- Gottlieb, DJ
- Hek, K
- Chen, T-H
- Watson, NF
- Eiriksdottir, G
- Byrne, EM
- Cornelis, M
- Warby, SC
- Bandinelli, S
- Cherkas, L
- Evans, DS
- Grabe, HJ
- Lahti, J
- Li, M
- Lehtimäki, T
- Lumley, T
- Marciante, KD
- Pérusse, L
- Psaty, BM
- Robbins, J
- Tranah, GJ
- Vink, JM
- Wilk, JB
- Stafford, JM
- Bellis, C
- Biffar, R
- Bouchard, C
- Cade, B
- Curhan, GC
- Eriksson, JG
- Ewert, R
- Ferrucci, L
- Fülöp, T
- Gehrman, PR
- Goodloe, R
- Harris, TB
- Heath, AC
- Hernandez, D
- Hofman, A
- Hottenga, J-J
- Hunter, DJ
- Jensen, MK
- Johnson, AD
- Kähönen, M
- Kao, L
- Kraft, P
- Larkin, EK
- Lauderdale, DS
- Luik, AI
- Medici, M
- Montgomery, GW
- Palotie, A
- Patel, SR
- Pistis, G
- Porcu, E
- Quaye, L
- Raitakari, O
- Redline, S
- Rimm, EB
- Rotter, JI
- Smith, AV
- Spector, TD
- Teumer, A
- Uitterlinden, AG
- Vohl, M-C
- Widen, E
- Willemsen, G
- Young, T
- Zhang, X
- Liu, Y
- Blangero, J
- Boomsma, DI
- Gudnason, V
- Hu, F
- Mangino, M
- Martin, NG
- O'Connor, GT
- Stone, KL
- Tanaka, T
- Viikari, J
- Gharib, SA
- Punjabi, NM
- Räikkönen, K
- Völzke, H
- Mignot, E
- Tiemeier, H
- et al.
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.