We conducted a comprehensive economic analysis of rodent control in swine production facilities. An interdisciplinary working group was assembled to identify all necessary input variables and values associated with rodent damage and control. We incorporated data from production models, scientific literature, product literature, producers and personal experience into an interactive STELLA systems model. The model generates cost-benefit analyses and predicts outcomes of various levels of control of house mice for site-specific swine confinement facilities. We developed a website on rodent control (http://rodent.swine.unl.edu/) to promote use of the model, increase producer awareness of the costs associated with house mouse damage, and provide information on integrated strategies for managing rodents. Although the model is relatively robust and comprehensive, we noted important gaps in research-based information, particularly associated with the economic impacts of rodents in disease transmission, feed contamination, food safety, quality assurance, and human dimensions. We will continue to improve the model and website as new information becomes available.