Latina women living in low-income communities frequently report a high prevalence of feeling physically and/or emotionally "unwell." Formative focus groups were used to design a 3-session stress reduction curriculum called ¡Venga y Relájese! (Come and relax yourself!). Survey data from 5 Milwaukee cohorts and 1 Peruvian cohort revealed statistically significant improvements in general health status, perceived stress status, and confidence to manage future stress among women who completed all sessions (n=54). The pilot ¡Venga y Relájese! stress reduction curriculum yielded benefits for Latina women living in low-income neighborhoods in Milwaukee, Wisconsin and Lima, Peru.