e^-$ collision data taken at $\sqrt s= 3.773~\rm GeV$ and 106.41$\times 10^{6}$ $\psi(3686)$ decays taken at $\sqrt s= 3.686~\rm GeV$ with the BESIII detector at the BEPCII collider, we measure the branching fraction and the partial decay width for $\psi(3770)\to\gamma\chi_{c0}$ to be ${\mathcal B}(\psi(3770)\to\gamma\chi_{c0})=(6.88\pm0.28\pm0.67)\times 10^{-3}$ and $\Gamma[\psi(3770)\to\gamma\chi_{c0}]=(187\pm8\pm19)~\rm keV$, respectively. These are the most precise measurements to date.

By analyzing 2.93 fb$^{-1}$ data collected at the center-of-mass energy $\sqrt s=3.773$ GeV with the BESIII detector, we measure the absolute branching fraction of the semileptonic decay $D^+\rightarrow\bar K^0 e^{+}\nu_{e}$ to be ${\mathcal B}(D^{+}\rightarrow\bar K^0 e^{+}\nu_{e})=(8.59 \pm 0.14 \pm 0.21)\%$ using $\bar K^0\to K^0_S\to \pi^0\pi^0$, where the first uncertainty is statistical and the second systematic. Our result is consistent with previous measurements within uncertainties.