- Ritter, McKenzie L
- Guo, Wei
- Samuels, Jack F
- Wang, Ying
- Nestadt, Paul S
- Krasnow, Janice
- Greenberg, Benjamin D
- Fyer, Abby J
- McCracken, James T
- Geller, Daniel A
- Murphy, Dennis L
- Knowles, James A
- Grados, Marco A
- Riddle, Mark A
- Rasmussen, Steven A
- McLaughlin, Nicole C
- Nurmi, Erika L
- Askland, Kathleen D
- Cullen, Bernadette
- Piacentini, John
- Pauls, David L
- Bienvenu, Joseph
- Stewart, Evelyn
- Goes, Fernando S
- Maher, Brion
- Pulver, Ann E
- Mattheisen, Manuel
- Qian, Ji
- Nestadt, Gerald
- Shugart, Yin Yao
- et al.
Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.