- Watts, Eleanor L
- Perez-Cornago, Aurora
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- Albanes, Demetrius
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- Bueno-de-Mesquita, H Bas
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- Chen, Chu
- Chubb, SA Paul
- Cook, Michael B
- Deschasaux, Mélanie
- Donovan, Jenny L
- English, Dallas R
- Flicker, Leon
- Freedman, Neal D
- Galan, Pilar
- Giles, Graham G
- Giovannucci, Edward L
- Gunter, Marc J
- Habel, Laurel A
- Häggström, Christel
- Haiman, Christopher
- Hamdy, Freddie C
- Hercberg, Serge
- Holly, Jeff M
- Huang, Jiaqi
- Huang, Wen-Yi
- Johansson, Mattias
- Kaaks, Rudolf
- Kubo, Tatsuhiko
- Lane, J Athene
- Layne, Tracy M
- Le Marchand, Loic
- Martin, Richard M
- Metter, E Jeffrey
- Mikami, Kazuya
- Milne, Roger L
- Morris, Howard A
- Mucci, Lorelei A
- Neal, David E
- Neuhouser, Marian L
- Oliver, Steven E
- Overvad, Kim
- Ozasa, Kotaro
- Pala, Valeria
- Pernar, Claire H
- Pollak, Michael
- Rowlands, Mari-Anne
- Schaefer, Catherine A
- Schenk, Jeannette M
- Stattin, Pär
- Tamakoshi, Akiko
- Thysell, Elin
- Touvier, Mathilde
- Trichopoulou, Antonia
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- et al.
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.