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Open Access Publications from the University of California

Scholarly Works (2 results)

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Project HX (2019)

Dear Readers,

Project Hx is a collection of narratives and photographs with a goal to highlight the rich diversity of the medical community. It is a portraiture of people’s stories and backgrounds, their experiences and adventures in healthcare, and ultimately a way to show a human side behind the oftentimes faceless nature of medicine. We aim to document these stories and perspectives in the form of biographical interviews and portrait photography as a way to provide our audience with daily glimpses into the human lives surrounding medicine. The people interviewed portray only a fraction of the countless number of unique attitudes and ideologies that represent the medical community, but we hope that it can serve as kindling for continued conversation. While reading the stories, please keep in mind that narratives are powerful only when they are genuine. They can be genuine only under the climate of acceptance and open-mindedness. Thus, we hope that each story is received free of judgment and prejudice.This year’s fourth issue is particularly personal, as it explores the thoughts and opinions that medical students and healthcare providers have regarding mental health in medicine, and their own personal journey towards finding strength in this profession. Given the intimate nature of this theme, most of our interviewees opted towards anonymity, but we are grateful that they were willing to step forward to reveal their personal struggles, and put a face - though not in the literal sense - on the true reality of mental health challenges that come with the rigorous journey towards becoming a physician.

Sincerely,

Project Hx Team

UC Irvine School of Medicine

Editor-In-Chiefs: Thalia Nguyen, Soe Thein; Design Editor: May Hui

    Cover page: Project Hx: Mental Health MattersCreative Commons 'BY' version 4.0 license
    • Article
    • Peer Reviewed
    UC Irvine Previously Published Works (2023)

    Background

    Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a clinicopathological construct proposed to facilitate studying TDP-43 pathology in older individuals.

    Objective

    Our aim was to describe clinical and cognitive characteristics of LATE-NC without Alzheimer's disease neuropathologic change (ADNC) and Lewy body (LB) and to compare this with ADNC and primary age related tauopathy (PART).

    Methods

    In 364 autopsies of the oldest old of The 90+ Study, we identified those with LATE-NC without ADNC and LB. Control groups were participants with ADNC and PART.

    Results

    Of 31% of participants who had LATE-NC, only 5 (1.4%) had LATE-NC without ADNC and LB, all of whom had tau. These participants had a gradual and progressive cognitive decline. Four (80%) had dementia at death, a rate that was higher than ADNC (50%) and PART (21.7%). Mean duration of cognitive impairment was twice as long in LATE-NC without ADNC and LB (6.2 years) compared to ADNC (2.9 years) and PART (3 years). LATE-NC without ADNC and LB group had a higher prevalence of syncope, depression, and extrapyramidal signs than the ADNC and PART groups.

    Conclusions

    Despite the high prevalence of LATE-NC, LATE-NC without ADNC and LB was rare in this large oldest-old cohort, highlighting the very high prevalence of multiple pathologic changes in the oldest old. Slowly progressive cognitive decline, ubiquitous memory impairment, history of syncope and depression, and extrapyramidal signs were prominent features among our LATE-NC without ADNC and LB group.
      Cover page: Characterizing Limbic-Predominant Age-Related TDP-43 Encephalopathy Without Alzheimer’s Disease and Lewy Body Dementia in the Oldest Old: A Case Series
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