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Scholarly Works (2 results)

Article
Peer Reviewed

An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions

Lomen-Hoerth, Catherine;
Pattee, GL;
Wymer, JP;
Appel, SH;
Formella, AE;
Pope, LE

UC San Francisco Previously Published Works (2014)

© 2014 Informa UK Ltd.Background: Pseudobulbar affect (PBA) is associated with neurological disorders or injury affecting the brain, and characterized by frequent, uncontrollable episodes of crying and/or laughing that are exaggerated or unrelated to the p

Article
Peer Reviewed

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.

McGrath, Michael;
Miller, RG;
Block, G;
Katz, JS;
Barohn, RJ;
Gopalakrishnan, V;
Cudkowicz, M;
Zhang, JR;
McGrath, MS;
Ludington, E;
Appel, SH

UC San Francisco Previously Published Works (2015)

To assess the safety, tolerability, and preliminary efficacy of NP001, a novel immune regulator of inflammatory monocytes/macrophages, for slowing progression of amyotrophic lateral sclerosis (ALS).This was a phase 2 randomized, double-blind, placebo-contr