A new probabilistic technique for establishing the existence of certain regular combinatorial structures has been introduced by Kuperberg, Lovett, and Peled (STOC 2012). Using this technique, it can be shown that under certain conditions, a randomly chosen structure has the required properties of a t-(n,k,λ) combinatorial design with tiny, yet positive, probability. The proof method of KLP is adapted to show the existence of large sets of designs and similar combinatorial structures as follows. We modify the random choice and the analysis to show that, under the same conditions, not only does a t-(n,k,λ) design exist but, in fact, with positive probability there exists a large set of such designs — that is, a partition of the set of k-subsets of [n] into t-(n,k,λ) designs. Specifically, using the probabilistic approach derived herein, we prove that for all sufficiently large n, large sets of t-(n,k,λ) designs exist whenever k>12t and the necessary divisibility conditions are satisfied. This resolves the existence conjecture for large sets of designs for all k>12t.