In 2010, the Health Resources and Services Administration (HRSA) established the Community Health Applied Research Net- work (CHARN) to build research infrastructure and capacity at community health centers (CHCs) and to promote comparative effectiveness research in these safety-net settings. A data warehouse with standardized data was created to capture, manage, and share patient-level data with all eighteen participating CHCs, including four CHCs primarily serving Asian American, Native Hawaiian, and Other Pacific Islanders (AANHOPI). AANHOPI patients face unique health risks, yet these large and diverse populations are historically understudied. The CHARN data warehouse provides important opportunities for understanding the health needs of this heterogeneous population.