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Scholarly Works (2 results)

Article
Peer Reviewed

Potential therapeutic benefit of C1-esterase inhibitor in neuromyelitis optica evaluated in vitro and in an experimental rat model

Verkman, Alan;
Tradtrantip, L;
Asavapanumas, N;
Phuan, PW;
Verkman, AS

UC San Francisco Previously Published Works (2014)

© 2014 Tradtrantip et al.Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system in which binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to astrocytes causes complement-dependent cytotoxicity (CDC) and i

Article
Peer Reviewed

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

Verkman, Alan;
Asavapanumas, N;
Ratelade, J;
Papadopoulos, MC;
Bennett, JL;
Levin, MH;
Verkman, AS

UC San Francisco Previously Published Works (2014)

Background: Although optic neuritis (ON) is a defining feature of neuromyelitis optica (NMO), appropriate animal models of NMO ON are lacking. Most NMO patients are seropositive for immunoglobulin G autoantibodies (NMO-IgG) against the astrocyte water chan