Interference alignment (IA) was shown to be effective for interference management in improving transmission rate in terms of the degree of freedom (DoF) gain. On the other hand, orthogonal space-time block codes were widely used in point-to-point multiantenna channels to enhance transmission reliability in terms of the diversity gain. In this paper, we connect these two ideas, i.e., IA and space-time block coding, to improve the designs of alignment precoders for multiuser networks. Specifically, we consider the use of Alamouti codes for IA because of their rate-one transmission and achievability of full diversity in point-to-point systems. The Alamouti codes protect the desired link by introducing orthogonality between the two symbols in one Alamouti codeword, and create alignment at the interfering receiver. We show that the proposed alignment methods can maintain the maximum DoF gain and improve the ergodic mutual information in the long-term regime, while increasing the diversity gain to 2 in the short-term regime. The presented examples of interference networks have two antennas at each node and include the two-user X channel, the interfering multiaccess channel, and the interfering broadcast channel. © 1963-2012 IEEE.